| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ningning He, Changyan Xiao, Yuxiao Sun, Yan Wang, Liqing Du, Yu Feng, Yang Liu, Qin Wang, Kaihua Ji, Jinhan Wang, Manman Zhang, Chang Xu, Qiang Li. Radiation Responses of Human Mesenchymal Stem Cells Derived From Different Sources. Dose-response : a publication of International Hormesis Society. vol 17. issue 4. 2020-09-29. PMID:31839760. |
in our study, a comparison of the results from cell proliferation, apoptosis, cell cycle, dna damage, and dna repair assays consistently showed that mscs derived from adipose tissue possess a significantly stronger radiation resistance capacity than mscs derived from umbilical cord and gingival, which is accompanied by a higher level of phosphorylated signal transducer and activator of transcription 3 (stat3) expression. |
2020-09-29 |
2023-08-13 |
human |
| Yi Xu, Yanyue Tong, Junjie Ying, Zhangming Lei, Lijun Wan, Xiuwen Zhu, Feng Ye, Penglei Mao, Xinkuan Wu, Renbing Pan, Bo Peng, Yukun Liu, Jianyong Zh. Chrysin induces cell growth arrest, apoptosis, and ER stress and inhibits the activation of STAT3 through the generation of ROS in bladder cancer cells. Oncology letters. vol 15. issue 6. 2020-09-28. PMID:29805643. |
chrysin induces cell growth arrest, apoptosis, and er stress and inhibits the activation of stat3 through the generation of ros in bladder cancer cells. |
2020-09-28 |
2023-08-13 |
Not clear |
| Joo Young Hong, Kyung-Sook Chung, Ji-Sun Shin, Jeong-Hun Lee, Hyo-Sun Gil, Hwi-Ho Lee, Eunwoo Choi, Jung-Hye Choi, Ahmed H E Hassan, Yong Sup Lee, Kyung-Tae Le. The Anti-Proliferative Activity of the Hybrid TMS-TMF-4f Compound Against Human Cervical Cancer Involves Apoptosis Mediated by STAT3 Inactivation. Cancers. vol 11. issue 12. 2020-09-28. PMID:31816985. |
the anti-proliferative activity of the hybrid tms-tmf-4f compound against human cervical cancer involves apoptosis mediated by stat3 inactivation. |
2020-09-28 |
2023-08-13 |
human |
| Filippo Severin, Federica Frezzato, Andrea Visentin, Veronica Martini, Valentina Trimarco, Samuela Carraro, Elena Tibaldi, Anna Maria Brunati, Francesco Piazza, Gianpietro Semenzato, Monica Facco, Livio Trenti. In Chronic Lymphocytic Leukemia the JAK2/STAT3 Pathway Is Constitutively Activated and Its Inhibition Leads to CLL Cell Death Unaffected by the Protective Bone Marrow Microenvironment. Cancers. vol 11. issue 12. 2020-09-28. PMID:31817171. |
treatment with ag490, but not stattic, caused stat3 and lyn dephosphorylation, through re-activation of shp-1, and triggered cll apoptosis even when leukemic cells were cultured on bmsc layers. |
2020-09-28 |
2023-08-13 |
Not clear |
| Muhammad Zubair Saleem, Muhammad Azhar Nisar, Mohammed Alshwmi, Syed Riaz Ud Din, Yaser Gamallat, Muhammad Khan, Tonghui M. Brevilin A Inhibits STAT3 Signaling and Induces ROS-Dependent Apoptosis, Mitochondrial Stress and Endoplasmic Reticulum Stress in MCF-7 Breast Cancer Cells. OncoTargets and therapy. vol 13. 2020-09-28. PMID:32021288. |
brevilin a inhibits stat3 signaling and induces ros-dependent apoptosis, mitochondrial stress and endoplasmic reticulum stress in mcf-7 breast cancer cells. |
2020-09-28 |
2023-08-13 |
Not clear |
| Xin Li, Xin Wang, Yuan-Sheng Liu, Xiao-Dong Wang, Jian Zhou, Hua Zho. Downregulation of miR-3568 Protects Against Ischemia/Reperfusion-Induced Cardiac Dysfunction in Rats and Apoptosis in H9C2 Cardiomyocytes Through Targeting TRIM62. Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32116696. |
mir-3568 mimic transfection in h9c2 cardiomyocytes significantly enhanced cell apoptosis, decreased the expression of bcl-2 and survivin, and activated stat3 signaling, which were reversed by mir-3568 inhibitor. |
2020-09-28 |
2023-08-13 |
rat |
| Xin Li, Xin Wang, Yuan-Sheng Liu, Xiao-Dong Wang, Jian Zhou, Hua Zho. Downregulation of miR-3568 Protects Against Ischemia/Reperfusion-Induced Cardiac Dysfunction in Rats and Apoptosis in H9C2 Cardiomyocytes Through Targeting TRIM62. Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32116696. |
trim62 overexpression or ag490, a selective inhibitor of jak2/stat3 significantly, significantly inhibited i/r and mir-3568 mimic induced cell apoptosis and stat3 activation. |
2020-09-28 |
2023-08-13 |
rat |
| Jeong-Hun Lee, Hwi-Ho Lee, Ki Deok Ryu, Misong Kim, Dohyeong Ko, Kyung-Sook Chung, Ahmed H E Hassan, Seung Hyeun Lee, Jae Yeol Lee, Kyung-Tae Le. KCP10043F Represses the Proliferation of Human Non-Small Cell Lung Cancer Cells by Caspase-Mediated Apoptosis via STAT3 Inactivation. Journal of clinical medicine. vol 9. issue 3. 2020-09-28. PMID:32150979. |
kcp10043f represses the proliferation of human non-small cell lung cancer cells by caspase-mediated apoptosis via stat3 inactivation. |
2020-09-28 |
2023-08-13 |
human |
| Zhangmei Chang, Yan Wang, Xin Zhou, Jian-Er Lon. STAT3 roles in viral infection: antiviral or proviral? Future virology. vol 13. issue 8. 2020-09-28. PMID:32201498. |
an activated stat3 translocates into the nucleus and combines with dna to regulate the expression of target genes involved in cell proliferation, differentiation, apoptosis and metastasis. |
2020-09-28 |
2023-08-13 |
human |
| Carla Pereira, Daniel Ferreira, Nuno Mendes, Pedro L Granja, Gabriela M Almeida, Carla Oliveir. Expression of CD44v6-Containing Isoforms Influences Cisplatin Response in Gastric Cancer Cells. Cancers. vol 12. issue 4. 2020-09-28. PMID:32252293. |
upon cisplatin treatment, cd44v6+ cells survive better and have lower apoptosis levels than cd44v6- cells, possibly due to concomitant activation of stat3 and p38. |
2020-09-28 |
2023-08-13 |
Not clear |
| Ju-Hee Kang, Yeong-Su Jang, Ha Jung Lee, Chang-Yong Lee, Dong Yun Shin, Seung Hyun O. Inhibition of STAT3 signaling induces apoptosis and suppresses growth of lung cancer: good and bad. Laboratory animal research. vol 35. 2020-09-28. PMID:32257917. |
inhibition of stat3 signaling induces apoptosis and suppresses growth of lung cancer: good and bad. |
2020-09-28 |
2023-08-13 |
mouse |
| Ju-Hee Kang, Yeong-Su Jang, Ha Jung Lee, Chang-Yong Lee, Dong Yun Shin, Seung Hyun O. Inhibition of STAT3 signaling induces apoptosis and suppresses growth of lung cancer: good and bad. Laboratory animal research. vol 35. 2020-09-28. PMID:32257917. |
signal transducer and activator of transcription 3 (stat3) modulates a variety of genes involved in the regulation of critical functions, including cell proliferation, differentiation, apoptosis, angiogenesis, metastasis, and immunity. |
2020-09-28 |
2023-08-13 |
mouse |
| Ju-Hee Kang, Yeong-Su Jang, Ha Jung Lee, Chang-Yong Lee, Dong Yun Shin, Seung Hyun O. Inhibition of STAT3 signaling induces apoptosis and suppresses growth of lung cancer: good and bad. Laboratory animal research. vol 35. 2020-09-28. PMID:32257917. |
stx-0119 also decreased the amount of stat3 in the nuclear fraction as well as induced apoptosis of these lung cancer cell lines as evidenced by increases in apoptotic cells (annexin v positive) and poly (adp-ribose) polymerase (parp) cleavage. |
2020-09-28 |
2023-08-13 |
mouse |
| Muhammad Khan, Amara Maryam, Muhammad Zubair Saleem, Hafiz Abdullah Shakir, Javed Iqbal Qazi, Yongming Li, Tonghui M. Brevilin A induces ROS-dependent apoptosis and suppresses STAT3 activation by direct binding in human lung cancer cells. Journal of Cancer. vol 11. issue 13. 2020-09-28. PMID:32328177. |
brevilin a induces ros-dependent apoptosis and suppresses stat3 activation by direct binding in human lung cancer cells. |
2020-09-28 |
2023-08-13 |
human |
| Miguel S Gonzalez-Mancera, Britt Johnson, Mehdi Mirsaeid. STAT3 gain-of-function mutation in a patient with pulmonary Respiratory medicine case reports. vol 30. 2020-09-28. PMID:32577366. |
stat3 gain-of-function mutation in a patient with pulmonary signal transducer and activator of transcription 3 (stat3) is a transcription factor involved in cellular proliferation, apoptosis, and differentiation. |
2020-09-28 |
2023-08-13 |
Not clear |
| Shoumei Zhang, Li Shuai, Dong Wang, Tingting Huang, Shengsheng Yang, Mingyong Miao, Fang Liu, Jiajun X. Pim-1 Protects Retinal Ganglion Cells by Enhancing Their Regenerative Ability Following Optic Nerve Crush. Experimental neurobiology. vol 29. issue 3. 2020-09-28. PMID:32624507. |
in addition, it enhanced the intrinsic regeneration capacity of rgcs after onc by activating stat3, akt1 and akt2 pathways, and inhibiting the mitochondrial apoptosis pathways. |
2020-09-28 |
2023-08-13 |
rat |
| Manyu Song, Chaoran Wang, Haotian Yang, Yongping Chen, Xiujing Feng, Bei Li, Honggang Fa. P-STAT3 Inhibition Activates Endoplasmic Reticulum Stress-Induced Splenocyte Apoptosis in Chronic Stress. Frontiers in physiology. vol 11. 2020-09-28. PMID:32714202. |
stat3 is a transcription factor that regulates immunity and apoptosis; however, it is unclear whether the increased expression of phosphorylated stat3 (p-stat3) observed in chronic stress is related to splenocyte apoptosis. |
2020-09-28 |
2023-08-13 |
rat |
| Manyu Song, Chaoran Wang, Haotian Yang, Yongping Chen, Xiujing Feng, Bei Li, Honggang Fa. P-STAT3 Inhibition Activates Endoplasmic Reticulum Stress-Induced Splenocyte Apoptosis in Chronic Stress. Frontiers in physiology. vol 11. 2020-09-28. PMID:32714202. |
to explore the relationship between splenocyte apoptosis and stat3 in chronic stress, we treated rats undergoing a 21-day chronic restraint stress program with the stat3 inhibitor s3i-201. |
2020-09-28 |
2023-08-13 |
rat |
| Xiaorui Hu, Lili Yuan, Teng M. Mechanisms of JAK-STAT signaling pathway mediated by CXCL8 gene silencing on epithelial-mesenchymal transition of human cutaneous melanoma cells. Oncology letters. vol 20. issue 2. 2020-09-28. PMID:32724443. |
compared with the blank group, the expression levels of jak2, stat3, vimentin and n-cadherin in cxcl8 sirna group, ag490 group and cxcl8 sirna + ag490 group were decreased, the expression of e-cadherin was increased, the cell proliferation ability was decreased and apoptosis was increased (p<0.05). |
2020-09-28 |
2023-08-13 |
human |
| Xiaorui Hu, Lili Yuan, Teng M. Mechanisms of JAK-STAT signaling pathway mediated by CXCL8 gene silencing on epithelial-mesenchymal transition of human cutaneous melanoma cells. Oncology letters. vol 20. issue 2. 2020-09-28. PMID:32724443. |
compared with cxcl8 sirna group, the expression of jak2, stat3, vimentin and n-cadherin in cxcl8 sirna + ag490 group were significantly decreased, the expression of e-cadherin was significantly increased, cell proliferation ability was decreased and apoptosis was increased (p<0.05). |
2020-09-28 |
2023-08-13 |
human |