| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aleksandra Adamska, Alice Domenichini, Emily Capone, Verena Damiani, Begum Gokcen Akkaya, Kenneth J Linton, Pierluigi Di Sebastiano, Xi Chen, Adam B Keeton, Veronica Ramirez-Alcantara, Yulia Maxuitenko, Gary A Piazza, Vincenzo De Laurenzi, Gianluca Sala, Marco Falasc. Pharmacological inhibition of ABCC3 slows tumour progression in animal models of pancreatic cancer. Journal of experimental & clinical cancer research : CR. vol 38. issue 1. 2020-01-09. PMID:31378204. |
abcc3-mediated regulation of pdac cell proliferation and tumour growth in vivo was demonstrated and was shown to be conferred by upregulation of stat3 signalling and regulation of apoptosis. |
2020-01-09 |
2023-08-13 |
Not clear |
| Jiajun Chen, Yue Zhou, Xiangyu Zhou, Jia Li, Feng Liu, Qingwei Zho. Inhibitory effects of plasmid small interfering RNA targeting signal transducer and activator of transcription‑3 in C6 glioma cells. Molecular medicine reports. vol 20. issue 3. 2020-01-06. PMID:31322201. |
the current study investigated the effect of plasmid small interfering rna (psirna)‑mediated silencing of signal transducer and activator of transcription‑3 (stat3) on the invasion, apoptosis, and expression levels of cyclin d1, caspase‑3 and b‑cell lymphoma‑2 (bcl‑2) in c6 glioma cells. |
2020-01-06 |
2023-08-13 |
Not clear |
| Tae-Rin Min, Hyun-Ji Park, Ki-Tae Ha, Gyoo-Yong Chi, Yung-Hyun Choi, Shin-Hyung Par. Suppression of EGFR/STAT3 activity by lupeol contributes to the induction of the apoptosis of human non‑small cell lung cancer cells. International journal of oncology. vol 55. issue 1. 2019-12-20. PMID:31115519. |
the constitutive activation of stat3 by stat3 y705d overexpression suppressed lupeol‑induced apoptosis, demonstrating that the inhibition of stat3 activity contributed to the induction of apoptosis. |
2019-12-20 |
2023-08-13 |
human |
| Senthil Kumaran Satyanarayanan, Driss El Kebir, Soaad Soboh, Sergei Butenko, Meriem Sekheri, Janan Saadi, Neta Peled, Simaan Assi, Amira Othman, Sagie Schif-Zuck, Yonatan Feuermann, Dalit Barkan, Noa Sher, János G Filep, Amiram Arie. IFN-β is a macrophage-derived effector cytokine facilitating the resolution of bacterial inflammation. Nature communications. vol 10. issue 1. 2019-12-16. PMID:31375662. |
stat3 signalling in response to ifn-β promotes apoptosis of human pmns. |
2019-12-16 |
2023-08-13 |
mouse |
| Wenda Zhang, Wenying Yu, Guiping Cai, Jiawen Zhu, Chao Zhang, Shanshan Li, Jianpeng Guo, Guoping Yin, Chen Chen, Lingyi Kon. A new synthetic derivative of cryptotanshinone KYZ3 as STAT3 inhibitor for triple-negative breast cancer therapy. Cell death & disease. vol 9. issue 11. 2019-12-10. PMID:30368518. |
a stat3 plasmid transfecting assay suggested that kyz3 induced tumor cell apoptosis mainly by targeting stat3. |
2019-12-10 |
2023-08-13 |
Not clear |
| Deok Yong Sim, Hyo-Jung Lee, Ji Hoon Jung, Eunji Im, Jisung Hwang, Dong Sub Kim, Sung-Hoon Ki. Suppression of STAT3 Phosphorylation and RelA/p65 Acetylation Mediated by MicroRNA134 Plays a Pivotal Role in the Apoptotic Effect of Lambertianic Acid. International journal of molecular sciences. vol 20. issue 12. 2019-12-10. PMID:31248140. |
overall, these findings suggest that la induced apoptosis via the mirna-134 mediated inhibition of stat3 and rela/p65 acetylation. |
2019-12-10 |
2023-08-13 |
Not clear |
| Xinlin Sun, Jihui Wang, Min Huang, Taoliang Chen, Jiansheng Chen, Fabing Zhang, Huijun Zeng, Zhimin Xu, Yiquan K. STAT3 promotes tumour progression in glioma by inducing FOXP1 transcription. Journal of cellular and molecular medicine. vol 22. issue 11. 2019-12-09. PMID:30134017. |
this paper investigated the effects of stat3 through promoting foxp1 transcription on proliferation, apoptosis and invasion in glioma cells. |
2019-12-09 |
2023-08-13 |
Not clear |
| Jia-Ru Wang, Gui-Nan Shen, Ying-Hua Luo, Xian-Ji Piao, Yi Zhang, Hao Wang, Jin-Qian Li, Wan-Ting Xu, Yu Zhang, Shi-Nong Wang, Tong Zhang, Hui Xue, Long-Kui Cao, Cheng-Hao Ji. 2-(4-methoxyphenylthio)-5,8-dimethoxy-1,4-naphthoquinone induces apoptosis via ROS-mediated MAPK and STAT3 signaling pathway in human gastric cancer cells. Journal of chemotherapy (Florence, Italy). vol 31. issue 4. 2019-12-09. PMID:31074342. |
2-(4-methoxyphenylthio)-5,8-dimethoxy-1,4-naphthoquinone induces apoptosis via ros-mediated mapk and stat3 signaling pathway in human gastric cancer cells. |
2019-12-09 |
2023-08-13 |
human |
| Jia-Ru Wang, Gui-Nan Shen, Ying-Hua Luo, Xian-Ji Piao, Yi Zhang, Hao Wang, Jin-Qian Li, Wan-Ting Xu, Yu Zhang, Shi-Nong Wang, Tong Zhang, Hui Xue, Long-Kui Cao, Cheng-Hao Ji. 2-(4-methoxyphenylthio)-5,8-dimethoxy-1,4-naphthoquinone induces apoptosis via ROS-mediated MAPK and STAT3 signaling pathway in human gastric cancer cells. Journal of chemotherapy (Florence, Italy). vol 31. issue 4. 2019-12-09. PMID:31074342. |
these findings showed that mptdmnq induced ags cell apoptosis via ros-mediated mapk and stat3 signaling pathways. |
2019-12-09 |
2023-08-13 |
human |
| Ying Huang, Zhe Chen, Yu Wang, Xin Ba, Yao Huang, Pan Shen, Hui Wang, Shenghao T. Triptolide exerts an anti-tumor effect on non‑small cell lung cancer cells by inhibiting activation of the IL‑6/STAT3 axis. International journal of molecular medicine. vol 44. issue 1. 2019-11-27. PMID:31115521. |
evidence indicates that stat3 participates in the initiation and progression of lung cancer during cell proliferation, apoptosis and migration; however, whether and how tp affects stat3 and its targets remain unclear. |
2019-11-27 |
2023-08-13 |
Not clear |
| Ying Huang, Zhe Chen, Yu Wang, Xin Ba, Yao Huang, Pan Shen, Hui Wang, Shenghao T. Triptolide exerts an anti-tumor effect on non‑small cell lung cancer cells by inhibiting activation of the IL‑6/STAT3 axis. International journal of molecular medicine. vol 44. issue 1. 2019-11-27. PMID:31115521. |
tp decreased the phosphorylation of stat3, inhibited stat3 translocation into the nucleus, and reduced the expression of stat3 target genes involved in cell survival, apoptosis and migration, e.g. |
2019-11-27 |
2023-08-13 |
Not clear |
| Yue Chen, Ming Ji, Shen Zhang, Nina Xue, Heng Xu, Songwen Lin, Xiaoguang Che. Bt354 as a new STAT3 signaling pathway inhibitor against triple negative breast cancer. Journal of drug targeting. vol 26. issue 10. 2019-11-25. PMID:29595328. |
furthermore, bt354 inhibited the nuclear translocation of stat3 and consequently induced cell growth inhibition, apoptosis and cell cycle g2/m arrest in triple negative breast cancer cells. |
2019-11-25 |
2023-08-13 |
mouse |
| Jamal Mohammadian, Mehdi Sabzichi, Ommoleila Molavi, Dariush Shanehbandi, Nasser Samad. Combined Treatment with Stattic and Docetaxel Alters the Bax/Bcl-2 Gene Expression Ratio in Human Prostate Cancer Cells Asian Pacific journal of cancer prevention : APJCP. vol 17. issue 11. 2019-11-20. PMID:28032735. |
our results suggest that combination of a stat3 inhibitorwith doctaxel can be considered as a potent strategy for induction of apoptosis via increasing bax mrna expression. |
2019-11-20 |
2023-08-13 |
human |
| Chun-Yu Liu, Ling-Ming Tseng, Jung-Chen Su, Kung-Chi Chang, Pei-Yi Chu, Wei-Tien Tai, Chung-Wai Shiau, Kuen-Feng Che. Erratum to: Novel sorafenib analogues induce apoptosis through SHP-1 dependent STAT3 inactivation in human breast cancer cells. Breast cancer research : BCR. vol 19. issue 1. 2019-11-20. PMID:28077164. |
erratum to: novel sorafenib analogues induce apoptosis through shp-1 dependent stat3 inactivation in human breast cancer cells. |
2019-11-20 |
2023-08-13 |
human |
| Zhong Ren, Wenshuang Zou, Junfeng Cui, Luping Liu, Yang Qing, Yongmei L. Geraniin suppresses tumor cell growth and triggers apoptosis in human glioma via inhibition of STAT3 signaling. Cytotechnology. vol 69. issue 5. 2019-11-20. PMID:28374108. |
geraniin suppresses tumor cell growth and triggers apoptosis in human glioma via inhibition of stat3 signaling. |
2019-11-20 |
2023-08-13 |
mouse |
| Zhong Ren, Wenshuang Zou, Junfeng Cui, Luping Liu, Yang Qing, Yongmei L. Geraniin suppresses tumor cell growth and triggers apoptosis in human glioma via inhibition of STAT3 signaling. Cytotechnology. vol 69. issue 5. 2019-11-20. PMID:28374108. |
overexpression of constitutively active stat3 significantly (p < 0.05) reversed geraniin-mediated growth suppression and apoptosis, which was accompanied by restoration of bcl-xl, mcl-1, bcl-2, and cyclin d1 expression. |
2019-11-20 |
2023-08-13 |
mouse |
| Peng Gao, Na Niu, Tianshu Wei, Hideto Tozawa, Xiaocui Chen, Caiqing Zhang, Jiandong Zhang, Youichiro Wada, Carolyn M Kapron, Ju Li. The roles of signal transducer and activator of transcription factor 3 in tumor angiogenesis. Oncotarget. vol 8. issue 40. 2019-11-20. PMID:28978186. |
signal transducer and activator of transcription factor 3 (stat3) is a transcription factor that regulates a variety of cellular events including proliferation, differentiation and apoptosis. |
2019-11-20 |
2023-08-13 |
Not clear |
| Fang Tian, Xiawen Yang, Ying Liu, Xiao Yuan, Tianli Fan, Fanmiao Zhang, Jimin Zhao, Jing Lu, Yanan Jiang, Ziming Dong, Yili Yan. Constitutive activated STAT3 is an essential regulator and therapeutic target in esophageal squamous cell carcinoma. Oncotarget. vol 8. issue 51. 2019-11-20. PMID:29179470. |
inhibition of stat3 also suppressed the growth and colony formation, and induced apoptosis in the esophageal squamous cell carcinoma cells containing constitutively activated stat3. |
2019-11-20 |
2023-08-13 |
Not clear |
| Mihwa Kim, Liza D Morales, Minwoo Baek, Thomas J Slaga, John DiGiovanni, Dae Joon Ki. UVB-induced nuclear translocation of TC-PTP by AKT/14-3-3σ axis inhibits keratinocyte survival and proliferation. Oncotarget. vol 8. issue 53. 2019-11-20. PMID:29207596. |
overexpression of tc45/t179a in keratinocytes resulted in a decrease of uvb-induced apoptosis which corresponded to an increase in nuclear phosphorylated stat3, and cell proliferation was higher in tc45/t179a-overexpressing keratinocytes compared to control keratinocytes following uvb irradiation. |
2019-11-20 |
2023-08-13 |
Not clear |
| Lee-Han Kim, Sachita Khadka, Ji-Ae Shin, Ji-Youn Jung, Mi-Heon Ryu, Hyun-Ju Yu, Hae Nim Lee, Boonsil Jang, In-Hyoung Yang, Dong-Hoon Won, Hye-Jeong Kwon, Joseph H Jeong, Seong Doo Hong, Nam-Pyo Cho, Sung-Dae Ch. Nitidine chloride acts as an apoptosis inducer in human oral cancer cells and a nude mouse xenograft model via inhibition of STAT3. Oncotarget. vol 8. issue 53. 2019-11-20. PMID:29207645. |
nitidine chloride acts as an apoptosis inducer in human oral cancer cells and a nude mouse xenograft model via inhibition of stat3. |
2019-11-20 |
2023-08-13 |
mouse |