| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lihong Yang, Xuehui Y. Naturally occurring Girinimbine alkaloid inhibits the proliferation, migration, and invasion of human breast cancer cells via induction of apoptosis and inhibition of MEK/ERK and STAT3 signalling pathways. Acta biochimica Polonica. vol 68. issue 4. 2021-12-07. PMID:34472799. |
naturally occurring girinimbine alkaloid inhibits the proliferation, migration, and invasion of human breast cancer cells via induction of apoptosis and inhibition of mek/erk and stat3 signalling pathways. |
2021-12-07 |
2023-08-13 |
human |
| Zixin Hou, Ji Chen, Huan Yang, Xiaoling Hu, Fengrui Yan. PIAS1 alleviates diabetic peripheral neuropathy through SUMOlation of PPAR-γ and miR-124-induced downregulation of EZH2/STAT3. Cell death discovery. vol 7. issue 1. 2021-12-03. PMID:34857740. |
furthermore, mir-124 targeted and inversely modulated ezh2 and stat3, promoting the autophagy of schwann cells and inhibiting their apoptosis. |
2021-12-03 |
2023-08-13 |
mouse |
| Sony Maharjan, Mijeong Kang, Jinsoo Kim, Dongbum Kim, Sangkyu Park, Minyoung Kim, Kyeongbin Baek, Younghee Lee, Hyung-Joo Kwo. Apoptosis Enhances the Replication of Human Coronavirus OC43. Viruses. vol 13. issue 11. 2021-12-01. PMID:34835005. |
dephosphorylation of stat1 and stat3, induced by hcov-oc43 infection, was also associated with hcov-oc43-mediated apoptosis. |
2021-12-01 |
2023-08-13 |
human |
| Ming-Jie Yuan, Tao Wan. Advances of the interleukin-21 signaling pathway in immunity and angiogenesis. Biomedical reports. vol 5. issue 1. 2021-11-30. PMID:27330746. |
il-21-mediated human b cell and dendritic cells differentiation requires signal transducer and activator of transcription 3 (stat3), and also induces b-cell apoptosis dependents on the toll-like receptor signal. |
2021-11-30 |
2023-08-13 |
human |
| Chengwu Tang, Wenming Feng, Ying Bao, Huimin D. Long non-coding RNA TINCR promotes hepatocellular carcinoma proliferation and invasion via STAT3 signaling by direct interacting with T-cell protein tyrosine phosphatase (TCPTP). Bioengineered. vol 12. issue 1. 2021-11-30. PMID:34057016. |
additionally, Δ1-360 tincr overexpression did not affect hcc cell growth, apoptosis, migration, infiltration, and stat3 target genes expression. |
2021-11-30 |
2023-08-13 |
human |
| Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Hye Sun Kim, Sang-Kyu Ye, Chung-Hyun Ch. STAT3 activation in microglia exacerbates hippocampal neuronal apoptosis in diabetic brains. Journal of cellular physiology. vol 236. issue 10. 2021-11-29. PMID:33754353. |
stat3 activation in microglia exacerbates hippocampal neuronal apoptosis in diabetic brains. |
2021-11-29 |
2023-08-13 |
mouse |
| Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Hye Sun Kim, Sang-Kyu Ye, Chung-Hyun Ch. STAT3 activation in microglia exacerbates hippocampal neuronal apoptosis in diabetic brains. Journal of cellular physiology. vol 236. issue 10. 2021-11-29. PMID:33754353. |
using a streptozotocin-induced type 1 dm model, we showed enhanced hippocampal neuronal apoptosis that was associated with increased stat3 activation. |
2021-11-29 |
2023-08-13 |
mouse |
| Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Hye Sun Kim, Sang-Kyu Ye, Chung-Hyun Ch. STAT3 activation in microglia exacerbates hippocampal neuronal apoptosis in diabetic brains. Journal of cellular physiology. vol 236. issue 10. 2021-11-29. PMID:33754353. |
we also demonstrated that stat3 activation in microglia increased tumor necrosis factor-α (tnf-α) expression; subsequently, tnf-α increased neuronal apoptosis by increasing reactive oxygen species (ros) levels in the neuronal cells. |
2021-11-29 |
2023-08-13 |
mouse |
| Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Hye Sun Kim, Sang-Kyu Ye, Chung-Hyun Ch. STAT3 activation in microglia exacerbates hippocampal neuronal apoptosis in diabetic brains. Journal of cellular physiology. vol 236. issue 10. 2021-11-29. PMID:33754353. |
we also took advantage of mice lacking stat3 in microglia and demonstrated that depletion of microglial stat3 reduced neuronal apoptosis in the diabetic hippocampus. |
2021-11-29 |
2023-08-13 |
mouse |
| Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Hye Sun Kim, Sang-Kyu Ye, Chung-Hyun Ch. STAT3 activation in microglia exacerbates hippocampal neuronal apoptosis in diabetic brains. Journal of cellular physiology. vol 236. issue 10. 2021-11-29. PMID:33754353. |
taken together, these results suggest that stat3 activation in microglia plays an important role in hyperglycemia-induced neuronal apoptosis in the diabetic hippocampus and provide a potential therapeutic benefit of stat3 inhibition in microglia for preventing diabetic neuronal lesions. |
2021-11-29 |
2023-08-13 |
mouse |
| Xin Zhang, He Nan, Jialong Guo, Jinyu Li. KDM4B Overexpression Promotes the Growth, Migration, and Invasion of Rheumatoid Arthritis Fibroblast-Like Synoviocytes by Activating STAT3 Pathway. Biochemical genetics. vol 59. issue 6. 2021-11-27. PMID:33909202. |
moreover, kdm4b overexpression could promote cell growth, migration and invasion, and suppress apoptosis in ra fls by activating stat3 signaling. |
2021-11-27 |
2023-08-13 |
Not clear |
| Masumeh Sanaei, Fraidoon Kavoosi, Mohammad Pourahmad. Effect of Decitabine (5-aza-2'-deoxycytidine, 5-aza-CdR) in Comparison with Vorinostat (Suberoylanilide Hydroxamic Acid, SAHA) on DNMT1, DNMT3a and DNMT3b, HDAC 1-3, SOCS 1, SOCS 3, JAK2, and STAT3 Gene Expression in Hepatocellular Carcinoma HLE and LCL-PI 11 Cell Lines. Asian Pacific journal of cancer prevention : APJCP. vol 22. issue 7. 2021-11-27. PMID:34319031. |
the current study aimed to investigate the effect of decitabine (5-aza-2'-deoxycytidine, 5-aza-cdr) in comparison to vorinostat (suberoylanilide hydroxamic acid, saha) on dnmt1, dnmt3a and dnmt3b, hdac 1-3, socs 1, socs 3, jak2, and stat3 gene expression, cell growth inhibition, and apoptosis induction of hcc hle and lcl-pi 11 cell lines. |
2021-11-27 |
2023-08-13 |
Not clear |
| Lian Zeng, Aohan Li, Zhen Zhang, Fuyu Zhang, Huaxian Chen, Ying Wang, Xudong Ding, Huiyu Lu. Ropivacaine Induces Cell Cycle Arrest in the G0/G1 Phase and Apoptosis of PC12 Cells via Inhibiting Mitochondrial STAT3 Translocation. Inflammation. vol 44. issue 6. 2021-11-26. PMID:34417665. |
ropivacaine induces cell cycle arrest in the g0/g1 phase and apoptosis of pc12 cells via inhibiting mitochondrial stat3 translocation. |
2021-11-26 |
2023-08-13 |
Not clear |
| Lian Zeng, Aohan Li, Zhen Zhang, Fuyu Zhang, Huaxian Chen, Ying Wang, Xudong Ding, Huiyu Lu. Ropivacaine Induces Cell Cycle Arrest in the G0/G1 Phase and Apoptosis of PC12 Cells via Inhibiting Mitochondrial STAT3 Translocation. Inflammation. vol 44. issue 6. 2021-11-26. PMID:34417665. |
our previous study revealed that apoptosis was an important mechanism of ropivacaine-induced neurotoxicity; this study is to illustrate the relationship between stat3 with ropivacaine-induced apoptosis. |
2021-11-26 |
2023-08-13 |
Not clear |
| Lian Zeng, Aohan Li, Zhen Zhang, Fuyu Zhang, Huaxian Chen, Ying Wang, Xudong Ding, Huiyu Lu. Ropivacaine Induces Cell Cycle Arrest in the G0/G1 Phase and Apoptosis of PC12 Cells via Inhibiting Mitochondrial STAT3 Translocation. Inflammation. vol 44. issue 6. 2021-11-26. PMID:34417665. |
in addition, the activator and inhibitor of mitostat3 translocation were used to demonstrate it was involved in ropivacaine-induced apoptosis; the results showed that enhancing the mitochondrial stat3 translocation could prevent ropivacaine-induced apoptosis. |
2021-11-26 |
2023-08-13 |
Not clear |
| Lian Zeng, Aohan Li, Zhen Zhang, Fuyu Zhang, Huaxian Chen, Ying Wang, Xudong Ding, Huiyu Lu. Ropivacaine Induces Cell Cycle Arrest in the G0/G1 Phase and Apoptosis of PC12 Cells via Inhibiting Mitochondrial STAT3 Translocation. Inflammation. vol 44. issue 6. 2021-11-26. PMID:34417665. |
we demonstrated that ropivacaine induced apoptosis by inhibiting the phosphorylation of stat3 at ser727 and the mitochondrial stat3 translocation. |
2021-11-26 |
2023-08-13 |
Not clear |
| Xin Liu, Lijuan Bian, Xiaoqin Duan, Xinming Zhuang, Yujie Sui, Longfei Yan. Alantolactone: A sesquiterpene lactone with diverse pharmacological effects. Chemical biology & drug design. vol 98. issue 6. 2021-11-25. PMID:34624172. |
the antitumor effects of ala have been demonstrated in vitro and in vivo via inducing intrinsic apoptosis, oxidative stress, er stress, cell cycle arrest and inhibiting autophagy and stat3 phosphorylation, which are also involved in its combination or synergy with other antitumor drugs. |
2021-11-25 |
2023-08-13 |
Not clear |
| Haosu Huang, Meng Wang, Zimeng Guo, Di Wu, Hanyue Wang, Yan Jia, Honghui Liu, Junjie Ding, Jie Pen. Rutaecarpine alleviates acute pancreatitis in mice and AR42J cells by suppressing the MAPK and NF-κB signaling pathways via calcitonin gene-related peptide. Phytotherapy research : PTR. vol 35. issue 11. 2021-11-25. PMID:34661951. |
cell-based studies revealed that rut significantly improved cell viability while suppressing the apoptosis of ar42j cells with cerulein-induced ap, downregulating il-6 and tnf-α, stimulating il-10 release, and inhibiting mapk, nf-κb, and stat3 signaling activation, all in a cgrp-dependent manner. |
2021-11-25 |
2023-08-13 |
mouse |
| Xu Chen, Yan Li, Haiqian Dai, Hao Zhang, Danyang Wan, Xinli Zhou, Chenghao Situ, Hui Zh. Cyclin-dependent kinase 7 is essential for spermatogenesis by regulating retinoic acid signaling pathways and the STAT3 molecular pathway. IUBMB life. vol 73. issue 12. 2021-11-24. PMID:34717033. |
we demonstrated that cdk7 affects germ cell apoptosis and sperm motility by activating stat3 and that stat3 further regulates cortactin expression to influence the nuclear elongation, chromatin condensation, and acrosome formation of sperm. |
2021-11-24 |
2023-08-13 |
mouse |
| Hyun-Ju Kim, Young-Jin Kim, Wansu Par. Berberine modulates hyper-inflammation in mouse macrophages stimulated with polyinosinic-polycytidylic acid via calcium-CHOP/STAT pathway. Scientific reports. vol 11. issue 1. 2021-11-19. PMID:34050236. |
levels of nitric oxide (no), prostaglandin e2 (pge2), first apoptosis signal receptor (fas; cd95), cytokines, intracellular calcium, phosphorylated i-kappa-b-alpha (ikb-α), phosphorylated p38 mitogen-activated protein kinase (mapk), phosphorylated erk1/2, phosphorylated signal transducer and activated transcription 3 (stat3), and mrna expression of inflammatory genes in poly i:c-induced raw 264.7 mouse macrophages were evaluated. |
2021-11-19 |
2023-08-13 |
mouse |