| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jong Hyun Lee, Chulwon Kim, Seok-Geun Lee, Gautam Sethi, Kwang Seok Ah. Ophiopogonin D, a Steroidal Glycoside Abrogates STAT3 Signaling Cascade and Exhibits Anti-Cancer Activity by Causing GSH/GSSG Imbalance in Lung Carcinoma. Cancers. vol 10. issue 11. 2020-09-30. PMID:30413072. |
our findings suggest that op-d can induce apoptosis and exert anti-tumor effects by inhibition of stat3 signaling pathways in nsclc. |
2020-09-30 |
2023-08-13 |
mouse |
| Yan Zhang, Meiwu Zhang, Xiaoxiang Fan, Dafeng Mao, Shuyi Lv, Ping Che. Effect of STAT3 decoy oligodeoxynucleotides mediated by ultrasound-targeted microbubbles combined with ultrasound on the growth of squamous cell carcinoma of the esophagus. Oncology letters. vol 17. issue 2. 2020-09-30. PMID:30675281. |
the transfection of stat3 decoy odn can significantly inhibit the activity of esophageal squamous cell carcinoma cells and enhance apoptosis of cells, which has potential clinical value. |
2020-09-30 |
2023-08-13 |
mouse |
| Dianhui Xiu, Dawei Wang, Jing Wang, Fujian Ji, Wenlei Zhan. MicroRNA-543 suppresses liver cancer growth and induces apoptosis via the JAK2/STAT3 signaling pathway. Oncology letters. vol 17. issue 2. 2020-09-30. PMID:30675310. |
the aim of the present study was to investigate the function of microrna-543 on liver cancer cell proliferation and apoptosis, and also to identify whether the janus kinase 2 (jak2)/signal transducer and activator of transcription 3 (stat3) signaling pathway was a direct target of microrna-543. |
2020-09-30 |
2023-08-13 |
Not clear |
| Praful R Nai. Delivering Combination Chemotherapies and Targeting Oncogenic Pathways via Polymeric Drug Delivery Systems. Polymers. vol 11. issue 4. 2020-09-30. PMID:30959799. |
these include inhibition of oncogenic pathways (including those involving her2, egfr, mapk, pi3k/akt, stat3, and hif-1α), augmentation of apoptosis by inhibiting anti-apoptosis proteins (bcl-2, bcl-xl, and survivin), and targeting dysregulated pathways such as wnt/β-catenin and hedgehog. |
2020-09-30 |
2023-08-13 |
Not clear |
| Amanda Thomaz, Kelly de Vargas Pinheiro, Bárbara Kunzler Souza, Lauro Gregianin, Algemir L Brunetto, André T Brunetto, Caroline Brunetto de Farias, Mariane da Cunha Jaeger, Vijay Ramaswamy, Carolina Nör, Michael D Taylor, Rafael Roesle. Antitumor Activities and Cellular Changes Induced by TrkB Inhibition in Medulloblastoma. Frontiers in pharmacology. vol 10. 2020-09-30. PMID:31297057. |
these effects were accompanied by increased apoptosis, reduced extracellular-regulated kinase (erk) activity, increased expression of signal transducer and activator of transcription 3 (stat3), and differential modulation of p21 expression dependent on the cell line. |
2020-09-30 |
2023-08-13 |
mouse |
| Peter Stärkel, Bernd Schnabl, Sophie Leclercq, Mina Komuta, Ramon Bataller, Josepmaria Argemi, Elena Palma, Shilpa Chokshi, Claus Hellerbrand, Luca Maccioni, Nicolas Lanthier, Isabelle Leclerc. Deficient IL-6/Stat3 Signaling, High TLR7, and Type I Interferons in Early Human Alcoholic Liver Disease: A Triad for Liver Damage and Fibrosis. Hepatology communications. vol 3. issue 7. 2020-09-30. PMID:31334440. |
in parallel, down-regulation of il-6, inhibition of the signal transducer and activator of transcription 3 (stat3) pathway, as well as blunted cyclin d expression in hepatocytes, reduced proliferation and favored hepatocyte apoptosis. |
2020-09-30 |
2023-08-13 |
human |
| Abdul Q Khan, Eiman I Ahmed, Noor Elareer, Hamna Fathima, Kirti S Prabhu, Kodappully S Siveen, Michal Kulinski, Fouad Azizi, Said Dermime, Aamir Ahmad, Martin Steinhoff, Shahab Uddi. Curcumin-Mediated Apoptotic Cell Death in Papillary Thyroid Cancer and Cancer Stem-Like Cells through Targeting of the JAK/STAT3 Signaling Pathway. International journal of molecular sciences. vol 21. issue 2. 2020-09-30. PMID:31936675. |
curcumin suppressed ptc cell survival in a dose-dependent manner via the induction of caspase-mediated apoptosis and caused the attenuation of constitutively active stat3 (the dephosphorylation of tyr705-stat3) without affecting stat3. |
2020-09-30 |
2023-08-13 |
Not clear |
| Abdul Q Khan, Eiman I Ahmed, Noor Elareer, Hamna Fathima, Kirti S Prabhu, Kodappully S Siveen, Michal Kulinski, Fouad Azizi, Said Dermime, Aamir Ahmad, Martin Steinhoff, Shahab Uddi. Curcumin-Mediated Apoptotic Cell Death in Papillary Thyroid Cancer and Cancer Stem-Like Cells through Targeting of the JAK/STAT3 Signaling Pathway. International journal of molecular sciences. vol 21. issue 2. 2020-09-30. PMID:31936675. |
finally, thyrospheres treated with curcumin and cisplatin showed suppressed stat3 phosphorylation, a reduced formation of thyrospheres, and the downregulated expression of stemness markers, in addition to apoptosis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Lei Zhang, Yan Wang, Junjie Ma, Xingqiang Lai, Jiali Fang, Guanghui Li, Lu Xu, Guanghui Pan, Zheng Che. Exogenous MSCs ameliorate hypoxia/reoxygenation injury in renal tubular epithelial cells through JAK/STAT signaling pathway-mediated regulation of HMGB1. American journal of translational research. vol 9. issue 5. 2020-09-29. PMID:28559991. |
when the cells were transfected with sirna stat3, the expression of stat3 at protein and mrna levels and jak2 and hmgb1 at mrna level was down-regulated; the cell viability was reduced and apoptosis increased. |
2020-09-29 |
2023-08-13 |
Not clear |
| Tahir Mehmood, Amara Maryam, Xiangge Tian, Muhammad Khan, Tonghui M. Santamarine Inhibits NF-кB and STAT3 Activation and Induces Apoptosis in HepG2 Liver Cancer Cells via Oxidative Stress. Journal of Cancer. vol 8. issue 18. 2020-09-29. PMID:29151958. |
santamarine inhibits nf-кb and stat3 activation and induces apoptosis in hepg2 liver cancer cells via oxidative stress. |
2020-09-29 |
2023-08-13 |
Not clear |
| Chao Zhou, Jie Ma, Mengyuan Su, Dan Shao, Jianan Zhao, Tongjian Zhao, Zhuoyao Song, Yan Meng, Ping Jia. Down-regulation of STAT3 induces the apoptosis and G1 cell cycle arrest in esophageal carcinoma ECA109 cells. Cancer cell international. vol 18. 2020-09-29. PMID:29636641. |
down-regulation of stat3 induces the apoptosis and g1 cell cycle arrest in esophageal carcinoma eca109 cells. |
2020-09-29 |
2023-08-13 |
Not clear |
| Chao Zhou, Jie Ma, Mengyuan Su, Dan Shao, Jianan Zhao, Tongjian Zhao, Zhuoyao Song, Yan Meng, Ping Jia. Down-regulation of STAT3 induces the apoptosis and G1 cell cycle arrest in esophageal carcinoma ECA109 cells. Cancer cell international. vol 18. 2020-09-29. PMID:29636641. |
to explore the biological role of stat3 in esophageal cancer, we used small hairpin rna to knockdown the expression of the stat3 gene in the esophageal carcinoma eca109 cell line and the cell apoptosis, cell cycle and cell migration were investigated. |
2020-09-29 |
2023-08-13 |
Not clear |
| Jing Li, You-Yu Liu, Xue-Feng Yang, Dao-Fu Shen, Hong-Zhi Sun, Ke-Qiang Huang, Hua-Chuan Zhen. Effects and mechanism of STAT3 silencing on the growth and apoptosis of colorectal cancer cells. Oncology letters. vol 16. issue 5. 2020-09-29. PMID:30344711. |
effects and mechanism of stat3 silencing on the growth and apoptosis of colorectal cancer cells. |
2020-09-29 |
2023-08-13 |
Not clear |
| Jing Li, You-Yu Liu, Xue-Feng Yang, Dao-Fu Shen, Hong-Zhi Sun, Ke-Qiang Huang, Hua-Chuan Zhen. Effects and mechanism of STAT3 silencing on the growth and apoptosis of colorectal cancer cells. Oncology letters. vol 16. issue 5. 2020-09-29. PMID:30344711. |
signal transducer and activator of transcription 3 (stat3) have roles in various cellular processes, including angiogenesis, apoptosis, cell cycle progression, cell migration and drug resistance. |
2020-09-29 |
2023-08-13 |
Not clear |
| Jing Li, You-Yu Liu, Xue-Feng Yang, Dao-Fu Shen, Hong-Zhi Sun, Ke-Qiang Huang, Hua-Chuan Zhen. Effects and mechanism of STAT3 silencing on the growth and apoptosis of colorectal cancer cells. Oncology letters. vol 16. issue 5. 2020-09-29. PMID:30344711. |
to clarify the effects of stat3 in colorectal cancer (crc) cells and the underlying molecular mechanisms, stat3 was directly silenced, and the effects of stat3 silencing on cell proliferation, apoptosis and growth with phenotype-associated molecules were examined.psh1-si-stat3 was successfully transfected into the crc hct-116 and sw480 cell lines, which was verified by gfp tagging under a fluorescence microscope. |
2020-09-29 |
2023-08-13 |
Not clear |
| Shengxing Wang, Gang Wu, Yinan Han, Peng Song, Jinhuo Chen, Yaoxi Wu, Jie Yang, Peiyu Lian. miR-124 regulates STAT3-mediated cell proliferation, migration and apoptosis in bladder cancer. Oncology letters. vol 16. issue 5. 2020-09-29. PMID:30344738. |
knockdown of stat3 expression led to increased apoptosis of t24 cells and reduced tumor growth |
2020-09-29 |
2023-08-13 |
Not clear |
| Xin Lu, Jun Qia. Downregulated MEG3 participates in rheumatoid arthritis via promoting proliferation of fibroblast-like synoviocytes. Experimental and therapeutic medicine. vol 17. issue 3. 2020-09-29. PMID:30783431. |
downregulated meg3 was able to promote proliferation and invasion, and inhibit apoptosis of fls via stat3 pathway. |
2020-09-29 |
2023-08-13 |
Not clear |
| Xiao-Yan Lei, Xing-Xing Chen, Yong-Hong Sun, Ming-Dong Gao, Xiao-Xia Hu, Yan-Hong Su. Hepatitis B virus X protein decreases nephrin expression and induces podocyte apoptosis via activating STAT3. Experimental and therapeutic medicine. vol 17. issue 5. 2020-09-29. PMID:31007753. |
hepatitis b virus x protein decreases nephrin expression and induces podocyte apoptosis via activating stat3. |
2020-09-29 |
2023-08-13 |
Not clear |
| Moli Wu, Danyang Song, Hui Li, Yang Yang, Xiaodong Ma, Sa Deng, Changle Ren, Xiaohong Sh. Negative regulators of STAT3 signaling pathway in cancers. Cancer management and research. vol 11. 2020-09-29. PMID:31213912. |
stat3 is the most ubiquitous member of the stat family and involved in many biological processes, such as cell proliferation, differentiation, and apoptosis. |
2020-09-29 |
2023-08-13 |
Not clear |
| Qiongtao Song, Ying Zhao, Qiang Li, Xue Han, Junguo Dua. Puerarin protects against iron overload-induced retinal injury through regulation of iron-handling proteins. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 122. 2020-09-29. PMID:31786468. |
moreover, puerarin inhibited the phosphorylation of p38 and erk mitogen-activated protein kinases (mapks) and signal transducer and activator of transcription 3 (stat3), thereby protecting the retinal cells from apoptosis by suppressing cytochrome c release, caspase activation, and poly (adp-ribose) polymerase cleavage in vivo. |
2020-09-29 |
2023-08-13 |
mouse |