| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lishan Cui, Lanxi Xu, Guanling Wang, Jing Wen, Lili Luo, Haitao Zhao, Shuide Chen, Mingcheng Zheng, Cuiling Sun, Xin Jin, Lichao Yan. STAT3-PTTG11 abrogation inhibits proliferation and induces apoptosis in malignant glioma cells. Oncology letters. vol 20. issue 4. 2020-09-28. PMID:32774480. |
the findings of the present study revealed that stat3 induced pttg11 expression, which subsequently induced downstream c-myc and bcl-2 expression while inhibiting bax expression, thereby promoting cell viability and inhibiting apoptosis. |
2020-09-28 |
2023-08-13 |
human |
| Lishan Cui, Lanxi Xu, Guanling Wang, Jing Wen, Lili Luo, Haitao Zhao, Shuide Chen, Mingcheng Zheng, Cuiling Sun, Xin Jin, Lichao Yan. STAT3-PTTG11 abrogation inhibits proliferation and induces apoptosis in malignant glioma cells. Oncology letters. vol 20. issue 4. 2020-09-28. PMID:32774480. |
pttg11 suppression via sirna inhibited the viability and increased the apoptosis of glioma cells induced by the stat3 activator s3i-201. |
2020-09-28 |
2023-08-13 |
human |
| Shefeng Zheng, Jinnv Liu, Zhangjian Zhao, Ruifang Son. Role of STAT3/mTOR pathway in chronic kidney injury. American journal of translational research. vol 12. issue 7. 2020-09-28. PMID:32774701. |
glomerular mesangial cells were divided into control group, model group, stat3 inhibitor (s3i-201) group followed by analysis of cell proliferation by mtt assay, cell apoptosis by flow cytometry, formation of autophagosomes by electron microscopy, expression of stat3/mtor signaling proteins and autophagy proteins lc3ii and p62 by western blot, expression of e-cadherin and vimentin by immunofluorescence. |
2020-09-28 |
2023-08-13 |
mouse |
| Shefeng Zheng, Jinnv Liu, Zhangjian Zhao, Ruifang Son. Role of STAT3/mTOR pathway in chronic kidney injury. American journal of translational research. vol 12. issue 7. 2020-09-28. PMID:32774701. |
folic acid-induced injury of mesangial cells showed inhibited cell proliferation, promoted apoptosis, increased lc3ii expression, decreased p62 expression, increased autophagic vacuoles and expression of stat3 and p-mtor as well as decreased e-cadherin expression and increased vimentin expression. |
2020-09-28 |
2023-08-13 |
mouse |
| Gui-Nan Shen, Cheng Wang, Ying-Hua Luo, Jia-Ru Wang, Rui Wang, Wan-Ting Xu, Yi Zhang, Yu Zhang, Dong-Jie Zhang, Cheng-Hao Ji. 2-(6-Hydroxyhexylthio)-5,8-dimethoxy-1,4-naphthoquinone Induces Apoptosis through ROS-Mediated MAPK, STAT3, and NF- Evidence-based complementary and alternative medicine : eCAM. vol 2020. 2020-09-28. PMID:32849902. |
2-(6-hydroxyhexylthio)-5,8-dimethoxy-1,4-naphthoquinone induces apoptosis through ros-mediated mapk, stat3, and nf- two novel compounds, 2-(2-hydroxyethylthio)-5,8-dimethoxy-1,4-naphthoquinone (hedmnq) and 2-(6-hydroxyhexylthio)-5,8-dimethoxy-1,4-naphthoquinone (hhdmnq), were synthesized to investigate the kill effects and mechanism of 1,4-naphthoquinone derivatives in lung cancer cells. |
2020-09-28 |
2023-08-13 |
Not clear |
| Gui-Nan Shen, Cheng Wang, Ying-Hua Luo, Jia-Ru Wang, Rui Wang, Wan-Ting Xu, Yi Zhang, Yu Zhang, Dong-Jie Zhang, Cheng-Hao Ji. 2-(6-Hydroxyhexylthio)-5,8-dimethoxy-1,4-naphthoquinone Induces Apoptosis through ROS-Mediated MAPK, STAT3, and NF- Evidence-based complementary and alternative medicine : eCAM. vol 2020. 2020-09-28. PMID:32849902. |
fluorescence microscopy and flow cytometry results indicated that hhdmnq could induce a549 cell apoptosis, and western blot analysis showed that hhdmnq induced apoptosis through regulating the mitochondria pathway, as well as the mapk, stat3, and nf- |
2020-09-28 |
2023-08-13 |
Not clear |
| Jiangqiang Chen, Zuhui Che. Downregulation of miR-19a inhibits the proliferation and promotes the apoptosis of osteosarcoma cells by regulating the JAK2/STAT3 pathway. Oncology letters. vol 20. issue 5. 2020-09-28. PMID:32934740. |
the present study was designed to explore the regulatory effects of microrna (mir)-19a on the proliferation and apoptosis of osteosarcoma cells, and its influence on the activation of the janus kinase 2 (jak2)/signal transducer and activator of transcription 3 (stat3) signaling pathway. |
2020-09-28 |
2023-08-13 |
Not clear |
| Q Li, W-X Ye, Z-J Huang, Q Zhang, Y-F H. Effect of IL-6-mediated STAT3 signaling pathway on myocardial apoptosis in mice with dilated cardiomyopathy. European review for medical and pharmacological sciences. vol 23. issue 7. 2020-09-08. PMID:31002169. |
effect of il-6-mediated stat3 signaling pathway on myocardial apoptosis in mice with dilated cardiomyopathy. |
2020-09-08 |
2023-08-13 |
mouse |
| Qi-Zhe Gong, Di Xiao, Gui-Yi Gong, Jian Xu, Xiao-Dong Wen, Feng Feng, Wei Q. EH-42: A Novel Small Molecule Induces Apoptosis and Inhibits Migration and Invasion of Human Hepatoma Cells through Suppressing STAT3 Signaling Pathway. Current cancer drug targets. vol 19. issue 7. 2020-09-03. PMID:30585547. |
eh-42: a novel small molecule induces apoptosis and inhibits migration and invasion of human hepatoma cells through suppressing stat3 signaling pathway. |
2020-09-03 |
2023-08-13 |
human |
| Efthalia Angelopoulou, Yam Nath Paudel, Christina Piper. miR-124 and Parkinson's disease: A biomarker with therapeutic potential. Pharmacological research. vol 150. 2020-08-24. PMID:31707035. |
accumulating pre-clinical evidence shows that mir-124 may act through calpain 1/p25/cyclin-dependent kinases 5 (cdk5), nuclear factor-kappa b (nf-κb), signal transducer and activator of transcription 3 (stat3), bcl-2-interacting mediator of cell death (bim), 5' adenosine monophosphate-activated protein kinase (ampk) and extracellular signal-regulated kinase (erk)-mediated pathways to regulate cell survival, apoptosis, autophagy, mitochondrial dysfunction, oxidative damage and neuroinflammation in pd. |
2020-08-24 |
2023-08-13 |
Not clear |
| Can Zhao, Beibei Zhang, Jing Jiang, Yongliang Wang, Yongquan W. Up-regulation of ANXA1 suppresses polymorphonuclear neutrophil infiltration and myeloperoxidase activity by activating STAT3 signaling pathway in rat models of myocardial ischemia-reperfusion injury. Cellular signalling. vol 62. 2020-08-20. PMID:31132398. |
following this, the anxa1 vector, sirna-anxa1, and stattic (inhibitor of stat3 signaling pathway) were utilized for analyzing the regulatory role of anxa1 in physiological indexes, hemodynamic parameters, inflammatory factors, myocardial infarct size, mpo activity, pmn infiltration, and apoptosis of pmns. |
2020-08-20 |
2023-08-13 |
rat |
| Xiang Lu Ji, Ming H. Sodium cantharidate targets STAT3 and abrogates EGFR inhibitor resistance in osteosarcoma. Aging. vol 11. issue 15. 2020-08-19. PMID:31422383. |
we found that sc repressed cell viability and migration and induced apoptosis in vitro, while combined sc and erlotinib treatment enhanced osteosarcoma growth suppression by preventing feedback activation of stat3. |
2020-08-19 |
2023-08-13 |
mouse |
| Yunan Liu, Wei Ga. [Interleukin-37 inhibits proliferation, migration and induces apoptosis of rheumatoid arthritis fibroblast-like synoviocytes (RAFLS) by inhibiting STAT3]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 36. issue 3. 2020-08-13. PMID:32389171. |
[interleukin-37 inhibits proliferation, migration and induces apoptosis of rheumatoid arthritis fibroblast-like synoviocytes (rafls) by inhibiting stat3]. |
2020-08-13 |
2023-08-13 |
Not clear |
| Yunan Liu, Wei Ga. [Interleukin-37 inhibits proliferation, migration and induces apoptosis of rheumatoid arthritis fibroblast-like synoviocytes (RAFLS) by inhibiting STAT3]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 36. issue 3. 2020-08-13. PMID:32389171. |
conclusion il-37 can inhibit the proliferation and migration of rafls and induces cell apoptosis by inhibiting the stat3 pathway. |
2020-08-13 |
2023-08-13 |
Not clear |
| Issa Tajmohammadi, Jamal Mohammadian, Mehdi Sabzichi, Shiva Mahmuodi, Mina Ramezani, Marjan Aghajani, Fatemeh Ramezan. Identification of Nrf2/STAT3 axis in induction of apoptosis through sub-G Journal of cellular biochemistry. vol 120. issue 8. 2020-08-12. PMID:30993753. |
identification of nrf2/stat3 axis in induction of apoptosis through sub-g we investigated the role of stattic as an adjuvant molecule to increase the cytotoxicity of 5-fluorouracil (5-fu) through specific inhibition of molecular targets, signal transducer and activator of transcription 3 (stat3) and nuclear factor erythroid 2-related factor 2 (nrf2) in ht-29 colon cancer cells. |
2020-08-12 |
2023-08-13 |
Not clear |
| Yongzhi Li, Benkang Shi, Fengming Dong, Xingwang Zhu, Bing Liu, Yili Li. Effects of inflammatory responses, apoptosis, and STAT3/NF-κB- and Nrf2-mediated oxidative stress on benign prostatic hyperplasia induced by a high-fat diet. Aging. vol 11. issue 15. 2020-08-10. PMID:31412319. |
this study determined whether or not benign prostatic hyperplasia (bph) induced by a high-fat diet (hfd) is involved in inflammatory responses, apoptosis, and the signal transducer and activator of transcription (stat3)/nuclear factor-kappa b (nf-κb)- and nuclear factor erythroid 2-related factor 2 (nrf2)-mediated oxidative stress pathways. |
2020-08-10 |
2023-08-13 |
rat |
| Yi-Xin Du, Lin-Xin Guo, Han-Song Pan, Yi-Min Liang, Xiang L. Circ_ANKIB1 stabilizes the regulation of miR-19b on SOCS3/STAT3 pathway to promote osteosarcoma cell growth and invasion. Human cell. vol 33. issue 1. 2020-08-04. PMID:31667786. |
when cotransfected with circ_ankib1 sirna and mir-19b mimics or socs3 sirna, the cell proliferation, apoptosis, and invasion levels did not change significantly, suggesting that circ_ankib1 could affect the stat3 pathway and osteosarcoma cell growth and invasion by enhancing the regulation of mir-19b on the downstream target gene socs3. |
2020-08-04 |
2023-08-13 |
Not clear |
| Chang-Qing Jiang, Ling-Ling Ma, Zhen-Dong Lv, Fan Feng, Zhi Chen, Zu-De Li. Polydatin induces apoptosis and autophagy via STAT3 signaling in human osteosarcoma MG-63 cells. Journal of natural medicines. vol 74. issue 3. 2020-07-27. PMID:32222939. |
polydatin induces apoptosis and autophagy via stat3 signaling in human osteosarcoma mg-63 cells. |
2020-07-27 |
2023-08-13 |
human |
| Chang-Qing Jiang, Ling-Ling Ma, Zhen-Dong Lv, Fan Feng, Zhi Chen, Zu-De Li. Polydatin induces apoptosis and autophagy via STAT3 signaling in human osteosarcoma MG-63 cells. Journal of natural medicines. vol 74. issue 3. 2020-07-27. PMID:32222939. |
in conclusion, these data demonstrated that polydatin induced mg-63 cell death through inducing apoptosis, and autophagy which was mediated via the stat3 signaling. |
2020-07-27 |
2023-08-13 |
human |
| Jong Hyun Lee, Chulwon Kim, Jeong-Hyeon Ko, Young Yun Jung, Sang Hoon Jung, Eunok Kim, Moonkyoo Kong, Arunachalam Chinnathambi, Tahani Awad Alahmadi, Sulaiman Ali Alharbi, Gautam Sethi, Kwang Seok Ah. Casticin inhibits growth and enhances ionizing radiation-induced apoptosis through the suppression of STAT3 signaling cascade. Journal of cellular biochemistry. vol 120. issue 6. 2020-07-15. PMID:30520154. |
casticin inhibits growth and enhances ionizing radiation-induced apoptosis through the suppression of stat3 signaling cascade. |
2020-07-15 |
2023-08-13 |
human |