| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rajina Shakya, Gyu Hwan Park, Sang Hoon Joo, Jung-Hyun Shim, Joon-Seok Cho. Hydroxyzine Induces Cell Death in Triple-Negative Breast Cancer Cells via Mitochondrial Superoxide and Modulation of Jak2/STAT3 Signaling. Biomolecules & therapeutics. vol 30. issue 6. 2022-10-28. PMID:36305293. |
western blot analysis showed that hydroxyzine-induced apoptosis was through down-regulation of the phosphorylation of jak2 and stat3 by hydroxyzine treatment. |
2022-10-28 |
2023-08-14 |
human |
| Xin Li, Wenkai Jiang, Shi Dong, Wancheng Li, Weixiong Zhu, Wence Zho. STAT3 Inhibitors: A Novel Insight for Anticancer Therapy of Pancreatic Cancer. Biomolecules. vol 12. issue 10. 2022-10-27. PMID:36291659. |
among them, stat3 is involved in cell proliferation, differentiation, apoptosis, and inflammatory responses. |
2022-10-27 |
2023-08-14 |
Not clear |
| Katja Seipel, Yvo Brügger, Harpreet Mandhair, Ulrike Bacher, Thomas Pabs. Rationale for Combining the BCL2 Inhibitor Venetoclax with the PI3K Inhibitor Bimiralisib in the Treatment of IDH2- and FLT3-Mutated Acute Myeloid Leukemia. International journal of molecular sciences. vol 23. issue 20. 2022-10-27. PMID:36293442. |
in this study, the bcl-xl inhibitor a1331852, mcl1-inhibitor s63845, dual pi3k-mtor inhibitor bimiralisib (pqr309), bmi-1 inhibitor unesbulin (ptc596), mek-inhibitor trametinib (gsk1120212), and stat3 inhibitor c-188-9 were assessed as single agents and in combination with venetoclax, for their ability to induce apoptosis and cell death in leukemic cells grown in the absence or presence of bone marrow stroma. |
2022-10-27 |
2023-08-14 |
Not clear |
| Feng Guan, Youming Ding, Yikang He, Lu Li, Xinyu Yang, Changhua Wang, Mingbai H. Involvement of adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 in diallyl trisulfide-induced cytotoxicity in hepatocellular carcinoma cells. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 26. issue 6. 2022-10-27. PMID:36302621. |
compared with wild-type appl1, overexpression of appl1 k63r mutant dramatically increased cell apoptosis and mitigated cell survival, along with a reduction of phosphorylation of stat3, akt, and erk1/2. |
2022-10-27 |
2023-08-14 |
human |
| Yueh-Shan Weng, I-Tsang Chiang, Jai-Jen Tsai, Yu-Chang Liu, Fei-Ting Hs. Lenvatinib Synergistically Promotes Radiation Therapy in Hepatocellular Carcinoma by Inhibiting Src/STAT3/NF-κB-Mediated Epithelial-Mesenchymal Transition and Metastasis. International journal of radiation oncology, biology, physics. 2022-10-17. PMID:36245124. |
this study suggested that lenvatinib may incapacitate hepatocellular carcinoma (hcc) to radiation treatment by abrogating radiation-induced src/signal transducer and the activator of transcription 3 signaling (stat3)/nuclear factor-κb (nf-κb) to escalate radiation-induced extrinsic and intrinsic apoptosis. |
2022-10-17 |
2023-08-14 |
Not clear |
| Jun-Kui Li, Hai-Tao Sun, Xiao-Li Jiang, Yi-Fei Chen, Zhu Zhang, Ying Wang, Wen-Qing Chen, Zhang Zhang, Stephen Cho Wing Sze, Pei-Li Zhu, Ken Kin Lam Yun. Polyphyllin II Induces Protective Autophagy and Apoptosis via Inhibiting PI3K/AKT/mTOR and STAT3 Signaling in Colorectal Cancer Cells. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36233191. |
polyphyllin ii induces protective autophagy and apoptosis via inhibiting pi3k/akt/mtor and stat3 signaling in colorectal cancer cells. |
2022-10-14 |
2023-08-14 |
Not clear |
| Tingting Kong, Zhenxue He, Shuying Wang, Chunxin Jiang, Fei Zhu, Jingjing Gao, Liu Li, Yanping Wang, Qing Xie, Yunsen L. Diterpenoid DGA induces apoptosis via endoplasmic reticulum stress caused by changes in glycosphingolipid composition and inhibition of STAT3 in glioma cells. Biochemical pharmacology. vol 205. 2022-10-10. PMID:36210604. |
diterpenoid dga induces apoptosis via endoplasmic reticulum stress caused by changes in glycosphingolipid composition and inhibition of stat3 in glioma cells. |
2022-10-10 |
2023-08-14 |
mouse |
| Tingting Kong, Zhenxue He, Shuying Wang, Chunxin Jiang, Fei Zhu, Jingjing Gao, Liu Li, Yanping Wang, Qing Xie, Yunsen L. Diterpenoid DGA induces apoptosis via endoplasmic reticulum stress caused by changes in glycosphingolipid composition and inhibition of STAT3 in glioma cells. Biochemical pharmacology. vol 205. 2022-10-10. PMID:36210604. |
moreover, western blotting showed dga inhibited the signal transducers and activators of transcription 3 (stat3) signaling pathway by reducing the phosphorylation of stat3 and its upstream kinases, which also promoted the apoptosis of glioma cells. |
2022-10-10 |
2023-08-14 |
mouse |
| Min Zhou, Ping Zhang, Mengting Da, Rui Yang, Yulian Ma, Jiuda Zhao, Tao Ma, Jiazeng Xia, Guoshuang Shen, Yu Chen, Daozhen Che. A pan-cancer analysis of the expression of STAT family genes in tumors and their relationship to the tumor microenvironment. Frontiers in oncology. vol 12. 2022-09-30. PMID:36176415. |
the signal transducer and activator of transcription (stat) protein family, a group of seven members (stat1, stat2, stat3, stat4, stat5a, stat5b, and stat6), has been widely used to investigate numerous biological functions including cell proliferation, differentiation, apoptosis, and immune regulation. |
2022-09-30 |
2023-08-14 |
Not clear |
| Shuzhen Liu, Dongmei Yu, Peng Wei, Jiansheng Cai, Min Xu, Haoyu He, Xu Tang, Chuntao Nong, Yi Wei, Xia Xu, Xiaoting Mo, Zhiyong Zhang, Jian Qi. JAK2/STAT3 Signaling Pathway and Klotho Gene in Cadmium-induced Neurotoxicity In Vitro and In Vivo. Biological trace element research. 2022-09-27. PMID:36166115. |
in comparison with the high-dose cd exposure group, after adding tyrphostin ag490 (ag490), the apoptosis rate of pc12 cells increased, whereas the phosphorylation levels of jak2 and stat3 in the cells decreased significantly (p < 0.05). |
2022-09-27 |
2023-08-14 |
rat |
| Xuqing Li, Li Wang, Xinwang Ying, Yujun Zheng, Qianqian Tan, Xiaolan Yu, Jiahong Gong, Ming Li, Xiaofeng Deng, Guanhu Yang, Shengcun Li, Songhe Jian. Electroacupuncture pre-treatment alleviates sepsis-induced cardiac inflammation and dysfunction by inhibiting the calpain-2/STAT3 pathway. Frontiers in physiology. vol 13. 2022-09-26. PMID:36160853. |
additionally, inhibition of calpain-2 expression using the corresponding sirna decreased the phosphorylation of stat3,pro-inflammatory factors and apoptosis in lipopolysaccharide- treated cardiomyocytes, confirming that calpain-2 activated p-stat3 participate in septic cardiomyopathy. |
2022-09-26 |
2023-08-14 |
mouse |
| Antonella Di Sotto, Marco Gullì, Marco Minacori, Romina Mancinelli, Stefania Garzoli, Ester Percaccio, Alessio Incocciati, Donatella Romaniello, Gabriela Mazzanti, Margherita Eufemi, Silvia Di Giacom. β-Caryophyllene Counteracts Chemoresistance Induced by Cigarette Smoke in Triple-Negative Breast Cancer MDA-MB-468 Cells. Biomedicines. vol 10. issue 9. 2022-09-23. PMID:36140359. |
β-caryophyllene was found to be able to increase the csc-induced death of mda-mb-468 cells, likely triggering oxidative stress, cell cycle arrest and apoptosis; moreover, it hindered cell recovery, autophagy activation and cell migration; at last, a marked inhibition of the signal transducer and activator of transcription 3 (stat3) activation was highlighted: this could represent a key mechanism of the chemoprevention by β-caryophyllene. |
2022-09-23 |
2023-08-14 |
human |
| Arshad Husain Rahmani, Mohammed A Alsahli, Ahmad Almatroudi, Mashael Abdullah Almogbel, Amjad Ali Khan, Shehwaz Anwar, Saleh A Almatrood. The Potential Role of Apigenin in Cancer Prevention and Treatment. Molecules (Basel, Switzerland). vol 27. issue 18. 2022-09-23. PMID:36144783. |
moreover, the anti-cancer potential of apigenin is confirmed through its ability to modulate various cell signalling pathways, including tumor suppressor genes, angiogenesis, apoptosis, cell cycle, inflammation, apoptosis, pi3k/akt, nf-κb, mapk/erk and stat3 pathways. |
2022-09-23 |
2023-08-14 |
Not clear |
| Qi-Bing Liu, Ren-Hui Zhou, Chong-Mei Li. TLR9/FCRL3 regulates B cell viability, apoptosis, and antibody and IL-10 production through ERK1/2, p38, and STAT3 signaling pathways. In vitro cellular & developmental biology. Animal. 2022-09-19. PMID:36121575. |
tlr9/fcrl3 regulates b cell viability, apoptosis, and antibody and il-10 production through erk1/2, p38, and stat3 signaling pathways. |
2022-09-19 |
2023-08-14 |
Not clear |
| Qi-Bing Liu, Ren-Hui Zhou, Chong-Mei Li. TLR9/FCRL3 regulates B cell viability, apoptosis, and antibody and IL-10 production through ERK1/2, p38, and STAT3 signaling pathways. In vitro cellular & developmental biology. Animal. 2022-09-19. PMID:36121575. |
these results indicate that tlr9 activation affects b cell proliferation, apoptosis, antibody production, and il-10 secretion by upregulating fcrl3 expression, and is associated with erk1/2, p38, and stat3 pathways. |
2022-09-19 |
2023-08-14 |
Not clear |
| Manal Alfwuaires, Hany Elsawy, Azza Sedk. Acacetin Inhibits Cell Proliferation and Induces Apoptosis in Human Hepatocellular Carcinoma Cell Lines. Molecules (Basel, Switzerland). vol 27. issue 17. 2022-09-09. PMID:36080130. |
we used a functional proteomics tumor pathway technology platform and multiple hcc cell lines to investigate the effects of acacetin (acn) on stat3 activation, protein kinases, phosphatases, products of stat3-regulated genes, and apoptosis. |
2022-09-09 |
2023-08-14 |
human |
| Wei Li, Tao Huang, Shenghan Xu, Bangwei Che, Ying Yu, Wenjun Zhang, Kaifa Tan. Molecular Mechanism of Tanshinone against Prostate Cancer. Molecules (Basel, Switzerland). vol 27. issue 17. 2022-09-09. PMID:36080361. |
several studies have shown that tanshinone can target various molecular pathways of pca, including the signal transducer and activator of transcription 3 (stat3) pathway, androgen receptor (ar) pathway, phosphatidylinositol-3-kinase (pi3k)/protein kinase b (akt)/mammalian target of rapamycin (mtor) pathway, and mitogen-activated protein kinase (mapk) pathway, which will affect the release of pro-inflammatory cytokines and affect cell proliferation, apoptosis, tumor metabolism, genomic stability, and tumor drug resistance. |
2022-09-09 |
2023-08-14 |
Not clear |
| Pengyu Zhang, Qiang Zhang, Zhenxia Sha. Silence of S1PR4 Represses the Activation of Fibroblast-like Synoviocytes by Regulating IL-17/STAT3 Signaling Pathway. Inflammation. 2022-09-06. PMID:36068391. |
the silence of s1pr4 decreases the proliferation, migration, proinflammation, and promotes the apoptosis of ra-flss, accompanied with repressing interleukin-17 (il-17)/signal transducer and activator of transcription 3 (stat3) signal pathway. |
2022-09-06 |
2023-08-14 |
human |
| Mateo Ruiz-Conca, Jaume Gardela, Teresa Mogas, Manel López-Béjar, Manuel Álvarez-Rodrígue. Apoptosis and glucocorticoid-related genes mRNA expression is modulated by coenzyme Q10 supplementation during in vitro maturation and vitrification of bovine oocytes and cumulus cells. Theriogenology. vol 192. 2022-09-05. PMID:36063671. |
we also studied the mrna expression of nr3c1-related genes belonging to the gc regulation pathway, such as hydroxysteroid dehydrogenases (hsd11b1; hsd11b2), immunophilins (fkbp4; fkbp5), signal transducers and activators of transcription (stat3; stat5a), the mineralocorticoid receptor (nr3c2), and to the apoptosis pathway, such as the anti- (bcl2) and pro-apoptotic (bax) mrna transcripts in oocytes and cumulus cells 1) after ivm, and 2) after vitrification, both in presence or absence of q10 supplementation during ivm. |
2022-09-05 |
2023-08-14 |
cattle |
| Yue Xie, Zhao-Wei Zheng, Hao-Ting He, Zhi-Bo Chan. LncRNA NEAT1 induces autophagy through the miR-128-3p/ADAM28 axis to suppress apoptosis of nonsmall-cell lung cancer. The Kaohsiung journal of medical sciences. 2022-09-02. PMID:36054559. |
furthermore, adam28 overexpression attenuated mir-128-3p overexpression-induced apoptosis and autophagy inhibition in nsclc by increasing the phosphorylation of jak2 and stat3. |
2022-09-02 |
2023-08-14 |
mouse |