| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Afshin Nikkhoo, Narges Rostami, Shohreh Farhadi, Maryam Esmaily, Sadaf Moghadaszadeh Ardebili, Fatemeh Atyabi, Masoumeh Baghaei, Navideh Haghnavaz, Mehdi Yousefi, Mohammad Reza Aliparasti, Ghasem Ghalamfarsa, Hamed Mohammadi, Mozhdeh Sojoodi, Farhad Jadidi-Niarag. Codelivery of STAT3 siRNA and BV6 by carboxymethyl dextran trimethyl chitosan nanoparticles suppresses cancer cell progression. International journal of pharmaceutics. vol 581. 2021-02-01. PMID:32240809. |
use of bv6, a well-known iap inhibitor, along with inhibition of signal transducer and activator of transcription 3 (stat3), which is an important factor in the survival of tumor cells, and nik as a mediator of bv6 unpredicted side effects, can induce effective apoptosis in tumor cells. |
2021-02-01 |
2023-08-13 |
Not clear |
| Renba Lian. Letter to the editor Re: Pan et al. "LLY17, a novel small molecule STAT3 inhibitor induces apoptosis and suppresses cell migration and tumor growth in triple-negative breast cancer". Breast cancer research and treatment. vol 184. issue 2. 2021-02-01. PMID:32803634. |
"lly17, a novel small molecule stat3 inhibitor induces apoptosis and suppresses cell migration and tumor growth in triple-negative breast cancer". |
2021-02-01 |
2023-08-13 |
Not clear |
| Yan-Qing Zang, Yu-Qing Zhai, Yan-Yu Feng, Xue-Ying Ju, Feng Zu. Molecular mechanisms of quinalizarin induces apoptosis and G0/G1 cell cycle of human esophageal cancer HCE-4 cells depends on MAPK, STAT3, and NF-κB signaling pathways. Environmental toxicology. vol 36. issue 2. 2021-01-25. PMID:33030807. |
molecular mechanisms of quinalizarin induces apoptosis and g0/g1 cell cycle of human esophageal cancer hce-4 cells depends on mapk, stat3, and nf-κb signaling pathways. |
2021-01-25 |
2023-08-13 |
human |
| Yan-Qing Zang, Yu-Qing Zhai, Yan-Yu Feng, Xue-Ying Ju, Feng Zu. Molecular mechanisms of quinalizarin induces apoptosis and G0/G1 cell cycle of human esophageal cancer HCE-4 cells depends on MAPK, STAT3, and NF-κB signaling pathways. Environmental toxicology. vol 36. issue 2. 2021-01-25. PMID:33030807. |
the pretreatment of n-acetyl-l-cysteine (nac) blocked the apoptosis induced by quina and inhibited the activities of mapk, stat3, and nf-κb signaling pathways. |
2021-01-25 |
2023-08-13 |
human |
| Yan-Qing Zang, Yu-Qing Zhai, Yan-Yu Feng, Xue-Ying Ju, Feng Zu. Molecular mechanisms of quinalizarin induces apoptosis and G0/G1 cell cycle of human esophageal cancer HCE-4 cells depends on MAPK, STAT3, and NF-κB signaling pathways. Environmental toxicology. vol 36. issue 2. 2021-01-25. PMID:33030807. |
these results indicate that quina induces the apoptosis in hce-4 cells, which is via accumulating ros generation and regulating mapk, stat3, and nf-κb. |
2021-01-25 |
2023-08-13 |
human |
| Yin Cai, Fan Ying, Hao Liu, Liang Ge, Erfei Song, Lin Wang, Dengwen Zhang, Eva Hoi Ching Tang, Zhengyuan Xia, Michael G Irwi. Deletion of Rap1 protects against myocardial ischemia/reperfusion injury through suppressing cell apoptosis via activation of STAT3 signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 3. 2021-01-21. PMID:32020680. |
deletion of rap1 protects against myocardial ischemia/reperfusion injury through suppressing cell apoptosis via activation of stat3 signaling. |
2021-01-21 |
2023-08-13 |
mouse |
| Yin Cai, Fan Ying, Hao Liu, Liang Ge, Erfei Song, Lin Wang, Dengwen Zhang, Eva Hoi Ching Tang, Zhengyuan Xia, Michael G Irwi. Deletion of Rap1 protects against myocardial ischemia/reperfusion injury through suppressing cell apoptosis via activation of STAT3 signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 3. 2021-01-21. PMID:32020680. |
in h9c2 and primary cardiomyocytes, rap1 knockdown or knockout significantly suppressed hypoxia/reoxygenation (h/r)-induced cell injury and apoptosis through increasing the phosphorylation/activation of stat3 at site ser |
2021-01-21 |
2023-08-13 |
mouse |
| Si-Yuan Jing, Zi-Dan Wu, Tie-Hua Zhang, Jie Zhang, Zheng-Yi We. In vitro antitumor effect of cucurbitacin E on human lung cancer cell line and its molecular mechanism. Chinese journal of natural medicines. vol 18. issue 7. 2021-01-20. PMID:32616188. |
the activated transcription factor stat3 and the apoptosis inhibitor protein survivin were also observed to be reduced. |
2021-01-20 |
2023-08-13 |
human |
| Jiehua Zhu, Jianglin Wang, Jialin Huang, Wensheng Du, Yingzhong He, Hongfei Pan, Junmin Lu. MicroRNA-140-5p regulates the proliferation, apoptosis and inflammation of RA FLSs by repressing STAT3. Experimental and therapeutic medicine. vol 21. issue 2. 2021-01-19. PMID:33456538. |
microrna-140-5p regulates the proliferation, apoptosis and inflammation of ra flss by repressing stat3. |
2021-01-19 |
2023-08-13 |
Not clear |
| Jiehua Zhu, Jianglin Wang, Jialin Huang, Wensheng Du, Yingzhong He, Hongfei Pan, Junmin Lu. MicroRNA-140-5p regulates the proliferation, apoptosis and inflammation of RA FLSs by repressing STAT3. Experimental and therapeutic medicine. vol 21. issue 2. 2021-01-19. PMID:33456538. |
notably, restoration of stat3 expression rescued the regulatory effect of mir-140 on the proliferation, apoptosis and inflammatory cytokine production of ra flss. |
2021-01-19 |
2023-08-13 |
Not clear |
| Jiehua Zhu, Jianglin Wang, Jialin Huang, Wensheng Du, Yingzhong He, Hongfei Pan, Junmin Lu. MicroRNA-140-5p regulates the proliferation, apoptosis and inflammation of RA FLSs by repressing STAT3. Experimental and therapeutic medicine. vol 21. issue 2. 2021-01-19. PMID:33456538. |
therefore, the current findings indicated that mir-140 is a crucial modulator of both proliferation and apoptosis, shedding light on the etiology behind ra fls viability, which is modulated by an interplay between mir-140 and stat3 in the context of ra. |
2021-01-19 |
2023-08-13 |
Not clear |
| Chunyan Dai, Li Shen, Weiyang Jin, Bing Lv, Pei Liu, Xi Wang, Yifei Yin, Yufei Fu, Liguo Liang, Zhongjun Ma, Xiaojian Zhang, Yiping Wang, Daogun Xu, Zhe Che. Physapubescin B enhances the sensitivity of gastric cancer cells to trametinib by inhibiting the STAT3 signaling pathway. Toxicology and applied pharmacology. vol 408. 2021-01-11. PMID:33035574. |
physapubescin b (pb), a steroidal compound extracted from the plant physalis pubescens l., inhibited the proliferation and induced the apoptosis of gc cells by suppressing stat3 phosphorylation. |
2021-01-11 |
2023-08-13 |
Not clear |
| Li Pan, Xiang Chen, Shengling Fu, Wenying Yu, Chenglong Li, Tiffany Wang, Hui-Wen Lo, Jiayuh Li. LLY17, a novel small molecule STAT3 inhibitor induces apoptosis and suppresses cell migration and tumor growth in triple-negative breast cancer. Breast cancer research and treatment. vol 181. issue 1. 2021-01-08. PMID:32240456. |
lly17, a novel small molecule stat3 inhibitor induces apoptosis and suppresses cell migration and tumor growth in triple-negative breast cancer. |
2021-01-08 |
2023-08-13 |
human |
| Wafaa R Mohamed, Amr S Kotb, Ola M Abd El-Raouf, Ebtehal Mohammad Fikr. Apigenin alleviated acetaminophen-induced hepatotoxicity in low protein-fed rats: Targeting oxidative stress, STAT3, and apoptosis signals. Journal of biochemical and molecular toxicology. vol 34. issue 5. 2021-01-07. PMID:32048452. |
apigenin alleviated acetaminophen-induced hepatotoxicity in low protein-fed rats: targeting oxidative stress, stat3, and apoptosis signals. |
2021-01-07 |
2023-08-13 |
rat |
| Jiaxing Wang, Fakun Huang, Caiyun Jiang, Pan Ch. Silencing Signal Transducer and Activator of Transcription 3 (STAT3) and Use of Anti-Programmed Cell Death-Ligand 1 (PD-L1) Antibody Induces Immune Response and Anti-Tumor Activity. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-01-04. PMID:32343679. |
tunel assay showed low level of apoptosis in mice injected with cells silenced for stat3 or injected with pd-l1 antibody, and higher level of apoptosis following combined treatment of stat3 silencing and pd-l1 antibody injection. |
2021-01-04 |
2023-08-13 |
mouse |
| Jiaxing Wang, Fakun Huang, Caiyun Jiang, Pan Ch. Silencing Signal Transducer and Activator of Transcription 3 (STAT3) and Use of Anti-Programmed Cell Death-Ligand 1 (PD-L1) Antibody Induces Immune Response and Anti-Tumor Activity. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-01-04. PMID:32343679. |
compared with treatment of stat3 silencing or pd-l1 antibody injection, the combined treatment enhanced apoptosis. |
2021-01-04 |
2023-08-13 |
mouse |
| Jiaxing Wang, Fakun Huang, Caiyun Jiang, Pan Ch. Silencing Signal Transducer and Activator of Transcription 3 (STAT3) and Use of Anti-Programmed Cell Death-Ligand 1 (PD-L1) Antibody Induces Immune Response and Anti-Tumor Activity. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-01-04. PMID:32343679. |
conclusions silencing stat3 and pd-l1 antibody injection in combination increased apoptosis in tumor cells and thus offers better anti-cancer activity. |
2021-01-04 |
2023-08-13 |
mouse |
| Ioannis Gkouveris, Nikolaos Nikitakis, Maria Karanikou, George Rassidakis, Alexandra Sklavouno. JNK1/2 expression and modulation of STAT3 signaling in oral cancer. Oncology letters. vol 12. issue 1. 2021-01-03. PMID:27347203. |
persistent activation of signal transducer and activator of transcription 3 (stat3), which is accompanied by increases in stat3 tyrosine phosphorylation, is associated with cell proliferation, differentiation and apoptosis in oral squamous cell carcinoma (oscc). |
2021-01-03 |
2023-08-13 |
Not clear |
| Donatella D'Eliseo, Livia Di Renzo, Angela Santoni, Francesca Velott. Docosahexaenoic acid (DHA) promotes immunogenic apoptosis in human multiple myeloma cells, induces autophagy and inhibits STAT3 in both tumor and dendritic cells. Genes & cancer. vol 8. issue 1-2. 2021-01-03. PMID:28435516. |
docosahexaenoic acid (dha) promotes immunogenic apoptosis in human multiple myeloma cells, induces autophagy and inhibits stat3 in both tumor and dendritic cells. |
2021-01-03 |
2023-08-13 |
human |
| Donatella D'Eliseo, Livia Di Renzo, Angela Santoni, Francesca Velott. Docosahexaenoic acid (DHA) promotes immunogenic apoptosis in human multiple myeloma cells, induces autophagy and inhibits STAT3 in both tumor and dendritic cells. Genes & cancer. vol 8. issue 1-2. 2021-01-03. PMID:28435516. |
combinatorial anticancer therapies, which induce immunogenic apoptosis, autophagy and stat3 inhibition have been proposed for long-term therapeutic success. |
2021-01-03 |
2023-08-13 |
human |