| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Debbie S Deben, Arjan J van Adrichem, Roosmarie Drent, Sabine Puts, Kelly E J M Pelzer, Adriaan A van Bodegraven, Dennis R Wong, Mathie P G Leer. Rac1/pSTAT3 expression: A pharmacodynamic marker panel as a first step toward optimization of thiopurine therapy in inflammatory bowel disease patients. Cytometry. Part A : the journal of the International Society for Analytical Cytology. 2021-10-08. PMID:34595833. |
the active thiopurine metabolite 6-thioguanine triphosphate (6-thio-gtp) causes t cell apoptosis via rac1 and the downstream transcription factor signal transducer and activator of transcription 3 (stat3). |
2021-10-08 |
2023-08-13 |
human |
| Ting Hong, Saiqi Li, Xiaoyu Guo, Yazhong Wei, Jingjing Zhang, Xiaohui Su, Miao Zhou, Haizhen Jin, Qing Miao, Lei Shen, Minfang Zhu, Bin H. IL-13 Derived Type 2 Innate Lymphocytes Ameliorates Cardiomyocyte Apoptosis Through STAT3 Signaling Pathway. Frontiers in cell and developmental biology. vol 9. 2021-10-08. PMID:34616745. |
il-13 derived type 2 innate lymphocytes ameliorates cardiomyocyte apoptosis through stat3 signaling pathway. |
2021-10-08 |
2023-08-13 |
mouse |
| Qian Wang, Bing Lu, Yi Zhang, Jing Yu, Jie Guo, Qianchi Zhou, Hong Lv, Yifeng Su. STAT3 inhibitor BBI608 enhances the antitumor effect of gefitinib on EGFR-mutated non-small cell lung cancer cells. Human cell. vol 34. issue 6. 2021-10-05. PMID:34370268. |
the colony formation, invasion, migration and apoptosis of hcc827 ge-r cells treated with gefitinib and/or stat3 inhibitor and/or oe-ror1 transfection were, respectively, detected by clone formation assay, transwell assay, wound healing assay and flow cytometry analysis. |
2021-10-05 |
2023-08-13 |
Not clear |
| Qian Wang, Bing Lu, Yi Zhang, Jing Yu, Jie Guo, Qianchi Zhou, Hong Lv, Yifeng Su. STAT3 inhibitor BBI608 enhances the antitumor effect of gefitinib on EGFR-mutated non-small cell lung cancer cells. Human cell. vol 34. issue 6. 2021-10-05. PMID:34370268. |
stat3 inhibitor bbi608 enhanced the ability of gefitinib to inhibit viability, invasion and migration while promoting apoptosis of hcc827 ge-r cells treated with gefitinib, which was partially reversed by ror1 overexpression. |
2021-10-05 |
2023-08-13 |
Not clear |
| Sijia Li, Kai Hu, Longjiang Li, Yi Shen, Jiayi Huang, Li Tang, Li Zhang, Ruyue Shao, Han Lu, Yongqiang Yan. Stattic alleviates acute hepatic damage induced by LPS/d-galactosamine in mice. Innate immunity. vol 27. issue 2. 2021-10-04. PMID:33576722. |
to investigate the effects of stat3 here, lps/d-galn-induced hepatic damage was induced in mice, the stat3 inhibitor stattic was administered, and the degree of liver injury, inflammation, and hepatocyte apoptosis were investigated. |
2021-10-04 |
2023-08-13 |
mouse |
| Ming Fu, Ledong Tan, Zefeng Lin, Vincent C H Lui, Paul K H Tam, Jonathan R Lamb, Yan Zhang, Huimin Xia, Ruizhong Zhang, Yan Che. Down-regulation of STAT3 enhanced chemokine expression and neutrophil recruitment in biliary atresia. Clinical science (London, England : 1979). vol 135. issue 7. 2021-10-01. PMID:33769466. |
inhibiting stat3 increased apoptosis of human becs together with up-regulated il-8 expression. |
2021-10-01 |
2023-08-13 |
mouse |
| Quan-Wen Liu, Yong Chen, Jing-Yuan Li, Ling Xiao, Wen-Jie Zhang, Jia-Le Zhao, Hao-Cheng Gu, Han-You Wu, Guo-Si-Lang Zuo, Ke-Yu Deng, Hong-Bo Xi. Bone marrow cells are differentiated into MDSCs by BCC-Ex through down-regulating the expression of CXCR4 and activating STAT3 signalling pathway. Journal of cellular and molecular medicine. vol 25. issue 12. 2021-10-01. PMID:33955151. |
western blot showed that bcc-ex significantly promoted the phosphorylation of stat3 in bone marrow cells, resulting in the inhibitions of the proliferation and apoptosis of bone marrow cells, and the aggravation of the differentiation of bone marrow cells into mdscs. |
2021-10-01 |
2023-08-13 |
mouse |
| Jinjing Jia, Ning Wang, Yan Zheng, Xiumei Mo, Yu Zhang, Siqi Ye, Junfeng Liu, Fenggen Yan, Hongyi Li, Dacan Che. RAS-association domain family 1A regulates the abnormal cell proliferation in psoriasis via inhibition of Yes-associated protein. Journal of cellular and molecular medicine. vol 25. issue 11. 2021-09-30. PMID:33960627. |
addition of the methylation inhibitor 5-aza-cdr or rassf1a-overexpressing lentivirus vector increased rassf1a and reduced yap expression; meanwhile improved skin lesions, reduced cell proliferation, induced cell cycle arrest in the g0/g1 phase, increased apoptosis, reduced inflammatory cytokines and activities of erk, stat3 and nf-κb signalling pathways. |
2021-09-30 |
2023-08-13 |
mouse |
| Jian-Sheng Liu, Chun-An Yeh, I-Chieh Huang, Guan-Yu Huang, Chih-Hao Chiu, B Mahalakshmi, Su-Ying Wen, Chih-Yang Huang, Wei-Wen Ku. Signal transducer and activator of transcription 3 mediates apoptosis inhibition through reducing mitochondrial ROS and activating Bcl-2 in gemcitabine-resistant lung cancer A549 cells. Journal of cellular physiology. vol 236. issue 5. 2021-09-29. PMID:33283880. |
taken together, the study demonstrated that stat3 acts as an essential regulator and moderates apoptosis through two major mechanisms to induce gemcitabine resistance in cells; and these findings provide a potential target for the treatment of gemcitabine-resistant lung cancer. |
2021-09-29 |
2023-08-13 |
Not clear |
| Jamal Mohammadian, Shiva Mahmoudi, Pirouz Pourmohammad, Mohammad Pirouzpanah, Fatemeh Salehnia, Nazila Fathi Maroufi, Nasser Samadi, Mehdi Sabzich. Formulation of Stattic as STAT3 inhibitor in nanostructured lipid carriers (NLCs) enhances efficacy of doxorubicin in melanoma cancer cells. Naunyn-Schmiedeberg's archives of pharmacology. vol 393. issue 12. 2021-09-24. PMID:32653978. |
here, we studied the effect of stattic (stat3 inhibitor) loaded in nanostructured lipid carriers (nlcs) on enhancing the efficacy, cytotoxicity, and induction of apoptosis of doxorubicin in b16f10 mouse melanoma cancer cell. |
2021-09-24 |
2023-08-13 |
mouse |
| Bashir Ahmad, Yaser Gamallat, Pengyu Su, Akbar Husain, Ata Ur Rehman, Mohamed Y Zaky, Ahmed Musa Hago Bakheet, Naeem Tahir, Yi Xin, Wang Lian. Alantolactone induces apoptosis in THP-1 cells through STAT3, survivin inhibition, and intrinsic apoptosis pathway. Chemical biology & drug design. vol 97. issue 2. 2021-09-22. PMID:32780548. |
alantolactone induces apoptosis in thp-1 cells through stat3, survivin inhibition, and intrinsic apoptosis pathway. |
2021-09-22 |
2023-08-13 |
Not clear |
| Jeong-Hun Lee, Kyung-Sook Chung, Hwi-Ho Lee, Dohyeong Ko, Minji Kang, Ho Yoo, JooHoon Ahn, Jae Yeol Lee, Kyung-Tae Le. Improved tumor-suppressive effect of OZ-001 combined with cisplatin mediated by mTOR/p70S6K and STAT3 inactivation in A549 human lung cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 142. 2021-09-22. PMID:34329824. |
moreover, our findings showed that mechanistic target of rapamycin (mtor), ribosomal protein s6 kinase (p70s6k), and signal transducer and activator of transcription (stat3) inactivation was required for apoptosis induced by the combination of oz-001 and cisplatin in in vitro and in vivo experiments. |
2021-09-22 |
2023-08-13 |
mouse |
| Chaosheng Li, Changyan Fan, Jilai Zhao, Meiqi Di, Chenyan Sui, Likun Han, Lingling H. Panaxatriol Saponins Promote M2 Polarization of BV2 Cells to Reduce Inflammation and Apoptosis after Glucose/Oxygen Deprivation by Activating STAT3. Inflammation. vol 43. issue 6. 2021-09-21. PMID:32725513. |
panaxatriol saponins promote m2 polarization of bv2 cells to reduce inflammation and apoptosis after glucose/oxygen deprivation by activating stat3. |
2021-09-21 |
2023-08-13 |
Not clear |
| Chaosheng Li, Changyan Fan, Jilai Zhao, Meiqi Di, Chenyan Sui, Likun Han, Lingling H. Panaxatriol Saponins Promote M2 Polarization of BV2 Cells to Reduce Inflammation and Apoptosis after Glucose/Oxygen Deprivation by Activating STAT3. Inflammation. vol 43. issue 6. 2021-09-21. PMID:32725513. |
after the addition of stat3 inhibitor stattic, it was found that pts could promote m2 polarization of bv2 cells by activating the stat3 pathway, thus inhibiting cell inflammation and apoptosis. |
2021-09-21 |
2023-08-13 |
Not clear |
| Chaosheng Li, Changyan Fan, Jilai Zhao, Meiqi Di, Chenyan Sui, Likun Han, Lingling H. Panaxatriol Saponins Promote M2 Polarization of BV2 Cells to Reduce Inflammation and Apoptosis after Glucose/Oxygen Deprivation by Activating STAT3. Inflammation. vol 43. issue 6. 2021-09-21. PMID:32725513. |
pts promoted m2 polarization in microglia cells by activating the stat3 pathway, thereby reducing cell inflammation and apoptosis after glucose/oxygen deprivation. |
2021-09-21 |
2023-08-13 |
Not clear |
| Xiaokun Zhou, Liang Lv, Yuan Tan, Zhongyi Zhang, Shuyang Wei, Shaowen Xia. Tanshinone IIA sensitizes TRAIL-induced apoptosis in glioblastoma through inducing the expression of death receptors (and suppressing STAT3 activation). Brain research. vol 1766. 2021-09-21. PMID:33984327. |
tanshinone iia sensitizes trail-induced apoptosis in glioblastoma through inducing the expression of death receptors (and suppressing stat3 activation). |
2021-09-21 |
2023-08-13 |
Not clear |
| Xinran Liu, Yiping Zhang, Yijie Wang, Meiwen Yang, Fenfang Hong, Shulong Yan. Protein Phosphorylation in Cancer: Role of Nitric Oxide Signaling Pathway. Biomolecules. vol 11. issue 7. 2021-09-21. PMID:34356634. |
phosphorylation of key proteins, including p38 mapk, erk, pi3k, stat3, and p53, modified by no in various signaling pathways affects different cancer-related processes including cell apoptosis, proliferation, angiogenesis, metastasis, and several cancer therapies. |
2021-09-21 |
2023-08-13 |
Not clear |
| Yaming Xu, Shini Feng, Bing Ni. Silencing Stat3 inhibits viability and induces apoptosis in BGC-823 human gastric cancer cell line. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 96. issue 1. 2021-09-17. PMID:32619110. |
silencing stat3 inhibits viability and induces apoptosis in bgc-823 human gastric cancer cell line. |
2021-09-17 |
2023-08-13 |
human |
| Yaming Xu, Shini Feng, Bing Ni. Silencing Stat3 inhibits viability and induces apoptosis in BGC-823 human gastric cancer cell line. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 96. issue 1. 2021-09-17. PMID:32619110. |
we investigated the effects of silencing stat3 and stat5b on the viability and apoptosis of the human gastric cancer cell line, bgc-823. |
2021-09-17 |
2023-08-13 |
human |
| Yaming Xu, Shini Feng, Bing Ni. Silencing Stat3 inhibits viability and induces apoptosis in BGC-823 human gastric cancer cell line. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 96. issue 1. 2021-09-17. PMID:32619110. |
silencing of stat3 caused significantly decreased viability and increased apoptosis, as well as attenuated b-cell lymphoma-2 (bcl-2) expression in bgc-823 cells. |
2021-09-17 |
2023-08-13 |
human |