| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xin-Yue Zhao, Ying-Ying Tian, Chuang Liu, Yi-Lin Li, Ying-Nan Lyu, Shang-Yue Yu, Shi-Qiu Tian, Hai-Luan Pei, Ze-Ping Zuo, Zhi-Bin Wan. [Morin induces autophagy and apoptosis in hepatocellular carcinoma cells through Akt/mTOR/STAT3 pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 16. 2023-10-06. PMID:37802874. |
this study investigated the effect and mechanism of morin in inducing autophagy and apoptosis in hepatocellular carcinoma cells through the protein kinase b(akt)/mammalian target of rapamycin(mtor)/signal transducer and activator of transcription protein 3(stat3) pathway. |
2023-10-06 |
2023-10-15 |
human |
| Xin-Yue Zhao, Ying-Ying Tian, Chuang Liu, Yi-Lin Li, Ying-Nan Lyu, Shang-Yue Yu, Shi-Qiu Tian, Hai-Luan Pei, Ze-Ping Zuo, Zhi-Bin Wan. [Morin induces autophagy and apoptosis in hepatocellular carcinoma cells through Akt/mTOR/STAT3 pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 16. 2023-10-06. PMID:37802874. |
compared with the control group, the morin groups showed decreased viability of sk-hep-1 cells in a time-and concentration-dependent manner, increased number of apoptotic cells, up-regulated expression level of apoptosis marker parp, up-regulated phosphorylation level of apoptosis-regulating protein h2ax, decreased number of positive cells and the colony formation rate, an upward trend of expression levels of autophagy-related proteins lc3-Ⅱ, atg5, and atg7, and decreased phosphorylation levels of akt, mtor, and stat3. |
2023-10-06 |
2023-10-15 |
human |
| Maedeh Bejari, Soheila Talesh Sasani, S Mohsen Asghari, Mozhgan Nabatzade Kolsha. Vascular endothelial growth factor antagonist peptides inhibit tumor growth and metastasis in breast cancer through repression of c-src and STAT3 genes. Molecular biology reports. 2023-10-03. PMID:37789224. |
given that src activates stat3 (signal transducers and activators of transcription) repressing apoptosis and promoting the cell cycle, it may be an important object for cancer treatment. |
2023-10-03 |
2023-10-07 |
Not clear |
| Caiqi Zhao, Wei Wang, Yan Bai, Gaurang Amonkar, Hongmei Mou, Judith Olejnik, Adam J Hume, Elke Mühlberger, Yinshan Fang, Jianwen Que, Rachel Fearns, Xingbin Ai, Paul H Lero. Age-related STAT3 signaling regulates severity of respiratory syncytial viral infection in human bronchial epithelial cells. bioRxiv : the preprint server for biology. 2023-10-02. PMID:37781574. |
mechanistically, rsv-infected neonatal ciliated cells displayed age-related impairment of stat3 activation, rendering susceptibility to apoptosis, which facilitated viral spread. |
2023-10-02 |
2023-10-07 |
human |
| Xinzhe Fang, Weiyi Huang, Qiang Sun, Yang Zhao, Rui Sun, Fang Liu, Danmei Huang, Yanmei Zhang, Fenfei Gao, Bin Wan. Melatonin attenuates cellular senescence and apoptosis in diabetic nephropathy by regulating STAT3 phosphorylation. Life sciences. 2023-09-22. PMID:37739161. |
melatonin attenuates cellular senescence and apoptosis in diabetic nephropathy by regulating stat3 phosphorylation. |
2023-09-22 |
2023-10-07 |
Not clear |
| Xinzhe Fang, Weiyi Huang, Qiang Sun, Yang Zhao, Rui Sun, Fang Liu, Danmei Huang, Yanmei Zhang, Fenfei Gao, Bin Wan. Melatonin attenuates cellular senescence and apoptosis in diabetic nephropathy by regulating STAT3 phosphorylation. Life sciences. 2023-09-22. PMID:37739161. |
to discover the possible mechanism by which melatonin prevents dn, we investigated the potential effects of melatonin on signal transducer and activator of transcription 3 (stat3) on the progression of cellular senescence and apoptosis. |
2023-09-22 |
2023-10-07 |
Not clear |
| Li Wang, Wenzhan Tu, Xuqing Li, Caiyan Li, Junhong Lu, Peng Dai, Yuewei Chen, Meilin Gu, Ming Li, Songhe Jiang, Guanhu Yang, Shengcun L. Exercise improves cardiac function and attenuates myocardial inflammation and apoptosis by regulating APJ/STAT3 in mice with stroke. Life sciences. 2023-09-01. PMID:37657526. |
stat3 inhibition also reduced apoptosis and proinflammatory factors in mice hearts. |
2023-09-01 |
2023-09-07 |
mouse |
| Linxiang Cai, Ying Wang, Hanhua Chen, Yehong Tan, Tao Yang, Shuren Zhang, Zijian Guo, Xiaoyong Wan. Platinum(IV) Complexes as Inhibitors of STAT3 and Regulators of the Tumor Microenvironment To Control Breast Cancer. Journal of medicinal chemistry. 2023-08-14. PMID:37578941. |
these complexes exerted remarkable antiproliferative activity against the triple-negative bc cells, suppressed the expression of phosphorylated stat3 and stat3-related cyclooxygenase-2 and il-6, and activated caspase-3 and cleaved poly adp-ribose polymerase, preventing the repair of dna lesions and inducing apoptosis. |
2023-08-14 |
2023-09-07 |
Not clear |
| Christopher A Lucchesi, Demitria M Vasilatis, Saisamkalpa Mantrala, Thenappan Chandrasekar, Maria Mudryj, Paramita M Ghos. Pesticides and Bladder Cancer: Mechanisms Leading to Anti-Cancer Drug Chemoresistance and New Chemosensitization Strategies. International journal of molecular sciences. vol 24. issue 14. 2023-07-29. PMID:37511154. |
this review highlights multiple pathways modulated by pesticide exposure with direct links to bladder cancer oncogenesis/metastasis (mmp-2, tgf-β, stat3) and chemoresistance (drug efflux, dna repair, and apoptosis resistance) and potential therapeutic tactics to counter these pesticide-induced affects. |
2023-07-29 |
2023-08-14 |
Not clear |
| Chao-Yu Hsu, Wei-Ting Yang, Ju-Hwa Lin, Chien-Hsing Lu, Kai-Cheng Hu, Tsuo-Hung Lan, Chia-Che Chan. Sertindole, an Antipsychotic Drug, Curbs the STAT3/BCL-xL Axis to Elicit Human Bladder Cancer Cell Apoptosis In Vitro. International journal of molecular sciences. vol 24. issue 14. 2023-07-29. PMID:37511611. |
notably, ectopic expression of the dominant-active stat3 mutant impaired sertindole-induced apoptosis in addition to restoring bcl-xl expression. |
2023-07-29 |
2023-08-14 |
human |
| Chao-Yu Hsu, Wei-Ting Yang, Ju-Hwa Lin, Chien-Hsing Lu, Kai-Cheng Hu, Tsuo-Hung Lan, Chia-Che Chan. Sertindole, an Antipsychotic Drug, Curbs the STAT3/BCL-xL Axis to Elicit Human Bladder Cancer Cell Apoptosis In Vitro. International journal of molecular sciences. vol 24. issue 14. 2023-07-29. PMID:37511611. |
moreover, bladder cancer cells overexpressing bcl-xl were refractory to sertindole's proapoptotic action, arguing that sertindole represses stat3 to downregulate bcl-xl, culminating in the induction of apoptosis. |
2023-07-29 |
2023-08-14 |
human |
| Hangcheng Guo, Zujian Hu, Xuejia Yang, Ziwei Yuan, Yuanyuan Gao, Jiawei Chen, Lili Xie, Chaoyue Chen, Yangyang Guo, Yongheng Ba. STAT3 inhibition enhances gemcitabine sensitivity in pancreatic cancer by suppressing EMT, immune escape and inducing oxidative stress damage. International immunopharmacology. vol 123. 2023-07-29. PMID:37515849. |
the effects of combined application of gemcitabine and stat3 inhibition on the proliferation, apoptosis, migration, and invasion of pc cells (pccs) were investigated. |
2023-07-29 |
2023-08-14 |
Not clear |
| Hangcheng Guo, Zujian Hu, Xuejia Yang, Ziwei Yuan, Yuanyuan Gao, Jiawei Chen, Lili Xie, Chaoyue Chen, Yangyang Guo, Yongheng Ba. STAT3 inhibition enhances gemcitabine sensitivity in pancreatic cancer by suppressing EMT, immune escape and inducing oxidative stress damage. International immunopharmacology. vol 123. 2023-07-29. PMID:37515849. |
stat3 inhibition enhanced mitochondrial-dependent apoptosis in gemcitabine-treated pccs, but did not induce autophagy and ferroptosis. |
2023-07-29 |
2023-08-14 |
Not clear |
| Kai-Di Wang, Miao-Lin Zhu, Cheng-Jiao Qin, Rui-Fang Dong, Cheng-Mei Xiao, Qing Lin, Rong-Yuan Wei, Xiao-Yu He, Xin Zang, Ling-Yi Kong, Yuan-Zheng Xi. Sanguinarine induces apoptosis in osteosarcoma by attenuating the binding of STAT3 to the SSBP1 promoter region. British journal of pharmacology. 2023-07-28. PMID:37501645. |
sanguinarine induces apoptosis in osteosarcoma by attenuating the binding of stat3 to the ssbp1 promoter region. |
2023-07-28 |
2023-08-14 |
Not clear |
| Qian-Wen Zheng, Qian-Zhi Ni, Bing Zhu, Xin Liang, Ning Ma, Yi-Kang Wang, Sheng Xu, Hui-Jun Cao, Ji Xia, Feng-Kun Zhang, Er-Bin Zhang, Xiao-Song Qiu, Xu-Fen Ding, Lin Qiu, Xi-Lin Zhang, Zhao-Hui Dong, Zhi-Gang Li, Xue-Li Zhang, Dong Xie, Jing-Jing L. Correction to: PPDPF promotes lung adenocarcinoma progression via inhibiting apoptosis and NK cell-mediated cytotoxicity through STAT3. Oncogene. 2023-07-26. PMID:37491607. |
correction to: ppdpf promotes lung adenocarcinoma progression via inhibiting apoptosis and nk cell-mediated cytotoxicity through stat3. |
2023-07-26 |
2023-08-14 |
Not clear |
| Wenqiong Ma, Zexiu Wu, Mazaher Maghsoudloo, Iqra Ijaz, Marzieh Dehghan Shasaltaneh, Yuqin Zhang, Qiao Weng, Junjiang Fu, Saber Imani, Qing Lian We. Dermokine mutations contribute to epithelial-mesenchymal transition and advanced melanoma through ERK/MAPK pathways. PloS one. vol 18. issue 7. 2023-07-12. PMID:37432950. |
furthermore, in vitro, knockdown of dmkn inhibited the cell proliferation, migration, invasion, and apoptosis of mm cancer cells by the activation of erk/mapk signaling pathways and regulator of stat3 in downstream molecular. |
2023-07-12 |
2023-08-14 |
human |
| Haiyan Yin, Yinuo Sun, Bailiu Ya, Yan Guo, Hao Zhao, Lili Zhang, Fan Wang, Weiwei Zhang, Qianqian Yan. Apelin-13 protects against cisplatin-induced ototoxicity by inhibiting apoptosis and regulating STAT1 and STAT3. Archives of toxicology. 2023-07-03. PMID:37395757. |
apelin-13 protects against cisplatin-induced ototoxicity by inhibiting apoptosis and regulating stat1 and stat3. |
2023-07-03 |
2023-08-14 |
mouse |
| Haiyan Yin, Yinuo Sun, Bailiu Ya, Yan Guo, Hao Zhao, Lili Zhang, Fan Wang, Weiwei Zhang, Qianqian Yan. Apelin-13 protects against cisplatin-induced ototoxicity by inhibiting apoptosis and regulating STAT1 and STAT3. Archives of toxicology. 2023-07-03. PMID:37395757. |
in conclusion, our results indicate that apelin-13 could be a potential otoprotective agent to prevent cisplatin-induced ototoxicity by inhibiting apoptosis, ros production, tnf-α and il-6 expression, and regulating phosphorylation of stat1 and stat3 transcription factors. |
2023-07-03 |
2023-08-14 |
mouse |
| Chao Zhang, Hong-Ying Yang, Long Gao, Ming-Zhen Bai, Wen-Kang Fu, Chong-Fei Huang, Ning-Ning Mi, Hai-Dong Ma, Ya-Wen Lu, Ning-Zu Jiang, Liang Tian, Teng Cai, Yan-Yan Lin, Xing-Xing Zheng, Kun Gao, Jian-Jun Chen, Wen-Bo Men. Lanatoside C decelerates proliferation and induces apoptosis through inhibition of STAT3 and ROS-mediated mitochondrial membrane potential transformation in cholangiocarcinoma. Frontiers in pharmacology. vol 14. 2023-07-03. PMID:37397486. |
lanatoside c decelerates proliferation and induces apoptosis through inhibition of stat3 and ros-mediated mitochondrial membrane potential transformation in cholangiocarcinoma. |
2023-07-03 |
2023-08-14 |
Not clear |
| Mehrdad Hashemi, Sahar Abbaszadeh, Mohsen Rashidi, Nafisesadat Amini, Kasra Talebi Anaraki, Motahhar Motahhary, Ensi Khalilipouya, Abdorrahma Harif Nashtifani, Sasan Shafiei, Marzieh Ramezani Farani, Noushin Nabavi, Shokooh Salimimoghadam, Amir Reza Aref, Rasoul Raesi, Afshin Taheriazam, Maliheh Entezari, Wenliang Zh. STAT3 as a newly emerging target in colorectal cancer therapy: Tumorigenesis, therapy response, and pharmacological/nanoplatform strategies. Environmental research. 2023-06-22. PMID:37348629. |
the biological and malignant characteristics of crc cells contribute to low survival rates in patients, as the upregulation of stat3 prevents apoptosis and promotes pro-survival autophagy, thereby accelerating tumorigenesis. |
2023-06-22 |
2023-08-14 |
human |