| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fengyun Zhou, Ting Feng, Xiangqi Lu, Huicheng Wang, Yangping Chen, Qiuxia Zhang, Xinlu Zhang, Jiancheng Xi. Interleukin 35 protects cardiomyocytes following ischemia/reperfusion-induced apoptosis via activation of mitochondrial STAT3. Acta biochimica et biophysica Sinica. vol 53. issue 4. 2021-07-16. PMID:33619515. |
meanwhile, il-35 remarkably activates mitochondrial stat3 (mitostat3) signaling, inhibits cytochrome c release, and reduces apoptosis signaling. |
2021-07-16 |
2023-08-13 |
mouse |
| Yue Zhao, Dongsheng Bai, Jiaying Du, Haochuan Ren, Zhenguo Zhang, Cheng Jiang, Na L. Induction of cell cycle arrest and apoptosis by CPUC002 through stabilization of p53 and suppression of STAT3 signaling pathway in multiple myeloma. Cell biology and toxicology. vol 37. issue 1. 2021-07-15. PMID:33126266. |
induction of cell cycle arrest and apoptosis by cpuc002 through stabilization of p53 and suppression of stat3 signaling pathway in multiple myeloma. |
2021-07-15 |
2023-08-13 |
human |
| Yue Zhao, Dongsheng Bai, Jiaying Du, Haochuan Ren, Zhenguo Zhang, Cheng Jiang, Na L. Induction of cell cycle arrest and apoptosis by CPUC002 through stabilization of p53 and suppression of STAT3 signaling pathway in multiple myeloma. Cell biology and toxicology. vol 37. issue 1. 2021-07-15. PMID:33126266. |
further studies showed that the cpuc002 also inhibited the stat3 signaling pathway, while knockdown of stat3 abolished cpuc002-induced apoptosis and cell cycle arrest. |
2021-07-15 |
2023-08-13 |
human |
| Yue Zhao, Dongsheng Bai, Jiaying Du, Haochuan Ren, Zhenguo Zhang, Cheng Jiang, Na L. Induction of cell cycle arrest and apoptosis by CPUC002 through stabilization of p53 and suppression of STAT3 signaling pathway in multiple myeloma. Cell biology and toxicology. vol 37. issue 1. 2021-07-15. PMID:33126266. |
together these findings indicate that cpuc002 induces apoptosis and g0/g1 cell cycle arrest in multiple myeloma cells by stabilizing p53 and inhibiting the stat3 signaling pathway. |
2021-07-15 |
2023-08-13 |
human |
| Shi-Zhong Cai, Qian-Wei Xiong, Li-Na Zhao, Yi-Ting Ji, Zheng-Xiang Luo, Zhou-Rui M. β-Elemene Triggers ROS-dependent Apoptosis in Glioblastoma Cells Through Suppressing STAT3 Signaling Pathway. Pathology oncology research : POR. vol 27. 2021-07-15. PMID:34257541. |
β-elemene triggers ros-dependent apoptosis in glioblastoma cells through suppressing stat3 signaling pathway. |
2021-07-15 |
2023-08-13 |
Not clear |
| Ningjuan Liang, Siwen Li, Yuehui Liang, Yu Ma, Sixuan Tang, Shuzi Ye, Fang Xia. Clusterin inhibits Cr(VI)-induced apoptosis via enhancing mitochondrial biogenesis through AKT-associated STAT3 activation in L02 hepatocytes. Ecotoxicology and environmental safety. vol 221. 2021-07-12. PMID:34175824. |
clusterin inhibits cr(vi)-induced apoptosis via enhancing mitochondrial biogenesis through akt-associated stat3 activation in l02 hepatocytes. |
2021-07-12 |
2023-08-13 |
Not clear |
| Ningjuan Liang, Siwen Li, Yuehui Liang, Yu Ma, Sixuan Tang, Shuzi Ye, Fang Xia. Clusterin inhibits Cr(VI)-induced apoptosis via enhancing mitochondrial biogenesis through AKT-associated STAT3 activation in L02 hepatocytes. Ecotoxicology and environmental safety. vol 221. 2021-07-12. PMID:34175824. |
signal transducer and activator of transcription 3 (stat3) was down-regulated in cr(vi)-induced apoptosis, and clu may regulate stat3 via protein kinase b (pkb/akt) in cr(vi)-exposed hepatocytes. |
2021-07-12 |
2023-08-13 |
Not clear |
| Ningjuan Liang, Siwen Li, Yuehui Liang, Yu Ma, Sixuan Tang, Shuzi Ye, Fang Xia. Clusterin inhibits Cr(VI)-induced apoptosis via enhancing mitochondrial biogenesis through AKT-associated STAT3 activation in L02 hepatocytes. Ecotoxicology and environmental safety. vol 221. 2021-07-12. PMID:34175824. |
we used the stat3 inhibitor c188-9 and the akt inhibitor uprosertib to eliminate the anti-apoptotic effect of clu, and found that clu inhibited cr(vi)-induced apoptosis by up-regulating akt/stat3 signal. |
2021-07-12 |
2023-08-13 |
Not clear |
| Ningjuan Liang, Siwen Li, Yuehui Liang, Yu Ma, Sixuan Tang, Shuzi Ye, Fang Xia. Clusterin inhibits Cr(VI)-induced apoptosis via enhancing mitochondrial biogenesis through AKT-associated STAT3 activation in L02 hepatocytes. Ecotoxicology and environmental safety. vol 221. 2021-07-12. PMID:34175824. |
based on the fact that both akt and stat3 are closely related to mitochondrial biogenesis and mitochondrial pathway-associated apoptosis, this study is the first time to link clu, stat3, akt and mitochondrial biogenesis function after cr(vi) exposure, to further enrich the experimental basis of cr(vi)-induced hepatotoxicity, clarify the molecular mechanism of clu helping cells to escape apoptosis, and also suggest that new ways can be sought to prevent and treat cr(vi)-induced hepatotoxicity by regulating mitochondrial biosynthesis. |
2021-07-12 |
2023-08-13 |
Not clear |
| Behrooz Johari, Mohammad Rahmati, Leila Nasehi, Yousef Mortazavi, Mohammad Hasan Faghfoori, Hamed Rezaeeja. Evaluation of STAT3 decoy oligodeoxynucleotides' synergistic effects on radiation and/or chemotherapy in metastatic breast cancer cell line. Cell biology international. vol 44. issue 12. 2021-07-09. PMID:32841450. |
synergistic effects of stat3 scr and decoy odns on cells were investigated by cell viability (mtt), cell cycle profile, apoptosis rate, migration, and invasion assays. |
2021-07-09 |
2023-08-13 |
Not clear |
| Behrooz Johari, Mohammad Rahmati, Leila Nasehi, Yousef Mortazavi, Mohammad Hasan Faghfoori, Hamed Rezaeeja. Evaluation of STAT3 decoy oligodeoxynucleotides' synergistic effects on radiation and/or chemotherapy in metastatic breast cancer cell line. Cell biology international. vol 44. issue 12. 2021-07-09. PMID:32841450. |
statistical analysis of obtained data showed that stat3 decoy odns significantly decreased the cell viability, arrested the growth at g0/g1 phase, increased apoptosis rate, and reduced migrated and invaded cells through transwell membrane, in xi, mtx, and xi/mtx exposed groups. |
2021-07-09 |
2023-08-13 |
Not clear |
| Junhe Zhang, Wenwen Yang, Yunxi Xiao, Linlin Sha. MiR-125b Inhibits Cell Proliferation and Induces Apoptosis in Human Colon Cancer SW480 Cells via Targeting STAT3. Recent patents on anti-cancer drug discovery. 2021-07-09. PMID:34238196. |
mir-125b inhibits cell proliferation and induces apoptosis in human colon cancer sw480 cells via targeting stat3. |
2021-07-09 |
2023-08-13 |
human |
| Chaoqun Wu, Guangwen Shu, Huiqi Huang, Kejian Pang, Xinzhou Yang, Guangzhong Yan. Methylgerambullin derived from plant Glyccsmis pentaphylla (Retz) correa. Mediates anti-hepatocellular carcinoma cancer effect by activating mitochondrial and endoplasmic reticulum stress signaling and inhibiting AKT and STAT3 pathways. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 149. 2021-07-06. PMID:33529679. |
overall, these results suggest that methylgerambullin can inhibit hcc cells proliferation by inducing mitochondrial apoptosis, activating ers signaling pathways and inhibiting the akt and stat3 pathways. |
2021-07-06 |
2023-08-13 |
mouse |
| Shiqi Dong, Xiying Wu, Yuting Xu, Guohua Yang, Ming Ya. Molecular vision. vol 26. 2021-07-02. PMID:32753832. |
signal transducer and activator of transcription 3 (stat3) is a dna-binding protein that regulates various biologic processes, including cell growth, apoptosis, and malignant transformation. |
2021-07-02 |
2023-08-13 |
Not clear |
| Aliaa M Mohassab, Heba A Hassan, Dalia Abdelhamid, Mohamed Abdel-Azi. STAT3 transcription factor as target for anti-cancer therapy. Pharmacological reports : PR. vol 72. issue 5. 2021-07-02. PMID:32880101. |
the activation of stat3 was observed to regulate multiple gene functions during cancer-like cell proliferation, differentiation, apoptosis, metastasis, inflammation, immunity, cell survival, and angiogenesis. |
2021-07-02 |
2023-08-13 |
Not clear |
| Zhenjiang Pan, Jing Bao, Liujun Zhang, Shepeng We. UBE2D3 Activates SHP-2 Ubiquitination to Promote Glycolysis and Proliferation of Glioma Frontiers in oncology. vol 11. 2021-07-02. PMID:34195079. |
by analysis with the cancer genome atlas-glioblastoma multiforme (tcga-gbm) dataset, we found that ube2d3 was highly expressed in glioma and it is positive correlation with glycolysis, apoptosis, and stat3 pathway. |
2021-07-02 |
2023-08-13 |
Not clear |
| Jijun Xiong, Jie Quan, Chaosheng Qin, Xiaogang Wang, Qinghua Dong, Bingdong Zhan. Dexmedetomidine Exerts Brain-Protective Effects Under Cardiopulmonary Bypass Through Inhibiting the Janus Kinase 2/Signal Transducers and Activators of Transcription 3 Pathway. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 40. issue 2. 2021-07-01. PMID:31834821. |
dex suppressed janus kinase 2 (jak2)/signal transducers and activators of transcription 3 (stat3) pathway activated by cpb, ameliorated cpb-induced brain injury in rats by reducing inflammatory response, and inhibited neuronal apoptosis. |
2021-07-01 |
2023-08-13 |
rat |
| Tadashi Matsuda, Kenji Oritan. STAP-2 Adaptor Protein Regulates Multiple Steps of Immune and Inflammatory Responses. Biological & pharmaceutical bulletin. vol 44. issue 7. 2021-07-01. PMID:34193686. |
stap-2 influences the stat3 and stat5 activity, integrin-mediated t cell adhesion, chemokine-induced t cell migration, fas-mediated t cell apoptosis, toll-like receptor-mediated macrophage functions, macrophage colony-stimulating factor-induced macrophage activation, and the high-affinity immunoglobulin e receptor-mediated mast cell activation. |
2021-07-01 |
2023-08-13 |
Not clear |
| Zhuan-Yi Yang, Ying Wang, Qing Liu, Ming W. microRNA cluster MC-let-7a-1~let-7d promotes autophagy and apoptosis of glioma cells by down-regulating STAT3. CNS neuroscience & therapeutics. vol 26. issue 3. 2021-06-30. PMID:31868319. |
microrna cluster mc-let-7a-1~let-7d promotes autophagy and apoptosis of glioma cells by down-regulating stat3. |
2021-06-30 |
2023-08-13 |
Not clear |
| G-J Wang, Z Yang, J Huai, Q-Q Xian. Pravastatin alleviates oxidative stress and decreases placental trophoblastic cell apoptosis through IL-6/STAT3 signaling pathway in preeclampsia rats. European review for medical and pharmacological sciences. vol 24. issue 24. 2021-06-30. PMID:33378046. |
the aim of this study was to explore the effects of pravastatin on oxidative stress and placental trophoblastic cell apoptosis in preeclampsia rats via the interleukin (il)-6/signal transducer and activator of transcription 3 (stat3) signaling pathway. |
2021-06-30 |
2023-08-13 |
rat |