| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Changjiang Zhang, Yinzhi Deng, Yuhua Lei, Jingbo Zhao, Wen Wei, Yuanhong L. Effects of selenium on myocardial apoptosis by modifying the activity of mitochondrial STAT3 and regulating potassium channel expression. Experimental and therapeutic medicine. vol 14. issue 3. 2020-09-30. PMID:28962142. |
in conclusion, selenium deficiency in cardiomyocytes leads to decreased potassium channel expression and decreased mitochondrial stat3 activity and mitochondrial function, which in turn promotes the apoptosis of cardiomyocytes. |
2020-09-30 |
2023-08-13 |
mouse |
| Satya Sahay, Prakash Tiwari, Krishna P Gupt. Onset of the lymphocytic infiltration and hyperplasia preceding the proliferation in F1 mouse lungs from the N-ethyl-N-nitrosourea exposed mothers: Prevention during the lactation period by inositol hexaphosphate. Toxicology reports. vol 2. 2020-09-30. PMID:28962394. |
analysis of pcna, nf-κb (p50), il-6, cox-2, pstat3, stat3, caspase-3, caspase-9, parp, akt signalling and downstream cyclin d1 along with mir-155, suggested the modulation of proliferation, inflammation and apoptosis at pnd12 and 24. |
2020-09-30 |
2023-08-13 |
mouse |
| Satya Sahay, Prakash Tiwari, Krishna P Gupt. Onset of the lymphocytic infiltration and hyperplasia preceding the proliferation in F1 mouse lungs from the N-ethyl-N-nitrosourea exposed mothers: Prevention during the lactation period by inositol hexaphosphate. Toxicology reports. vol 2. 2020-09-30. PMID:28962394. |
ip6 administration to the predisposed mothers prevented the proliferation, inflammation and enhanced apoptosis in f1 lung as showed by a reduction in pcna, nf-κb (p50), il-6, cox-2, pstat3, stat3, mir-155 and increase in caspases, cleavage of poly (adp-ribose) polymerase. |
2020-09-30 |
2023-08-13 |
mouse |
| Yang Gao, Kai Kang, Haitao Liu, Weilan Kong, Qiuyuan Han, Xing Zhang, Rui Huang, Jingdong Qu, Hongliang Wang, Sicong Wang, Ruijin Liu, Yansong Liu, Kaijiang Y. GTS-21 attenuates LPS-induced renal injury via the cholinergic anti-inflammatory pathway in mice. American journal of translational research. vol 9. issue 10. 2020-09-30. PMID:29118926. |
the pathological examinations were performed on he stained renal tissues, apoptosis was determined using tunel assay, mrna expression of nf-kb p65, caspase-3, caspase-8, bcl-2, bax, p53 and a7nach was quantified using qrt-pcr, protein levels of il-6, il-1β, tnf-α and phosphorylated stat3 (p-stat3) were analyzed using western blots. |
2020-09-30 |
2023-08-13 |
mouse |
| Feng-Tao Yi, Qi-Ping L. Mucin 1 promotes radioresistance in hepatocellular carcinoma cells through activation of JAK2/STAT3 signaling. Oncology letters. vol 14. issue 6. 2020-09-30. PMID:29344203. |
mechanistically, muc1 inhibited irradiation-induced apoptosis through activation of janus kinase 2 (jak2) and stat3, and induction of anti-apoptotic proteins induced myeloid leukemia cell differentiation protein mcl-1 (mcl-1) and bcl2 like 1 (bcl-xl). |
2020-09-30 |
2023-08-13 |
human |
| Feng-Tao Yi, Qi-Ping L. Mucin 1 promotes radioresistance in hepatocellular carcinoma cells through activation of JAK2/STAT3 signaling. Oncology letters. vol 14. issue 6. 2020-09-30. PMID:29344203. |
small hairpin rna-mediated knockdown of stat3 or muc1 resensitized muc1-overexpressing cells to irradiation-induced apoptosis, which was accompanied by reduced expression of bcl-xl and mcl-1. |
2020-09-30 |
2023-08-13 |
human |
| Hua Li, Hang Lu, Meng Lv, Qingsheng Wang, Yuping Su. Parthenolide facilitates apoptosis and reverses drug-resistance of human gastric carcinoma cells by inhibiting the STAT3 signaling pathway. Oncology letters. vol 15. issue 3. 2020-09-30. PMID:29467878. |
parthenolide facilitates apoptosis and reverses drug-resistance of human gastric carcinoma cells by inhibiting the stat3 signaling pathway. |
2020-09-30 |
2023-08-13 |
human |
| Zaiyun Zhang, Jihua Wang, Jian Cheng, Xiaoming Y. Effects of miR-126 on the STAT3 signaling pathway and the regulation of malignant behavior in lung cancer cells. Oncology letters. vol 15. issue 6. 2020-09-30. PMID:29805576. |
based on our findings, the cancer-promoting mir-126 can mediate the activation of the stat3 signal pathway to regulate the malignant biological behavior of nsclc cells affecting their proliferation, migration, cycle and apoptosis susceptibility. |
2020-09-30 |
2023-08-13 |
Not clear |
| Loukik Arora, Alan Prem Kumar, Frank Arfuso, Wee Joo Chng, Gautam Seth. The Role of Signal Transducer and Activator of Transcription 3 (STAT3) and Its Targeted Inhibition in Hematological Malignancies. Cancers. vol 10. issue 9. 2020-09-30. PMID:30217007. |
this review focuses on the role of stat3 in pathogenesis i.e., proliferation, differentiation, migration, and apoptosis of hematological malignancies viz. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yingying Wang, Linlin Wu, Haiyan Cai, Hu Lei, Chun-Min Ma, Li Yang, Hanzhang Xu, Qi Zhu, Zhujun Yao, Yingli W. YL064 directly inhibits STAT3 activity to induce apoptosis of multiple myeloma cells. Cell death discovery. vol 4. 2020-09-30. PMID:30302278. |
yl064 directly inhibits stat3 activity to induce apoptosis of multiple myeloma cells. |
2020-09-30 |
2023-08-13 |
human |
| Jong Hyun Lee, Chulwon Kim, Seok-Geun Lee, Gautam Sethi, Kwang Seok Ah. Ophiopogonin D, a Steroidal Glycoside Abrogates STAT3 Signaling Cascade and Exhibits Anti-Cancer Activity by Causing GSH/GSSG Imbalance in Lung Carcinoma. Cancers. vol 10. issue 11. 2020-09-30. PMID:30413072. |
our findings suggest that op-d can induce apoptosis and exert anti-tumor effects by inhibition of stat3 signaling pathways in nsclc. |
2020-09-30 |
2023-08-13 |
mouse |
| Yan Zhang, Meiwu Zhang, Xiaoxiang Fan, Dafeng Mao, Shuyi Lv, Ping Che. Effect of STAT3 decoy oligodeoxynucleotides mediated by ultrasound-targeted microbubbles combined with ultrasound on the growth of squamous cell carcinoma of the esophagus. Oncology letters. vol 17. issue 2. 2020-09-30. PMID:30675281. |
the transfection of stat3 decoy odn can significantly inhibit the activity of esophageal squamous cell carcinoma cells and enhance apoptosis of cells, which has potential clinical value. |
2020-09-30 |
2023-08-13 |
mouse |
| Dianhui Xiu, Dawei Wang, Jing Wang, Fujian Ji, Wenlei Zhan. MicroRNA-543 suppresses liver cancer growth and induces apoptosis via the JAK2/STAT3 signaling pathway. Oncology letters. vol 17. issue 2. 2020-09-30. PMID:30675310. |
the aim of the present study was to investigate the function of microrna-543 on liver cancer cell proliferation and apoptosis, and also to identify whether the janus kinase 2 (jak2)/signal transducer and activator of transcription 3 (stat3) signaling pathway was a direct target of microrna-543. |
2020-09-30 |
2023-08-13 |
Not clear |
| Praful R Nai. Delivering Combination Chemotherapies and Targeting Oncogenic Pathways via Polymeric Drug Delivery Systems. Polymers. vol 11. issue 4. 2020-09-30. PMID:30959799. |
these include inhibition of oncogenic pathways (including those involving her2, egfr, mapk, pi3k/akt, stat3, and hif-1α), augmentation of apoptosis by inhibiting anti-apoptosis proteins (bcl-2, bcl-xl, and survivin), and targeting dysregulated pathways such as wnt/β-catenin and hedgehog. |
2020-09-30 |
2023-08-13 |
Not clear |
| Amanda Thomaz, Kelly de Vargas Pinheiro, Bárbara Kunzler Souza, Lauro Gregianin, Algemir L Brunetto, André T Brunetto, Caroline Brunetto de Farias, Mariane da Cunha Jaeger, Vijay Ramaswamy, Carolina Nör, Michael D Taylor, Rafael Roesle. Antitumor Activities and Cellular Changes Induced by TrkB Inhibition in Medulloblastoma. Frontiers in pharmacology. vol 10. 2020-09-30. PMID:31297057. |
these effects were accompanied by increased apoptosis, reduced extracellular-regulated kinase (erk) activity, increased expression of signal transducer and activator of transcription 3 (stat3), and differential modulation of p21 expression dependent on the cell line. |
2020-09-30 |
2023-08-13 |
mouse |
| Peter Stärkel, Bernd Schnabl, Sophie Leclercq, Mina Komuta, Ramon Bataller, Josepmaria Argemi, Elena Palma, Shilpa Chokshi, Claus Hellerbrand, Luca Maccioni, Nicolas Lanthier, Isabelle Leclerc. Deficient IL-6/Stat3 Signaling, High TLR7, and Type I Interferons in Early Human Alcoholic Liver Disease: A Triad for Liver Damage and Fibrosis. Hepatology communications. vol 3. issue 7. 2020-09-30. PMID:31334440. |
in parallel, down-regulation of il-6, inhibition of the signal transducer and activator of transcription 3 (stat3) pathway, as well as blunted cyclin d expression in hepatocytes, reduced proliferation and favored hepatocyte apoptosis. |
2020-09-30 |
2023-08-13 |
human |
| Abdul Q Khan, Eiman I Ahmed, Noor Elareer, Hamna Fathima, Kirti S Prabhu, Kodappully S Siveen, Michal Kulinski, Fouad Azizi, Said Dermime, Aamir Ahmad, Martin Steinhoff, Shahab Uddi. Curcumin-Mediated Apoptotic Cell Death in Papillary Thyroid Cancer and Cancer Stem-Like Cells through Targeting of the JAK/STAT3 Signaling Pathway. International journal of molecular sciences. vol 21. issue 2. 2020-09-30. PMID:31936675. |
curcumin suppressed ptc cell survival in a dose-dependent manner via the induction of caspase-mediated apoptosis and caused the attenuation of constitutively active stat3 (the dephosphorylation of tyr705-stat3) without affecting stat3. |
2020-09-30 |
2023-08-13 |
Not clear |
| Abdul Q Khan, Eiman I Ahmed, Noor Elareer, Hamna Fathima, Kirti S Prabhu, Kodappully S Siveen, Michal Kulinski, Fouad Azizi, Said Dermime, Aamir Ahmad, Martin Steinhoff, Shahab Uddi. Curcumin-Mediated Apoptotic Cell Death in Papillary Thyroid Cancer and Cancer Stem-Like Cells through Targeting of the JAK/STAT3 Signaling Pathway. International journal of molecular sciences. vol 21. issue 2. 2020-09-30. PMID:31936675. |
finally, thyrospheres treated with curcumin and cisplatin showed suppressed stat3 phosphorylation, a reduced formation of thyrospheres, and the downregulated expression of stemness markers, in addition to apoptosis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Lei Zhang, Yan Wang, Junjie Ma, Xingqiang Lai, Jiali Fang, Guanghui Li, Lu Xu, Guanghui Pan, Zheng Che. Exogenous MSCs ameliorate hypoxia/reoxygenation injury in renal tubular epithelial cells through JAK/STAT signaling pathway-mediated regulation of HMGB1. American journal of translational research. vol 9. issue 5. 2020-09-29. PMID:28559991. |
when the cells were transfected with sirna stat3, the expression of stat3 at protein and mrna levels and jak2 and hmgb1 at mrna level was down-regulated; the cell viability was reduced and apoptosis increased. |
2020-09-29 |
2023-08-13 |
Not clear |
| Tahir Mehmood, Amara Maryam, Xiangge Tian, Muhammad Khan, Tonghui M. Santamarine Inhibits NF-кB and STAT3 Activation and Induces Apoptosis in HepG2 Liver Cancer Cells via Oxidative Stress. Journal of Cancer. vol 8. issue 18. 2020-09-29. PMID:29151958. |
santamarine inhibits nf-кb and stat3 activation and induces apoptosis in hepg2 liver cancer cells via oxidative stress. |
2020-09-29 |
2023-08-13 |
Not clear |