| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chun Luo, Binru Li, Lang Chen, Lili Zhao, Yinghai We. IL-27 Protects the Brain from Ischemia-Reperfusion Injury via the gp130/STAT3 Signaling Pathway. Journal of molecular neuroscience : MN. vol 71. issue 9. 2021-09-07. PMID:33851350. |
our results indicated that il-27 could bind to its receptor of gp130 to attenuate the i/r injury-induced impairment function and cerebral infarction volume, and decrease inflammatory cytokines tnf-α, il-1β and mcp-1 but increase anti-inflammatory factors il-10 and tgf-β in vivo, while inhibiting ldh leakage and neuronal apoptosis through activation of stat3 to antagonize i/r induction. |
2021-09-07 |
2023-08-13 |
mouse |
| Luying Zhang, Kamil Kuca, Li You, Yingying Zhao, Kamil Musilek, Eugenie Nepovimova, Qinghua Wu, Wenda Wu, Vojtech Ada. Signal transducer and activator of transcription 3 signaling in tumor immune evasion. Pharmacology & therapeutics. 2021-09-03. PMID:34450232. |
stat3 controls autophagy molecules that impair ctl-mediated tumor cell lysis, inhibiting natural killer cells and inducing apoptosis in t lymphocytes to create an immunosuppressive environment. |
2021-09-03 |
2023-08-13 |
human |
| Yang Sun, Wei Nie, Bo Qiu, Xiangjun Guo, Jian Zhang, Jianming We. Inhibition of microRNA-17 enhances cisplatin-induced apoptosis of human tongue squamous carcinoma cell. Journal of bioenergetics and biomembranes. vol 53. issue 2. 2021-09-02. PMID:33462751. |
mechanically, mir-17 inhibition promotes apoptosis and autophagy through stat3 signaling pathway. |
2021-09-02 |
2023-08-13 |
human |
| Junbiao Wang, Romilde Iannarelli, Stefania Pucciarelli, Emiliano Laudadio, Roberta Galeazzi, Mara Giangrossi, Maurizio Falconi, Lishan Cui, Aleix Marti Navia, Michela Buccioni, Gabriella Marucci, Daniele Tomassoni, Laura Serini, Stefania Sut, Filippo Maggi, Stefano Dall'Acqua, Cristina Marchini, Augusto Amic. Acetylshikonin isolated from Lithospermum erythrorhizon roots inhibits dihydrofolate reductase and hampers autochthonous mammary carcinogenesis in Δ16HER2 transgenic mice. Pharmacological research. vol 161. 2021-09-01. PMID:32822867. |
acetylshikonin anticancer effect depends on its ability to act as a potent inhibitor of dihydrofolate reductase (dhfr), to down-regulate key mediators governing cancer growth and progression, such as her2, src and stat3, and to induce apoptosis by caspase-3 activation. |
2021-09-01 |
2023-08-13 |
mouse |
| Baodan Yu, Lixia Zheng, Huiqin Tang, Weixin Wang, Yongping Li. Cucurbitacin B enhances apoptosis in gefitinib resistant non‑small cell lung cancer by modulating the miR‑17‑5p/STAT3 axis. Molecular medicine reports. vol 24. issue 4. 2021-08-31. PMID:34396444. |
overexpression of stat3 increased proliferation and decreased apoptosis and the protein levels of apoptosis‑related factors cleaved caspase‑3 and cleaved caspase‑9 of pc9/gr cells. |
2021-08-31 |
2023-08-13 |
Not clear |
| Ying-Ying Fang, Jing-Hui Zhan. MFG-E8 alleviates oxygen-glucose deprivation-induced neuronal cell apoptosis by STAT3 regulating the selective polarization of microglia. The International journal of neuroscience. vol 131. issue 1. 2021-08-26. PMID:32098538. |
mfg-e8 alleviates oxygen-glucose deprivation-induced neuronal cell apoptosis by stat3 regulating the selective polarization of microglia. |
2021-08-26 |
2023-08-13 |
Not clear |
| Xitao Liu, Defang Zha. CKS1B promotes the progression of hepatocellular carcinoma by activating JAK/STAT3 signal pathway. Animal cells and systems. vol 25. issue 4. 2021-08-20. PMID:34408811. |
furthermore, knockdown of cks1b also downregulated stat3 target genes timp-1, bcl-2 and vegf, which were involved in controlling cell apoptosis and migration. |
2021-08-20 |
2023-08-13 |
Not clear |
| Ying Li, Qi Qi, Wan-Cheng Yang, Tian-Liang Zhang, Chen-Chen Lu, Yu-Juan Yao, Wei-Hua Kong, Jing Zha. Sphingosylphosphorylcholine alleviates hypoxia-caused apoptosis in cardiac myofibroblasts via CaM/p38/STAT3 pathway. Apoptosis : an international journal on programmed cell death. vol 25. issue 11-12. 2021-08-19. PMID:33068199. |
furthermore, the employment of inhibitor and agonist of p38 and stat3 suggests that spc inhibits myofibroblast apoptosis by regulating the phosphorylation of p38 and stat3, and they act as downstream of cam. |
2021-08-19 |
2023-08-13 |
Not clear |
| Di Zhao, Jie Chen, Yan Wang, Lingyuan Zhang, Jing Zhang, Weimin Zhang, Jiawen Fan, Jinting Li, Qimin Zha. Feed-forward activation of STAT3 signaling limits the efficacy of c-Met inhibitors in esophageal squamous cell carcinoma (ESCC) treatment. Molecular carcinogenesis. vol 60. issue 7. 2021-08-19. PMID:34018249. |
importantly, combined c-met and stat3 inhibitors synergistically suppressed tumor growth and promoted the apoptosis of tumor cells without producing systematic toxicity. |
2021-08-19 |
2023-08-13 |
Not clear |
| Xiunan Yu, Xiaohong L. microRNA-1906 protects cerebral ischemic injury through activating Janus kinase 2/signal transducer and activator of transcription 3 pathway in rats. Neuroreport. vol 31. issue 12. 2021-08-13. PMID:32427806. |
after treating with jak2/stat3 pathway inhibitor ag490, the phosphorylation of jak2 and stat3 was inhibited and the effects of mir-1906 on neurological score, infarct volume, brain water content, neuronal apoptosis and inflammatory factors were reversed. |
2021-08-13 |
2023-08-13 |
rat |
| Li-Bin Gao, Xin-Le Zhu, Jing-Xian Shi, Ling Yang, Zhen-Qiang Xu, Song-Lin Sh. HnRNPA2B1 promotes the proliferation of breast cancer MCF-7 cells via the STAT3 pathway. Journal of cellular biochemistry. vol 122. issue 3-4. 2021-08-12. PMID:33399232. |
collectively, our results demonstrate that hnrnpa2/b1 promotes tumor cell growth in vitro and in vivo by activating the stat3 pathway, regulating apoptosis and autophagy. |
2021-08-12 |
2023-08-13 |
mouse |
| Chen Sun, Ming Bai, Weiwei Ke, Xiaoxun Wang, Xiangxuan Zhao, Zaiming L. The HSP90 inhibitor, XL888, enhanced cell apoptosis via downregulating STAT3 after insufficient radiofrequency ablation in hepatocellular carcinoma. Life sciences. vol 282. 2021-08-12. PMID:34186047. |
the hsp90 inhibitor, xl888, enhanced cell apoptosis via downregulating stat3 after insufficient radiofrequency ablation in hepatocellular carcinoma. |
2021-08-12 |
2023-08-13 |
Not clear |
| Aikai Zhang, Fenfang Yu, Wande Yu, Peng Ye, Pengfei Liu, Yue Gu, Shaoliang Chen, Hang Zhan. Pyruvate kinase M2 activation protects against the proliferation and migration of pulmonary artery smooth muscle cells. Cell and tissue research. vol 382. issue 3. 2021-08-10. PMID:32719938. |
pkm2 phosphorylation promoted the dimerization activation and nuclear translocation of stat3, a transcription factor regulating proliferation, growth, and apoptosis. |
2021-08-10 |
2023-08-13 |
mouse |
| Jing Li, Yubing Wang, Lisha Li, Penelope M-Y Or, Chi Wai Wong, Tian Liu, Wayne L H Ho, Andrew M Cha. Tumour-derived substrate-adherent cells promote neuroblastoma survival through secreted trophic factors. Molecular oncology. vol 15. issue 8. 2021-08-10. PMID:33932101. |
overall, the tumour-derived s-type cells prevented apoptosis in the n-type cells via alk-independent stat3 activation triggered by secreted factors. |
2021-08-10 |
2023-08-13 |
Not clear |
| Rong-Rong Li, De-Yu Zen. The effects and mechanism of α-mangostin on chemosensitivity of gastric cancer cells. The Kaohsiung journal of medical sciences. vol 37. issue 8. 2021-08-10. PMID:34003591. |
cell proliferation and apoptosis were assessed as well as the levels of ebi3, stat3, p-stat3, autophagy-related proteins, and apoptosis-related proteins. |
2021-08-10 |
2023-08-13 |
Not clear |
| Liang Li, Minbiao Chen, Gao Li, Renzhong Ca. Raddeanin A induced apoptosis of non-small cell lung cancer cells by promoting ROS-mediated STAT3 inactivation. Tissue & cell. vol 71. 2021-08-09. PMID:34146943. |
raddeanin a induced apoptosis of non-small cell lung cancer cells by promoting ros-mediated stat3 inactivation. |
2021-08-09 |
2023-08-13 |
Not clear |
| Ping Cui, Fen Wei, Jingjing Hou, Ying Su, Jijun Wang, Sicen Wan. STAT3 inhibition induced temozolomide-resistant glioblastoma apoptosis via triggering mitochondrial STAT3 translocation and respiratory chain dysfunction. Cellular signalling. vol 71. 2021-08-05. PMID:32165236. |
stat3 inhibition induced temozolomide-resistant glioblastoma apoptosis via triggering mitochondrial stat3 translocation and respiratory chain dysfunction. |
2021-08-05 |
2023-08-13 |
Not clear |
| Ping Cui, Fen Wei, Jingjing Hou, Ying Su, Jijun Wang, Sicen Wan. STAT3 inhibition induced temozolomide-resistant glioblastoma apoptosis via triggering mitochondrial STAT3 translocation and respiratory chain dysfunction. Cellular signalling. vol 71. 2021-08-05. PMID:32165236. |
in the present study, we demonstrated that the salicylic acid-based compound sh-4-54 was quite toxic to temozolomide (tmz)-resistant gbm cells and could trigger apoptosis in these cells via enhancing mitochondrial translocation-dependent non-canonical stat3 pathway. |
2021-08-05 |
2023-08-13 |
Not clear |
| Chenglong Chen, Hongliang Zhang, Yiyang Yu, Qingshan Huang, Wei Wang, Jianfang Niu, Jingbing Lou, Tingting Ren, Yi Huang, Wei Gu. Chloroquine suppresses proliferation and invasion and induces apoptosis of osteosarcoma cells associated with inhibition of phosphorylation of STAT3. Aging. vol 13. issue 13. 2021-08-04. PMID:34170850. |
chloroquine suppresses proliferation and invasion and induces apoptosis of osteosarcoma cells associated with inhibition of phosphorylation of stat3. |
2021-08-04 |
2023-08-13 |
Not clear |
| Shibin Zhang, Tingting Meng, Chunzhi Tang, Shengdong Li, Xudong Cai, Dawei Wang, Min Che. MicroRNA-340-5p suppressed rheumatoid arthritis synovial fibroblast proliferation and induces apoptotic cell number by targeting signal transducers and activators of transcription 3. Autoimmunity. vol 53. issue 6. 2021-07-26. PMID:32706318. |
overexpression of stat3 could reverse the outcome of microrna-340-5p on cell proliferation and apoptosis in rheumatoid arthritis fibroblast-like synoviocytes. |
2021-07-26 |
2023-08-13 |
human |