| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi Bai, Hao Wu, Jinrui Zhang, Sai Zhang, Zhixin Zhang, Hao Wang, Yamin Zhang, Zhongyang She. IL-22 Protects against Biliary Ischemia-Reperfusion Injury after Liver Transplantation via Activating STAT3 and Reducing Apoptosis and Oxidative Stress Levels In Vitro and In Vivo. Oxidative medicine and cellular longevity. vol 2022. 2022-05-20. PMID:35592531. |
il-22 protects against biliary ischemia-reperfusion injury after liver transplantation via activating stat3 and reducing apoptosis and oxidative stress levels in vitro and in vivo. |
2022-05-20 |
2023-08-13 |
human |
| Yi Bai, Hao Wu, Jinrui Zhang, Sai Zhang, Zhixin Zhang, Hao Wang, Yamin Zhang, Zhongyang She. IL-22 Protects against Biliary Ischemia-Reperfusion Injury after Liver Transplantation via Activating STAT3 and Reducing Apoptosis and Oxidative Stress Levels In Vitro and In Vivo. Oxidative medicine and cellular longevity. vol 2022. 2022-05-20. PMID:35592531. |
this study confirmed that il-22 could promote cholangiocyte proliferation, decrease the apoptosis rate of cholangiocytes and tissues, decrease mda levels, and increase sod levels by activating stat3. |
2022-05-20 |
2023-08-13 |
human |
| Ruijie Chen, Yuan-Yuan Zhai, Lining Sun, Zeqing Wang, Xing Xia, Qing Yao, Longfa Ko. Alantolactone-loaded chitosan/hyaluronic acid nanoparticles suppress psoriasis by deactivating STAT3 pathway and restricting immune cell recruitment. Asian journal of pharmaceutical sciences. vol 17. issue 2. 2022-05-18. PMID:35582636. |
chalt effectively abrogated the hyperproliferation by inducing ros-mediated apoptosis with loss of mitochondrial membrane potential, and also inhibited il-6-induced stat3 signaling activation and inflammatory reaction in hacat cell line. |
2022-05-18 |
2023-08-13 |
human |
| Ehsan Khabazian, Faezeh Vakhshiteh, Parisa Norouzi, Yousef Fatahi, Rassoul Dinarvand, Fatemeh Atyab. Cationic liposome decorated with cyclic RGD peptide for targeted delivery of anti-STAT3 siRNA to melanoma cancer cells. Journal of drug targeting. vol 30. issue 5. 2022-05-16. PMID:34482780. |
furthermore, incorporating peptide on the surface of liposomes resulted in considerably high cytotoxicity, a 2.1-times raise in apoptosis induction, and a significantly enhanced stat3 gene suppression as compared with the corresponding non-targeted formulation on b16f10 murine melanoma cells. |
2022-05-16 |
2023-08-16 |
mouse |
| Yaseen Hussain, Abdullah, Khalaf F Alsharif, Michael Aschner, Abdulrahman Theyab, Fazlullah Khan, Luciano Saso, Haroon Kha. Therapeutic Role of Carotenoids in Blood Cancer: Mechanistic Insights and Therapeutic Potential. Nutrients. vol 14. issue 9. 2022-05-14. PMID:35565917. |
carotenoids, through various signaling pathways and mechanisms, such as the activation of ampk, expression of autophagy biochemical markers (p62/lc3-ii), activation of keap1-nrf2/epre/are signaaling pathway, nuclear factor kappa-light-chain-enhancer of activated b cells (nf-κb), increased level of reactive oxygen species, cleaved poly (adp-ribose) polymerase (c-parp), c-caspase-3, -7, decreased level of bcl-xl, cycle arrest at the g0/g1 phase, and decreasing stat3 expression results in apoptosis induction and inhibition of cancer cell proliferation. |
2022-05-14 |
2023-08-13 |
Not clear |
| Noura M Darwish, Mohamed M A Elshaer, Saeedah Musaed Almutairi, Tse-Wei Chen, Mohamed Othman Mohamed, Wael B A Ghaly, Rabab Ahmed Rashee. Omega-3 Polyunsaturated Fatty Acids Provoke Apoptosis in Hepatocellular Carcinoma through Knocking Down the STAT3 Activated Signaling Pathway: In Vivo and In Vitro Study. Molecules (Basel, Switzerland). vol 27. issue 9. 2022-05-14. PMID:35566382. |
omega-3 polyunsaturated fatty acids provoke apoptosis in hepatocellular carcinoma through knocking down the stat3 activated signaling pathway: in vivo and in vitro study. |
2022-05-14 |
2023-08-13 |
rat |
| Noura M Darwish, Mohamed M A Elshaer, Saeedah Musaed Almutairi, Tse-Wei Chen, Mohamed Othman Mohamed, Wael B A Ghaly, Rabab Ahmed Rashee. Omega-3 Polyunsaturated Fatty Acids Provoke Apoptosis in Hepatocellular Carcinoma through Knocking Down the STAT3 Activated Signaling Pathway: In Vivo and In Vitro Study. Molecules (Basel, Switzerland). vol 27. issue 9. 2022-05-14. PMID:35566382. |
signal transducer and activator of transcription 3 (stat3) is involved in hcc progression, migration, and suppression of apoptosis. |
2022-05-14 |
2023-08-13 |
rat |
| Noura M Darwish, Mohamed M A Elshaer, Saeedah Musaed Almutairi, Tse-Wei Chen, Mohamed Othman Mohamed, Wael B A Ghaly, Rabab Ahmed Rashee. Omega-3 Polyunsaturated Fatty Acids Provoke Apoptosis in Hepatocellular Carcinoma through Knocking Down the STAT3 Activated Signaling Pathway: In Vivo and In Vitro Study. Molecules (Basel, Switzerland). vol 27. issue 9. 2022-05-14. PMID:35566382. |
here we report that n-3 pufas may be an ideal cancer chemo-preventive candidate by targeting stat3 signaling, which is involved in cell proliferation and apoptosis. |
2022-05-14 |
2023-08-13 |
rat |
| Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Seung-Hoon Kim, Sang-Kyu Ye, Chung-Hyun Ch. STAT3 activation in microglia increases pericyte apoptosis in diabetic retinas through TNF-ɑ/AKT/p70S6 kinase signaling. Biochemical and biophysical research communications. vol 613. 2022-05-13. PMID:35561580. |
stat3 activation in microglia increases pericyte apoptosis in diabetic retinas through tnf-ɑ/akt/p70s6 kinase signaling. |
2022-05-13 |
2023-08-13 |
mouse |
| Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Seung-Hoon Kim, Sang-Kyu Ye, Chung-Hyun Ch. STAT3 activation in microglia increases pericyte apoptosis in diabetic retinas through TNF-ɑ/AKT/p70S6 kinase signaling. Biochemical and biophysical research communications. vol 613. 2022-05-13. PMID:35561580. |
we identified tnf-α as a potent inducer of pericyte apoptosis in diabetic retinas from the gene expression analysis and found that stat3 activation in microglia increased tnf-α expression in the diabetic retinas. |
2022-05-13 |
2023-08-13 |
mouse |
| Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Seung-Hoon Kim, Sang-Kyu Ye, Chung-Hyun Ch. STAT3 activation in microglia increases pericyte apoptosis in diabetic retinas through TNF-ɑ/AKT/p70S6 kinase signaling. Biochemical and biophysical research communications. vol 613. 2022-05-13. PMID:35561580. |
moreover, we took advantage of mice lacking stat3 in microglia and demonstrated that stat3 ablation in microglia reduced the pericyte apoptosis and tnf-α expression in the diabetic retinas. |
2022-05-13 |
2023-08-13 |
mouse |
| Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Seung-Hoon Kim, Sang-Kyu Ye, Chung-Hyun Ch. STAT3 activation in microglia increases pericyte apoptosis in diabetic retinas through TNF-ɑ/AKT/p70S6 kinase signaling. Biochemical and biophysical research communications. vol 613. 2022-05-13. PMID:35561580. |
these results suggest that stat3 activation in microglia plays an important role in pericyte apoptosis in the diabetic retinas through increased tnf-α expression and provide stat3 activation in microglia as a potential therapeutic target for preventing pericyte loss in dr. |
2022-05-13 |
2023-08-13 |
mouse |
| Xin-Hua Guo, Yang Zheng, Jia-Hui Wang, Hong-Hong Wang, Shu-Juan Luo, Na Huang, Tie-Jian Zhao, Bo-Wen Zheng, Xin-Yun Liang, Ri-Zhou Wu, Qiu-Yi Re. [Research progress on role of traditional Chinese medicine in hepatic fibrosis based on miRNA-mediated activation of NLRP3 inflammasome]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 9. 2022-05-09. PMID:35531688. |
different mirna molecules regulated liver fibrosis by mediating nlrp3 inflammasome activation, including mirna-350-3 p(mir-350-3 p)/interleukin-6(il-6)-mediated signal transducer and activator of transcription 3(stat3)/c-myc signaling pathway, mir-148 a-induced autophagy and apoptosis of hepatic stellate cells via hedgehog signaling pathway, mir-155-mediated nlrp3 inflammasome by the negative feedback of the suppressor of cytokine signaling-1(socs-1), mir-181 a-mediated downstream nlrp3 inflammatory pathway activation through mitogen-activated protein kinase kinase(mek)/extracellular signal-regulated kinase(erk)/nuclear transcription factor κb(nf-κb) inflammatory pathway, mir-21-promoted expression of nf-κb and nlrp3 of raw264.7 cells in mice by inhibiting tumor necrosis factor-α inducible protein 3(a20), and mir-20 b-promoted expression of il-1β and il-18 by activating nlrp3 signaling pathway. |
2022-05-09 |
2023-08-13 |
mouse |
| Sukru Cekic, Huzeyfe Huriyet, Melika Hortoglu, Nurhan Kasap, Ahmet Ozen, Elif Karakoc-Aydiner, Ayse Metin, Gokhan Ocakoglu, Candan Demiroz Abakay, Sehime G Temel, Sebnem Ozemri Sag, Safa Baris, Tolga Cavas, Sara Sebnem Kili. Full Increased radiosensitivity and impaired DNA repair in patients with STAT3-LOF and ZNF341 deficiency, potentially contributing to malignant transformations. Clinical and experimental immunology. 2022-05-05. PMID:35511492. |
stat3 plays an important role in various complex and sometimes contradictory pathways such as proliferation, differentiation, migration, inflammation, and apoptosis. |
2022-05-05 |
2023-08-13 |
Not clear |
| Ting Xu, Kun Wu, Jin Shi, Lindong Ji, Xudong Song, Guoquan Tao, Shutao Zheng, Li Zhang, Baofei Jian. LINC00858 promotes colon cancer progression through activation of STAT3/5 signaling by recruiting transcription factor RAD21 to upregulate PCNP. Cell death discovery. vol 8. issue 1. 2022-04-26. PMID:35468892. |
western blot was conducted to determine rad21, pcnp, phosphorylated (p)-stat3, stat3, p-stat5 and stat5 and apoptosis related proteins. |
2022-04-26 |
2023-08-13 |
mouse |
| Victoria Abzianidze, Natalia Moiseeva, Diana Suponina, Sofya Zakharenkova, Nadezhda Rogovskaya, Lidia Laletina, Alvin A Holder, Denis Krivorotov, Alexander Bogachenkov, Alexander Garabadzhiu, Anton Ukolov, Vyacheslav Kosoruko. Natural Phaeosphaeride A Derivatives Overcome Drug Resistance of Tumor Cells and Modulate Signaling Pathways. Pharmaceuticals (Basel, Switzerland). vol 15. issue 4. 2022-04-23. PMID:35455394. |
milliplex map multi-pathway magnetic bead 9-plex was used, which allowed for the simultaneous detection of the following nine phosphorylated protein markers of the main intracellular signaling pathways: a universal transcription factor that controls the expression of immune-response genes, apoptosis and cell cycle nfκb (ps536); camp-dependent transcription factor (creb (ps133); mitogen-activated kinase p38 (pt180/py182); stress-activated protein kinase jnk (pt183/py185); ribosomal sk; transcription factors stat3 (ps727) and stat5a/b (py694/699); protein kinase b (akt) (ps473); and kinase regulated by extracellular signals erk1/2 (pt185/py187). |
2022-04-23 |
2023-08-13 |
human |
| Rishabh Khera, Sidharth Mehan, Sumit Kumar, Pranshul Sethi, Sonalika Bhalla, Aradhana Prajapat. Role of JAK-STAT and PPAR-Gamma Signalling Modulators in the Prevention of Autism and Neurological Dysfunctions. Molecular neurobiology. 2022-04-19. PMID:35437700. |
jak activation phosphorylates stat3 in astrocytes and microglia, and this phosphorylation has been linked to mitochondrial damage, apoptosis, neuroinflammation, reactive astrogliosis, and genetic mutations. |
2022-04-19 |
2023-08-13 |
Not clear |
| Wei-Ting Chang, Jhih-Yuan Shih, Yu-Wen Lin, Zhih-Cherng Chen, Wei-Chih Kan, Tsung-Hsien Lin, Chon-Seng Hon. Dapagliflozin protects against doxorubicin-induced cardiotoxicity by restoring STAT3. Archives of toxicology. 2022-04-19. PMID:35438302. |
using stat3 sirna, we further examined the effects of stat3 effect on dapa-associated protection against dox-induced apoptosis. |
2022-04-19 |
2023-08-13 |
rat |
| Wei-Ting Chang, Jhih-Yuan Shih, Yu-Wen Lin, Zhih-Cherng Chen, Wei-Chih Kan, Tsung-Hsien Lin, Chon-Seng Hon. Dapagliflozin protects against doxorubicin-induced cardiotoxicity by restoring STAT3. Archives of toxicology. 2022-04-19. PMID:35438302. |
conversely, knocking down stat3 in cardiomyocytes reversed the dapa-related protective effects on dox-induced cell apoptosis and ros. |
2022-04-19 |
2023-08-13 |
rat |
| Yuyang Gao, Xiaoyan Feng, Wenting Song, Hongwen Li, Cunzhen Shi, Mengyuan Jin, Zhaoming Li, Lei Zhang, Mingzhi Zhan. The Potential Efficacy and Mechanism of Bendamustine in Entra-nodal NK/T Cell Lymphoma. Hematological oncology. 2022-04-19. PMID:35439335. |
bendamustine also inhibited phosphorylation of transcriptional factor stat3, contributing to cell apoptosis and proliferation inhibition. |
2022-04-19 |
2023-08-13 |
mouse |