| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shaoqing Lei, Wating Su, Zhong-Yuan Xia, Yafeng Wang, Lu Zhou, Shigang Qiao, Bo Zhao, Zhengyuan Xia, Michael G Irwi. Hyperglycemia-Induced Oxidative Stress Abrogates Remifentanil Preconditioning-Mediated Cardioprotection in Diabetic Rats by Impairing Caveolin-3-Modulated PI3K/Akt and JAK2/STAT3 Signaling. Oxidative medicine and cellular longevity. vol 2019. 2020-03-20. PMID:31583053. |
rpc significantly attenuated postischemic infarction, cardiac dysfunction, myocardial apoptosis, and 15-f2t-isoprostane production (a specific marker of oxidative stress), accompanied with increased cav-3 expression and enhanced akt and stat3 activation in control but not in diabetic rats. |
2020-03-20 |
2023-08-13 |
rat |
| Hao Tan, Xiang Li, Wei Han Yang, Yong Kan. A flavone, Wogonin from Scutellaria baicalensis inhibits the proliferation of human colorectal cancer cells by inducing of autophagy, apoptosis and G2/M cell cycle arrest via modulating the PI3K/AKT and STAT3 signalling pathways. Journal of B.U.ON. : official journal of the Balkan Union of Oncology. vol 24. issue 3. 2020-03-17. PMID:31424673. |
a flavone, wogonin from scutellaria baicalensis inhibits the proliferation of human colorectal cancer cells by inducing of autophagy, apoptosis and g2/m cell cycle arrest via modulating the pi3k/akt and stat3 signalling pathways. |
2020-03-17 |
2023-08-13 |
human |
| Qianqian Zhang, Hong Sun, Shougang Zhuang, Na Liu, Xiaowei Bao, Xiandong Liu, Huijuan Ren, Diyu Lv, Zhe Li, Jianwen Bai, Xiaohui Zhou, Lunxian Tan. Novel pharmacological inhibition of EZH2 attenuates septic shock by altering innate inflammatory responses to sepsis. International immunopharmacology. vol 76. 2020-03-17. PMID:31518916. |
blockage of ezh2 also suppressed the progression of lung injury and alleviated inflammation by decreasing the pulmonary cell apoptosis, reducing inflammatory cells infiltration and cytokines release through inhibition of the stat3 signaling pathway and recovery of pparγ activation. |
2020-03-17 |
2023-08-13 |
mouse |
| Yi Zhang, Ying-Hua Luo, Xian-Ji Piao, Gui-Nan Shen, Jia-Ru Wang, Yu-Chao Feng, Jin-Qian Li, Wan-Ting Xu, Yu Zhang, Tong Zhang, Chang-Yuan Wang, Cheng-Hao Ji. The design of 1,4-naphthoquinone derivatives and mechanisms underlying apoptosis induction through ROS-dependent MAPK/Akt/STAT3 pathways in human lung cancer cells. Bioorganic & medicinal chemistry. vol 27. issue 8. 2020-03-12. PMID:30846406. |
in addition, they induced the apoptosis of a549 lung cancer cells by increasing the phosphorylation of p38 and c-jun n-terminal kinase (p-jnk), and decreasing the phosphorylation of extracellular signal-related kinase (p-erk), protein kinase b (akt), and signal transducer and activator of transcription 3 (stat3). |
2020-03-12 |
2023-08-13 |
human |
| Yi Zhang, Ying-Hua Luo, Xian-Ji Piao, Gui-Nan Shen, Jia-Ru Wang, Yu-Chao Feng, Jin-Qian Li, Wan-Ting Xu, Yu Zhang, Tong Zhang, Chang-Yuan Wang, Cheng-Hao Ji. The design of 1,4-naphthoquinone derivatives and mechanisms underlying apoptosis induction through ROS-dependent MAPK/Akt/STAT3 pathways in human lung cancer cells. Bioorganic & medicinal chemistry. vol 27. issue 8. 2020-03-12. PMID:30846406. |
in conclusion, epdmnq and endmnq induced g1 phase cell cycle arrest and apoptosis in a549 cells via the ros-mediated activation of mitogen activated protein kinase (mapk), akt and stat3 signaling pathways. |
2020-03-12 |
2023-08-13 |
human |
| Xiao Huang, Mengru Cao, Shuhong Wu, Li Wang, Jing Hu, Reza J Mehran, Jack A Roth, Stephen G Swisher, Rui-Yu Wang, Hagop M Kantarjian, Michael Andreeff, Xiaoping Sun, Bingliang Fan. Anti-leukemia activity of NSC-743380 in SULT1A1-expressing acute myeloid leukemia cells is associated with inhibitions of cFLIP expression and PI3K/AKT/mTOR activities. Oncotarget. vol 8. issue 60. 2020-03-09. PMID:29254232. |
our recent study showed that acute myeloid leukemia (aml) cells expressing sult1a1 are highly sensitive to nsc-743380, a small molecule that inhibits stat3 activity and induces sult1a1-dependent apoptosis of various cancer cell lines. |
2020-03-09 |
2023-08-13 |
Not clear |
| Ning Li, Dong Mao, Yansha Cao, Hua Li, Fu Ren, Keyan L. Downregulation of SIRT6 by miR-34c-5p is associated with poor prognosis and promotes colon cancer proliferation through inhibiting apoptosis via the JAK2/STAT3 signaling pathway. International journal of oncology. vol 52. issue 5. 2020-03-06. PMID:29512698. |
the proliferation and apoptotic assays demonstrated that sirt6 was able to suppress colon cancer cell proliferation and induce apoptosis via the janus kinase 2 (jak2)/signal transducer and activator of transcription 3 (stat3) signaling pathway. |
2020-03-06 |
2023-08-13 |
Not clear |
| Pikun Cao, Bin Liu, Feng Du, Dong Li, Yongzheng Wang, Xiaoyan Yan, Xiao Li, Yuliang L. Scutellarin suppresses proliferation and promotes apoptosis in A549 lung adenocarcinoma cells via AKT/mTOR/4EBP1 and STAT3 pathways. Thoracic cancer. vol 10. issue 3. 2020-03-04. PMID:30666790. |
scutellarin suppresses proliferation and promotes apoptosis in a549 lung adenocarcinoma cells via akt/mtor/4ebp1 and stat3 pathways. |
2020-03-04 |
2023-08-13 |
Not clear |
| Shuli Yang, Lihui Si, Yan Jia, Wenwen Jian, Qing Yu, Min Wang, Ruixin Li. Kaempferol exerts anti-proliferative effects on human ovarian cancer cells by inducing apoptosis, G0/G1 cell cycle arrest and modulation of MEK/ERK and STAT3 pathways. Journal of B.U.ON. : official journal of the Balkan Union of Oncology. vol 24. issue 3. 2020-03-02. PMID:31424650. |
kaempferol exerts anti-proliferative effects on human ovarian cancer cells by inducing apoptosis, g0/g1 cell cycle arrest and modulation of mek/erk and stat3 pathways. |
2020-03-02 |
2023-08-13 |
human |
| Hongyi Li, Yanping Qian, Xi Wang, Ruyu Pi, Xia Zhao, Xiawei We. Targeted activation of Stat3 in combination with paclitaxel results in increased apoptosis in epithelial ovarian cancer cells and a reduced tumour burden. Cell proliferation. vol 53. issue 1. 2020-02-25. PMID:31778258. |
targeted activation of stat3 in combination with paclitaxel results in increased apoptosis in epithelial ovarian cancer cells and a reduced tumour burden. |
2020-02-25 |
2023-08-13 |
Not clear |
| Yuzo Maeda, Hiroki Takahashi, Nozomu Nakai, Takeshi Yanagita, Nanako Ando, Tomotaka Okubo, Kenta Saito, Kazuyoshi Shiga, Takahisa Hirokawa, Masayasu Hara, Hideyuki Ishiguro, Yoichi Matsuo, Shuji Takiguch. Apigenin induces apoptosis by suppressing Bcl-xl and Mcl-1 simultaneously via signal transducer and activator of transcription 3 signaling in colon cancer. International journal of oncology. vol 52. issue 5. 2020-02-24. PMID:29512707. |
the results of the current study therefore determined that apigenin induces the apoptosis of colon cancer cells by inhibiting the phosphorylation of stat3 and consequently downregulates the anti-apoptotic proteins bcl-xl and mcl-1. |
2020-02-24 |
2023-08-13 |
Not clear |
| Hanli Fan, Jianbo Li, Jiwu Wang, Zange H. Long Non-Coding RNAs (lncRNAs) Tumor-Suppressive Role of lncRNA on Chromosome 8p12 (TSLNC8) Inhibits Tumor Metastasis and Promotes Apoptosis by Regulating Interleukin 6 (IL-6)/Signal Transducer and Activator of Transcription 3 (STAT3)/Hypoxia-Inducible Factor 1-alpha (HIF-1α) Signaling Pathway in Non-Small Cell Lung Cancer. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-02-20. PMID:31601776. |
long non-coding rnas (lncrnas) tumor-suppressive role of lncrna on chromosome 8p12 (tslnc8) inhibits tumor metastasis and promotes apoptosis by regulating interleukin 6 (il-6)/signal transducer and activator of transcription 3 (stat3)/hypoxia-inducible factor 1-alpha (hif-1α) signaling pathway in non-small cell lung cancer. |
2020-02-20 |
2023-08-13 |
human |
| Lina Liu, Haoran Zhang, Hongyu Mao, Xiaohong Li, Yamin H. Exosomal miR-320d derived from adipose tissue-derived MSCs inhibits apoptosis in cardiomyocytes with atrial fibrillation (AF). Artificial cells, nanomedicine, and biotechnology. vol 47. issue 1. 2020-02-19. PMID:31591913. |
inhibition of stat3 abolished the effect of modified exosomes in cardiomyocytes, causing decreased apoptosis and increased cell viability. |
2020-02-19 |
2023-08-13 |
Not clear |
| Mengqiu Dang, Xiangjun Zeng, Buxing Chen, Hongxia Wang, Huihua Li, Yu Liu, Xiuling Zhang, Xianxian Cao, Fenghe Du, Caixia Gu. Soluble receptor for advance glycation end-products inhibits ischemia/reperfusion-induced myocardial autophagy via the STAT3 pathway. Free radical biology & medicine. vol 130. 2020-02-17. PMID:30367996. |
soluble receptor for advanced glycation end-products (srage) exerts protective effects during i/r by decreasing cardiac apoptosis, which is mediated via increasing the ubiquitin proteasome system (ups) and signal transducer and activator of transcription 3 (stat3). |
2020-02-17 |
2023-08-13 |
mouse |
| Raquel Santana da Cruz, Fabia de Oliveira Andrade, Vivian Montes de Oca Carioni, Mariana Papaléo Rosim, Mayara Lilian Paulino Miranda, Camile Castilho Fontelles, Pedro Vitoriano de Oliveira, Luis Fernando Barbisan, Inar Alves Castro, Thomas Prates On. Dietary zinc deficiency or supplementation during gestation increases breast cancer susceptibility in adult female mice offspring following a J-shaped pattern and through distinct mechanisms. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 134. 2020-02-17. PMID:31505237. |
this was accompanied by a decreased number of terminal end buds, increased cell proliferation and apoptosis, and increased tumor suppressors p21, p53 and rassf1, zfp382 and stat3 expression in mammary glands, as well as increased zinc status. |
2020-02-17 |
2023-08-13 |
mouse |
| Karolina Swiatek-Machado, Bozena Kaminsk. STAT Signaling in Glioma Cells. Advances in experimental medicine and biology. vol 1202. 2020-02-11. PMID:32034715. |
while stat1 is believed to play an important role in growth arrest and apoptosis, and to act as a tumor suppressor, stat3 and 5 are involved in promoting cell cycle progression, cellular transformation, and preventing apoptosis. |
2020-02-11 |
2023-08-13 |
human |
| Yan Liu, Yingru Zhi, Haizhu Song, Mingzhu Zong, Jun Yi, Guoxin Mao, Longbang Chen, Guichun Huan. S1PR1 promotes proliferation and inhibits apoptosis of esophageal squamous cell carcinoma through activating STAT3 pathway. Journal of experimental & clinical cancer research : CR. vol 38. issue 1. 2020-02-10. PMID:31438989. |
s1pr1 promotes proliferation and inhibits apoptosis of esophageal squamous cell carcinoma through activating stat3 pathway. |
2020-02-10 |
2023-08-13 |
Not clear |
| Haeri Lee, Ae Jin Jeong, Sang-Kyu Y. Highlighted STAT3 as a potential drug target for cancer therapy. BMB reports. vol 52. issue 7. 2020-02-04. PMID:31186087. |
signal transducer and activator of transcription 3 (stat3) is a cytoplasmic transcription factor that regulates cell proliferation, differentiation, apoptosis, angiogenesis, inflammation and immune responses. |
2020-02-04 |
2023-08-13 |
human |
| Hyejin Ko, Jong Hyun Lee, Hyun Su Kim, Taewoo Kim, Young Taek Han, Young-Ger Suh, Jaemoo Chun, Yeong Shik Kim, Kwang Seok Ah. Novel Galiellalactone Analogues Can Target STAT3 Phosphorylation and Cause Apoptosis in Triple-Negative Breast Cancer. Biomolecules. vol 9. issue 5. 2020-01-30. PMID:31058868. |
novel galiellalactone analogues can target stat3 phosphorylation and cause apoptosis in triple-negative breast cancer. |
2020-01-30 |
2023-08-13 |
Not clear |
| Hyejin Ko, Jong Hyun Lee, Hyun Su Kim, Taewoo Kim, Young Taek Han, Young-Ger Suh, Jaemoo Chun, Yeong Shik Kim, Kwang Seok Ah. Novel Galiellalactone Analogues Can Target STAT3 Phosphorylation and Cause Apoptosis in Triple-Negative Breast Cancer. Biomolecules. vol 9. issue 5. 2020-01-30. PMID:31058868. |
moreover, sg-1721 not only inhibited nuclear translocation and dna binding of stat3 but also induced apoptosis, and decreased expression of diverse oncogenic proteins. |
2020-01-30 |
2023-08-13 |
Not clear |