| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yaming Xu, Shini Feng, Bing Ni. Silencing Stat3 inhibits viability and induces apoptosis in BGC-823 human gastric cancer cell line. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 96. issue 1. 2021-09-17. PMID:32619110. |
stat3, but not stat5b, plays an important role in the viability and apoptosis of human gastric cancer cell line, bgc-823, which suggests that stat3 is a potential target for gastric cancer therapy. |
2021-09-17 |
2023-08-13 |
human |
| Mi-So Jeong, Kang-Wook Lee, Yu-Jeong Choi, Yun-Gyeong Kim, Hyun-Ha Hwang, Seo-Yeon Lee, Se-Eun Jung, Sun-Ah Park, Jin-Hee Lee, Yong-Joon Joo, Sung-Gook Cho, Seong-Gyu K. Synergistic Antitumor Activity of SH003 and Docetaxel via EGFR Signaling Inhibition in Non-Small Cell Lung Cancer. International journal of molecular sciences. vol 22. issue 16. 2021-09-16. PMID:34445110. |
moreover, sh003 and dtx induced the apoptosis of h460 cells via the suppression of the egfr and signal transducer and activator of transcription 3 (stat3) signaling pathways. |
2021-09-16 |
2023-08-13 |
human |
| Zuohua Xie, Bing Lin, Xinju Jia, Ting Su, Ying Wei, Jiping Tang, Chengzhi Yang, Chuanbao Cui, Jinxiang Li. Enhanced IL-10 inhibits proliferation and promotes apoptosis of HUVECs through STAT3 signaling pathway in sepsis. Histology and histopathology. 2021-09-16. PMID:34528700. |
enhanced il-10 inhibits proliferation and promotes apoptosis of huvecs through stat3 signaling pathway in sepsis. |
2021-09-16 |
2023-08-13 |
Not clear |
| Leandro M Colli, Lea Jessop, Timothy A Myers, Sabrina Y Camp, Mitchell J Machiela, Jiyeon Choi, Renato Cunha, Olusegun Onabajo, Grace C Mills, Virginia Schmid, Seth A Brodie, Olivier Delattre, David R Mole, Mark P Purdue, Kai Yu, Kevin M Brown, Stephen J Chanoc. Altered regulation of DPF3, a member of the SWI/SNF complexes, underlies the 14q24 renal cancer susceptibility locus. American journal of human genetics. vol 108. issue 9. 2021-09-15. PMID:34390653. |
our results indicate that germline variation in dpf3, a component of the baf complex, part of the swi/snf complexes, can lead to reduced apoptosis and activation of the stat3 pathway, both critical in rcc carcinogenesis. |
2021-09-15 |
2023-08-13 |
Not clear |
| Jungjoong Hwang, Insuk Song, Kwangho Lee, Hyoung Rae Kim, Eun-Hye Hong, Jung Soon Hwang, Sung-Hoon Ahn, Jongkook Le. KRCA-0008 suppresses ALK-positive anaplastic large-cell lymphoma growth. Investigational new drugs. vol 38. issue 5. 2021-09-14. PMID:31956933. |
additionally, it induced g0/g1 cell cycle arrest and apoptosis by blocking downstream signals including stat3, akt, and erk1/2. |
2021-09-14 |
2023-08-13 |
mouse |
| Wenfeng Lin, Jingkai Sun, Takuya Sadahira, Naijin Xu, Koichiro Wada, Chunxiao Liu, Motoo Araki, Abai Xu, Masami Watanabe, Yasutomo Nasu, Peng Huan. Discovery and Validation of Nitroxoline as a Novel STAT3 Inhibitor in Drug-resistant Urothelial Bladder Cancer. International journal of biological sciences. vol 17. issue 12. 2021-09-10. PMID:34421363. |
these results suggested that ntx-induced p-gp reversal, g0/g1 arrest, and apoptosis in drug-resistant ubc were mediated by inhibition of stat3 signaling. |
2021-09-10 |
2023-08-13 |
mouse |
| Wenfeng Lin, Jingkai Sun, Takuya Sadahira, Naijin Xu, Koichiro Wada, Chunxiao Liu, Motoo Araki, Abai Xu, Masami Watanabe, Yasutomo Nasu, Peng Huan. Discovery and Validation of Nitroxoline as a Novel STAT3 Inhibitor in Drug-resistant Urothelial Bladder Cancer. International journal of biological sciences. vol 17. issue 12. 2021-09-10. PMID:34421363. |
our findings repurpose ntx as a novel stat3 inhibitor to induce p-gp reversal, g0/g1 arrest, and apoptosis in drug-resistant ubc. |
2021-09-10 |
2023-08-13 |
mouse |
| Jingjie Sun, Yuping Du, Xinxin Zhang, Zhuoya Wang, Yuxi Lin, Qiaoling Song, Xiao Wang, Jihui Guo, Shanshan Li, Jing Nan, Jinbo Yan. Discovery and evaluation of Atopaxar hydrobromide, a novel JAK1 and JAK2 inhibitor, selectively induces apoptosis of cancer cells with constitutively activated STAT3. Investigational new drugs. vol 38. issue 4. 2021-09-09. PMID:31612426. |
discovery and evaluation of atopaxar hydrobromide, a novel jak1 and jak2 inhibitor, selectively induces apoptosis of cancer cells with constitutively activated stat3. |
2021-09-09 |
2023-08-13 |
Not clear |
| Sayeh Mottaghi, Hassan Abbaszade. The anticarcinogenic and anticancer effects of the dietary flavonoid, morin: Current status, challenges, and future perspectives. Phytotherapy research : PTR. 2021-09-09. PMID:34498311. |
a variety of molecular targets and signaling pathways such as apoptosis, cell cycle, reactive oxygen species (ros), matrix metalloproteinases (mmps), epithelial-mesenchymal transition (emt), and micrornas (mirnas) as well as signal transducer and activator of transcription 3 (stat3), nf-κb, phosphatidylinositol 3-kinase (pi3k)/akt, mitogen-activated protein kinase (mapk), and hippo pathways have been found to be involved in the anticancer effects of morin. |
2021-09-09 |
2023-08-13 |
Not clear |
| Wu Liu, Eskandar Qaed, Han Guo Zhu, Ma Xiao Dong, ZeYao Tan. Non-energy mechanism of phosphocreatine on the protection of cell survival. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 141. 2021-09-08. PMID:34174505. |
interestingly, pcr results in delaying the time to enter pathological metabolism through the delayed activation of ampk pathway, which is different from previous studies, now we propose the hypothesis that the "mirna-jak2/stat3 -cypd pathway" may take part in protecting cells from apoptosis, pcr may be further be involved in the dynamic relationship between cypd and stat3. |
2021-09-08 |
2023-08-13 |
Not clear |
| Ting Zhang, Liang He, Zhihong Wang, Wenwu Dong, Wei Sun, Yuan Qin, Ping Zhang, Hao Zhan. Calcitriol enhances Doxorubicin-induced apoptosis in papillary thyroid carcinoma cells via regulating VDR/PTPN2/p-STAT3 pathway. Journal of cellular and molecular medicine. vol 24. issue 10. 2021-09-07. PMID:32285621. |
calcitriol treatment up-regulated vdr and protein tyrosine phosphatase n 2 (ptpn2) expression, down-regulated signal transducers and activators of transcription (stat3) phosphorylation and thereby facilitating chemotherapy drug doxorubicin-induced apoptosis in ptc cell lines. |
2021-09-07 |
2023-08-13 |
Not clear |
| Chun Luo, Binru Li, Lang Chen, Lili Zhao, Yinghai We. IL-27 Protects the Brain from Ischemia-Reperfusion Injury via the gp130/STAT3 Signaling Pathway. Journal of molecular neuroscience : MN. vol 71. issue 9. 2021-09-07. PMID:33851350. |
our results indicated that il-27 could bind to its receptor of gp130 to attenuate the i/r injury-induced impairment function and cerebral infarction volume, and decrease inflammatory cytokines tnf-α, il-1β and mcp-1 but increase anti-inflammatory factors il-10 and tgf-β in vivo, while inhibiting ldh leakage and neuronal apoptosis through activation of stat3 to antagonize i/r induction. |
2021-09-07 |
2023-08-13 |
mouse |
| Luying Zhang, Kamil Kuca, Li You, Yingying Zhao, Kamil Musilek, Eugenie Nepovimova, Qinghua Wu, Wenda Wu, Vojtech Ada. Signal transducer and activator of transcription 3 signaling in tumor immune evasion. Pharmacology & therapeutics. 2021-09-03. PMID:34450232. |
stat3 controls autophagy molecules that impair ctl-mediated tumor cell lysis, inhibiting natural killer cells and inducing apoptosis in t lymphocytes to create an immunosuppressive environment. |
2021-09-03 |
2023-08-13 |
human |
| Yang Sun, Wei Nie, Bo Qiu, Xiangjun Guo, Jian Zhang, Jianming We. Inhibition of microRNA-17 enhances cisplatin-induced apoptosis of human tongue squamous carcinoma cell. Journal of bioenergetics and biomembranes. vol 53. issue 2. 2021-09-02. PMID:33462751. |
mechanically, mir-17 inhibition promotes apoptosis and autophagy through stat3 signaling pathway. |
2021-09-02 |
2023-08-13 |
human |
| Junbiao Wang, Romilde Iannarelli, Stefania Pucciarelli, Emiliano Laudadio, Roberta Galeazzi, Mara Giangrossi, Maurizio Falconi, Lishan Cui, Aleix Marti Navia, Michela Buccioni, Gabriella Marucci, Daniele Tomassoni, Laura Serini, Stefania Sut, Filippo Maggi, Stefano Dall'Acqua, Cristina Marchini, Augusto Amic. Acetylshikonin isolated from Lithospermum erythrorhizon roots inhibits dihydrofolate reductase and hampers autochthonous mammary carcinogenesis in Δ16HER2 transgenic mice. Pharmacological research. vol 161. 2021-09-01. PMID:32822867. |
acetylshikonin anticancer effect depends on its ability to act as a potent inhibitor of dihydrofolate reductase (dhfr), to down-regulate key mediators governing cancer growth and progression, such as her2, src and stat3, and to induce apoptosis by caspase-3 activation. |
2021-09-01 |
2023-08-13 |
mouse |
| Baodan Yu, Lixia Zheng, Huiqin Tang, Weixin Wang, Yongping Li. Cucurbitacin B enhances apoptosis in gefitinib resistant non‑small cell lung cancer by modulating the miR‑17‑5p/STAT3 axis. Molecular medicine reports. vol 24. issue 4. 2021-08-31. PMID:34396444. |
overexpression of stat3 increased proliferation and decreased apoptosis and the protein levels of apoptosis‑related factors cleaved caspase‑3 and cleaved caspase‑9 of pc9/gr cells. |
2021-08-31 |
2023-08-13 |
Not clear |
| Ying-Ying Fang, Jing-Hui Zhan. MFG-E8 alleviates oxygen-glucose deprivation-induced neuronal cell apoptosis by STAT3 regulating the selective polarization of microglia. The International journal of neuroscience. vol 131. issue 1. 2021-08-26. PMID:32098538. |
mfg-e8 alleviates oxygen-glucose deprivation-induced neuronal cell apoptosis by stat3 regulating the selective polarization of microglia. |
2021-08-26 |
2023-08-13 |
Not clear |
| Xitao Liu, Defang Zha. CKS1B promotes the progression of hepatocellular carcinoma by activating JAK/STAT3 signal pathway. Animal cells and systems. vol 25. issue 4. 2021-08-20. PMID:34408811. |
furthermore, knockdown of cks1b also downregulated stat3 target genes timp-1, bcl-2 and vegf, which were involved in controlling cell apoptosis and migration. |
2021-08-20 |
2023-08-13 |
Not clear |
| Ying Li, Qi Qi, Wan-Cheng Yang, Tian-Liang Zhang, Chen-Chen Lu, Yu-Juan Yao, Wei-Hua Kong, Jing Zha. Sphingosylphosphorylcholine alleviates hypoxia-caused apoptosis in cardiac myofibroblasts via CaM/p38/STAT3 pathway. Apoptosis : an international journal on programmed cell death. vol 25. issue 11-12. 2021-08-19. PMID:33068199. |
furthermore, the employment of inhibitor and agonist of p38 and stat3 suggests that spc inhibits myofibroblast apoptosis by regulating the phosphorylation of p38 and stat3, and they act as downstream of cam. |
2021-08-19 |
2023-08-13 |
Not clear |
| Di Zhao, Jie Chen, Yan Wang, Lingyuan Zhang, Jing Zhang, Weimin Zhang, Jiawen Fan, Jinting Li, Qimin Zha. Feed-forward activation of STAT3 signaling limits the efficacy of c-Met inhibitors in esophageal squamous cell carcinoma (ESCC) treatment. Molecular carcinogenesis. vol 60. issue 7. 2021-08-19. PMID:34018249. |
importantly, combined c-met and stat3 inhibitors synergistically suppressed tumor growth and promoted the apoptosis of tumor cells without producing systematic toxicity. |
2021-08-19 |
2023-08-13 |
Not clear |