| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ju-Hee Kang, Yeong-Su Jang, Ha Jung Lee, Chang-Yong Lee, Dong Yun Shin, Seung Hyun O. Inhibition of STAT3 signaling induces apoptosis and suppresses growth of lung cancer: good and bad. Laboratory animal research. vol 35. 2020-09-28. PMID:32257917. |
inhibition of stat3 signaling induces apoptosis and suppresses growth of lung cancer: good and bad. |
2020-09-28 |
2023-08-13 |
mouse |
| Ju-Hee Kang, Yeong-Su Jang, Ha Jung Lee, Chang-Yong Lee, Dong Yun Shin, Seung Hyun O. Inhibition of STAT3 signaling induces apoptosis and suppresses growth of lung cancer: good and bad. Laboratory animal research. vol 35. 2020-09-28. PMID:32257917. |
signal transducer and activator of transcription 3 (stat3) modulates a variety of genes involved in the regulation of critical functions, including cell proliferation, differentiation, apoptosis, angiogenesis, metastasis, and immunity. |
2020-09-28 |
2023-08-13 |
mouse |
| Ju-Hee Kang, Yeong-Su Jang, Ha Jung Lee, Chang-Yong Lee, Dong Yun Shin, Seung Hyun O. Inhibition of STAT3 signaling induces apoptosis and suppresses growth of lung cancer: good and bad. Laboratory animal research. vol 35. 2020-09-28. PMID:32257917. |
stx-0119 also decreased the amount of stat3 in the nuclear fraction as well as induced apoptosis of these lung cancer cell lines as evidenced by increases in apoptotic cells (annexin v positive) and poly (adp-ribose) polymerase (parp) cleavage. |
2020-09-28 |
2023-08-13 |
mouse |
| Muhammad Khan, Amara Maryam, Muhammad Zubair Saleem, Hafiz Abdullah Shakir, Javed Iqbal Qazi, Yongming Li, Tonghui M. Brevilin A induces ROS-dependent apoptosis and suppresses STAT3 activation by direct binding in human lung cancer cells. Journal of Cancer. vol 11. issue 13. 2020-09-28. PMID:32328177. |
brevilin a induces ros-dependent apoptosis and suppresses stat3 activation by direct binding in human lung cancer cells. |
2020-09-28 |
2023-08-13 |
human |
| Miguel S Gonzalez-Mancera, Britt Johnson, Mehdi Mirsaeid. STAT3 gain-of-function mutation in a patient with pulmonary Respiratory medicine case reports. vol 30. 2020-09-28. PMID:32577366. |
stat3 gain-of-function mutation in a patient with pulmonary signal transducer and activator of transcription 3 (stat3) is a transcription factor involved in cellular proliferation, apoptosis, and differentiation. |
2020-09-28 |
2023-08-13 |
Not clear |
| Shoumei Zhang, Li Shuai, Dong Wang, Tingting Huang, Shengsheng Yang, Mingyong Miao, Fang Liu, Jiajun X. Pim-1 Protects Retinal Ganglion Cells by Enhancing Their Regenerative Ability Following Optic Nerve Crush. Experimental neurobiology. vol 29. issue 3. 2020-09-28. PMID:32624507. |
in addition, it enhanced the intrinsic regeneration capacity of rgcs after onc by activating stat3, akt1 and akt2 pathways, and inhibiting the mitochondrial apoptosis pathways. |
2020-09-28 |
2023-08-13 |
rat |
| Manyu Song, Chaoran Wang, Haotian Yang, Yongping Chen, Xiujing Feng, Bei Li, Honggang Fa. P-STAT3 Inhibition Activates Endoplasmic Reticulum Stress-Induced Splenocyte Apoptosis in Chronic Stress. Frontiers in physiology. vol 11. 2020-09-28. PMID:32714202. |
stat3 is a transcription factor that regulates immunity and apoptosis; however, it is unclear whether the increased expression of phosphorylated stat3 (p-stat3) observed in chronic stress is related to splenocyte apoptosis. |
2020-09-28 |
2023-08-13 |
rat |
| Manyu Song, Chaoran Wang, Haotian Yang, Yongping Chen, Xiujing Feng, Bei Li, Honggang Fa. P-STAT3 Inhibition Activates Endoplasmic Reticulum Stress-Induced Splenocyte Apoptosis in Chronic Stress. Frontiers in physiology. vol 11. 2020-09-28. PMID:32714202. |
to explore the relationship between splenocyte apoptosis and stat3 in chronic stress, we treated rats undergoing a 21-day chronic restraint stress program with the stat3 inhibitor s3i-201. |
2020-09-28 |
2023-08-13 |
rat |
| Xiaorui Hu, Lili Yuan, Teng M. Mechanisms of JAK-STAT signaling pathway mediated by CXCL8 gene silencing on epithelial-mesenchymal transition of human cutaneous melanoma cells. Oncology letters. vol 20. issue 2. 2020-09-28. PMID:32724443. |
compared with the blank group, the expression levels of jak2, stat3, vimentin and n-cadherin in cxcl8 sirna group, ag490 group and cxcl8 sirna + ag490 group were decreased, the expression of e-cadherin was increased, the cell proliferation ability was decreased and apoptosis was increased (p<0.05). |
2020-09-28 |
2023-08-13 |
human |
| Xiaorui Hu, Lili Yuan, Teng M. Mechanisms of JAK-STAT signaling pathway mediated by CXCL8 gene silencing on epithelial-mesenchymal transition of human cutaneous melanoma cells. Oncology letters. vol 20. issue 2. 2020-09-28. PMID:32724443. |
compared with cxcl8 sirna group, the expression of jak2, stat3, vimentin and n-cadherin in cxcl8 sirna + ag490 group were significantly decreased, the expression of e-cadherin was significantly increased, cell proliferation ability was decreased and apoptosis was increased (p<0.05). |
2020-09-28 |
2023-08-13 |
human |
| Lishan Cui, Lanxi Xu, Guanling Wang, Jing Wen, Lili Luo, Haitao Zhao, Shuide Chen, Mingcheng Zheng, Cuiling Sun, Xin Jin, Lichao Yan. STAT3-PTTG11 abrogation inhibits proliferation and induces apoptosis in malignant glioma cells. Oncology letters. vol 20. issue 4. 2020-09-28. PMID:32774480. |
the findings of the present study revealed that stat3 induced pttg11 expression, which subsequently induced downstream c-myc and bcl-2 expression while inhibiting bax expression, thereby promoting cell viability and inhibiting apoptosis. |
2020-09-28 |
2023-08-13 |
human |
| Lishan Cui, Lanxi Xu, Guanling Wang, Jing Wen, Lili Luo, Haitao Zhao, Shuide Chen, Mingcheng Zheng, Cuiling Sun, Xin Jin, Lichao Yan. STAT3-PTTG11 abrogation inhibits proliferation and induces apoptosis in malignant glioma cells. Oncology letters. vol 20. issue 4. 2020-09-28. PMID:32774480. |
pttg11 suppression via sirna inhibited the viability and increased the apoptosis of glioma cells induced by the stat3 activator s3i-201. |
2020-09-28 |
2023-08-13 |
human |
| Shefeng Zheng, Jinnv Liu, Zhangjian Zhao, Ruifang Son. Role of STAT3/mTOR pathway in chronic kidney injury. American journal of translational research. vol 12. issue 7. 2020-09-28. PMID:32774701. |
glomerular mesangial cells were divided into control group, model group, stat3 inhibitor (s3i-201) group followed by analysis of cell proliferation by mtt assay, cell apoptosis by flow cytometry, formation of autophagosomes by electron microscopy, expression of stat3/mtor signaling proteins and autophagy proteins lc3ii and p62 by western blot, expression of e-cadherin and vimentin by immunofluorescence. |
2020-09-28 |
2023-08-13 |
mouse |
| Shefeng Zheng, Jinnv Liu, Zhangjian Zhao, Ruifang Son. Role of STAT3/mTOR pathway in chronic kidney injury. American journal of translational research. vol 12. issue 7. 2020-09-28. PMID:32774701. |
folic acid-induced injury of mesangial cells showed inhibited cell proliferation, promoted apoptosis, increased lc3ii expression, decreased p62 expression, increased autophagic vacuoles and expression of stat3 and p-mtor as well as decreased e-cadherin expression and increased vimentin expression. |
2020-09-28 |
2023-08-13 |
mouse |
| Gui-Nan Shen, Cheng Wang, Ying-Hua Luo, Jia-Ru Wang, Rui Wang, Wan-Ting Xu, Yi Zhang, Yu Zhang, Dong-Jie Zhang, Cheng-Hao Ji. 2-(6-Hydroxyhexylthio)-5,8-dimethoxy-1,4-naphthoquinone Induces Apoptosis through ROS-Mediated MAPK, STAT3, and NF- Evidence-based complementary and alternative medicine : eCAM. vol 2020. 2020-09-28. PMID:32849902. |
2-(6-hydroxyhexylthio)-5,8-dimethoxy-1,4-naphthoquinone induces apoptosis through ros-mediated mapk, stat3, and nf- two novel compounds, 2-(2-hydroxyethylthio)-5,8-dimethoxy-1,4-naphthoquinone (hedmnq) and 2-(6-hydroxyhexylthio)-5,8-dimethoxy-1,4-naphthoquinone (hhdmnq), were synthesized to investigate the kill effects and mechanism of 1,4-naphthoquinone derivatives in lung cancer cells. |
2020-09-28 |
2023-08-13 |
Not clear |
| Gui-Nan Shen, Cheng Wang, Ying-Hua Luo, Jia-Ru Wang, Rui Wang, Wan-Ting Xu, Yi Zhang, Yu Zhang, Dong-Jie Zhang, Cheng-Hao Ji. 2-(6-Hydroxyhexylthio)-5,8-dimethoxy-1,4-naphthoquinone Induces Apoptosis through ROS-Mediated MAPK, STAT3, and NF- Evidence-based complementary and alternative medicine : eCAM. vol 2020. 2020-09-28. PMID:32849902. |
fluorescence microscopy and flow cytometry results indicated that hhdmnq could induce a549 cell apoptosis, and western blot analysis showed that hhdmnq induced apoptosis through regulating the mitochondria pathway, as well as the mapk, stat3, and nf- |
2020-09-28 |
2023-08-13 |
Not clear |
| Jiangqiang Chen, Zuhui Che. Downregulation of miR-19a inhibits the proliferation and promotes the apoptosis of osteosarcoma cells by regulating the JAK2/STAT3 pathway. Oncology letters. vol 20. issue 5. 2020-09-28. PMID:32934740. |
the present study was designed to explore the regulatory effects of microrna (mir)-19a on the proliferation and apoptosis of osteosarcoma cells, and its influence on the activation of the janus kinase 2 (jak2)/signal transducer and activator of transcription 3 (stat3) signaling pathway. |
2020-09-28 |
2023-08-13 |
Not clear |
| Q Li, W-X Ye, Z-J Huang, Q Zhang, Y-F H. Effect of IL-6-mediated STAT3 signaling pathway on myocardial apoptosis in mice with dilated cardiomyopathy. European review for medical and pharmacological sciences. vol 23. issue 7. 2020-09-08. PMID:31002169. |
effect of il-6-mediated stat3 signaling pathway on myocardial apoptosis in mice with dilated cardiomyopathy. |
2020-09-08 |
2023-08-13 |
mouse |
| Qi-Zhe Gong, Di Xiao, Gui-Yi Gong, Jian Xu, Xiao-Dong Wen, Feng Feng, Wei Q. EH-42: A Novel Small Molecule Induces Apoptosis and Inhibits Migration and Invasion of Human Hepatoma Cells through Suppressing STAT3 Signaling Pathway. Current cancer drug targets. vol 19. issue 7. 2020-09-03. PMID:30585547. |
eh-42: a novel small molecule induces apoptosis and inhibits migration and invasion of human hepatoma cells through suppressing stat3 signaling pathway. |
2020-09-03 |
2023-08-13 |
human |
| Efthalia Angelopoulou, Yam Nath Paudel, Christina Piper. miR-124 and Parkinson's disease: A biomarker with therapeutic potential. Pharmacological research. vol 150. 2020-08-24. PMID:31707035. |
accumulating pre-clinical evidence shows that mir-124 may act through calpain 1/p25/cyclin-dependent kinases 5 (cdk5), nuclear factor-kappa b (nf-κb), signal transducer and activator of transcription 3 (stat3), bcl-2-interacting mediator of cell death (bim), 5' adenosine monophosphate-activated protein kinase (ampk) and extracellular signal-regulated kinase (erk)-mediated pathways to regulate cell survival, apoptosis, autophagy, mitochondrial dysfunction, oxidative damage and neuroinflammation in pd. |
2020-08-24 |
2023-08-13 |
Not clear |