| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bo Chen, Yingjun Yang, Jinbo Wu, Jianjiang Song, Jia L. microRNA-17-5p downregulation inhibits autophagy and myocardial remodelling after myocardial infarction by targeting STAT3. Autoimmunity. 2021-11-10. PMID:34755577. |
then, after inhibiting stat3 expression using stat3 inhibitor s31-201, the fibrosis, scarring, and cardiomyocyte apoptosis were deteriorated, along with the rise of lc3-ii/lc3-i and beclin-1 expression, the reduction of p62 expression and the reversion of mi attenuation. |
2021-11-10 |
2023-08-13 |
mouse |
| Zoleykha Asadi, Mojtaba Fathi, Elham Rismani, Zahra Bigdelou, Behrooz Johar. Application of decoy oligodeoxynucleotides strategy for inhibition of cell growth and reduction of metastatic properties in nonresistant and erlotinib-resistant SW480 cell line. Cell biology international. vol 45. issue 5. 2021-11-08. PMID:33377576. |
signal transducer and activator of transcription 3 (stat3) is a critical regulator for angiogenesis, cell cycle progression, apoptosis, and drug resistance. |
2021-11-08 |
2023-08-13 |
Not clear |
| Zoleykha Asadi, Mojtaba Fathi, Elham Rismani, Zahra Bigdelou, Behrooz Johar. Application of decoy oligodeoxynucleotides strategy for inhibition of cell growth and reduction of metastatic properties in nonresistant and erlotinib-resistant SW480 cell line. Cell biology international. vol 45. issue 5. 2021-11-08. PMID:33377576. |
a considerable decrease in proliferation of colon cancer cells was observed with blockade of stat3 signaling due to cell cycle arrest and induced apoptosis via downregulation of cyclin d1 and bcl-xl, respectively. |
2021-11-08 |
2023-08-13 |
Not clear |
| Shujun Yang, Yaodong Song, Qiaofang Wang, Yanna Liu, Zhongwei Wu, Xiaojia Duan, Yan Zhang, Xiuqian Bi, Yuanzhang Geng, Sanyang Chen, Changju Zh. Daphnetin ameliorates acute lung injury in mice with severe acute pancreatitis by inhibiting the JAK2-STAT3 pathway. Scientific reports. vol 11. issue 1. 2021-11-03. PMID:34075160. |
immunostaining of inflammatory and apoptotic cells was used to demonstrate lung tissue inflammation and apoptosis; elisa analysis of serum and tissue cytokine levels; and western blotting and immunohistochemical staining for the activated janus kinase 2 (jak2)-signal transducer and activator of transcription protein 3 (stat3) signalling pathway in lung tissues. |
2021-11-03 |
2023-08-13 |
mouse |
| Kauê R Martins, Cristina S Haas, Monique T Rovani, Fabiana Moreira, André L F Goetten, Juliana G Ferst, Valério M Portela, Raj Duggavathi, Vilceu Bordignon, Paulo B D Gonçalves, Bernardo G Gasperin, Thomaz Luci. Regulation and function of leptin during ovarian follicular development in cows. Animal reproduction science. vol 227. 2021-11-01. PMID:33667875. |
supplementation of in vitro culture medium with different leptin concentations did not affect (p > 0.05) the relative abundance of hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 (hsd3b1), cytochrome p450 family 11 subfamily a member 1 (cyp11a1), signal transducer and activator of transcription 3 (stat3) and x-linked inhibitor of apoptosis protein (xiap) mrna transcripts in granulosa cells. |
2021-11-01 |
2023-08-13 |
cattle |
| Chengliang Yuan, Guoping Chen, Chengbao Jing, Mengxue Liu, Bo Liang, Guojin Gong, Mei Y. Eriocitrin, a dietary flavonoid suppressed cell proliferation, induced apoptosis through modulation of JAK2/STAT3 and JNK/p38 MAPKs signaling pathway in MCF-7 cells. Journal of biochemical and molecular toxicology. 2021-11-01. PMID:34724282. |
oxidative stress causes abnormal stimulation of signal transducer and activator of transcription 3 (stat3) and c-jun nh2-terminal kinase (jnk), p38 mitogen-activated protein kinases (mapks) signaling has been strongly connected with the ruling of cell survival and apoptosis of cancer cells. |
2021-11-01 |
2023-08-13 |
Not clear |
| Chengliang Yuan, Guoping Chen, Chengbao Jing, Mengxue Liu, Bo Liang, Guojin Gong, Mei Y. Eriocitrin, a dietary flavonoid suppressed cell proliferation, induced apoptosis through modulation of JAK2/STAT3 and JNK/p38 MAPKs signaling pathway in MCF-7 cells. Journal of biochemical and molecular toxicology. 2021-11-01. PMID:34724282. |
eriocitrin induced apoptosis via suppression of stat3 signaling regulated proteins, activating proapoptotic factors bax, caspase 7, 8, 9 and suppressing bcl-2, bcl-x expression in mcf-7 cells. |
2021-11-01 |
2023-08-13 |
Not clear |
| Yingying Chen, Fujue Wang, Pengqiang Wu, Shuaige Gong, Jie Gao, Huan Tao, Qianqing Shen, Shuoting Wang, Zhencang Zhou, Yongqian Ji. Artesunate induces apoptosis, autophagy and ferroptosis in diffuse large B cell lymphoma cells by impairing STAT3 signaling. Cellular signalling. vol 88. 2021-10-29. PMID:34628002. |
artesunate induces apoptosis, autophagy and ferroptosis in diffuse large b cell lymphoma cells by impairing stat3 signaling. |
2021-10-29 |
2023-08-13 |
Not clear |
| Yingying Chen, Fujue Wang, Pengqiang Wu, Shuaige Gong, Jie Gao, Huan Tao, Qianqing Shen, Shuoting Wang, Zhencang Zhou, Yongqian Ji. Artesunate induces apoptosis, autophagy and ferroptosis in diffuse large B cell lymphoma cells by impairing STAT3 signaling. Cellular signalling. vol 88. 2021-10-29. PMID:34628002. |
in conclusion, the findings of the current study suggested that art may induce apoptosis and cell cycle arrest to inhibit cell proliferation, and regulate autophagy and ferroptosis via impairing the stat3 signaling pathway in dlbcl cells. |
2021-10-29 |
2023-08-13 |
Not clear |
| Yu-Xiao Liu, Wei-Tong Su, Yu L. [Biological functions of CREB/ATF bZIP transcription factor in metabolism and cell growth]. Sheng li xue bao : [Acta physiologica Sinica]. vol 73. issue 5. 2021-10-29. PMID:34708233. |
intriguingly, crebzf also regulates cell proliferation and apoptosis via interaction with several transcription factors including stat3, p53 and hcf-1. |
2021-10-29 |
2023-08-13 |
mouse |
| Jiaqi Zhu, Peter Langer, Claas Ulrich, Jürgen Eberl. Crucial Role of Reactive Oxygen Species (ROS) for the Proapoptotic Effects of Indirubin Derivatives in Cutaneous SCC Cells. Antioxidants (Basel, Switzerland). vol 10. issue 10. 2021-10-26. PMID:34679649. |
concerning the pathways, complete activation of caspases cascades (caspases-3, -4, -6, -7, -8 and -9), loss of mitochondrial membrane potential, activation of proapoptotic pkcδ (protein kinase c delta), inhibition of stat3 (signal transducer and activator of transcription 3), downregulation of antiapoptotic xiap (x-linked inhibitor of apoptosis protein) and survivin as well as upregulation of the proapoptotic bcl-2 protein puma and the cell cycle inhibitor p21 were obtained. |
2021-10-26 |
2023-08-13 |
Not clear |
| b' N Garc\\xc3\\xada-D\\xc3\\xadaz, B Casar, R Alonso-Alonso, L Quevedo, M Rodr\\xc3\\xadguez, F Ruso-Julve, A Esteve-Codina, M Gut, A A Gru, M C Gonz\\xc3\\xa1lez-Vela, I Gut, J L Rodriguez-Peralto, I Varela, P L Ortiz-Romero, M A Piris, J P Vaqu\\xc3\\xa. PLC\\xce\\xb31/PKC\\xce\\xb8 Downstream Signaling Controls Cutaneous T-Cell Lymphoma Development And Progression. The Journal of investigative dermatology. 2021-10-23. PMID:34687742.' |
downstream of plcγ1, the pharmacological inhibition and genetic knockdown of pkcθ inhibited stat3 activation, impaired proliferation, and promoted apoptosis in ctcl cells. |
2021-10-23 |
2023-08-13 |
human |
| Kyung-Ran Park, Hyun Hee Leem, Joonyeop Lee, Il Keun Kwon, Jin Tae Hong, Hyung-Mun Yu. Anti-cancer effects of Hederoside C, a pentacyclic triterpene saponin, through the intrinsic apoptosis and STAT3 signaling pathways in osteosarcoma. American journal of cancer research. vol 11. issue 9. 2021-10-22. PMID:34659904. |
anti-cancer effects of hederoside c, a pentacyclic triterpene saponin, through the intrinsic apoptosis and stat3 signaling pathways in osteosarcoma. |
2021-10-22 |
2023-08-13 |
Not clear |
| Chuan Zhang, Kun Ma, Yanmei Yang, Fuqiang Wang, Wuyin L. Corrigendum to Glaucocalyxin A suppresses inflammatory responses and induces apoptosis in TNF-a-induced human rheumatoid arthritis via modulation of the STAT3 pathway [Chem. Biol. Interact. 2021 May 25; 341 109451]. Chemico-biological interactions. 2021-10-22. PMID:34674846. |
corrigendum to glaucocalyxin a suppresses inflammatory responses and induces apoptosis in tnf-a-induced human rheumatoid arthritis via modulation of the stat3 pathway [chem. |
2021-10-22 |
2023-08-13 |
human |
| Wei Li, Hongfei Tong, Xiaojie Huang, Wen Wang, Hao Wu, Shengzhang Li. High levels of β-catenin promote IFNγ-induced apoptosis in hepatocellular carcinoma cells. Oncology letters. vol 4. issue 5. 2021-10-21. PMID:23162658. |
the caspase inhibitor z-vad-fmk and the stat3 inhibitor blocked this ifnγ-induced apoptosis. |
2021-10-21 |
2023-08-12 |
Not clear |
| Tian-Xiao Wang, Zhong-Qing Zhang, Yue Cong, Xiao-Yan Shi, Ying-Hua Liu, Fang-Li Zha. Prosapogenin A induces apoptosis in human cancer cells Oncology letters. vol 6. issue 5. 2021-10-21. PMID:24179517. |
prosapogenin a induces apoptosis in human cancer cells signal transducer and activator of transcription 3 (stat3) is considered to be an oncogene. |
2021-10-21 |
2023-08-12 |
human |
| Tian-Xiao Wang, Zhong-Qing Zhang, Yue Cong, Xiao-Yan Shi, Ying-Hua Liu, Fang-Li Zha. Prosapogenin A induces apoptosis in human cancer cells Oncology letters. vol 6. issue 5. 2021-10-21. PMID:24179517. |
blocking stat3 signaling may induce growth arrest and apoptosis in different types of tumors. |
2021-10-21 |
2023-08-12 |
human |
| Ling Liu, Feng Ding, Jiwei Chen, Boyong Wang, Zhisu Li. hSulf-1 inhibits cell proliferation and migration and promotes apoptosis by suppressing stat3 signaling in hepatocellular carcinoma. Oncology letters. vol 7. issue 4. 2021-10-21. PMID:24944651. |
hsulf-1 inhibits cell proliferation and migration and promotes apoptosis by suppressing stat3 signaling in hepatocellular carcinoma. |
2021-10-21 |
2023-08-13 |
human |
| Ling Liu, Feng Ding, Jiwei Chen, Boyong Wang, Zhisu Li. hSulf-1 inhibits cell proliferation and migration and promotes apoptosis by suppressing stat3 signaling in hepatocellular carcinoma. Oncology letters. vol 7. issue 4. 2021-10-21. PMID:24944651. |
however, hsulf-1 has not been previously shown to mediate the signal transducer and activator of transcription 3 (stat3) signaling pathway, which is known to regulate cell proliferation, motility and apoptosis. |
2021-10-21 |
2023-08-13 |
human |
| Viktoria von Manstein, Chul Min Yang, Diane Richter, Natalia Delis, Vida Vafaizadeh, Bernd Grone. Resistance of Cancer Cells to Targeted Therapies Through the Activation of Compensating Signaling Loops. Current signal transduction therapy. vol 8. issue 3. 2021-10-21. PMID:25045345. |
the treatment of hnscc with a specific inhibitor of c-src, initially resulted in reduced stat3 and stat5 activation and subsequently an arrest of cell proliferation and increased apoptosis. |
2021-10-21 |
2023-08-13 |
Not clear |