| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yingying Chen, Huan Tao, Fujue Wang, Pengqiang Wu, Jie Gao, Xue Zhang, Zhengcang He, Zhencang Zhou, Yongqian Ji. Artesunate synergistically promotes sorafenib‑induced apoptosis and ferroptosis in non‑Hodgkin lymphoma cells through inhibition of the STAT3 pathway. Oncology reports. vol 50. issue 1. 2023-06-16. PMID:37326033. |
artesunate synergistically promotes sorafenib‑induced apoptosis and ferroptosis in non‑hodgkin lymphoma cells through inhibition of the stat3 pathway. |
2023-06-16 |
2023-08-14 |
Not clear |
| Yingying Chen, Huan Tao, Fujue Wang, Pengqiang Wu, Jie Gao, Xue Zhang, Zhengcang He, Zhencang Zhou, Yongqian Ji. Artesunate synergistically promotes sorafenib‑induced apoptosis and ferroptosis in non‑Hodgkin lymphoma cells through inhibition of the STAT3 pathway. Oncology reports. vol 50. issue 1. 2023-06-16. PMID:37326033. |
further studies revealed that signal transducer and activator of transcription 3 (stat3) contributed to ferroptosis induced by art and sor in nhl cells, and genetic inhibition of stat3 promoted art/sor‑induced ferroptosis and apoptosis, concomitantly reducing the expression levels of glutathione peroxidase 4 and myeloid cell leukemia‑1. |
2023-06-16 |
2023-08-14 |
Not clear |
| Yingying Chen, Huan Tao, Fujue Wang, Pengqiang Wu, Jie Gao, Xue Zhang, Zhengcang He, Zhencang Zhou, Yongqian Ji. Artesunate synergistically promotes sorafenib‑induced apoptosis and ferroptosis in non‑Hodgkin lymphoma cells through inhibition of the STAT3 pathway. Oncology reports. vol 50. issue 1. 2023-06-16. PMID:37326033. |
collectively, these findings indicated that art acted synergistically with sor to inhibit cell viability, and to induce apoptosis and ferroptosis through regulating the stat3 pathway in nhl. |
2023-06-16 |
2023-08-14 |
Not clear |
| Lintong Men, Junyi Guo, Yu Cao, Bingyu Huang, Qian Wang, Shengqi Huo, Moran Wang, Dewei Peng, Lulu Peng, Wei Shi, Sheng Li, Li Lin, Jiagao L. IL-6/gp130/STAT3 signaling contributed to the activation of the PERK arm of the unfolded protein response in response to chronic β-adrenergic stimulation. Free radical biology & medicine. 2023-06-12. PMID:37307935. |
inhibiting il-6/gp130 pathway by bazedoxifene and inhibiting stat3 by stattic both reversed isoproterenol-induced stat3-y705 phosphorylation, ros production, perk activation, ire1α activation, and cardiomyocytes apoptosis in vitro. |
2023-06-12 |
2023-08-14 |
mouse |
| Moli Wu, Danyang Song, Hui Li, Nisar Ahmad, Hong Xu, Xiaobo Yang, Qian Wang, Xiaoxin Cheng, Sa Deng, Xiaohong Sh. Resveratrol Enhances Temozolomide Efficacy in Glioblastoma Cells through Downregulated MGMT and Negative Regulators-Related STAT3 Inactivation. International journal of molecular sciences. vol 24. issue 11. 2023-06-11. PMID:37298405. |
the combined use of res and tmz downregulated stat3 activity and stat3-regulated gene products, thus inhibited cell proliferation and migration, as well as induced apoptosis, accompanied by increased levels of its negative regulators: pias3, shp1, shp2, and socs3. |
2023-06-11 |
2023-08-14 |
Not clear |
| Che-Jui Yang, Zhao-Lin Tan, Jr-Di Yang, Fei-Ting Hsu, Chih-Hung Chian. Fluoxetine inactivates STAT3/NF-κB signaling and promotes sensitivity to cisplatin in bladder cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 164. 2023-06-05. PMID:37276643. |
in summary, the induction of apoptosis and the inhibition of invasion triggered by fluoxetine are associated with the inactivation of stat3 and nf-κb. |
2023-06-05 |
2023-08-14 |
mouse |
| P Kurowska, K Gazdzik, A Jasinska, E Mlyczynska, D Wachowska, A Ra. Resistin as a new player in the regulation of porcine corpus luteum luteolysis: in vitro effect on proliferation/viability, apoptosis and autophagy. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 74. issue 1. 2023-05-28. PMID:37245230. |
thus, the aim of the present study was to examine the in vitro effect of resistin on the proliferation/viability, apoptosis and autophagy of porcine luteal cells as well as the involvement of mitogen-activated kinase (map3/1), protein kinase b (akt) and signal transducer and activator of transcription 3 (stat3) in these processes. |
2023-05-28 |
2023-08-14 |
Not clear |
| Jeonghyeon Seo, Da Eun Lee, Seong Mi Kim, Eunjung Kim, Jin-Kyung Ki. Licochalcone A Exerts Anti-Cancer Activity by Inhibiting STAT3 in SKOV3 Human Ovarian Cancer Cells. Biomedicines. vol 11. issue 5. 2023-05-27. PMID:37238935. |
the expression levels of proteins regulating cell apoptosis, cell cycle, and the signal transducer and activator of transcription 3 (stat3) signaling pathways were examined using western blotting analysis. |
2023-05-27 |
2023-08-14 |
human |
| Jeonghyeon Seo, Da Eun Lee, Seong Mi Kim, Eunjung Kim, Jin-Kyung Ki. Licochalcone A Exerts Anti-Cancer Activity by Inhibiting STAT3 in SKOV3 Human Ovarian Cancer Cells. Biomedicines. vol 11. issue 5. 2023-05-27. PMID:37238935. |
furthermore, lica induced an increase in ros levels, a reduction in mitochondrial membrane potential, and apoptosis accompanied by an increase in cleaved caspases and cytoplasmic cytochrome c. additionally, lica caused a dramatic decrease in stat3 protein levels, but not mrna levels, in skov3 cells. |
2023-05-27 |
2023-08-14 |
human |
| Zhenyan Hou, Songwen Lin, Tingting Du, Mingjin Wang, Weida Wang, Shen You, Nina Xue, Yichen Liu, Ming Ji, Heng Xu, Xiaoguang Che. S-72, a Novel Orally Available Tubulin Inhibitor, Overcomes Paclitaxel Resistance via Inactivation of the STING Pathway in Breast Cancer. Pharmaceuticals (Basel, Switzerland). vol 16. issue 5. 2023-05-27. PMID:37242532. |
as a characterized tubulin inhibitor, s-72 typically inhibits tubulin polymerization and further triggers mitosis-phase cell cycle arrest and cell apoptosis, in addition to suppressing stat3 signaling. |
2023-05-27 |
2023-08-14 |
Not clear |
| Yan Li, Ying Zhang, Lei Gua. MiR-708 regulates the biological behavior of childhood leukemia cells by binding to the 3'utr end of the target gene and reducing the level of the target gene. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 2. 2023-05-25. PMID:37224029. |
the results showed that the cell proliferation inhibition rate, apoptosis rate, g1 phase ratio, bax protein, and cntfr protein in the mir-708 overexpression group were significantly lower than those in the control group at each time point, while the s phase ratio, bcl-2 protein, cell migration ability, jak3 and stat3 protein were significantly higher than those in the control group (p<0.05). |
2023-05-25 |
2023-08-14 |
human |
| Canli Yuan, Mei Yuan, Wenyu Li, Hai Cheng, Jianping Luo, Qi Zhang, Mengya Shi, Mingshan Niu, Jiajia Yang, Zengtian Sun, Zhiling Yan, Kailin Xu, Zhenyu Li, Yao Ya. The STAT3 inhibitor stattic overcome bortezomib-resistance in multiple myeloma via decreasing PSMB6. Experimental cell research. 2023-05-19. PMID:37207970. |
interestingly, a stat3 inhibitor, stattic, is shown to selectively inhibit psmb6 and induce apoptosis in bortezomib resistant and sensitive mm cells, even with il-6 induction. |
2023-05-19 |
2023-08-14 |
Not clear |
| Rebai Ben Amma. Potential Effects of Geraniol on Cancer and Inflammation-Related Diseases: A Review of the Recent Research Findings. Molecules (Basel, Switzerland). vol 28. issue 9. 2023-05-14. PMID:37175079. |
in addition, gnl induces apoptosis and cell cycle arrest, modulates multiple molecular targets, including p53 and stat3, activates caspases, and modulates inflammation via transcriptional regulation. |
2023-05-14 |
2023-08-14 |
Not clear |
| Xuehua Zhang, Leilei Zhao, Jinlong Xiao, Yudi Wang, Yunmeng Li, Chaoqun Zhu, He Zhang, Yurui Zhang, Xiao Zhu, Yucui Don. 5-Demethylnobiletin mediates cell cycle arrest and apoptosis Frontiers in oncology. vol 13. 2023-05-04. PMID:37139163. |
mechanically, 5-demethylnobiletin trigged g0/g1 phase arrest and apoptosis by inhibiting the erk1/2, akt and stat3 signaling pathway. |
2023-05-04 |
2023-08-14 |
Not clear |
| Carmen Amititeloaie, Liliana Chelaru, Gabriela Luminiţa Geleţu, Anca Sava, Alexandra Jităreanu, Andreea Mihaela Tibeică, Marcel Costulean. Apoptosis of pro-B lymphocytes induced by NR4A1 activation in the presence of gingival fibroblast exosomes and TNFα, caspase 8, STAT3, and Akt pathways modulators. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 64. issue 1. 2023-05-02. PMID:37128789. |
apoptosis of pro-b lymphocytes induced by nr4a1 activation in the presence of gingival fibroblast exosomes and tnfα, caspase 8, stat3, and akt pathways modulators. |
2023-05-02 |
2023-08-14 |
Not clear |
| Carmen Amititeloaie, Liliana Chelaru, Gabriela Luminiţa Geleţu, Anca Sava, Alexandra Jităreanu, Andreea Mihaela Tibeică, Marcel Costulean. Apoptosis of pro-B lymphocytes induced by NR4A1 activation in the presence of gingival fibroblast exosomes and TNFα, caspase 8, STAT3, and Akt pathways modulators. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 64. issue 1. 2023-05-02. PMID:37128789. |
in order to experimentally evaluate the apoptosis of pro-b type lymphocytes, induced as a result of the known activation of orphan nuclear receptor 4a1 (nr4a1), through cytosporone b (csn-b, 10 μm), in the presence or absence of exosomes derived from gingival fibroblasts, we administered as a treatment: 1 μm r-7050 [functional inhibitor of tumor necrosis factor alpha (tnfα)], 1 μm z-ietd-fmk (functional inhibitor of caspase 8), 1 μm gsk690693 (functional inhibitor of akt 1∕2∕3 pathways) and, last but not least, 1 μm scutellarin [functional inhibitor of receptor activator of nuclear factor-kappa b ligand (rankl)] and therefore of the signal transducer and activator of transcription 3 (stat3) pathway. |
2023-05-02 |
2023-08-14 |
Not clear |
| Tingting Xia, Meng Zhang, Wei Lei, Ruilin Yang, Shengping Fu, Zhenhai Fan, Ying Yang, Tao Zhan. Advances in the role of STAT3 in macrophage polarization. Frontiers in immunology. vol 14. 2023-04-21. PMID:37081874. |
the physiological processes of cell growth, proliferation, differentiation, and apoptosis are closely related to stat3, and it has been demonstrated that aberrant stat3 expression has an impact on the onset and progression of a number of inflammatory immunological disorders, fibrotic diseases, and malignancies. |
2023-04-21 |
2023-08-14 |
Not clear |
| Mehrdad Hashemi, Eisa Sabouni, Parham Rahmanian, Maliheh Entezari, Mahsa Mojtabavi, Behnaz Raei, Mohammad Arad Zandieh, Mitra Behroozaghdam, Sepideh Mirzaei, Kiavash Hushmandi, Noushin Nabavi, Shokooh Salimimoghadam, Jun Ren, Mohsen Rashidi, Rasoul Raesi, Afshin Taheriazam, Athanasios Alexiou, Marios Papadakis, Shing Cheng Ta. Deciphering STAT3 signaling potential in hepatocellular carcinoma: tumorigenesis, treatment resistance, and pharmacological significance. Cellular & molecular biology letters. vol 28. issue 1. 2023-04-21. PMID:37085753. |
this review addresses the function of stat3 as an oncogenic factor in hcc, as stat3 is able to prevent apoptosis and thus promote the progression of hcc. |
2023-04-21 |
2023-08-14 |
human |
| Yue Wang, Fengyi Deng, Xing Zhong, Yijun Du, Xingyu Fan, Hong Su, Tianrong Pa. Dulaglutide provides protection against sepsis-induced lung injury in mice by inhibiting inflammation and apoptosis. European journal of pharmacology. 2023-04-16. PMID:37062504. |
collectively, our data demonstrated that glp-1ra exerts a protective effect against sepsis-induced lung injury through mechanisms related to the inhibition of inflammation, apoptosis, and stat3 signaling. |
2023-04-16 |
2023-08-14 |
mouse |
| Aisha Nawaz, Sumera Zaib, Imtiaz Khan, Abrar Ahmed, Kiran Shahzadi, Huma Ria. Silybum marianum: an overview of its phytochemistry and pharmacological activities with emphasis on potential anticancer properties. Anti-cancer agents in medicinal chemistry. 2023-04-14. PMID:37055902. |
sm exhibited anticancer properties due to being capable of modifying the induction of apoptosis, inhibiting the stat3 pathway, decreasing the transcription of various growth factors, impeding the growth of 4t1 cells and inducing cell cycle arrest in various types of cancers, i.e., skin cancer, liver cancer, breast cancer, ovarian cancer etc. |
2023-04-14 |
2023-08-14 |
Not clear |