| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Muhammad Zubair Saleem, Mohammed Alshwmi, He Zhang, Syed Riaz Ud Din, Muhammad Azhar Nisar, Muhammad Khan, Shahid Alam, Gulzar Alam, Lingling Jin, Tonghui M. Inhibition of JNK-Mediated Autophagy Promotes Proscillaridin A- Induced Apoptosis Frontiers in pharmacology. vol 11. 2020-10-06. PMID:33013353. |
in our study, psd-a restricted cell growth, inhibited stat3 activation and induced apoptosis and autophagy in breast cancer cells |
2020-10-06 |
2023-08-13 |
Not clear |
| Adetola Shodeinde, Kalyani Ginjupalli, H Dan Lewis, Sheraz Riaz, Beverly E Barto. STAT3 Inhibition Induces Apoptosis in Cancer Cells Independent of STAT1 or STAT2. Journal of molecular biochemistry. vol 2. issue 1. 2020-10-01. PMID:25364701. |
stat3 inhibition induces apoptosis in cancer cells independent of stat1 or stat2. |
2020-10-01 |
2023-08-13 |
Not clear |
| Adetola Shodeinde, Kalyani Ginjupalli, H Dan Lewis, Sheraz Riaz, Beverly E Barto. STAT3 Inhibition Induces Apoptosis in Cancer Cells Independent of STAT1 or STAT2. Journal of molecular biochemistry. vol 2. issue 1. 2020-10-01. PMID:25364701. |
previously we reported that single-stranded oligonucleotides containing consensus stat3 binding sequences (13410 and 13411) were more effective for inducing apoptosis in prostate cancer cells than antisense stat3 oligonucleotides. |
2020-10-01 |
2023-08-13 |
Not clear |
| Maria Cosenza, Monica Civallero, Stefania Fiorcari, Samantha Pozzi, Luigi Marcheselli, Alessia Bari, Paola Ferri, Stefano Sacch. The histone deacetylase inhibitor romidepsin synergizes with lenalidomide and enhances tumor cell death in T-cell lymphoma cell lines. Cancer biology & therapy. vol 17. issue 10. 2020-10-01. PMID:27657380. |
apoptosis was associated with increased hallmarks of er stress and activation of upr sensors and was mediated by dephosphorylation of the akt, mapk/erk, and stat3 pathways.the combination of romidepsin and lenalidomide shows promise as a possible treatment for t-cell lymphoma. |
2020-10-01 |
2023-08-13 |
Not clear |
| Gang Wang, Yue Jing, Lingsen Cao, Changchang Gong, Zhunan Gong, Xiangrong Ca. A novel synthetic Asiatic acid derivative induces apoptosis and inhibits proliferation and mobility of gastric cancer cells by suppressing STAT3 signaling pathway. OncoTargets and therapy. vol 10. 2020-10-01. PMID:28053540. |
a novel synthetic asiatic acid derivative induces apoptosis and inhibits proliferation and mobility of gastric cancer cells by suppressing stat3 signaling pathway. |
2020-10-01 |
2023-08-13 |
human |
| Jun Ouyang, Xiaohui Pan, Hui Lin, Zecheng Hu, Ping Xiao, Haobin H. GKN2 increases apoptosis, reduces the proliferation and invasion ability of gastric cancer cells through down-regulating the JAK/STAT signaling pathway. American journal of translational research. vol 9. issue 2. 2020-10-01. PMID:28337309. |
to investigate the effect of gastric motility protein 2 (gkn2) on the proliferation, apoptosis and invasion of gastric cancer cell and on the jak/signal transducer and activator of transcription 3 (stat3) signaling pathway. |
2020-10-01 |
2023-08-13 |
Not clear |
| Ritika Ramani, Gail Megason, Jason Schallheim, Cynthia Karlson, Vani Vijayakumar, Srinivasan Vijayakumar, Chindo Hick. Integrative Analysis of MicroRNA-Mediated Gene Signatures and Pathways Modulating White Blood Cell Count in Childhood Acute Lymphoblastic Leukemia. Biomarker insights. vol 12. 2020-10-01. PMID:28469402. |
in addition, we identified molecular networks and biological pathways, among them pi3/akt, jak/stat, il-17, tgf-β, apoptosis, il-15, stat3, igf-1, fgf, mtor, vegf, nf-kb, and p53 signaling pathways, enriched for or targeted by mirnas. |
2020-10-01 |
2023-08-13 |
Not clear |
| Deyou Wang, Sifeng Tang, Qiwen Zhan. Maslinic acid suppresses the growth of human gastric cells by inducing apoptosis via inhibition of the interleukin-6 mediated Janus kinase/signal transducer and activator of transcription 3 signaling pathway. Oncology letters. vol 13. issue 6. 2020-10-01. PMID:28599489. |
western blot analysis was performed in order to determine the differential expression levels of janus kinase (jak), signal transducer and activator of transcription 3 (stat3) and apoptosis associated proteins b-cell lymphoma 2 (bcl-2), bcl-2 associated x protein (bax) and bcl-2 associated agonist of cell death (bad). |
2020-10-01 |
2023-08-13 |
human |
| Kilmer S McCull. Hyperhomocysteinemia, Suppressed Immunity, and Altered Oxidative Metabolism Caused by Pathogenic Microbes in Atherosclerosis and Dementia. Frontiers in aging neuroscience. vol 9. 2020-10-01. PMID:29056905. |
diallyl trisulfide and napabucasin inhibit the signaling by the signal transducer and activator of transcription 3 (stat3), potentially enhancing immune function by effects on t helper lymphocytes and promotion of apoptosis. |
2020-10-01 |
2023-08-13 |
Not clear |
| Weilan Kong, Kai Kang, Yang Gao, Haitao Liu, Xianglin Meng, Songliu Yang, Kaijiang Yu, Mingyan Zha. Dexmedetomidine alleviates LPS-induced septic cardiomyopathy via the cholinergic anti-inflammatory pathway in mice. American journal of translational research. vol 9. issue 11. 2020-10-01. PMID:29218102. |
the pathological examinations were performed on he- stained myocardium tissues, apoptosis was determined using tunel assay, mrna expression of nf-κb p65, caspase-3, caspase-8, bcl-2, bax, p53 and α7nach was quantified using qrt-pcr, protein levels of il-6, il-1β, tnf-α and phosphorylated stat3 (p-stat3) were analyzed using western blot analysis. |
2020-10-01 |
2023-08-13 |
mouse |
| Fei Tian, Ligang Jia, Zhaoping Chu, Hua Han, Yuan Zhang, Jianhui Ca. MicroRNA-519a inhibits the proliferation and promotes the apoptosis of ovarian cancer cells through targeting signal transducer and activator of transcription 3. Experimental and therapeutic medicine. vol 15. issue 2. 2020-10-01. PMID:29434770. |
furthermore, transient overexpression of mir-519a inhibited the proliferation and promoted the apoptosis of skov3 cells, as well as decreased the mrna and protein expression levels of stat3, mcl-1 and bcl-xl. |
2020-10-01 |
2023-08-13 |
Not clear |
| Tomoyuki Yoshikawa, Morikazu Miyamoto, Tadashi Aoyama, Hiroaki Soyama, Tomoko Goto, Junko Hirata, Ayako Suzuki, Isao Nagaoka, Hitoshi Tsuda, Kenichi Furuya, Masashi Takan. JAK2/STAT3 pathway as a therapeutic target in ovarian cancers. Oncology letters. vol 15. issue 4. 2020-10-01. PMID:29545902. |
the effect of an inhibitor of stat3, niclosamide, was evaluated in ovarian clear-cell cancer cells, and niclosamide treatment decreased expression of p-stat3, leading to increased apoptosis in a dose-dependent manner |
2020-10-01 |
2023-08-13 |
Not clear |
| Huitao Xu, Ying Zhou, Wei Li, Bin Zhang, Huanhuan Zhang, Shaolin Zhao, Ping Zheng, Huiyi Wu, Jin Yan. Tumor-derived mesenchymal-stem-cell-secreted IL-6 enhances resistance to cisplatin via the STAT3 pathway in breast cancer. Oncology letters. vol 15. issue 6. 2020-10-01. PMID:29844821. |
mtt and flow cytometry analysis measured cell vitality and apoptosis, respectively, and activation of signal transduced and activator of transcription 3 (stat3) was evaluated by western blotting. |
2020-10-01 |
2023-08-13 |
Not clear |
| Mulu Geletu, Zaid Taha, Patrick T Gunning, Leda Rapti. PI3k and Stat3: Oncogenes that are Required for Gap Junctional, Intercellular Communication. Cancers. vol 11. issue 2. 2020-10-01. PMID:30717267. |
pi3k and stat3 constitute potent survival signals, so that their inhibition in non-transformed cells triggers apoptosis which, in turn, has been independently demonstrated to suppress gjic. |
2020-10-01 |
2023-08-13 |
human |
| Dawei Wang, Zhuoxin Cheng, Ming Zhao, Chengbin Jiao, Qinghui Meng, Huayang Pan, Yu Xie, Long Li, Yexing Zhu, Wei Wang, Chunlei Qu, Deshen Lian. PTPN9 induces cell apoptosis by mitigating the activation of Stat3 and acts as a tumor suppressor in colorectal cancer. Cancer management and research. vol 11. 2020-10-01. PMID:30804683. |
ptpn9 induces cell apoptosis by mitigating the activation of stat3 and acts as a tumor suppressor in colorectal cancer. |
2020-10-01 |
2023-08-13 |
Not clear |
| Wenting Zhang, Aiguo Men. MicroRNA-124 expression in the brains of rats during early cerebral ischemia and reperfusion injury is associated with cell apoptosis involving STAT3. Experimental and therapeutic medicine. vol 17. issue 4. 2020-10-01. PMID:30906474. |
microrna-124 expression in the brains of rats during early cerebral ischemia and reperfusion injury is associated with cell apoptosis involving stat3. |
2020-10-01 |
2023-08-13 |
rat |
| Wenting Zhang, Aiguo Men. MicroRNA-124 expression in the brains of rats during early cerebral ischemia and reperfusion injury is associated with cell apoptosis involving STAT3. Experimental and therapeutic medicine. vol 17. issue 4. 2020-10-01. PMID:30906474. |
as signal transducer and activator of transcription 3 (stat3) is involved in cell apoptosis and associated with bcl-2, the protein expression of stat3 and its active form, phosphorylated (p-)stat3, were analyzed by western blot analysis. |
2020-10-01 |
2023-08-13 |
rat |
| Wenting Zhang, Aiguo Men. MicroRNA-124 expression in the brains of rats during early cerebral ischemia and reperfusion injury is associated with cell apoptosis involving STAT3. Experimental and therapeutic medicine. vol 17. issue 4. 2020-10-01. PMID:30906474. |
in summary, during the early stage of cerebral ischemia and reperfusion, the dynamic expression of microrna-124 exhibited protective effects through the inhibition of apoptosis via anti-apoptotic proteins bcl-2 and stat3. |
2020-10-01 |
2023-08-13 |
rat |
| Tsung-Teng Huang, Ying-Wei Lan, Chuan-Mu Chen, Yun-Fei Ko, David M Ojcius, Jan Martel, John D Young, Kowit-Yu Chon. Antrodia cinnamomea induces anti-tumor activity by inhibiting the STAT3 signaling pathway in lung cancer cells. Scientific reports. vol 9. issue 1. 2020-10-01. PMID:30914735. |
our findings therefore indicate that acee inhibits lung tumor growth and metastasis by inducing apoptosis and by inhibiting the stat3 signaling pathway in cancer cells. |
2020-10-01 |
2023-08-13 |
mouse |
| Savita Bisht, Jens Nolting, Jörg Wenzel, Peter Brossart, Georg Feldman. EF24 Suppresses Cholangiocellular Carcinoma Progression, Inhibits STAT3 Phosphorylation, and Induces Apoptosis via ROS-Mediated Oxidative Stress. Journal of oncology. vol 2019. 2020-10-01. PMID:30949204. |
ef24 suppresses cholangiocellular carcinoma progression, inhibits stat3 phosphorylation, and induces apoptosis via ros-mediated oxidative stress. |
2020-10-01 |
2023-08-13 |
Not clear |