| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei Jing, Na Song, Yun-Peng Liu, Xiu-Juan Qu, Ya-Fei Qi, Ce Li, Ke-Zuo Hou, Xiao-Fang Che, Xiang-Hong Yan. DNMT3a promotes proliferation by activating the STAT3 signaling pathway and depressing apoptosis in pancreatic cancer. Cancer management and research. vol 11. 2020-10-01. PMID:31372043. |
dnmt3a promotes proliferation by activating the stat3 signaling pathway and depressing apoptosis in pancreatic cancer. |
2020-10-01 |
2023-08-13 |
Not clear |
| Chongyang Wang, Mingyu Zheng, Yunho Choi, Jingzhi Jiang, Li Li, Junfeng Li, Chang Xu, Zhemin Xian, Yan Li, Hongmei Piao, Liangchang Li, Guanghai Ya. Cryptotanshinone Attenuates Airway Remodeling by Inhibiting Crosstalk Between Tumor Necrosis Factor-Like Weak Inducer of Apoptosis and Transforming Growth Factor Beta 1 Signaling Pathways in Asthma. Frontiers in pharmacology. vol 10. 2020-10-01. PMID:31780948. |
cts also inhibited the expressions of alpha-smooth muscle actin, tumor necrosis factor-like weak inducer of apoptosis (tweak), fn14, transforming growth factor (tgf)-β1, smad4, and phosphorylation of smad2/3 and stat3 (tyr705). |
2020-10-01 |
2023-08-13 |
mouse |
| Max Kullberg, Alexandra Francian, Ameneh Arabi, Troy Olsson, Kristine Mann, Holly A Martinso. Liposome Delivery of Natural STAT3 Inhibitors for the Treatment of Cancer. Pharmaceutical frontiers. vol 1. 2020-10-01. PMID:31886474. |
stat3 activation in cancer cells drives tumorigenic changes that allow for increased survival, proliferation, and resistance to apoptosis. |
2020-10-01 |
2023-08-13 |
Not clear |
| Michael E Grossmann, Da-Qing Yang, Zhijun Guo, David A Potter, Margot P Clear. Metformin Treatment for the Prevention and/or Treatment of Breast/Mammary Tumorigenesis. Current pharmacology reports. vol 1. issue 5. 2020-09-30. PMID:26405648. |
in addition to the anticancer effect of metformin mediated through the ampk pathway, additional mechanisms of action that directly target tissues have been identified including effects on stem cells, apoptosis, stat3 and her2. |
2020-09-30 |
2023-08-13 |
Not clear |
| Shulong Jiang, Yebo Gao, Wei Hou, Rui Liu, Xin Qi, Xia Xu, Jie Li, Yanju Bao, Honggang Zheng, Baojin Hu. Sinomenine inhibits A549 human lung cancer cell invasion by mediating the STAT3 signaling pathway. Oncology letters. vol 12. issue 2. 2020-09-30. PMID:27446441. |
signal transducer and activator of transcription 3 (stat3), an epithelial-mesenchymal transition-inducing transcription factor, is a key signaling molecule involved in the proliferation, apoptosis, invasion and metastasis of tumor cells. |
2020-09-30 |
2023-08-13 |
human |
| Cheng-Cao Sun, Shu-Jun Li, Feng Zhang, Ya-Dong Zhang, Zhen-Yu Zuo, Yong-Yong Xi, Liang Wang, De-Jia L. The Novel miR-9600 Suppresses Tumor Progression and Promotes Paclitaxel Sensitivity in Non-small-cell Lung Cancer Through Altering STAT3 Expression. Molecular therapy. Nucleic acids. vol 5. issue 11. 2020-09-30. PMID:27845771. |
furthermore, we identified that mir-9600 augmented paclitaxel and cisplatin sensitivity by downregulating stat3 and promoting chemotherapy-induced apoptosis. |
2020-09-30 |
2023-08-13 |
mouse |
| Lingyi Shi, Hailun Zheng, Wanle Hu, Bin Zhou, Xuanxuan Dai, Yi Zhang, Zhiguo Liu, Xiaoping Wu, Chengguang Zhao, Guang Lian. Niclosamide inhibition of STAT3 synergizes with erlotinib in human colon cancer. OncoTargets and therapy. vol 10. 2020-09-30. PMID:28367059. |
combined inhibition of epidermal growth factor receptor and stat3 by erlotinib and niclosamide synergistically induces apoptosis and antiproliferation in colon cancer cell lines. |
2020-09-30 |
2023-08-13 |
human |
| María Florencia Gottardo, Mariela Moreno Ayala, Jimena Ferraris, Sandra Zárate, Daniel Pisera, Marianela Candolfi, Gabriela Jaita, Adriana Seilicovic. Humanin inhibits apoptosis in pituitary tumor cells through several signaling pathways including NF-κB activation. Journal of cell communication and signaling. vol 11. issue 4. 2020-09-30. PMID:28378125. |
stat3 inhibition reversed the inhibitory effect of hn on tnf-α-induced apoptosis in normal and pituitary tumor cells, indicating that stat3 signaling pathway mediates the antiapoptotic effect of hn on pituitary cells. |
2020-09-30 |
2023-08-13 |
rat |
| Changjiang Zhang, Yinzhi Deng, Yuhua Lei, Jingbo Zhao, Wen Wei, Yuanhong L. Effects of selenium on myocardial apoptosis by modifying the activity of mitochondrial STAT3 and regulating potassium channel expression. Experimental and therapeutic medicine. vol 14. issue 3. 2020-09-30. PMID:28962142. |
effects of selenium on myocardial apoptosis by modifying the activity of mitochondrial stat3 and regulating potassium channel expression. |
2020-09-30 |
2023-08-13 |
mouse |
| Changjiang Zhang, Yinzhi Deng, Yuhua Lei, Jingbo Zhao, Wen Wei, Yuanhong L. Effects of selenium on myocardial apoptosis by modifying the activity of mitochondrial STAT3 and regulating potassium channel expression. Experimental and therapeutic medicine. vol 14. issue 3. 2020-09-30. PMID:28962142. |
the present study investigated the effects of myocardial mitochondrial signal transduction and activator of transcription 3 (stat3), succinate dehydrogenase activity and changes of potassium channel expression on cardiomyocyte apoptosis under low selenium conditions. |
2020-09-30 |
2023-08-13 |
mouse |
| Changjiang Zhang, Yinzhi Deng, Yuhua Lei, Jingbo Zhao, Wen Wei, Yuanhong L. Effects of selenium on myocardial apoptosis by modifying the activity of mitochondrial STAT3 and regulating potassium channel expression. Experimental and therapeutic medicine. vol 14. issue 3. 2020-09-30. PMID:28962142. |
in conclusion, selenium deficiency in cardiomyocytes leads to decreased potassium channel expression and decreased mitochondrial stat3 activity and mitochondrial function, which in turn promotes the apoptosis of cardiomyocytes. |
2020-09-30 |
2023-08-13 |
mouse |
| Satya Sahay, Prakash Tiwari, Krishna P Gupt. Onset of the lymphocytic infiltration and hyperplasia preceding the proliferation in F1 mouse lungs from the N-ethyl-N-nitrosourea exposed mothers: Prevention during the lactation period by inositol hexaphosphate. Toxicology reports. vol 2. 2020-09-30. PMID:28962394. |
analysis of pcna, nf-κb (p50), il-6, cox-2, pstat3, stat3, caspase-3, caspase-9, parp, akt signalling and downstream cyclin d1 along with mir-155, suggested the modulation of proliferation, inflammation and apoptosis at pnd12 and 24. |
2020-09-30 |
2023-08-13 |
mouse |
| Satya Sahay, Prakash Tiwari, Krishna P Gupt. Onset of the lymphocytic infiltration and hyperplasia preceding the proliferation in F1 mouse lungs from the N-ethyl-N-nitrosourea exposed mothers: Prevention during the lactation period by inositol hexaphosphate. Toxicology reports. vol 2. 2020-09-30. PMID:28962394. |
ip6 administration to the predisposed mothers prevented the proliferation, inflammation and enhanced apoptosis in f1 lung as showed by a reduction in pcna, nf-κb (p50), il-6, cox-2, pstat3, stat3, mir-155 and increase in caspases, cleavage of poly (adp-ribose) polymerase. |
2020-09-30 |
2023-08-13 |
mouse |
| Yang Gao, Kai Kang, Haitao Liu, Weilan Kong, Qiuyuan Han, Xing Zhang, Rui Huang, Jingdong Qu, Hongliang Wang, Sicong Wang, Ruijin Liu, Yansong Liu, Kaijiang Y. GTS-21 attenuates LPS-induced renal injury via the cholinergic anti-inflammatory pathway in mice. American journal of translational research. vol 9. issue 10. 2020-09-30. PMID:29118926. |
the pathological examinations were performed on he stained renal tissues, apoptosis was determined using tunel assay, mrna expression of nf-kb p65, caspase-3, caspase-8, bcl-2, bax, p53 and a7nach was quantified using qrt-pcr, protein levels of il-6, il-1β, tnf-α and phosphorylated stat3 (p-stat3) were analyzed using western blots. |
2020-09-30 |
2023-08-13 |
mouse |
| Feng-Tao Yi, Qi-Ping L. Mucin 1 promotes radioresistance in hepatocellular carcinoma cells through activation of JAK2/STAT3 signaling. Oncology letters. vol 14. issue 6. 2020-09-30. PMID:29344203. |
mechanistically, muc1 inhibited irradiation-induced apoptosis through activation of janus kinase 2 (jak2) and stat3, and induction of anti-apoptotic proteins induced myeloid leukemia cell differentiation protein mcl-1 (mcl-1) and bcl2 like 1 (bcl-xl). |
2020-09-30 |
2023-08-13 |
human |
| Feng-Tao Yi, Qi-Ping L. Mucin 1 promotes radioresistance in hepatocellular carcinoma cells through activation of JAK2/STAT3 signaling. Oncology letters. vol 14. issue 6. 2020-09-30. PMID:29344203. |
small hairpin rna-mediated knockdown of stat3 or muc1 resensitized muc1-overexpressing cells to irradiation-induced apoptosis, which was accompanied by reduced expression of bcl-xl and mcl-1. |
2020-09-30 |
2023-08-13 |
human |
| Hua Li, Hang Lu, Meng Lv, Qingsheng Wang, Yuping Su. Parthenolide facilitates apoptosis and reverses drug-resistance of human gastric carcinoma cells by inhibiting the STAT3 signaling pathway. Oncology letters. vol 15. issue 3. 2020-09-30. PMID:29467878. |
parthenolide facilitates apoptosis and reverses drug-resistance of human gastric carcinoma cells by inhibiting the stat3 signaling pathway. |
2020-09-30 |
2023-08-13 |
human |
| Zaiyun Zhang, Jihua Wang, Jian Cheng, Xiaoming Y. Effects of miR-126 on the STAT3 signaling pathway and the regulation of malignant behavior in lung cancer cells. Oncology letters. vol 15. issue 6. 2020-09-30. PMID:29805576. |
based on our findings, the cancer-promoting mir-126 can mediate the activation of the stat3 signal pathway to regulate the malignant biological behavior of nsclc cells affecting their proliferation, migration, cycle and apoptosis susceptibility. |
2020-09-30 |
2023-08-13 |
Not clear |
| Loukik Arora, Alan Prem Kumar, Frank Arfuso, Wee Joo Chng, Gautam Seth. The Role of Signal Transducer and Activator of Transcription 3 (STAT3) and Its Targeted Inhibition in Hematological Malignancies. Cancers. vol 10. issue 9. 2020-09-30. PMID:30217007. |
this review focuses on the role of stat3 in pathogenesis i.e., proliferation, differentiation, migration, and apoptosis of hematological malignancies viz. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yingying Wang, Linlin Wu, Haiyan Cai, Hu Lei, Chun-Min Ma, Li Yang, Hanzhang Xu, Qi Zhu, Zhujun Yao, Yingli W. YL064 directly inhibits STAT3 activity to induce apoptosis of multiple myeloma cells. Cell death discovery. vol 4. 2020-09-30. PMID:30302278. |
yl064 directly inhibits stat3 activity to induce apoptosis of multiple myeloma cells. |
2020-09-30 |
2023-08-13 |
human |