| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chao Liang, Ying Bai, Rui Miao, Xuelian Yang, Lu Gao, Yafeng Liu, Jiawei Zhou, Jianqiang Guo, Dong Hu, Jing W. Celastrol as a candidate drug for silicosis: From bioinformatics and network pharmacology to experimental validation. International immunopharmacology. vol 125. issue Pt B. 2023-11-10. PMID:37948856. |
in vitro, celastrol suppressed cs-induced cytokine expression, apoptosis of macrophages and activation of stat3 and erk1/2 signals. |
2023-11-10 |
2023-11-20 |
mouse |
| J Arévalo, I Campoy, M Durán, S Nemours, A Areny, M Vall-Palomar, C Martínez, G Cantero-Recasens, A Mesegue. STAT3 phosphorylation at serine 727 activates specific genetic programs and promotes clear cell renal cell carcinoma (ccRCC) aggressiveness. Scientific reports. vol 13. issue 1. 2023-11-09. PMID:37945711. |
the signal transducer and activator of transcription 3 (stat3) is a transcription factor mainly activated by phosphorylation in either tyrosine 705 (y705) or serine 727 (s727) residues that regulates essential processes such as cell differentiation, apoptosis inhibition, or cell survival. |
2023-11-09 |
2023-11-20 |
human |
| Zhizhuan Guo, Wenwen Zhong, Zhengshou Zo. miR-98-5p Prevents Hippocampal Neurons from Oxidative Stress and Apoptosis by Targeting STAT3 in Epilepsy in vitro. Neuropsychiatric disease and treatment. vol 19. 2023-11-06. PMID:37928166. |
mir-98-5p prevents hippocampal neurons from oxidative stress and apoptosis by targeting stat3 in epilepsy in vitro. |
2023-11-06 |
2023-11-08 |
Not clear |
| Po-Chang Shih, Miyako Naganuma, Genichiro Tsuji, Yosuke Demizu, Mikihiko Nait. Development of decoy oligonucleotide-warheaded chimeric molecules targeting STAT3. Bioorganic & medicinal chemistry. vol 95. 2023-11-03. PMID:37922656. |
a double-stranded decoy oligonucleotide specific to stat3 was conjugated to e3 binders (pomalidomide, vh032, and lcl161) to generate protac molecules that recruited different e3 ubiquitin ligases cereblon (crbn), von hippel-lindau (vhl), and inhibitor of apoptosis protein (iap), respectively. |
2023-11-03 |
2023-11-08 |
Not clear |
| Linyan Xu, Jun Jiao, Mengdi Liu, Yuanyuan Qin, Meng Zhang, Dongmei Yan, Kailin Xu, Wei San. A Combination of CPI-0610 and SAHA Induces Apoptosis through STAT3 and p38 Signalling Pathways in Diffuse Large B-cell Lymphoma Cells. Current medicinal chemistry. 2023-11-02. PMID:37916635. |
a combination of cpi-0610 and saha induces apoptosis through stat3 and p38 signalling pathways in diffuse large b-cell lymphoma cells. |
2023-11-02 |
2023-11-08 |
Not clear |
| Rajina Shakya, Mi Ran Byun, Sang Hoon Joo, Kyung-Soo Chun, Joon-Seok Cho. Domperidone Exerts Antitumor Activity in Triple-Negative Breast Cancer Cells by Modulating Reactive Oxygen Species and JAK/STAT3 Signaling. Biomolecules & therapeutics. vol 31. issue 6. 2023-10-30. PMID:37899746. |
immunoblot analysis showed that domperidone-induced apoptosis occurred through the down-regulation of the phosphorylation of jak2 and stat3. |
2023-10-30 |
2023-11-08 |
human |
| Min Hee Yang, Gautam Sethi, Akshay Ravish, Arun Kumar Mohan, Vijay Pandey, Peter E Lobie, Shreeja Basappa, Basappa Basappa, Kwang Seok Ah. Discovery of imidazopyridine-pyrazoline-hybrid structure as SHP-1 agonist that suppresses phospho-STAT3 signaling in human breast cancer cells. Chemico-biological interactions. 2023-10-25. PMID:37879592. |
further, silencing of shp-1 gene reversed the dip-induced attenuation of stat3 activation and apoptosis. |
2023-10-25 |
2023-11-08 |
human |
| Shuaishuai Huang, Minyi Sun, Yu Ren, Ting Luo, Xue Wang, Guobin Weng, Dong Ce. Solamargine induces apoptosis of human renal carcinoma cells via downregulating phosphorylated STAT3 expression. Oncology letters. vol 26. issue 5. 2023-10-20. PMID:37854861. |
solamargine induces apoptosis of human renal carcinoma cells via downregulating phosphorylated stat3 expression. |
2023-10-20 |
2023-11-08 |
human |
| Qiang Gu, Ying-Bin Xiao, Yong Wan. Silencing suppressor of cytokine signaling 3 induces apoptosis and activates the p-STAT3/NF-κB pathway in hypoxic cultivated H9c2 cells. Journal of physiology and biochemistry. 2023-10-19. PMID:37856074. |
in the study, we investigated the effect of socs3 on the p65 and stat3 signaling pathways and further examined the potential molecular mechanism involved in regulating apoptosis. |
2023-10-19 |
2023-11-08 |
Not clear |
| Bingge Zhang, Huali Wan, Maimaitijian Maierwufu, Qian Liu, Ting Li, Ye He, Xin Wang, Gongping Liu, Xiaoyue Hong, Qiong Fen. STAT3 ameliorates truncated tau-induced cognitive deficits. Neural regeneration research. vol 19. issue 4. 2023-10-16. PMID:37843229. |
evidence suggests that signal transduction and activator of transcription-3 (stat3) is associated with modulating synaptic plasticity, cell apoptosis, and cognitive function. |
2023-10-16 |
2023-11-08 |
mouse |
| Xin-Yue Zhao, Ying-Ying Tian, Chuang Liu, Yi-Lin Li, Ying-Nan Lyu, Shang-Yue Yu, Shi-Qiu Tian, Hai-Luan Pei, Ze-Ping Zuo, Zhi-Bin Wan. [Morin induces autophagy and apoptosis in hepatocellular carcinoma cells through Akt/mTOR/STAT3 pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 16. 2023-10-06. PMID:37802874. |
this study investigated the effect and mechanism of morin in inducing autophagy and apoptosis in hepatocellular carcinoma cells through the protein kinase b(akt)/mammalian target of rapamycin(mtor)/signal transducer and activator of transcription protein 3(stat3) pathway. |
2023-10-06 |
2023-10-15 |
human |
| Xin-Yue Zhao, Ying-Ying Tian, Chuang Liu, Yi-Lin Li, Ying-Nan Lyu, Shang-Yue Yu, Shi-Qiu Tian, Hai-Luan Pei, Ze-Ping Zuo, Zhi-Bin Wan. [Morin induces autophagy and apoptosis in hepatocellular carcinoma cells through Akt/mTOR/STAT3 pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 16. 2023-10-06. PMID:37802874. |
compared with the control group, the morin groups showed decreased viability of sk-hep-1 cells in a time-and concentration-dependent manner, increased number of apoptotic cells, up-regulated expression level of apoptosis marker parp, up-regulated phosphorylation level of apoptosis-regulating protein h2ax, decreased number of positive cells and the colony formation rate, an upward trend of expression levels of autophagy-related proteins lc3-Ⅱ, atg5, and atg7, and decreased phosphorylation levels of akt, mtor, and stat3. |
2023-10-06 |
2023-10-15 |
human |
| Maedeh Bejari, Soheila Talesh Sasani, S Mohsen Asghari, Mozhgan Nabatzade Kolsha. Vascular endothelial growth factor antagonist peptides inhibit tumor growth and metastasis in breast cancer through repression of c-src and STAT3 genes. Molecular biology reports. 2023-10-03. PMID:37789224. |
given that src activates stat3 (signal transducers and activators of transcription) repressing apoptosis and promoting the cell cycle, it may be an important object for cancer treatment. |
2023-10-03 |
2023-10-07 |
Not clear |
| Caiqi Zhao, Wei Wang, Yan Bai, Gaurang Amonkar, Hongmei Mou, Judith Olejnik, Adam J Hume, Elke Mühlberger, Yinshan Fang, Jianwen Que, Rachel Fearns, Xingbin Ai, Paul H Lero. Age-related STAT3 signaling regulates severity of respiratory syncytial viral infection in human bronchial epithelial cells. bioRxiv : the preprint server for biology. 2023-10-02. PMID:37781574. |
mechanistically, rsv-infected neonatal ciliated cells displayed age-related impairment of stat3 activation, rendering susceptibility to apoptosis, which facilitated viral spread. |
2023-10-02 |
2023-10-07 |
human |
| Xinzhe Fang, Weiyi Huang, Qiang Sun, Yang Zhao, Rui Sun, Fang Liu, Danmei Huang, Yanmei Zhang, Fenfei Gao, Bin Wan. Melatonin attenuates cellular senescence and apoptosis in diabetic nephropathy by regulating STAT3 phosphorylation. Life sciences. 2023-09-22. PMID:37739161. |
melatonin attenuates cellular senescence and apoptosis in diabetic nephropathy by regulating stat3 phosphorylation. |
2023-09-22 |
2023-10-07 |
Not clear |
| Xinzhe Fang, Weiyi Huang, Qiang Sun, Yang Zhao, Rui Sun, Fang Liu, Danmei Huang, Yanmei Zhang, Fenfei Gao, Bin Wan. Melatonin attenuates cellular senescence and apoptosis in diabetic nephropathy by regulating STAT3 phosphorylation. Life sciences. 2023-09-22. PMID:37739161. |
to discover the possible mechanism by which melatonin prevents dn, we investigated the potential effects of melatonin on signal transducer and activator of transcription 3 (stat3) on the progression of cellular senescence and apoptosis. |
2023-09-22 |
2023-10-07 |
Not clear |
| Li Wang, Wenzhan Tu, Xuqing Li, Caiyan Li, Junhong Lu, Peng Dai, Yuewei Chen, Meilin Gu, Ming Li, Songhe Jiang, Guanhu Yang, Shengcun L. Exercise improves cardiac function and attenuates myocardial inflammation and apoptosis by regulating APJ/STAT3 in mice with stroke. Life sciences. 2023-09-01. PMID:37657526. |
stat3 inhibition also reduced apoptosis and proinflammatory factors in mice hearts. |
2023-09-01 |
2023-09-07 |
mouse |
| Linxiang Cai, Ying Wang, Hanhua Chen, Yehong Tan, Tao Yang, Shuren Zhang, Zijian Guo, Xiaoyong Wan. Platinum(IV) Complexes as Inhibitors of STAT3 and Regulators of the Tumor Microenvironment To Control Breast Cancer. Journal of medicinal chemistry. 2023-08-14. PMID:37578941. |
these complexes exerted remarkable antiproliferative activity against the triple-negative bc cells, suppressed the expression of phosphorylated stat3 and stat3-related cyclooxygenase-2 and il-6, and activated caspase-3 and cleaved poly adp-ribose polymerase, preventing the repair of dna lesions and inducing apoptosis. |
2023-08-14 |
2023-09-07 |
Not clear |
| Christopher A Lucchesi, Demitria M Vasilatis, Saisamkalpa Mantrala, Thenappan Chandrasekar, Maria Mudryj, Paramita M Ghos. Pesticides and Bladder Cancer: Mechanisms Leading to Anti-Cancer Drug Chemoresistance and New Chemosensitization Strategies. International journal of molecular sciences. vol 24. issue 14. 2023-07-29. PMID:37511154. |
this review highlights multiple pathways modulated by pesticide exposure with direct links to bladder cancer oncogenesis/metastasis (mmp-2, tgf-β, stat3) and chemoresistance (drug efflux, dna repair, and apoptosis resistance) and potential therapeutic tactics to counter these pesticide-induced affects. |
2023-07-29 |
2023-08-14 |
Not clear |
| Chao-Yu Hsu, Wei-Ting Yang, Ju-Hwa Lin, Chien-Hsing Lu, Kai-Cheng Hu, Tsuo-Hung Lan, Chia-Che Chan. Sertindole, an Antipsychotic Drug, Curbs the STAT3/BCL-xL Axis to Elicit Human Bladder Cancer Cell Apoptosis In Vitro. International journal of molecular sciences. vol 24. issue 14. 2023-07-29. PMID:37511611. |
notably, ectopic expression of the dominant-active stat3 mutant impaired sertindole-induced apoptosis in addition to restoring bcl-xl expression. |
2023-07-29 |
2023-08-14 |
human |