| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jianyong Chen, Longchuan Bai, Denzil Bernard, Zaneta Nikolovska-Coleska, Cindy Gomez, Jian Zhang, Han Yi, Shaomeng Wan. Structure-Based Design of Conformationally Constrained, Cell-Permeable STAT3 Inhibitors. ACS medicinal chemistry letters. vol 1. issue 2. 2021-10-20. PMID:20596242. |
compound 11 (cj-1383) binds to stat3 with a k(i) value of 0.95 µm, dose-dependently inhibits cellular stat3 signaling and cancer cell growth, and induces apoptosis in the mda-mb-468 cancer cell line with constitutively activated stat3. |
2021-10-20 |
2023-08-12 |
Not clear |
| Yang Du, Chuize Kon. STAT3 regulates miR93-mediated apoptosis through inhibiting DAPK1 in renal cell carcinoma. Cancer gene therapy. vol 28. issue 5. 2021-10-18. PMID:33230258. |
stat3 regulates mir93-mediated apoptosis through inhibiting dapk1 in renal cell carcinoma. |
2021-10-18 |
2023-08-13 |
Not clear |
| Xiufeng Wang, Zhijun Liu, Fang Wan. MicroRNA-93 Blocks Signal Transducers and Activator of Transcription 3 to Reduce Neuronal Damage in Parkinson's Disease. Neurochemical research. vol 46. issue 7. 2021-10-18. PMID:33900518. |
furthermore, both mir-93 overexpression and stat3 knockdown reduced lps-induced bv2 cell apoptosis, whereas stat3 overexpression eliminated the inhibitory effect of mir-93 on lps-induced bv2 cell apoptosis. |
2021-10-18 |
2023-08-13 |
mouse |
| Li Pan, Ruijie Zhang, Ling Ma, Christopher R Pierson, Jonathan L Finlay, Chenglong Li, Jiayuh Li. STAT3 inhibitor in combination with irradiation significantly inhibits cell viability, cell migration, invasion and tumorsphere growth of human medulloblastoma cells. Cancer biology & therapy. vol 22. issue 7-9. 2021-10-15. PMID:34254873. |
combining either stat3 inhibitor with irradiation reduces the expression of stat3 downstream targets, cyclin d1 and survivin, and induces apoptosis in medulloblastoma cells. |
2021-10-15 |
2023-08-13 |
human |
| Binglin Zeng, Yu Cheng, Kailu Zheng, Shuoxiao Liu, Longying Shen, Jinping Hu, Yan Li, Xiandao Pa. Design, synthesis and in vivo anticancer activity of novel parthenolide and micheliolide derivatives as NF-κB and STAT3 inhibitors. Bioorganic chemistry. vol 111. 2021-10-14. PMID:34004586. |
anticancer mechanism studies revealed that 9-oxomicheliolide exhibited inhibition effect against nf-κb and stat3 signaling pathways, as well as induction effects of cell apoptosis. |
2021-10-14 |
2023-08-13 |
mouse |
| Xiang Chen, Li Pan, Jia Wei, Ruijie Zhang, Xiaozhi Yang, Jinhua Song, Ren-Yuan Bai, Shengling Fu, Christopher R Pierson, Jonathan L Finlay, Chenglong Li, Jiayuh Li. LLL12B, a small molecule STAT3 inhibitor, induces growth arrest, apoptosis, and enhances cisplatin-mediated cytotoxicity in medulloblastoma cells. Scientific reports. vol 11. issue 1. 2021-10-13. PMID:33753770. |
lll12b, a small molecule stat3 inhibitor, induces growth arrest, apoptosis, and enhances cisplatin-mediated cytotoxicity in medulloblastoma cells. |
2021-10-13 |
2023-08-13 |
human |
| Jonggul Lee, Donggu Lee, Yangjin Ki. Mathematical model of STAT signalling pathways in cancer development and optimal control approaches. Royal Society open science. vol 8. issue 9. 2021-10-12. PMID:34631119. |
in this study, we investigate how an intracellular signalling network (stat1, stat3, bcl-2 and bax) regulates important cellular states, either anti-apoptosis or apoptosis of cancer cells. |
2021-10-12 |
2023-08-13 |
Not clear |
| Saeko Ando, Katsumi Fukamachi, Eri Yoshimoto, Harutoshi Matsumoto, Munekazu Iinuma, Masumi Suzu. Palmitoyl piperidinopiperidine, a novel derivative of 10‑hydroxy‑2‑decenoic acid, as a potent and selective anticancer agent against human colon carcinoma cell lines. International journal of oncology. vol 58. issue 2. 2021-10-11. PMID:33491745. |
as regards the possible molecular mechanisms, it is suggested that the inhibition of stat3 by ppi may affect the function of molecules that are related to apoptosis, angiogenesis and cell cycle progression, eventually contributing to the ppi‑induced growth inhibitory effects. |
2021-10-11 |
2023-08-13 |
human |
| Zijia Qin, Hang Tong, Tinghao Li, Honghao Cao, Junlong Zhu, Siwen Yin, Weiyang H. SPHK1 contributes to cisplatin resistance in bladder cancer cells via the NONO/STAT3 axis. International journal of molecular medicine. vol 48. issue 5. 2021-10-08. PMID:34549307. |
a potential mechanism underlying sphk1‑induced cisplatin resistance and apoptosis inhibition may be activation of stat3 via binding non‑pou domain containing octamer binding. |
2021-10-08 |
2023-08-13 |
Not clear |
| Debbie S Deben, Arjan J van Adrichem, Roosmarie Drent, Sabine Puts, Kelly E J M Pelzer, Adriaan A van Bodegraven, Dennis R Wong, Mathie P G Leer. Rac1/pSTAT3 expression: A pharmacodynamic marker panel as a first step toward optimization of thiopurine therapy in inflammatory bowel disease patients. Cytometry. Part A : the journal of the International Society for Analytical Cytology. 2021-10-08. PMID:34595833. |
the active thiopurine metabolite 6-thioguanine triphosphate (6-thio-gtp) causes t cell apoptosis via rac1 and the downstream transcription factor signal transducer and activator of transcription 3 (stat3). |
2021-10-08 |
2023-08-13 |
human |
| Ting Hong, Saiqi Li, Xiaoyu Guo, Yazhong Wei, Jingjing Zhang, Xiaohui Su, Miao Zhou, Haizhen Jin, Qing Miao, Lei Shen, Minfang Zhu, Bin H. IL-13 Derived Type 2 Innate Lymphocytes Ameliorates Cardiomyocyte Apoptosis Through STAT3 Signaling Pathway. Frontiers in cell and developmental biology. vol 9. 2021-10-08. PMID:34616745. |
il-13 derived type 2 innate lymphocytes ameliorates cardiomyocyte apoptosis through stat3 signaling pathway. |
2021-10-08 |
2023-08-13 |
mouse |
| Qian Wang, Bing Lu, Yi Zhang, Jing Yu, Jie Guo, Qianchi Zhou, Hong Lv, Yifeng Su. STAT3 inhibitor BBI608 enhances the antitumor effect of gefitinib on EGFR-mutated non-small cell lung cancer cells. Human cell. vol 34. issue 6. 2021-10-05. PMID:34370268. |
the colony formation, invasion, migration and apoptosis of hcc827 ge-r cells treated with gefitinib and/or stat3 inhibitor and/or oe-ror1 transfection were, respectively, detected by clone formation assay, transwell assay, wound healing assay and flow cytometry analysis. |
2021-10-05 |
2023-08-13 |
Not clear |
| Qian Wang, Bing Lu, Yi Zhang, Jing Yu, Jie Guo, Qianchi Zhou, Hong Lv, Yifeng Su. STAT3 inhibitor BBI608 enhances the antitumor effect of gefitinib on EGFR-mutated non-small cell lung cancer cells. Human cell. vol 34. issue 6. 2021-10-05. PMID:34370268. |
stat3 inhibitor bbi608 enhanced the ability of gefitinib to inhibit viability, invasion and migration while promoting apoptosis of hcc827 ge-r cells treated with gefitinib, which was partially reversed by ror1 overexpression. |
2021-10-05 |
2023-08-13 |
Not clear |
| Sijia Li, Kai Hu, Longjiang Li, Yi Shen, Jiayi Huang, Li Tang, Li Zhang, Ruyue Shao, Han Lu, Yongqiang Yan. Stattic alleviates acute hepatic damage induced by LPS/d-galactosamine in mice. Innate immunity. vol 27. issue 2. 2021-10-04. PMID:33576722. |
to investigate the effects of stat3 here, lps/d-galn-induced hepatic damage was induced in mice, the stat3 inhibitor stattic was administered, and the degree of liver injury, inflammation, and hepatocyte apoptosis were investigated. |
2021-10-04 |
2023-08-13 |
mouse |
| Ming Fu, Ledong Tan, Zefeng Lin, Vincent C H Lui, Paul K H Tam, Jonathan R Lamb, Yan Zhang, Huimin Xia, Ruizhong Zhang, Yan Che. Down-regulation of STAT3 enhanced chemokine expression and neutrophil recruitment in biliary atresia. Clinical science (London, England : 1979). vol 135. issue 7. 2021-10-01. PMID:33769466. |
inhibiting stat3 increased apoptosis of human becs together with up-regulated il-8 expression. |
2021-10-01 |
2023-08-13 |
mouse |
| Quan-Wen Liu, Yong Chen, Jing-Yuan Li, Ling Xiao, Wen-Jie Zhang, Jia-Le Zhao, Hao-Cheng Gu, Han-You Wu, Guo-Si-Lang Zuo, Ke-Yu Deng, Hong-Bo Xi. Bone marrow cells are differentiated into MDSCs by BCC-Ex through down-regulating the expression of CXCR4 and activating STAT3 signalling pathway. Journal of cellular and molecular medicine. vol 25. issue 12. 2021-10-01. PMID:33955151. |
western blot showed that bcc-ex significantly promoted the phosphorylation of stat3 in bone marrow cells, resulting in the inhibitions of the proliferation and apoptosis of bone marrow cells, and the aggravation of the differentiation of bone marrow cells into mdscs. |
2021-10-01 |
2023-08-13 |
mouse |
| Jinjing Jia, Ning Wang, Yan Zheng, Xiumei Mo, Yu Zhang, Siqi Ye, Junfeng Liu, Fenggen Yan, Hongyi Li, Dacan Che. RAS-association domain family 1A regulates the abnormal cell proliferation in psoriasis via inhibition of Yes-associated protein. Journal of cellular and molecular medicine. vol 25. issue 11. 2021-09-30. PMID:33960627. |
addition of the methylation inhibitor 5-aza-cdr or rassf1a-overexpressing lentivirus vector increased rassf1a and reduced yap expression; meanwhile improved skin lesions, reduced cell proliferation, induced cell cycle arrest in the g0/g1 phase, increased apoptosis, reduced inflammatory cytokines and activities of erk, stat3 and nf-κb signalling pathways. |
2021-09-30 |
2023-08-13 |
mouse |
| Jian-Sheng Liu, Chun-An Yeh, I-Chieh Huang, Guan-Yu Huang, Chih-Hao Chiu, B Mahalakshmi, Su-Ying Wen, Chih-Yang Huang, Wei-Wen Ku. Signal transducer and activator of transcription 3 mediates apoptosis inhibition through reducing mitochondrial ROS and activating Bcl-2 in gemcitabine-resistant lung cancer A549 cells. Journal of cellular physiology. vol 236. issue 5. 2021-09-29. PMID:33283880. |
taken together, the study demonstrated that stat3 acts as an essential regulator and moderates apoptosis through two major mechanisms to induce gemcitabine resistance in cells; and these findings provide a potential target for the treatment of gemcitabine-resistant lung cancer. |
2021-09-29 |
2023-08-13 |
Not clear |
| Jamal Mohammadian, Shiva Mahmoudi, Pirouz Pourmohammad, Mohammad Pirouzpanah, Fatemeh Salehnia, Nazila Fathi Maroufi, Nasser Samadi, Mehdi Sabzich. Formulation of Stattic as STAT3 inhibitor in nanostructured lipid carriers (NLCs) enhances efficacy of doxorubicin in melanoma cancer cells. Naunyn-Schmiedeberg's archives of pharmacology. vol 393. issue 12. 2021-09-24. PMID:32653978. |
here, we studied the effect of stattic (stat3 inhibitor) loaded in nanostructured lipid carriers (nlcs) on enhancing the efficacy, cytotoxicity, and induction of apoptosis of doxorubicin in b16f10 mouse melanoma cancer cell. |
2021-09-24 |
2023-08-13 |
mouse |
| Bashir Ahmad, Yaser Gamallat, Pengyu Su, Akbar Husain, Ata Ur Rehman, Mohamed Y Zaky, Ahmed Musa Hago Bakheet, Naeem Tahir, Yi Xin, Wang Lian. Alantolactone induces apoptosis in THP-1 cells through STAT3, survivin inhibition, and intrinsic apoptosis pathway. Chemical biology & drug design. vol 97. issue 2. 2021-09-22. PMID:32780548. |
alantolactone induces apoptosis in thp-1 cells through stat3, survivin inhibition, and intrinsic apoptosis pathway. |
2021-09-22 |
2023-08-13 |
Not clear |