| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| John D Landua, Ricardo Moraes, Ellen M Carpenter, Michael T Lewi. Hoxd10 Is Required Systemically for Secretory Activation in Lactation and Interacts Genetically with Hoxd9. Journal of mammary gland biology and neoplasia. vol 25. issue 2. 2021-06-04. PMID:32705545. |
affected regions of Δhoxd10 and Δhoxd9/d10 mutants showed reduced prolactin receptor expression, reduced signal transducer and activator transcription protein 5 (stat5) phosphorylation, reduced expression of downstream milk proteins, mislocalized glucose transporter 1 (glut1), increased stat3 expression and phosphorylation, recruitment of leukocytes, altered cell cycle status, and increased apoptosis relative to unaffected regions and wild type control glands. |
2021-06-04 |
2023-08-13 |
mouse |
| Dongfang Tang, Haoyao Jiang, Zhigang Li, Wen Gao, Yifeng Su. The mechanism of ABL1 upregulating the expression of PD-L1 and the therapeutic effect of PD-L1 and STAT3 inhibitors in lung adenocarcinoma. Neoplasma. vol 68. issue 3. 2021-06-02. PMID:33147049. |
lastly, we observed the apoptosis and expression of stat3 and pd-l1 before and after treatments in transfected and knocked down cell lines. |
2021-06-02 |
2023-08-13 |
Not clear |
| Dongfang Tang, Haoyao Jiang, Zhigang Li, Wen Gao, Yifeng Su. The mechanism of ABL1 upregulating the expression of PD-L1 and the therapeutic effect of PD-L1 and STAT3 inhibitors in lung adenocarcinoma. Neoplasma. vol 68. issue 3. 2021-06-02. PMID:33147049. |
furthermore, the stat3 inhibitor might induce more apoptosis than the pd-l1 inhibitor in both h1975 and pc-9 cell lines (both p<0.01) the stat3 inhibitor combined with pd-l1 inhibitor had a synergistic effect on the pc-9 cell line, and the antagonistic effect was observed on the h1975 cell line. |
2021-06-02 |
2023-08-13 |
Not clear |
| Heriberto Torres-Moreno, Maria C Marcotullio, Carlos Velazquez, Víctor M Arenas-Luna, Salomón Hernández-Gutiérrez, Ramón E Robles-Zeped. Cucurbitacin IIb from Ibervillea sonorae Induces Apoptosis and Cell Cycle Arrest via STAT3 Inhibition. Anti-cancer agents in medicinal chemistry. vol 20. issue 10. 2021-05-28. PMID:32294048. |
cucurbitacin iib from ibervillea sonorae induces apoptosis and cell cycle arrest via stat3 inhibition. |
2021-05-28 |
2023-08-13 |
Not clear |
| Shiwen Xu, Chunyan Yu, Xiaoxia Ma, Yan Li, Yangyang Shen, Yan Chen, Suhui Huang, Tongshuo Zhang, Weimin Deng, Yue Wan. IL-6 promotes nuclear translocation of HIF-1α to aggravate chemoresistance of ovarian cancer cells. European journal of pharmacology. vol 894. 2021-05-28. PMID:33345849. |
proliferation assay and apoptosis assay were applied and proved that il-6 enhances the chemoresistance of ovca cells against cisplatin through the upregulation of hif-1α via the stat3 signaling in vitro. |
2021-05-28 |
2023-08-13 |
Not clear |
| Il Je Cho, Jae Kwang Kim, Eun Ok Kim, Sang Mi Park, Sang Chan Kim, Sung Hwan Ki, Sae Kwang K. Hemistepsin a Induces Apoptosis of Hepatocellular Carcinoma Cells by Downregulating STAT3. International journal of molecular sciences. vol 22. issue 9. 2021-05-28. PMID:33947048. |
hemistepsin a induces apoptosis of hepatocellular carcinoma cells by downregulating stat3. |
2021-05-28 |
2023-08-13 |
Not clear |
| Jisheng Wang, Binghao Bao, Junlong Feng, Qi Zhao, Hengheng Dai, Fanchao Meng, Sheng Deng, Bin Wang, Haisong L. Effects of Diabetes Mellitus on Sperm Quality in the Db/Db Mouse Model and the Role of the FoxO1 Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 27. 2021-05-24. PMID:33589581. |
conclusions this study demonstrated that dm inhibited the expression of pi3k, akt, and stat3 proteins and mrnas in the foxo1 pathway and promoted the expression of foxo1, fasl, and il-6 proteins and mrnas, leading to abnormal apoptosis of testicular tissue cells and functional damage, and eventually spermatogenic dysfunction. |
2021-05-24 |
2023-08-13 |
mouse |
| Yifeng Ni, Hao Zhang, Jing Zhang, Zhi Li, Zubing L. Inhibition of JAK2 by AG490 promotes TNF-α-induced apoptosis by inhibiting autophagy in MC3T3-E1 cells. Die Pharmazie. vol 75. issue 6. 2021-05-20. PMID:32539921. |
this study demonstrated for the first time that jak2 inhibition by ag490 may play a crucial role in tnf-α-induced apoptosis by inhibiting autophagy and inhibiting the stat3, akt, and erk signaling pathways. |
2021-05-20 |
2023-08-13 |
Not clear |
| Xiaobo Zhang, Ying Zhu, Ying Zhou, Bingru Fe. Interleukin 37 (IL-37) Reduces High Glucose-Induced Inflammation, Oxidative Stress, and Apoptosis of Podocytes by Inhibiting the STAT3-Cyclophilin A (CypA) Signaling Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-20. PMID:32931486. |
overexpression of stat3 and cypa inhibited the effects of il-37 on the alleviation of inflammation and oxidative stress and on the reduction of apoptosis of high glucose-treated podocytes. |
2021-05-20 |
2023-08-13 |
Not clear |
| Xiaowen Bao, Jianwei Zhu, Chaoxing Ren, Ang Zhao, Mingya Zhang, Zhiming Zhu, Xuanzhao Lu, Yuning Zhang, Xiaotian Li, Xinyu Sima, Jiaqi Li, Qi Zhang, Bo M. β-elemonic acid inhibits growth and triggers apoptosis in human castration-resistant prostate cancer cells through the suppression of JAK2/STAT3/MCL-1 and NF-ĸB signal pathways. Chemico-biological interactions. vol 342. 2021-05-19. PMID:33878321. |
the silencing of nf-κb/p65, jak2 and stat3, respectively, increased the sensitivity of the pca cells to β-ea induced apoptosis. |
2021-05-19 |
2023-08-13 |
human |
| Shibo Wu, Weizhuang Chen, Kaitai Liu, Feng Ren, Dawei Zheng, Feng Xu, Hongcheng W. Saikosaponin D inhibits proliferation and induces apoptosis of non-small cell lung cancer cells by inhibiting the STAT3 pathway. The Journal of international medical research. vol 48. issue 9. 2021-05-14. PMID:32962498. |
saikosaponin d inhibits proliferation and induces apoptosis of non-small cell lung cancer cells by inhibiting the stat3 pathway. |
2021-05-14 |
2023-08-13 |
human |
| Tao Lv, Zhen Jian, Dejian Li, Rongguang Ao, Xu Zhang, Baoqing Y. Oxyresveratrol induces apoptosis and inhibits cell viability via inhibition of the STAT3 signaling pathway in Saos‑2 cells. Molecular medicine reports. vol 22. issue 6. 2021-05-13. PMID:33174060. |
oxyresveratrol induces apoptosis and inhibits cell viability via inhibition of the stat3 signaling pathway in saos‑2 cells. |
2021-05-13 |
2023-08-13 |
Not clear |
| Tao Lv, Zhen Jian, Dejian Li, Rongguang Ao, Xu Zhang, Baoqing Y. Oxyresveratrol induces apoptosis and inhibits cell viability via inhibition of the STAT3 signaling pathway in Saos‑2 cells. Molecular medicine reports. vol 22. issue 6. 2021-05-13. PMID:33174060. |
inhibition of cell viability and apoptosis induction by ores were rescued by enhancement of stat3 activation upon treatment with il‑6. |
2021-05-13 |
2023-08-13 |
Not clear |
| Tao Lv, Zhen Jian, Dejian Li, Rongguang Ao, Xu Zhang, Baoqing Y. Oxyresveratrol induces apoptosis and inhibits cell viability via inhibition of the STAT3 signaling pathway in Saos‑2 cells. Molecular medicine reports. vol 22. issue 6. 2021-05-13. PMID:33174060. |
collectively, the present study indicated that ores induced apoptosis and inhibited cell viability, which may be associated with the inhibition of stat3 activation; thus, ores represents a promising agent for treating osteosarcoma. |
2021-05-13 |
2023-08-13 |
Not clear |
| Xingyuan Shi, Manman Xu, Kai Luo, Wenjin Huang, Hongwei Yu, Tongchong Zho. Anticancer activity of bergenin against cervical cancer cells involves apoptosis, cell cycle arrest, inhibition of cell migration and the STAT3 signalling pathway. Experimental and therapeutic medicine. vol 21. issue 6. 2021-05-11. PMID:33968183. |
anticancer activity of bergenin against cervical cancer cells involves apoptosis, cell cycle arrest, inhibition of cell migration and the stat3 signalling pathway. |
2021-05-11 |
2023-08-13 |
Not clear |
| Xingyuan Shi, Manman Xu, Kai Luo, Wenjin Huang, Hongwei Yu, Tongchong Zho. Anticancer activity of bergenin against cervical cancer cells involves apoptosis, cell cycle arrest, inhibition of cell migration and the STAT3 signalling pathway. Experimental and therapeutic medicine. vol 17. issue 5. 2021-05-10. PMID:30988733. |
anticancer activity of bergenin against cervical cancer cells involves apoptosis, cell cycle arrest, inhibition of cell migration and the stat3 signalling pathway. |
2021-05-10 |
2023-08-13 |
Not clear |
| Hongchao He, Ran Zhuo, Jun Dai, Xiaojing Wang, Xin Huang, Haofei Wang, Danfeng X. Chelerythrine induces apoptosis via ROS-mediated endoplasmic reticulum stress and STAT3 pathways in human renal cell carcinoma. Journal of cellular and molecular medicine. vol 24. issue 1. 2021-05-10. PMID:31568643. |
chelerythrine induces apoptosis via ros-mediated endoplasmic reticulum stress and stat3 pathways in human renal cell carcinoma. |
2021-05-10 |
2023-08-13 |
human |
| Hongchao He, Ran Zhuo, Jun Dai, Xiaojing Wang, Xin Huang, Haofei Wang, Danfeng X. Chelerythrine induces apoptosis via ROS-mediated endoplasmic reticulum stress and STAT3 pathways in human renal cell carcinoma. Journal of cellular and molecular medicine. vol 24. issue 1. 2021-05-10. PMID:31568643. |
in addition, che increased cellular ros level, leading to endoplasmic reticulum (er) stress, inactivating stat3 activities and inducing apoptosis in rcc cells which were suppressed by nac, a special ros inhibitor. |
2021-05-10 |
2023-08-13 |
human |
| Hongchao He, Ran Zhuo, Jun Dai, Xiaojing Wang, Xin Huang, Haofei Wang, Danfeng X. Chelerythrine induces apoptosis via ROS-mediated endoplasmic reticulum stress and STAT3 pathways in human renal cell carcinoma. Journal of cellular and molecular medicine. vol 24. issue 1. 2021-05-10. PMID:31568643. |
we further found that both knockdown of atf4 protein and overexpression of stat3 protein could reduce che-induced apoptosis in caki cells. |
2021-05-10 |
2023-08-13 |
human |
| Hongchao He, Ran Zhuo, Jun Dai, Xiaojing Wang, Xin Huang, Haofei Wang, Danfeng X. Chelerythrine induces apoptosis via ROS-mediated endoplasmic reticulum stress and STAT3 pathways in human renal cell carcinoma. Journal of cellular and molecular medicine. vol 24. issue 1. 2021-05-10. PMID:31568643. |
these results demonstrated that the apoptosis induced by che was mediated by ros-caused er stress and stat3 inactivation. |
2021-05-10 |
2023-08-13 |
human |