| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Muqaddas Masood, Azhar Rasul, Iqra Sarfraz, Faiza Jabeen, Sitong Liu, Xintong Liu, Wei Wei, Jiang Li, Xiaomeng L. Hispolon induces apoptosis against prostate DU145 cancer cells via modulation of mitochondrial and STAT3 pathways. Pakistan journal of pharmaceutical sciences. vol 32. issue 5(Supplementary). 2020-06-29. PMID:31894049. |
contemporaneously, these results represent that hispolon's anticancer mechanism of action proceeds via downregulating the phosphorylation of stat3 and induction of apoptosis via mitochondrial pathway. |
2020-06-29 |
2023-08-13 |
Not clear |
| Piyong Ma, Chunmei Zhang, Pengfei Huo, Yan Li, Hailing Yan. A novel role of the miR-152-3p/ERRFI1/STAT3 pathway modulates the apoptosis and inflammatory response after acute kidney injury. Journal of biochemical and molecular toxicology. 2020-06-25. PMID:32583487. |
summarily, our study confirmed that mir-152-3p could promote the expression of stat3 by targeting errfi1, aggravate cell apoptosis and inflammatory response, and thereby aggravate kidney injury in sepsis aki. |
2020-06-25 |
2023-08-13 |
rat |
| Xuehui Sun, Yun Han, Ying Liu, Yanchun Tang, Jibo Wan. Proliferation and apoptosis of rheumatoid arthritis fibroblast-like synoviocytes following signal transducer and activator of transcription 3 RNA interference delivery. Journal of cellular biochemistry. vol 120. issue 3. 2020-06-17. PMID:29236318. |
in this study, we investigated the effects of delivering small interfering rna (sirna) for efficient stat3 downregulation on propagation and apoptosis of rheumatoid arthritis fibroblast-like synoviocytes (ra-fls). |
2020-06-17 |
2023-08-13 |
Not clear |
| Rosie M Butler, Robert C McKenzie, Christine L Jones, Charlotte E Flanagan, Wesley J Woollard, Maria Demontis, Silvia Ferreira, Isabella Tosi, Susan John, Sean J Whittaker, Tracey J Mitchel. Contribution of STAT3 and RAD23B in Primary Sézary Cells to Histone Deacetylase Inhibitor FK228 Resistance. The Journal of investigative dermatology. vol 139. issue 9. 2020-06-15. PMID:30910759. |
critically, sézary cells harboring the common stat3 y640f variant were less sensitive to fk228-induced apoptosis and exogenous expression of stat3 y640f, and d661y conferred partial resistance to stat3 transcriptional inhibition by fk228 (p ≤ 0.0024). |
2020-06-15 |
2023-08-13 |
Not clear |
| Maria Boichuck, Jonathan Zorea, Moshe Elkabets, Marina Wolfson, Vadim E Fraifel. c-Met as a new marker of cellular senescence. Aging. vol 11. issue 9. 2020-06-12. PMID:31085799. |
considering the anti-apoptotic activity of akt and the involvement of stat3 in mediating the effects of proinflammatory cytokines, the findings of this study indicate that c-met could contribute through its downstream targets or partners to at least two major phenotypical features of cs - resistance to apoptosis and senescence-associated secretory phenotype. |
2020-06-12 |
2023-08-13 |
human |
| Yuki Uchihara, Tomoyuki Ohe, Tadahiko Mashino, Takayuki Kidokoro, Kenji Tago, Hiroomi Tamura, Megumi Funakoshi-Tag. N-Acetyl cysteine prevents activities of STAT3 inhibitors, Stattic and BP-1-102 independently of its antioxidant properties. Pharmacological reports : PR. vol 71. issue 6. 2020-06-11. PMID:31627175. |
inhibitors for signal transducer and activator of transcription 3 (stat3), stattic, bp-1-102, and lll12 significantly induce apoptosis in transformed ba/f3 cells expressing an oncogenic fusion protein, nucleophosmin-anaplastic lymphoma kinase (npm-alk) that induces the activation of stat3. |
2020-06-11 |
2023-08-13 |
Not clear |
| Yuki Uchihara, Tomoyuki Ohe, Tadahiko Mashino, Takayuki Kidokoro, Kenji Tago, Hiroomi Tamura, Megumi Funakoshi-Tag. N-Acetyl cysteine prevents activities of STAT3 inhibitors, Stattic and BP-1-102 independently of its antioxidant properties. Pharmacological reports : PR. vol 71. issue 6. 2020-06-11. PMID:31627175. |
we found that the antioxidant reagent, n-acetyl cysteine (nac) prevented the abilities of stattic and bp-1-102, but not lll12 to induce apoptosis in transformed cells expressing npm-alk, providing a novel problem in use of stat3 inhibitors. |
2020-06-11 |
2023-08-13 |
Not clear |
| Zhe Liu, Xianmin Ge, Yuchen Gu, Yingying Huang, Hao Liu, Meiling Yu, Yamin Li. Small molecule STAT3 inhibitor, 6Br-6a suppresses breast cancer growth in vitro and in vivo. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 121. 2020-06-04. PMID:31707351. |
signal transducer and activator of transcription 3 (stat3) protein frequently overexpressed in many malignancies and plays an essential role in regulating proliferation, apoptosis, migration and invasion in cancer cells. |
2020-06-04 |
2023-08-13 |
mouse |
| Zhe Liu, Xianmin Ge, Yuchen Gu, Yingying Huang, Hao Liu, Meiling Yu, Yamin Li. Small molecule STAT3 inhibitor, 6Br-6a suppresses breast cancer growth in vitro and in vivo. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 121. 2020-06-04. PMID:31707351. |
our data demonstrated that 6br-6a significantly induced cell cycle arrest and cell apoptosis in breast cancer via blocking the activation of stat3. |
2020-06-04 |
2023-08-13 |
mouse |
| Zhe Liu, Xianmin Ge, Yuchen Gu, Yingying Huang, Hao Liu, Meiling Yu, Yamin Li. Small molecule STAT3 inhibitor, 6Br-6a suppresses breast cancer growth in vitro and in vivo. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 121. 2020-06-04. PMID:31707351. |
in conclusion, 6br-6a effectively inhibited activation of stat3 and induced cell cycle arrest and apoptosis via regulating cyclin d1 and bcl-2 expression. |
2020-06-04 |
2023-08-13 |
mouse |
| Ruth Herrmann, Joseph Skaf, Jeanette Roller, Christine Polednik, Ulrike Holzgrabe, Marianne Schmid. Anticancer effects of NSC‑631570 (Ukrain) in head and neck cancer cells: In vitro analysis of growth, invasion, angiogenesis and gene expression. Oncology reports. vol 43. issue 1. 2020-06-01. PMID:31789425. |
microarray analysis revealed the downregulation of genes encoding key regulators, including egfr, akt2, jak1, stat3 and ß‑catenin (ctnnb1), all of which are involved in cell proliferation, migration, angiogenesis, apoptosis as well as the radiation‑ and chemo‑resistance of hnscc. |
2020-06-01 |
2023-08-13 |
human |
| Wan-Ting Xu, Tian-Zhu Li, Shu-Mei Li, Cheng Wang, Hao Wang, Ying-Hua Luo, Xian-Ji Piao, Jia-Ru Wang, Yu Zhang, Tong Zhang, Hui Xue, Long-Kui Cao, Cheng-Hao Ji. Cytisine exerts anti-tumour effects on lung cancer cells by modulating reactive oxygen species-mediated signalling pathways. Artificial cells, nanomedicine, and biotechnology. vol 48. issue 1. 2020-06-01. PMID:31852250. |
during apoptosis, cytisine increased the phosphorylation levels of jnk, p38, and i-κb, and decreased the phosphorylation levels of erk, stat3, and nf-κb. |
2020-06-01 |
2023-08-13 |
human |
| Dingyuan Luo, Magdalena Fraga-Lauhirat, Jonathan Millings, Cristella Ho, Emily M Villarreal, Teresa C Fletchinger, James V Bonfiglio, Leyda Mata, Matthew D Nemesure, Lauren E Bartels, Ruixue Wang, Basil Rigas, Gerardo G Mackenzi. Phospho-valproic acid (MDC-1112) suppresses glioblastoma growth in preclinical models through the inhibition of STAT3 phosphorylation. Carcinogenesis. vol 40. issue 12. 2020-05-27. PMID:30994173. |
in addition, mdc-1112 reduced stat3 levels in the mitochondria and enhanced mitochondrial levels of reactive oxygen species, which triggered apoptosis. |
2020-05-27 |
2023-08-13 |
mouse |
| Fang Gan, Xuan Zhou, Yajiao Zhou, Lili Hou, Xingxiang Chen, Cuiling Pan, Kehe Huan. Nephrotoxicity instead of immunotoxicity of OTA is induced through DNMT1-dependent activation of JAK2/STAT3 signaling pathway by targeting SOCS3. Archives of toxicology. vol 93. issue 4. 2020-05-22. PMID:30923867. |
dnmt inhibitor (5-aza-2-dc), promoted socs3 expression, inhibited jak2 and stat3 expression, alleviated cytotoxicity, apoptosis and dna damage induced by ota at 4.0 µg/ml in pk15 cells. |
2020-05-22 |
2023-08-13 |
Not clear |
| Fang Gan, Xuan Zhou, Yajiao Zhou, Lili Hou, Xingxiang Chen, Cuiling Pan, Kehe Huan. Nephrotoxicity instead of immunotoxicity of OTA is induced through DNMT1-dependent activation of JAK2/STAT3 signaling pathway by targeting SOCS3. Archives of toxicology. vol 93. issue 4. 2020-05-22. PMID:30923867. |
while, in pams, 5-aza-2-dc had no effects on socs3 expression induced by ota at 4.0 µg/ml, but inhibited jak2 and stat3 expression, and alleviated cytotoxicity, apoptosis and dna damage induced by ota. |
2020-05-22 |
2023-08-13 |
Not clear |
| Fangfang Li, Haiping Zhao, Ziping Han, Rongliang Wang, Zhen Tao, Zhibin Fan, Sijia Zhang, Guangwen Li, Zhigang Chen, Yumin Lu. Xuesaitong May Protect Against Ischemic Stroke by Modulating Microglial Phenotypes and Inhibiting Neuronal Cell Apoptosis via the STAT3 Signaling Pathway. CNS & neurological disorders drug targets. vol 18. issue 2. 2020-05-13. PMID:30426907. |
xuesaitong may protect against ischemic stroke by modulating microglial phenotypes and inhibiting neuronal cell apoptosis via the stat3 signaling pathway. |
2020-05-13 |
2023-08-13 |
Not clear |
| Ying-Hua Luo, Jin-Qian Li, Yi Zhang, Jia-Ru Wang, Wan-Ting Xu, Yu Zhang, Yu-Chao Feng, Shi-Ze Li, Cheng-Hao Ji. Quinalizarin induces cycle arrest and apoptosis via reactive oxygen species-mediated signaling pathways in human melanoma A375 cells. Drug development research. vol 80. issue 8. 2020-05-07. PMID:31432559. |
quinalizarin treatment led to apoptosis of a375 cells via activation of mapk and inhibition of stat3 signaling pathways. |
2020-05-07 |
2023-08-13 |
human |
| Ying-Hua Luo, Jin-Qian Li, Yi Zhang, Jia-Ru Wang, Wan-Ting Xu, Yu Zhang, Yu-Chao Feng, Shi-Ze Li, Cheng-Hao Ji. Quinalizarin induces cycle arrest and apoptosis via reactive oxygen species-mediated signaling pathways in human melanoma A375 cells. Drug development research. vol 80. issue 8. 2020-05-07. PMID:31432559. |
in addition, quinalizarin increased the level of ros, but ros scavenger nac inhibited quinalizarin-induced apoptosis by regulating mapk and stat3 signaling pathways. |
2020-05-07 |
2023-08-13 |
human |
| Ying-Hua Luo, Jin-Qian Li, Yi Zhang, Jia-Ru Wang, Wan-Ting Xu, Yu Zhang, Yu-Chao Feng, Shi-Ze Li, Cheng-Hao Ji. Quinalizarin induces cycle arrest and apoptosis via reactive oxygen species-mediated signaling pathways in human melanoma A375 cells. Drug development research. vol 80. issue 8. 2020-05-07. PMID:31432559. |
in summary, quinalizarin induces cell cycle arrest and apoptosis via ros-mediated mapk and stat3 signaling pathways in human melanoma a375 cells, and quinalizarin may be used as a novel and effective antimelanoma therapeutic. |
2020-05-07 |
2023-08-13 |
human |
| Zongye Cai, Jian Li, Qi Zhuang, Xueming Zhang, Ancai Yuan, Lan Shen, Kang Kang, Bo Qu, Yuanjia Tang, Jun Pu, Deming Gou, Jieyan She. MiR-125a-5p ameliorates monocrotaline-induced pulmonary arterial hypertension by targeting the TGF-β1 and IL-6/STAT3 signaling pathways. Experimental & molecular medicine. vol 50. issue 4. 2020-04-20. PMID:29700287. |
taken together, these findings suggest that mir-125a-5p ameliorates mct-pah in rats, has a negative feedback regulation with tgf-β1 and il-6, and regulates the proliferation and apoptosis of pasmcs by directly targeting stat3. |
2020-04-20 |
2023-08-13 |
rat |