| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei Sun, Nai-Dan Zhang, Tong Zhang, Yan-Nan Li, Hui Xue, Jing-Long Cao, Wen-Shuang Hou, Jian Liu, Ying Wang, Cheng-Hao Ji. Cyanidin-3-O-Glucoside Induces the Apoptosis of Human Gastric Cancer MKN-45 Cells through ROS-Mediated Signaling Pathways. Molecules (Basel, Switzerland). vol 28. issue 2. 2023-01-21. PMID:36677726. |
in conclusion, c3g caused mkn-45 cells to undergo apoptosis; arrested the cell cycle in the g2/m phase; hindered cell migration; and activated the mapk, stat3, and nf-κb signaling pathways, by inducing an increase in ros levels. |
2023-01-21 |
2023-08-14 |
human |
| Peyman Amini, Reza Moazamiyanfar, Mohammad Sedigh Dakkali, Emad Jafarzadeh, Maryam Ganjizadeh, Nima Rastegar-Pouyani, Kave Mouludi, Ehsan Khodamoradi, Shahram Taeb, Masoud Najaf. Induction of Cancer Cell Death by Apigenin: A Review on Different Cell Death Pathways. Mini reviews in medicinal chemistry. 2023-01-20. PMID:36658710. |
it seems that apigenin enhances apoptosis by inducing anticancer immunity and tumor suppressor genes, like p53 and pten, and also by inhibiting stat3 and nf-κb signaling pathways. |
2023-01-20 |
2023-08-14 |
Not clear |
| Minxiao Chen, Chenchen Qian, Bo Jin, Chenghong Hu, Lingxi Zhang, Minshan Wang, Bin Zhou, Wei Zuo, Lijiang Huang, Yi Wan. Curcumin analog WZ26 induces ROS and cell death via inhibition of STAT3 in cholangiocarcinoma. Cancer biology & therapy. vol 24. issue 1. 2023-01-16. PMID:36647192. |
treatment of wz26 increased reactive oxygen species (ros) generation, subsequently decreased mitochondrial membrane potential and inhibited the phosphorylation of signal transducer and activator of transcription 3 (stat3), thereby inducing g2/m cell cycle arrest and cell apoptosis. |
2023-01-16 |
2023-08-14 |
mouse |
| Andra Fortner, Alexandra Chera, Antoanela Tanca, Octavian Bucu. Apoptosis regulation by the tyrosine-protein kinase CSK. Frontiers in cell and developmental biology. vol 10. 2022-12-29. PMID:36578781. |
as sfks play a vital role in apoptosis, cell proliferation and survival regulation, sfk inhibition by csk has a pro-apoptotic effect, which is mediated by the inhibition of cellular signaling cascades controlled by sfks, such as the mapk/erk, stat3 and pi3k/akt signaling pathways. |
2022-12-29 |
2023-08-14 |
Not clear |
| Yanan Wang, Jiapeng Lei, Song Zhang, Xiaomei Wang, Jiangbo Jin, Yufeng Liu, Mingxi Gan, Yi Yuan, Longhua Sun, Xiaolei Li, Tianyu Han, Jian-Bin Wan. 4EBP1 senses extracellular glucose deprivation and initiates cell death signaling in lung cancer. Cell death & disease. vol 13. issue 12. 2022-12-27. PMID:36575176. |
after that, 4ebp1 translocated to cytoplasm and interacted with stat3 by competing with jak and erk, leading to the inactivation of stat3 in the cytoplasm, resulting in apoptosis under glucose withdrawal conditions. |
2022-12-27 |
2023-08-14 |
Not clear |
| Erratum to "A novel 4'-brominated derivative of fisetin induces cell cycle arrest and apoptosis and inhibits EGFR/ERK1/2/ STAT3 pathways in non-small-cell lung cancer without any adverse effects in mice". FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 37. issue 1. 2022-12-17. PMID:36527405. |
erratum to "a novel 4'-brominated derivative of fisetin induces cell cycle arrest and apoptosis and inhibits egfr/erk1/2/ stat3 pathways in non-small-cell lung cancer without any adverse effects in mice". |
2022-12-17 |
2023-08-14 |
mouse |
| Guojing Sun, Jingwei Lu, Zhenfang Wu, Xian Zhang, Yunfan T. STAT3 expression in patients with fragility fractures and its effect on the biological function of osteoblasts. Cell and tissue banking. 2022-12-12. PMID:36508120. |
we observed stat3 mrna expression in the patients with ffs and controls and altered stat3 mrna to detect changes in the proliferation, invasion, and apoptosis of osteoblasts. |
2022-12-12 |
2023-08-14 |
human |
| Guojing Sun, Jingwei Lu, Zhenfang Wu, Xian Zhang, Yunfan T. STAT3 expression in patients with fragility fractures and its effect on the biological function of osteoblasts. Cell and tissue banking. 2022-12-12. PMID:36508120. |
transfection of stat3 mrna mimics resulted in increased stat3 mrna expression, inhibited cell proliferation as detected by an mtt assay, and increased apoptosis rate, which was determined using flow cytometry with human fetal osteoblastic cell line 1.19 cells. |
2022-12-12 |
2023-08-14 |
human |
| Guojing Sun, Jingwei Lu, Zhenfang Wu, Xian Zhang, Yunfan T. STAT3 expression in patients with fragility fractures and its effect on the biological function of osteoblasts. Cell and tissue banking. 2022-12-12. PMID:36508120. |
regulating stat3 mrna can inhibit the proliferation and induce the osteoblasts apoptosis. |
2022-12-12 |
2023-08-14 |
human |
| Jinmei Jin, Yaping Wu, Zeng Zhao, Ye Wu, Yu-Dong Zhou, Sanhong Liu, Qingyan Sun, Guizhu Yang, Jiayi Lin, Dale G Nagle, Jiangjiang Qin, Zhiyuan Zhang, Hong-Zhuan Chen, Weidong Zhang, Shuyang Sun, Xin Lua. Small-molecule PROTAC mediates targeted protein degradation to treat STAT3-dependent epithelial cancer. JCI insight. vol 7. issue 22. 2022-12-12. PMID:36509291. |
the following mechanistic investigation identifies the reduced expression of critical downstream stat3 effectors, through which tsm-1 promotes cell cycle arrest and apoptosis in tumor cells. |
2022-12-12 |
2023-08-14 |
Not clear |
| Yumin Huang, Yingge Wang, Zuowei Duan, Jingyan Liang, Yijun Xu, Shuai Zhang, Tieyu Tan. Retraction Note: Restored microRNA-326-5p Inhibits Neuronal Apoptosis and Attenuates Mitochondrial Damage via Suppressing STAT3 in Cerebral Ischemia/Reperfusion Injury. Nanoscale research letters. vol 17. issue 1. 2022-12-09. PMID:36484973. |
retraction note: restored microrna-326-5p inhibits neuronal apoptosis and attenuates mitochondrial damage via suppressing stat3 in cerebral ischemia/reperfusion injury. |
2022-12-09 |
2023-08-14 |
Not clear |
| E A Blinova, V S Nikiforov, A I Kotikova, M A Yanishevskaya, A V Akleye. [Methylation Status of Apoptosis Genes and Intensity of Apoptotic Death of Peripheral Blood Lymphocytes in Persons Chronically Exposed to Radiation]. Molekuliarnaia biologiia. vol 56. issue 6. 2022-12-07. PMID:36475490. |
here, the methylation level of cpg islands of the promoter regions of apoptosis genes (bcl2, atm, mdm2, cdkn1a, stat3, and nfkb1), and also its influence on apoptosis of peripheral blood lymphocytes in chronically exposed persons were studied. |
2022-12-07 |
2023-08-14 |
human |
| Yuzhou Xue, Minghao Luo, Xiankang Hu, Xiang Li, Jian Shen, Wenyan Zhu, Longxiang Huang, Yu Hu, Yongzheng Guo, Lin Liu, Lingbang Wang, Suxin Lu. Macrophages regulate vascular smooth muscle cell function during atherosclerosis progression through IL-1β/STAT3 signaling. Communications biology. vol 5. issue 1. 2022-12-01. PMID:36456628. |
il-1β promots the adhesion, inflammation, and apoptosis of macrophage-like vsmcs in a stat3 dependent manner. |
2022-12-01 |
2023-08-14 |
human |
| Shohei Fukada, Kouji Ohta, Miyuki Sakuma, Misaki Akagi, Hiroki Kato, Takako Naruse, Takayuki Nakagawa, Hideo Shigeishi, Hiromi Nishi, Masaaki Takechi, Tomonao Aikaw. Sunitinib promotes apoptosis via p38 MAPK activation and STAT3 downregulation in oral keratinocytes. Oral diseases. 2022-11-30. PMID:36447393. |
sunitinib promotes apoptosis via p38 mapk activation and stat3 downregulation in oral keratinocytes. |
2022-11-30 |
2023-08-14 |
Not clear |
| Guanghua Tang, Linyue Pan, Zhixiang Wang, Hua Zhu, Yong Yang, Zijian Wang, Hongqin Yue, Yuhua Shi, Dichen Wu, Zhilong Jiang, Danbin Jian. Knockdown of membrane-bound complement regulatory proteins suppresses colon cancer growth in mice through inducing tumor cell apoptosis. International immunopharmacology. vol 114. 2022-11-29. PMID:36446233. |
in addition, stat3, stat6, and p38 mapk inhibitors, including c188-9, as1517499 and sb203580 effectively reduced the expression of cd46 in the treated colon cells, associated with increased cell apoptosis and ldh release. |
2022-11-29 |
2023-08-14 |
mouse |
| Yongmei Zhao, Mao Ding, Feng Yan, Jie Yin, Wenjuan Shi, Nan Yang, Haiping Zhao, Yalan Fang, Yuyou Huang, Yangmin Zheng, Xueqi Yang, Wei Li, Xunming Ji, Yumin Lu. Inhibition of the JAK2/STAT3 pathway and cell cycle re-entry contribute to the protective effect of remote ischemic pre-conditioning of rat hindlimbs on cerebral ischemia/reperfusion injury. CNS neuroscience & therapeutics. 2022-11-24. PMID:36419252. |
in the present study, we investigated the role of janus-activated kinase 2 (jak2)/signal transducer and activator of transcription 3 (stat3) pathway and cell cycle arrest, and their relationship with neuronal apoptosis following ripc. |
2022-11-24 |
2023-08-14 |
rat |
| Joaquim Carreras, Giovanna Roncador, Rifat Hamoud. Artificial Intelligence Predicted Overall Survival and Classified Mature B-Cell Neoplasms Based on Immuno-Oncology and Immune Checkpoint Panels. Cancers. vol 14. issue 21. 2022-11-11. PMID:36358737. |
oncogenes and tumor suppressor genes were highlighted (myc, bcl2, and tp53), along with immune microenvironment markers of tumor-associated macrophages (m2-like tams), t-cells and regulatory t lymphocytes (tregs) (cd68, cd163, marco, csf1r, csf1, pd-l1/cd274, sirpa, cd85a/lilrb3, cd47, il10, tnfrsf14/hvem, tnfaip8, ikaros, stat3, nfkb, mapk, pd-1/pdcd1, btla, and foxp3), apoptosis (bcl2, casp3, casp8, parp, and pathway-related mdm2, e2f1, cdk6, myb, and lmo2), and metabolism (eno3, gga3). |
2022-11-11 |
2023-08-14 |
Not clear |
| Jing Wang, Qiwen Man, Niannian Zhong, Hanqi Wang, Chenxi Zhang, Suran Li, Linlin Bu, Bing Li. ENO1 Binds to ApoC3 and Impairs the Proliferation of T Cells via IL-8/STAT3 Pathway in OSCC. International journal of molecular sciences. vol 23. issue 21. 2022-11-11. PMID:36361568. |
mechanistically, oscc cells activated the stat3 signaling pathway on jurkat t cells through il-8 secretion, promoted apoptosis, and inhibited the proliferation of jurkat t cells. |
2022-11-11 |
2023-08-14 |
Not clear |
| Qianqian Zhao, Adrian Kohut, Yi-Jia Li, Antons Martincuks, Theresa Austria, Chunyan Zhang, Nicole Lugo Santiago, Rosemarie Martinez Borrero, Xuan Thuy Phan, Laleh Melstrom, Lorna Rodriguez-Rodriguez, Hua Y. Niraparib-induced STAT3 inhibition increases its antitumor effects. Frontiers in oncology. vol 12. 2022-11-03. PMID:36324587. |
moreover, niraparib regulates the expression of several stat3 downstream genes involved in apoptosis. |
2022-11-03 |
2023-08-14 |
Not clear |
| Qianqian Zhao, Adrian Kohut, Yi-Jia Li, Antons Martincuks, Theresa Austria, Chunyan Zhang, Nicole Lugo Santiago, Rosemarie Martinez Borrero, Xuan Thuy Phan, Laleh Melstrom, Lorna Rodriguez-Rodriguez, Hua Y. Niraparib-induced STAT3 inhibition increases its antitumor effects. Frontiers in oncology. vol 12. 2022-11-03. PMID:36324587. |
overexpression of a constitutively activated stat3 mutant rescues niraparib-induced cancer cell apoptosis. |
2022-11-03 |
2023-08-14 |
Not clear |