| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiehua Zhu, Jianglin Wang, Jialin Huang, Wensheng Du, Yingzhong He, Hongfei Pan, Junmin Lu. MicroRNA-140-5p regulates the proliferation, apoptosis and inflammation of RA FLSs by repressing STAT3. Experimental and therapeutic medicine. vol 21. issue 2. 2021-01-19. PMID:33456538. |
therefore, the current findings indicated that mir-140 is a crucial modulator of both proliferation and apoptosis, shedding light on the etiology behind ra fls viability, which is modulated by an interplay between mir-140 and stat3 in the context of ra. |
2021-01-19 |
2023-08-13 |
Not clear |
| Chunyan Dai, Li Shen, Weiyang Jin, Bing Lv, Pei Liu, Xi Wang, Yifei Yin, Yufei Fu, Liguo Liang, Zhongjun Ma, Xiaojian Zhang, Yiping Wang, Daogun Xu, Zhe Che. Physapubescin B enhances the sensitivity of gastric cancer cells to trametinib by inhibiting the STAT3 signaling pathway. Toxicology and applied pharmacology. vol 408. 2021-01-11. PMID:33035574. |
physapubescin b (pb), a steroidal compound extracted from the plant physalis pubescens l., inhibited the proliferation and induced the apoptosis of gc cells by suppressing stat3 phosphorylation. |
2021-01-11 |
2023-08-13 |
Not clear |
| Li Pan, Xiang Chen, Shengling Fu, Wenying Yu, Chenglong Li, Tiffany Wang, Hui-Wen Lo, Jiayuh Li. LLY17, a novel small molecule STAT3 inhibitor induces apoptosis and suppresses cell migration and tumor growth in triple-negative breast cancer. Breast cancer research and treatment. vol 181. issue 1. 2021-01-08. PMID:32240456. |
lly17, a novel small molecule stat3 inhibitor induces apoptosis and suppresses cell migration and tumor growth in triple-negative breast cancer. |
2021-01-08 |
2023-08-13 |
human |
| Wafaa R Mohamed, Amr S Kotb, Ola M Abd El-Raouf, Ebtehal Mohammad Fikr. Apigenin alleviated acetaminophen-induced hepatotoxicity in low protein-fed rats: Targeting oxidative stress, STAT3, and apoptosis signals. Journal of biochemical and molecular toxicology. vol 34. issue 5. 2021-01-07. PMID:32048452. |
apigenin alleviated acetaminophen-induced hepatotoxicity in low protein-fed rats: targeting oxidative stress, stat3, and apoptosis signals. |
2021-01-07 |
2023-08-13 |
rat |
| Jiaxing Wang, Fakun Huang, Caiyun Jiang, Pan Ch. Silencing Signal Transducer and Activator of Transcription 3 (STAT3) and Use of Anti-Programmed Cell Death-Ligand 1 (PD-L1) Antibody Induces Immune Response and Anti-Tumor Activity. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-01-04. PMID:32343679. |
tunel assay showed low level of apoptosis in mice injected with cells silenced for stat3 or injected with pd-l1 antibody, and higher level of apoptosis following combined treatment of stat3 silencing and pd-l1 antibody injection. |
2021-01-04 |
2023-08-13 |
mouse |
| Jiaxing Wang, Fakun Huang, Caiyun Jiang, Pan Ch. Silencing Signal Transducer and Activator of Transcription 3 (STAT3) and Use of Anti-Programmed Cell Death-Ligand 1 (PD-L1) Antibody Induces Immune Response and Anti-Tumor Activity. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-01-04. PMID:32343679. |
compared with treatment of stat3 silencing or pd-l1 antibody injection, the combined treatment enhanced apoptosis. |
2021-01-04 |
2023-08-13 |
mouse |
| Jiaxing Wang, Fakun Huang, Caiyun Jiang, Pan Ch. Silencing Signal Transducer and Activator of Transcription 3 (STAT3) and Use of Anti-Programmed Cell Death-Ligand 1 (PD-L1) Antibody Induces Immune Response and Anti-Tumor Activity. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-01-04. PMID:32343679. |
conclusions silencing stat3 and pd-l1 antibody injection in combination increased apoptosis in tumor cells and thus offers better anti-cancer activity. |
2021-01-04 |
2023-08-13 |
mouse |
| Ioannis Gkouveris, Nikolaos Nikitakis, Maria Karanikou, George Rassidakis, Alexandra Sklavouno. JNK1/2 expression and modulation of STAT3 signaling in oral cancer. Oncology letters. vol 12. issue 1. 2021-01-03. PMID:27347203. |
persistent activation of signal transducer and activator of transcription 3 (stat3), which is accompanied by increases in stat3 tyrosine phosphorylation, is associated with cell proliferation, differentiation and apoptosis in oral squamous cell carcinoma (oscc). |
2021-01-03 |
2023-08-13 |
Not clear |
| Donatella D'Eliseo, Livia Di Renzo, Angela Santoni, Francesca Velott. Docosahexaenoic acid (DHA) promotes immunogenic apoptosis in human multiple myeloma cells, induces autophagy and inhibits STAT3 in both tumor and dendritic cells. Genes & cancer. vol 8. issue 1-2. 2021-01-03. PMID:28435516. |
docosahexaenoic acid (dha) promotes immunogenic apoptosis in human multiple myeloma cells, induces autophagy and inhibits stat3 in both tumor and dendritic cells. |
2021-01-03 |
2023-08-13 |
human |
| Donatella D'Eliseo, Livia Di Renzo, Angela Santoni, Francesca Velott. Docosahexaenoic acid (DHA) promotes immunogenic apoptosis in human multiple myeloma cells, induces autophagy and inhibits STAT3 in both tumor and dendritic cells. Genes & cancer. vol 8. issue 1-2. 2021-01-03. PMID:28435516. |
combinatorial anticancer therapies, which induce immunogenic apoptosis, autophagy and stat3 inhibition have been proposed for long-term therapeutic success. |
2021-01-03 |
2023-08-13 |
human |
| Donatella D'Eliseo, Livia Di Renzo, Angela Santoni, Francesca Velott. Docosahexaenoic acid (DHA) promotes immunogenic apoptosis in human multiple myeloma cells, induces autophagy and inhibits STAT3 in both tumor and dendritic cells. Genes & cancer. vol 8. issue 1-2. 2021-01-03. PMID:28435516. |
stat3 pathway, essential for mm survival, contributed to cancer cell apoptosis by dha. |
2021-01-03 |
2023-08-13 |
human |
| Xiuyun Lv, Lihong Wang, Tianji Zh. MiR-20a-5p suppressed TGF-β1-triggered apoptosis of human bronchial epithelial BEAS-2B cells by targeting STAT3. Molecular and cellular probes. vol 50. 2020-12-30. PMID:31883454. |
mir-20a-5p suppressed tgf-β1-triggered apoptosis of human bronchial epithelial beas-2b cells by targeting stat3. |
2020-12-30 |
2023-08-13 |
human |
| Mahnaz Mohammadi Kian, Mahdieh Salemi, Mohammad Bahadoran, Atousa Haghi, Nasrin Dashti, Saeed Mohammadi, Shahrbano Rostami, Bahram Chahardouli, Davood Babakhani, Mohsen Nikbakh. Curcumin Combined with Thalidomide Reduces Expression of Drug design, development and therapy. vol 14. 2020-12-22. PMID:32021103. |
the aim of this study was to evaluate the effect of curcumin (cur) and thalidomide (thal) on apoptosis induction and also the alteration of the mrna expression level of stat3 and bcl-xl mrna on aml cell line compounds. |
2020-12-22 |
2023-08-13 |
human |
| Hua Fang, Fang-Xiang Zhang, Hua-Feng Li, Miao Yang, Ren Liao, Ru-Rong Wang, Quan-Yun Wang, Peng-Cheng Zheng, Jian-Ping Zhan. PRR34-AS1 overexpression promotes protection of propofol pretreatment against ischemia/reperfusion injury in a mouse model after total knee arthroplasty via blockade of the JAK1-dependent JAK-STAT signaling pathway. Journal of cellular physiology. vol 235. issue 3. 2020-12-17. PMID:31556112. |
upregulated prr34-as1 diminished expression of jak1, stat1, jak2, and stat3 as well as cell apoptosis, while enhancing cell proliferation in vitro. |
2020-12-17 |
2023-08-13 |
mouse |
| Tohid Gharibi, Zohreh Babaloo, Arezoo Hosseini, Meghdad Abdollahpour-Alitappeh, Vida Hashemi, Faroogh Marofi, Kazem Nejati, Behzad Baradara. Targeting STAT3 in cancer and autoimmune diseases. European journal of pharmacology. vol 878. 2020-12-17. PMID:32278856. |
stat3 is the key regulator of cell proliferation, survival and apoptosis and is constitutively activated in most human cancers, indicating that it can be an important potential therapeutic target for cancer treatment. |
2020-12-17 |
2023-08-13 |
human |
| Linbao Wen, Jingwei Sun, Xionggao Chen, Ruili D. miR-135b-dependent downregulation of S100B promotes neural stem cell differentiation in a hypoxia/ischemia-induced cerebral palsy rat model. American journal of physiology. Cell physiology. vol 319. issue 6. 2020-12-15. PMID:32491925. |
s100b downregulation targeted by mir-135b overexpression contributed to the inactivation of the signal transducer and activator of transcription-3 (stat3) pathway, which promoted nsc differentiation and proliferation but inhibited nsc apoptosis. |
2020-12-15 |
2023-08-13 |
rat |
| Hong-Tao Song, Yuan Cui, Li-Li Zhang, Guang Cao, Lin Li, Gang Li, Xin-Ju Ji. Ruxolitinib attenuates intimal hyperplasia via inhibiting JAK2/STAT3 signaling pathway activation induced by PDGF-BB in vascular smooth muscle cells. Microvascular research. vol 132. 2020-12-15. PMID:32818511. |
ruxolitinib, a potent janus kinase (jak) 1 and 2 inhibitor, has been reported to significantly block the proliferation-related signaling pathway of jak2/signal transducers and activators of transcription 3 (stat3) and harbor a broad spectrum of anti-cancer activities, including proliferation inhibition, apoptosis induction, and anti-inflammation. |
2020-12-15 |
2023-08-13 |
Not clear |
| Radhika Saraf, Aniruddha Datta, Chao Sima, Jianping Hua, Rosana Lopes, Michael L Bittner, Tasha Miller, Heather M Wilson-Roble. In silico modeling of the induction of apoptosis by Cryptotanshinone in osteosarcoma cell lines. IEEE/ACM transactions on computational biology and bioinformatics. vol PP. 2020-12-15. PMID:33180729. |
we show that the action of the herbal drug, cryptotanshinone on os cell lines induces apoptosis by increasing sensitivity to tnf-related apoptosis-inducing ligand (trail) through its multi-pronged action on stat3, drp1 and dr5. |
2020-12-15 |
2023-08-13 |
Not clear |
| I Gkouveris, N Nikitakis, A Sklavouno. p38 Expression and Modulation of STAT3 Signaling in Oral Cancer. Pathology oncology research : POR. vol 26. issue 1. 2020-12-11. PMID:29564744. |
persistent activation of stat3 has been associated with cell proliferation, differentiation and apoptosis in oral squamous cell carcinoma (oscc). |
2020-12-11 |
2023-08-13 |
Not clear |
| Zhu-Xia Jia, Xu-Zhang Lu, Jin-Yuan He, Xiao-Hui Cai, Wei Qin, Wen-Min Han, Min Zhou, Wei X. [Mechanism of Anti Apoptosis and Immune Evasion in Drug-Resistant Leukemia Cells Mediated by STAT3]. Zhongguo shi yan xue ye xue za zhi. vol 28. issue 6. 2020-12-08. PMID:33283701. |
[mechanism of anti apoptosis and immune evasion in drug-resistant leukemia cells mediated by stat3]. |
2020-12-08 |
2023-08-13 |
Not clear |