| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chun Yu Zhang, Cheng-Huei Hung, Yi-Ling Hsiao, Tung-Miao Chang, Yu-Chieh Su, Li-Chiu Wang, Shih-Min Wang, Shun-Hua Che. Miltefosine reduces coxsackievirus B3 lethality of mice with enhanced STAT3 activation. Antiviral research. 2024-02-03. PMID:38309307. |
mouse studies demonstrated that miltefosine pretreatment reduced cvb3 lethality of mice with decreased virus loads, organ damage, and apoptosis, but enhanced stat3 activation. |
2024-02-03 |
2024-02-06 |
mouse |
| Sowmiya Arun, Praveen Kumar Patel, Kaviarasan Lakhmanan, Rajangopal Kalirajan, Gowramma Byra. Targeting STAT3 Enzyme for Cancer Treatment. Mini reviews in medicinal chemistry. 2024-02-01. PMID:38299278. |
tumor cells undergo apoptosis when stat3 activation is suppressed. |
2024-02-01 |
2024-02-03 |
human |
| JongYeob Choi, MinWha Jo, EunYoung Lee, Sung Eun Kim, Dong-Yun Lee, DooSeok Cho. Dienogest attenuates STAT3 activation in ovarian endometriotic cysts. European journal of obstetrics, gynecology, and reproductive biology. vol 294. 2024-02-01. PMID:38301500. |
recent studies have suggested that endometriosis could be the result of excessive activation of signal transducer and activator of transcription 3 (stat3), which is associated with the regulation of essential cellular mechanisms such as proliferation, invasion, and apoptosis. |
2024-02-01 |
2024-02-04 |
Not clear |
| Nian Jiang, Sanhua Li, Lingjie Meng, Yao Zhang, Changyan Yu, Yi Xiao, Yun Li. Gamabufotalin inhibits colitis-associated colorectal cancer by suppressing transcription factor STAT3. European journal of pharmacology. 2024-02-01. PMID:38301817. |
furthermore, gam induced apoptosis to inhibit the viability of hct-116 and ht-29 cell lines in dose-dependent manner by suppressing the transcription factor stat3. |
2024-02-01 |
2024-02-04 |
mouse |
| JiaHao Lu, XiuYang Yan, WuJi Lai, Li-He Jiang, Li-Qun Shen, Ai-Qun Wu, Chengguang Zha. Design, synthesis, and biological evaluation of naphthoylamide derivatives as inhibitors of STAT3 phosphorylation. Archiv der Pharmazie. 2024-01-31. PMID:38294206. |
the results showed that 3d and 4d have exceptional inhibitory ability against three different colorectal cancer (crc) cell lines, and can induce apoptosis of crc cells by inhibiting stat3 phosphorylation, while having no killing effect on normal human cells. |
2024-01-31 |
2024-02-02 |
mouse |
| Talar Ahmad Merza Mohammad, Badraldin Kareem Hamad, Avin Mohammad Arif Maroof, Shokhan Osman Mahmu. STA-21 regulates Th-17/Treg balance and synovial fibroblasts functions in rheumatoid arthritis. International journal of rheumatic diseases. vol 27. issue 1. 2024-01-30. PMID:38287543. |
in addition, results showed that sta-21 can reduce the expression of stat3 target genes related to cell proliferation, apoptosis, and inflammation leading to a decrease in proliferation and conversely increase in apoptosis of ra-sfs. |
2024-01-30 |
2024-02-01 |
Not clear |
| Zhiyue Chang, Yanhui Zhang, Lu Wang, Huizhen Wang, Ling Tian, Juan Qia. Analysis of the improvement effect of Astragalus extract on oxidative stress injury in viral myocarditis through STAT3/IL-6. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 15. 2024-01-27. PMID:38279453. |
colivelin, a specific activator of stat3, further aggravated the apoptosis, inflammatory reaction and os response of myo cells (p < 0.05), but its impacts on myo cells could be reversed by as. |
2024-01-27 |
2024-01-29 |
Not clear |
| Zhang Wenfu, Luo Bin, Rao Binchan, Luo Jingling, Wang Zhenchang, Wan Zhengdi, Yang Le. DNA methylation-mediated repression of microRNA-410 promotes the growth of human glioma cells and triggers cell apoptosis through its interaction with STAT3. Scientific reports. vol 14. issue 1. 2024-01-18. PMID:38238515. |
dna methylation-mediated repression of microrna-410 promotes the growth of human glioma cells and triggers cell apoptosis through its interaction with stat3. |
2024-01-18 |
2024-01-21 |
human |
| Yu Wang, Qianqian Zhou, Chao Liu, Ruizhe Zhang, Bofan Xing, Jiang Du, Lin Dong, Jianwei Zheng, Zhiqiang Chen, Mengyu Sun, Xiaofeng Yao, Yu Ren, Xuan Zho. Targeting IL-6/STAT3 signaling abrogates EGFR-TKI resistance through inhibiting Beclin-1 dependent autophagy in HNSCC. Cancer letters. 2024-01-11. PMID:38211653. |
mechanistically, phosphorylated stat3 was proven to enhance oncogenic autophagic flux, protecting cancer cells and preventing egfr-tki-induced tumor apoptosis. |
2024-01-11 |
2024-01-14 |
Not clear |
| Jin-Wen Xu, Ming-Yan Wang, Yan Mao, Zheng-Yun Hu, Xiao-Lin Miao, Feng Jiang, Guo-Ping Zho. Inhibition of STAT3 alleviates LPS-induced apoptosis and inflammation in renal tubular epithelial cells by transcriptionally down-regulating TASL. European journal of medical research. vol 29. issue 1. 2024-01-06. PMID:38184662. |
inhibition of stat3 alleviates lps-induced apoptosis and inflammation in renal tubular epithelial cells by transcriptionally down-regulating tasl. |
2024-01-06 |
2024-01-09 |
Not clear |
| Jhin-Baek Choi, Deok Yong Sim, Hyo-Jung Lee, Ji Eon Park, Chi-Hoon Ahn, Su-Yeon Park, Hwan-Joo Ko, Jae-Ho Khil, Bum-Sang Shim, Bonglee Kim, Sung-Hoon Ki. The microRNA-193a-5p induced ROS production and disturbed colocalization between STAT3 and androgen receptor play critical roles in cornin induced apoptosis. Phytotherapy research : PTR. 2023-12-30. PMID:38158648. |
the microrna-193a-5p induced ros production and disturbed colocalization between stat3 and androgen receptor play critical roles in cornin induced apoptosis. |
2023-12-30 |
2024-01-05 |
Not clear |
| Yue Fei, Xiaoyan Zhang, Xiaohui Wang, Yifei Sun, Jin He, Xia Liu, Zheng Song, Lanfang Li, Lihua Qiu, Zhengzi Qian, Shiyong Zhou, Xianming Liu, Huilai Zhang, Xianhuo Wan. Upregulation of tumor suppressor PIAS3 by Honokiol promotes tumor cell apoptosis via selective inhibition of STAT3 tyrosine 705 phosphorylation. Journal of natural medicines. 2023-12-11. PMID:38082192. |
upregulation of tumor suppressor pias3 by honokiol promotes tumor cell apoptosis via selective inhibition of stat3 tyrosine 705 phosphorylation. |
2023-12-11 |
2023-12-17 |
mouse |
| Yue Fei, Xiaoyan Zhang, Xiaohui Wang, Yifei Sun, Jin He, Xia Liu, Zheng Song, Lanfang Li, Lihua Qiu, Zhengzi Qian, Shiyong Zhou, Xianming Liu, Huilai Zhang, Xianhuo Wan. Upregulation of tumor suppressor PIAS3 by Honokiol promotes tumor cell apoptosis via selective inhibition of STAT3 tyrosine 705 phosphorylation. Journal of natural medicines. 2023-12-11. PMID:38082192. |
then sirna constructs specific for pias3, pias3 overexpression plasmid and the mutation of the stat3 tyr705 residue were used to confirm the mechanism of honokiol-induced apoptosis. |
2023-12-11 |
2023-12-17 |
mouse |
| Yue Fei, Xiaoyan Zhang, Xiaohui Wang, Yifei Sun, Jin He, Xia Liu, Zheng Song, Lanfang Li, Lihua Qiu, Zhengzi Qian, Shiyong Zhou, Xianming Liu, Huilai Zhang, Xianhuo Wan. Upregulation of tumor suppressor PIAS3 by Honokiol promotes tumor cell apoptosis via selective inhibition of STAT3 tyrosine 705 phosphorylation. Journal of natural medicines. 2023-12-11. PMID:38082192. |
pias3 knockdown and overexpression in tumor cells altered stat3 activation and associated dna binding activity through the control of tyr705 phosphorylation via pias3-stat3 complex formation, ultimately shaping honokiol-induced tumor cell apoptosis. |
2023-12-11 |
2023-12-17 |
mouse |
| Sara Molenda, Agata Sikorska, Anna Florczak, Patryk Lorenc, Hanna Dams-Kozlowsk. Oligonucleotide-Based Therapeutics for STAT3 Targeting in Cancer-Drug Carriers Matter. Cancers. vol 15. issue 23. 2023-12-09. PMID:38067351. |
the constitutive activation of stat3 in cancer affects processes such as cell proliferation, apoptosis, metastasis, angiogenesis, and drug resistance. |
2023-12-09 |
2023-12-17 |
Not clear |
| Zhifang Tang, Jingyuan Li, Chuan L. Post-Transcriptional Regulator RBM47 Stabilizes FBXO2 mRNA to Advance Osteoarthritis Development: WGCNA Analysis and Experimental Validation. Biochemical genetics. 2023-12-09. PMID:38070024. |
results from the recovery assay showed that the re-activation of stat3 signaling by overexpressing fbxo2 or stat3 counteracted the alleviating effect of rbm47 downregulation on il-1β-induced inflammation, apoptosis, and ecm degradation. |
2023-12-09 |
2023-12-17 |
Not clear |
| Songxian Zhu, Jingjing Guo, Li Yu, Jun Liu, Jixiang Chen, Jinxin Xin, Yuqiang Zhang, Jie Luo, Chao Dua. Synergistic effect of cryptotanshinone and temozolomide treatment against human glioblastoma cells. Scientific reports. vol 13. issue 1. 2023-12-09. PMID:38071213. |
furthermore, cell viability, dna damage, apoptosis rate, and signal transducer and activator of transcription 3 (stat3) protein were measured using cytotoxic assay, comet assay, flow cytometry, and western blotting analysis, respectively. |
2023-12-09 |
2023-12-17 |
human |
| Zhengchen Jiang, Wanzhen Li, Shuna Yu, Xuyang Wang, Hongxin Jiang, Chen Bai, Ming Li, Fangfang Chu, Jiying Jiang, Xiaomin M. IL-22 Relieves Hepatic Ischemia-Reperfusion Injury by Inhibiting Mitochondrial Apoptosis Based on the Activation of STAT3. The international journal of biochemistry & cell biology. 2023-11-30. PMID:38036287. |
il-22 relieves hepatic ischemia-reperfusion injury by inhibiting mitochondrial apoptosis based on the activation of stat3. |
2023-11-30 |
2023-12-10 |
Not clear |
| Zhengchen Jiang, Wanzhen Li, Shuna Yu, Xuyang Wang, Hongxin Jiang, Chen Bai, Ming Li, Fangfang Chu, Jiying Jiang, Xiaomin M. IL-22 Relieves Hepatic Ischemia-Reperfusion Injury by Inhibiting Mitochondrial Apoptosis Based on the Activation of STAT3. The international journal of biochemistry & cell biology. 2023-11-30. PMID:38036287. |
this study aimed to explore the change of il-22 and il-22 receptor 1 (il-22r1) axis in hiri and its role in mitochondrial apoptosis associated with stat3 activation. |
2023-11-30 |
2023-12-10 |
Not clear |
| Jinxiang Liu, Dan Fei, Jie Xing, Juan D. Retraction notice to "MicroRNA-29a inhibits proliferation and induces apoptosis in rheumatoid arthritis fibroblast-like synoviocytes by repressing STAT3" [Biomed. Pharmacother. 96 (2017) 173-181]. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023-11-26. PMID:38008610. |
retraction notice to "microrna-29a inhibits proliferation and induces apoptosis in rheumatoid arthritis fibroblast-like synoviocytes by repressing stat3" [biomed. |
2023-11-26 |
2023-11-28 |
Not clear |