| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhiqiao Xu, Xiaojing Tie, Ning Li, Zhenying Yi, Fengqian Shen, Yan Zhan. Circular RNA hsa_circ_0000654 promotes esophageal squamous cell carcinoma progression by regulating the miR-149-5p/IL-6/STAT3 pathway. IUBMB life. vol 72. issue 3. 2021-04-14. PMID:31778020. |
furthermore, interleukin 6 (il-6) and signal transducer and activator of transcription 3 (stat3) expression in cells was detected by rt-pcr and western blot analysis, while cck8, brdu, flow cytometry, and transwell assays were used to monitor cell proliferation, apoptosis, migration and invasion, respectively. |
2021-04-14 |
2023-08-13 |
mouse |
| Decheng Yin, Chengxiang Kong, Muhu Che. Effect of hnRNPA2/B1 on the proliferation and apoptosis of glioma U251 cells via the regulation of AKT and STAT3 pathways. Bioscience reports. vol 40. issue 7. 2021-04-14. PMID:32463472. |
effect of hnrnpa2/b1 on the proliferation and apoptosis of glioma u251 cells via the regulation of akt and stat3 pathways. |
2021-04-14 |
2023-08-13 |
human |
| Amirhossein Jahangiri, Maryam Dadmanesh, Khodayar Ghorba. STAT3 inhibition reduced PD-L1 expression and enhanced antitumor immune responses. Journal of cellular physiology. vol 235. issue 12. 2021-04-06. PMID:32401358. |
stat3 inhibition suppressed pd-l1 expression and induced apoptosis in hct-15 cells. |
2021-04-06 |
2023-08-13 |
Not clear |
| Amirhossein Jahangiri, Maryam Dadmanesh, Khodayar Ghorba. STAT3 inhibition reduced PD-L1 expression and enhanced antitumor immune responses. Journal of cellular physiology. vol 235. issue 12. 2021-04-06. PMID:32401358. |
these findings suggest that stat3 inhibition through either induction of apoptosis in the colon cancer cells and/or activation of efficient immune responses can lead to overcome cancer-induced immune tolerance. |
2021-04-06 |
2023-08-13 |
Not clear |
| Jensen M Spear, Zhixin Lu, Wade A Russ. Pharmacological Inhibition of CDK8 in Triple-Negative Breast Cancer Cell Line MDA-MB-468 Increases E2F1 Protein, Induces Phosphorylation of STAT3 and Apoptosis. Molecules (Basel, Switzerland). vol 25. issue 23. 2021-04-05. PMID:33291686. |
pharmacological inhibition of cdk8 in triple-negative breast cancer cell line mda-mb-468 increases e2f1 protein, induces phosphorylation of stat3 and apoptosis. |
2021-04-05 |
2023-08-13 |
Not clear |
| Yuxuan Luo, Ying Lu, Bing Long, Yansi Lin, Yanling Yang, Yichuang Xu, Xiangzhong Zhang, Jingwen Zhan. Blocking DNA Damage Repair May Be Involved in Stattic (STAT3 Inhibitor)-Induced FLT3-ITD AML Cell Apoptosis. Frontiers in cell and developmental biology. vol 9. 2021-04-03. PMID:33796529. |
blocking dna damage repair may be involved in stattic (stat3 inhibitor)-induced flt3-itd aml cell apoptosis. |
2021-04-03 |
2023-08-13 |
Not clear |
| Qinjie Weng, Mengting Zhao, Jiahuan Zheng, Lijun Yang, Zijie Xu, Zhikang Zhang, Jincheng Wang, Jiajia Wang, Bo Yang, Q Richard Lu, Meidan Ying, Qiaojun H. STAT3 dictates β-cell apoptosis by modulating PTEN in streptozocin-induced hyperglycemia. Cell death and differentiation. vol 27. issue 1. 2021-04-02. PMID:31097787. |
stat3 dictates β-cell apoptosis by modulating pten in streptozocin-induced hyperglycemia. |
2021-04-02 |
2023-08-13 |
mouse |
| Qinjie Weng, Mengting Zhao, Jiahuan Zheng, Lijun Yang, Zijie Xu, Zhikang Zhang, Jincheng Wang, Jiajia Wang, Bo Yang, Q Richard Lu, Meidan Ying, Qiaojun H. STAT3 dictates β-cell apoptosis by modulating PTEN in streptozocin-induced hyperglycemia. Cell death and differentiation. vol 27. issue 1. 2021-04-02. PMID:31097787. |
mechanistically, accumulating pten, induced by stat3 deficiency, directly represses phosphorylation of akt, which negatively modulates transcription factor activation, dysregulates β-cell function, positively promotes apoptotic signaling, and finally induces β-cell apoptosis. |
2021-04-02 |
2023-08-13 |
mouse |
| Qinjie Weng, Mengting Zhao, Jiahuan Zheng, Lijun Yang, Zijie Xu, Zhikang Zhang, Jincheng Wang, Jiajia Wang, Bo Yang, Q Richard Lu, Meidan Ying, Qiaojun H. STAT3 dictates β-cell apoptosis by modulating PTEN in streptozocin-induced hyperglycemia. Cell death and differentiation. vol 27. issue 1. 2021-04-02. PMID:31097787. |
thus our data suggest that stat3 is a vital modulator of β-cell survival and function, highlighting a critical role for stat3 in the negative regulation of pten-akt signaling pathway associated with β-cell dysfunction and apoptosis. |
2021-04-02 |
2023-08-13 |
mouse |
| b' Iva Poto\\xc4\\x8dnjak, Jelena Marini\\xc4\\x87, Lara Bati\\xc4\\x8di\\xc4\\x87, Lidija \\xc5\\xa0imi\\xc4\\x87, Dalibor Brozni\\xc4\\x87, Robert Domitrovi\\xc4\\x8. Aucubin administered by either oral or parenteral route protects against cisplatin-induced acute kidney injury in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 142. 2021-03-29. PMID:32504734.' |
mechanistically, aucubin suppressed the activation of several signaling pathways involved in inflammation and apoptosis, including nuclear factor-kappa b (nf-κb), signal transducer and activator of transcription 3 (stat3), akt, extracellular signal-regulated kinase 1/2 (erk1/2) and forkhead box o3a (foxo3a). |
2021-03-29 |
2023-08-13 |
mouse |
| Na Li, Jinfeng Ou, Na Bao, Cheng Chen, Zhixian Shi, Li Chen, Jianbo Su. Design, synthesis and biological evaluation of novel plumbagin derivatives as potent antitumor agents with STAT3 inhibition. Bioorganic chemistry. vol 104. 2021-03-29. PMID:32919131. |
furthermore, molecular docking indicated that 7a bound to stat3 more tightly than pl, and it could significantly induce the apoptosis of cancer cells in vitro. |
2021-03-29 |
2023-08-13 |
human |
| Linyu Geng, Xiaojun Tang, Shiying Wang, Yue Sun, Dandan Wang, Betty P Tsao, Xuebing Feng, Lingyun Su. Reduced Let-7f in Bone Marrow-Derived Mesenchymal Stem Cells Triggers Treg/Th17 Imbalance in Patients With Systemic Lupus Erythematosus. Frontiers in immunology. vol 11. 2021-03-25. PMID:32133007. |
transient transfection of bm-mscs with let-7f mimics or inhibitors showed reduced levels of let-7f impaired the proliferation rate of bm-mscs, bm-msc-mediated downregulation of th17 cells and upregulation of treg cells, increased the apoptosis rate of bm-mscs through targeting il-6 and activating signal transducers and activators of transcription-3 (stat3) pathway, but had no significant effect on the differentiation of th1 and th2. |
2021-03-25 |
2023-08-13 |
Not clear |
| Lixue Yang, Hui Xue, Yanfu Sun, Lei Zhang, Feng Xue, Ruiliang G. CircularRNA-9119 protects hepatocellular carcinoma cells from apoptosis by intercepting miR-26a/JAK1/STAT3 signaling. Cell death & disease. vol 11. issue 7. 2021-03-25. PMID:32732872. |
administration of the jak1 inhibitor, baricitinib, caused the activation of signal transducer and activator of transcription 3 (stat3) and revealed an effect similar to that of circ9119 silencing on cell proliferation and apoptosis. |
2021-03-25 |
2023-08-13 |
Not clear |
| Ying Hu, Rong Xu, Yue He, Zhibo Zhao, Xudong Mao, Ling Lin, Jun H. Downregulation of microRNA‑106a‑5p alleviates ox‑LDL‑mediated endothelial cell injury by targeting STAT3. Molecular medicine reports. vol 22. issue 2. 2021-03-23. PMID:32626987. |
in addition, it was shown that stat3 is a direct target of mir‑106a‑5p in huvecs, and silencing of stat3 impaired the protective effects of mir‑106a‑5p inhibition on cell apoptosis and oxidative injury induced by ox‑ldl. |
2021-03-23 |
2023-08-13 |
human |
| Ying Hu, Rong Xu, Yue He, Zhibo Zhao, Xudong Mao, Ling Lin, Jun H. Downregulation of microRNA‑106a‑5p alleviates ox‑LDL‑mediated endothelial cell injury by targeting STAT3. Molecular medicine reports. vol 22. issue 2. 2021-03-23. PMID:32626987. |
collectively, these results indicated that mir‑106a‑5p participated in ox‑ldl‑stimulated apoptosis and oxidative injury in huvecs by regulating stat3. |
2021-03-23 |
2023-08-13 |
human |
| Sung Min Kim, Jung-Il Kang, Hoon-Seok Yoon, Youn Kyung Choi, Ji Soo Go, Sun Kyung Oh, Meejung Ahn, Jeongtae Kim, Young Sang Koh, Jin Won Hyun, Eun-Sook Yoo, Hee-Kyoung Kan. HNG, A Humanin Analogue, Promotes Hair Growth by Inhibiting Anagen-to-Catagen Transition. International journal of molecular sciences. vol 21. issue 12. 2021-03-22. PMID:32604799. |
hng stimulated the anagen phase longer with vegf up-regulation, and it prevented apoptosis by activating erk1/2, akt, and stat3 signaling. |
2021-03-22 |
2023-08-13 |
mouse |
| Bashir Ahmad, Yaser Gamallat, Muhammad Fiaz Khan, Syed Riaz Din, Muhammad Israr, Manzoor Ahmad, Naeem Tahir, Nasir Azam, Khalil Ur Rahman, Wang Xin, Wang Zexu, Peng Linjie, Pengyu Su, Wang Lian. Natural Polyphyllins (I, II, D, VI, VII) Reverses Cancer Through Apoptosis, Autophagy, Mitophagy, Inflammation, and Necroptosis. OncoTargets and therapy. vol 14. 2021-03-20. PMID:33732000. |
nps cure cancer by regulating different pathways, such as pi3k/akt/mtor, er stress, jnk, wnt, stat3, mapks, nf-kb, mek-erk, inflammation, oxidative stress, apoptosis, autophagy, mitophagy, and necroptosis. |
2021-03-20 |
2023-08-13 |
Not clear |
| Hao Wang, Zhennan Tao, Ming Feng, Xuetao Li, Zhitong Deng, Guozheng Zhao, Haoran Yin, Tingzheng Pan, Guangliang Chen, Zibin Feng, Yanyan Li, Youxin Zho. Dual PLK1 and STAT3 inhibition promotes glioblastoma cells apoptosis through MYC. Biochemical and biophysical research communications. vol 533. issue 3. 2021-03-18. PMID:32962858. |
dual plk1 and stat3 inhibition promotes glioblastoma cells apoptosis through myc. |
2021-03-18 |
2023-08-13 |
Not clear |
| Hao Wang, Zhennan Tao, Ming Feng, Xuetao Li, Zhitong Deng, Guozheng Zhao, Haoran Yin, Tingzheng Pan, Guangliang Chen, Zibin Feng, Yanyan Li, Youxin Zho. Dual PLK1 and STAT3 inhibition promotes glioblastoma cells apoptosis through MYC. Biochemical and biophysical research communications. vol 533. issue 3. 2021-03-18. PMID:32962858. |
compared to monotherapy, combined treatment of glioma cells with plk1 and stat3 inhibitors, bi2536 and stattic, respectively, showed lower expression of myc, synergistic induction of cell invasion and apoptosis in vitro, and tumor inhibition in xenografts. |
2021-03-18 |
2023-08-13 |
Not clear |
| Hao Wang, Zhennan Tao, Ming Feng, Xuetao Li, Zhitong Deng, Guozheng Zhao, Haoran Yin, Tingzheng Pan, Guangliang Chen, Zibin Feng, Yanyan Li, Youxin Zho. Dual PLK1 and STAT3 inhibition promotes glioblastoma cells apoptosis through MYC. Biochemical and biophysical research communications. vol 533. issue 3. 2021-03-18. PMID:32962858. |
plk1 and stat3 were able to directly regulate the expression of myc and induce apoptosis of glioma cells through the regulation of myc. |
2021-03-18 |
2023-08-13 |
Not clear |