| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guangjie Zhan, Jun Hu, Benjian Xiao, Xianli Wang, Zixian Yang, Guohua Yang, Lili L. Trillin prevents proliferation and induces apoptosis through inhibiting STAT3 nuclear translocation in hepatoma carcinoma cells. Medical oncology (Northwood, London, England). vol 37. issue 5. 2020-11-12. PMID:32270306. |
this study demonstrated that trillin could dramatically inhibit hepatoma carcinoma cell proliferation, induce apoptosis and decrease migration and invasion through suppressing phosphorylated stat3 translocated to nucleus. |
2020-11-12 |
2023-08-13 |
Not clear |
| Jae Young So, Nicolas Skrypek, Howard H Yang, Anand S Merchant, George W Nelson, Wei-Dong Chen, Hiroki Ishii, Jennifer M Chen, Gangqing Hu, Bhagelu R Achyut, Esther C Yoon, Liying Han, Chuanshu Huang, Margaret C Cam, Keji Zhao, Maxwell P Lee, Li Yan. Induction of DNMT3B by PGE2 and IL6 at Distant Metastatic Sites Promotes Epigenetic Modification and Breast Cancer Colonization. Cancer research. vol 80. issue 12. 2020-11-06. PMID:32265226. |
multiomics analysis and spontaneous metastatic mouse models revealed that dnmt3b alters multiple pathways including stat3, nfκb, pi3k/akt, β-catenin, and notch signaling, which are critical for cancer cell survival, apoptosis, proliferation, invasion, and colonization. |
2020-11-06 |
2023-08-13 |
mouse |
| Kyung-Ran Park, Hyung-Mun Yun, Jin Tae Hon. G721-0282 inhibits cell growth and induces apoptosis in human osteosarcoma through down-regulation of the STAT3 pathway. International journal of biological sciences. vol 16. issue 2. 2020-11-02. PMID:31929760. |
g721-0282 inhibits cell growth and induces apoptosis in human osteosarcoma through down-regulation of the stat3 pathway. |
2020-11-02 |
2023-08-13 |
human |
| Di Chen, Yangmin Ma, Zhiyu Guo, Li Liu, Yaru Yang, Yuru Wang, Bonan Pan, Luyang Wu, Yuyu Hui, Wenjuan Yan. Two Natural Alkaloids Synergistically Induce Apoptosis in Breast Cancer Cells by Inhibiting STAT3 Activation. Molecules (Basel, Switzerland). vol 25. issue 1. 2020-11-02. PMID:31948057. |
two natural alkaloids synergistically induce apoptosis in breast cancer cells by inhibiting stat3 activation. |
2020-11-02 |
2023-08-13 |
Not clear |
| Di Chen, Yangmin Ma, Zhiyu Guo, Li Liu, Yaru Yang, Yuru Wang, Bonan Pan, Luyang Wu, Yuyu Hui, Wenjuan Yan. Two Natural Alkaloids Synergistically Induce Apoptosis in Breast Cancer Cells by Inhibiting STAT3 Activation. Molecules (Basel, Switzerland). vol 25. issue 1. 2020-11-02. PMID:31948057. |
furthermore, apoptosis and stat3 signaling pathway-associated protein levels were analyzed. |
2020-11-02 |
2023-08-13 |
Not clear |
| Di Chen, Yangmin Ma, Zhiyu Guo, Li Liu, Yaru Yang, Yuru Wang, Bonan Pan, Luyang Wu, Yuyu Hui, Wenjuan Yan. Two Natural Alkaloids Synergistically Induce Apoptosis in Breast Cancer Cells by Inhibiting STAT3 Activation. Molecules (Basel, Switzerland). vol 25. issue 1. 2020-11-02. PMID:31948057. |
we demonstrated that pp and pl in combination inhibit stat3 phosphorylation and regulate downstream molecules to induce apoptosis in breast cancer cells. |
2020-11-02 |
2023-08-13 |
Not clear |
| Pengfei Li, Huina Lv, Min Xu, Bin Zang, Yegang M. ARHGAP6 Promotes Apoptosis and Inhibits Glycolysis in Lung Adenocarcinoma Through STAT3 Signaling Pathway. Cancer management and research. vol 12. 2020-10-30. PMID:33116826. |
arhgap6 promotes apoptosis and inhibits glycolysis in lung adenocarcinoma through stat3 signaling pathway. |
2020-10-30 |
2023-08-13 |
Not clear |
| Juan Tornin, Miguel Mateu-Sanz, Aida Rodríguez, Cédric Labay, Rene Rodríguez, Cristina Cana. Pyruvate Plays a Main Role in the Antitumoral Selectivity of Cold Atmospheric Plasma in Osteosarcoma. Scientific reports. vol 9. issue 1. 2020-10-23. PMID:31337843. |
os cells show higher sensitivity to pam treatment than healthy cells, both in medium with and without pyruvate, activating apoptosis, dna damage and deregulating cellular pathways mediated by c-jun, akt, ampk or stat3. |
2020-10-23 |
2023-08-13 |
Not clear |
| Mahdieh Safaei, Hadi Maleki, Hamidreza Soleimanpour, Amir Norouzy, Hossein Shahbani Zahiri, Hojatollah Vali, Kambiz Akbari Noghab. Development of a novel method for the purification of C-phycocyanin pigment from a local cyanobacterial strain Limnothrix sp. NS01 and evaluation of its anticancer properties. Scientific reports. vol 9. issue 1. 2020-10-13. PMID:31263160. |
the reduced expression levels of anti-apoptotic proteins, bcl2 and stat3, plus cell cycle regulator protein, cyclin d1, using real-time pcr confirm that the c-pc-induced death of mcf-7 human breast cancer cells occurred through the mitochondrial pathway of apoptosis. |
2020-10-13 |
2023-08-13 |
human |
| M-H Li, Z-Y Wu, Y Wang, F-Z Chen, Y Li. Expression of miR-29 and STAT3 in osteosarcoma and its effect on proliferation regulation of osteosarcoma cells. European review for medical and pharmacological sciences. vol 23. issue 17. 2020-10-06. PMID:31539114. |
this study investigated whether mir-29 regulates the stat3 expression and affects the proliferation and apoptosis of osteosarcoma cells. |
2020-10-06 |
2023-08-13 |
Not clear |
| Muhammad Zubair Saleem, Mohammed Alshwmi, He Zhang, Syed Riaz Ud Din, Muhammad Azhar Nisar, Muhammad Khan, Shahid Alam, Gulzar Alam, Lingling Jin, Tonghui M. Inhibition of JNK-Mediated Autophagy Promotes Proscillaridin A- Induced Apoptosis Frontiers in pharmacology. vol 11. 2020-10-06. PMID:33013353. |
in our study, psd-a restricted cell growth, inhibited stat3 activation and induced apoptosis and autophagy in breast cancer cells |
2020-10-06 |
2023-08-13 |
Not clear |
| Adetola Shodeinde, Kalyani Ginjupalli, H Dan Lewis, Sheraz Riaz, Beverly E Barto. STAT3 Inhibition Induces Apoptosis in Cancer Cells Independent of STAT1 or STAT2. Journal of molecular biochemistry. vol 2. issue 1. 2020-10-01. PMID:25364701. |
stat3 inhibition induces apoptosis in cancer cells independent of stat1 or stat2. |
2020-10-01 |
2023-08-13 |
Not clear |
| Adetola Shodeinde, Kalyani Ginjupalli, H Dan Lewis, Sheraz Riaz, Beverly E Barto. STAT3 Inhibition Induces Apoptosis in Cancer Cells Independent of STAT1 or STAT2. Journal of molecular biochemistry. vol 2. issue 1. 2020-10-01. PMID:25364701. |
previously we reported that single-stranded oligonucleotides containing consensus stat3 binding sequences (13410 and 13411) were more effective for inducing apoptosis in prostate cancer cells than antisense stat3 oligonucleotides. |
2020-10-01 |
2023-08-13 |
Not clear |
| Maria Cosenza, Monica Civallero, Stefania Fiorcari, Samantha Pozzi, Luigi Marcheselli, Alessia Bari, Paola Ferri, Stefano Sacch. The histone deacetylase inhibitor romidepsin synergizes with lenalidomide and enhances tumor cell death in T-cell lymphoma cell lines. Cancer biology & therapy. vol 17. issue 10. 2020-10-01. PMID:27657380. |
apoptosis was associated with increased hallmarks of er stress and activation of upr sensors and was mediated by dephosphorylation of the akt, mapk/erk, and stat3 pathways.the combination of romidepsin and lenalidomide shows promise as a possible treatment for t-cell lymphoma. |
2020-10-01 |
2023-08-13 |
Not clear |
| Gang Wang, Yue Jing, Lingsen Cao, Changchang Gong, Zhunan Gong, Xiangrong Ca. A novel synthetic Asiatic acid derivative induces apoptosis and inhibits proliferation and mobility of gastric cancer cells by suppressing STAT3 signaling pathway. OncoTargets and therapy. vol 10. 2020-10-01. PMID:28053540. |
a novel synthetic asiatic acid derivative induces apoptosis and inhibits proliferation and mobility of gastric cancer cells by suppressing stat3 signaling pathway. |
2020-10-01 |
2023-08-13 |
human |
| Jun Ouyang, Xiaohui Pan, Hui Lin, Zecheng Hu, Ping Xiao, Haobin H. GKN2 increases apoptosis, reduces the proliferation and invasion ability of gastric cancer cells through down-regulating the JAK/STAT signaling pathway. American journal of translational research. vol 9. issue 2. 2020-10-01. PMID:28337309. |
to investigate the effect of gastric motility protein 2 (gkn2) on the proliferation, apoptosis and invasion of gastric cancer cell and on the jak/signal transducer and activator of transcription 3 (stat3) signaling pathway. |
2020-10-01 |
2023-08-13 |
Not clear |
| Ritika Ramani, Gail Megason, Jason Schallheim, Cynthia Karlson, Vani Vijayakumar, Srinivasan Vijayakumar, Chindo Hick. Integrative Analysis of MicroRNA-Mediated Gene Signatures and Pathways Modulating White Blood Cell Count in Childhood Acute Lymphoblastic Leukemia. Biomarker insights. vol 12. 2020-10-01. PMID:28469402. |
in addition, we identified molecular networks and biological pathways, among them pi3/akt, jak/stat, il-17, tgf-β, apoptosis, il-15, stat3, igf-1, fgf, mtor, vegf, nf-kb, and p53 signaling pathways, enriched for or targeted by mirnas. |
2020-10-01 |
2023-08-13 |
Not clear |
| Deyou Wang, Sifeng Tang, Qiwen Zhan. Maslinic acid suppresses the growth of human gastric cells by inducing apoptosis via inhibition of the interleukin-6 mediated Janus kinase/signal transducer and activator of transcription 3 signaling pathway. Oncology letters. vol 13. issue 6. 2020-10-01. PMID:28599489. |
western blot analysis was performed in order to determine the differential expression levels of janus kinase (jak), signal transducer and activator of transcription 3 (stat3) and apoptosis associated proteins b-cell lymphoma 2 (bcl-2), bcl-2 associated x protein (bax) and bcl-2 associated agonist of cell death (bad). |
2020-10-01 |
2023-08-13 |
human |
| Kilmer S McCull. Hyperhomocysteinemia, Suppressed Immunity, and Altered Oxidative Metabolism Caused by Pathogenic Microbes in Atherosclerosis and Dementia. Frontiers in aging neuroscience. vol 9. 2020-10-01. PMID:29056905. |
diallyl trisulfide and napabucasin inhibit the signaling by the signal transducer and activator of transcription 3 (stat3), potentially enhancing immune function by effects on t helper lymphocytes and promotion of apoptosis. |
2020-10-01 |
2023-08-13 |
Not clear |
| Weilan Kong, Kai Kang, Yang Gao, Haitao Liu, Xianglin Meng, Songliu Yang, Kaijiang Yu, Mingyan Zha. Dexmedetomidine alleviates LPS-induced septic cardiomyopathy via the cholinergic anti-inflammatory pathway in mice. American journal of translational research. vol 9. issue 11. 2020-10-01. PMID:29218102. |
the pathological examinations were performed on he- stained myocardium tissues, apoptosis was determined using tunel assay, mrna expression of nf-κb p65, caspase-3, caspase-8, bcl-2, bax, p53 and α7nach was quantified using qrt-pcr, protein levels of il-6, il-1β, tnf-α and phosphorylated stat3 (p-stat3) were analyzed using western blot analysis. |
2020-10-01 |
2023-08-13 |
mouse |