| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hao Yu, Qun Zhong, Yali Xia, Enchun Li, Shufang Wang, Rong Re. MicroRNA-2861 targets STAT3 and MMP2 to regulate the proliferation and apoptosis of ectopic endometrial cells in endometriosis. Die Pharmazie. vol 74. issue 4. 2019-06-14. PMID:30940310. |
microrna-2861 targets stat3 and mmp2 to regulate the proliferation and apoptosis of ectopic endometrial cells in endometriosis. |
2019-06-14 |
2023-08-13 |
Not clear |
| Hao Yu, Qun Zhong, Yali Xia, Enchun Li, Shufang Wang, Rong Re. MicroRNA-2861 targets STAT3 and MMP2 to regulate the proliferation and apoptosis of ectopic endometrial cells in endometriosis. Die Pharmazie. vol 74. issue 4. 2019-06-14. PMID:30940310. |
additionally, stat3 and mmp2 were confirmed as the targets of mir-2861, and the effects of knockdown of stat3 or mmp2on regulating cell proliferation and apoptosis were opposite with inhibition of mir-2861. |
2019-06-14 |
2023-08-13 |
Not clear |
| Danesh H Sopariwala, Vikas Yadav, Pierre-Marie Badin, Neah Likhite, Megha Sheth, Sabina Lorca, Isabelle K Vila, Eun Ran Kim, Qingchun Tong, Min Sup Song, George G Rodney, Vihang A Narka. Long-term PGC1β overexpression leads to apoptosis, autophagy and muscle wasting. Scientific reports. vol 7. issue 1. 2019-06-11. PMID:28860475. |
concurrently, pgc1β up-regulates apoptosis and/or autophagy transcriptional factors such as e2f1, atf3, stat1, and stat3, which may be facilitating myopathy. |
2019-06-11 |
2023-08-13 |
mouse |
| Jianying Jin, Qunyi Guo, Jingjing Xie, Dan Jin, Yanan Zh. Combination of MEK Inhibitor and the JAK2-STAT3 Pathway Inhibition for the Therapy of Colon Cancer. Pathology oncology research : POR. vol 25. issue 2. 2019-06-10. PMID:30706361. |
in vitro, we examined the hct116 cell viability by cck8, cell apoptosis by flow cytometry; western blot measured p-erk, p-jak2, p-stat3 and stat3 expression. |
2019-06-10 |
2023-08-13 |
mouse |
| Jesse M Mast, Dan Tse, Kevin Shee, M Lakshmi Kuppusamy, Maciej M Kmiec, Tamás Kálai, Periannan Kuppusam. Diarylidenylpiperidones, H-4073 and HO-3867, Induce G2/M Cell-Cycle Arrest, Apoptosis and Inhibit STAT3 Phosphorylation in Human Pancreatic Cancer Cells. Cell biochemistry and biophysics. vol 77. issue 2. 2019-06-10. PMID:31089934. |
diarylidenylpiperidones, h-4073 and ho-3867, induce g2/m cell-cycle arrest, apoptosis and inhibit stat3 phosphorylation in human pancreatic cancer cells. |
2019-06-10 |
2023-08-13 |
human |
| Jesse M Mast, Dan Tse, Kevin Shee, M Lakshmi Kuppusamy, Maciej M Kmiec, Tamás Kálai, Periannan Kuppusam. Diarylidenylpiperidones, H-4073 and HO-3867, Induce G2/M Cell-Cycle Arrest, Apoptosis and Inhibit STAT3 Phosphorylation in Human Pancreatic Cancer Cells. Cell biochemistry and biophysics. vol 77. issue 2. 2019-06-10. PMID:31089934. |
we found that both the compounds exhibited potential cytotoxicity to aspc-1 cells by inducing g2/m cell-cycle arrest, apoptosis, and cell death, by mitochondrial damage and inhibition of stat3 phosphorylation. |
2019-06-10 |
2023-08-13 |
human |
| Jesse M Mast, Dan Tse, Kevin Shee, M Lakshmi Kuppusamy, Maciej M Kmiec, Tamás Kálai, Periannan Kuppusam. Diarylidenylpiperidones, H-4073 and HO-3867, Induce G2/M Cell-Cycle Arrest, Apoptosis and Inhibit STAT3 Phosphorylation in Human Pancreatic Cancer Cells. Cell biochemistry and biophysics. vol 77. issue 2. 2019-06-10. PMID:31089934. |
in summary, h-4073 and ho-3867 are cytotoxic to aspc-1 cells and seem to act through similar mechanisms, including stat3 inhibition, cell-cycle arrest, and apoptosis. |
2019-06-10 |
2023-08-13 |
human |
| Zhi Lan Guo, Jing Zhe Li, Yan Yan Ma, Dan Qian, Ju Ying Zhong, Meng Meng Jin, Peng Huang, Lu Yang Che, Bing Pan, Yi Wang, Zhen Xiao Sun, Chang Zhen Li. Shikonin sensitizes A549 cells to TRAIL-induced apoptosis through the JNK, STAT3 and AKT pathways. BMC cell biology. vol 19. issue 1. 2019-05-31. PMID:30594131. |
shikonin sensitizes a549 cells to trail-induced apoptosis through the jnk, stat3 and akt pathways. |
2019-05-31 |
2023-08-13 |
human |
| Lihua Liu, Linlin Liu, Sijing L. lncRNA H19 promotes viability and epithelial-mesenchymal transition of lung adenocarcinoma cells by targeting miR-29b-3p and modifying STAT3. International journal of oncology. vol 54. issue 3. 2019-05-29. PMID:30747209. |
ultimately, stat3 was identified to decrease lung adenocarcinoma cell viability, survival, apoptosis and emt imposed by mir‑29b‑3p. |
2019-05-29 |
2023-08-13 |
human |
| Ying Zhou, Jing Yang, Qilin Zhang, Qihua Xu, Lihua Lu, Jiening Wang, Wei Xi. P4HB knockdown induces human HT29 colon cancer cell apoptosis through the generation of reactive oxygen species and inactivation of STAT3 signaling. Molecular medicine reports. vol 19. issue 1. 2019-05-28. PMID:30431122. |
p4hb knockdown induces human ht29 colon cancer cell apoptosis through the generation of reactive oxygen species and inactivation of stat3 signaling. |
2019-05-28 |
2023-08-13 |
human |
| Ying Zhou, Jing Yang, Qilin Zhang, Qihua Xu, Lihua Lu, Jiening Wang, Wei Xi. P4HB knockdown induces human HT29 colon cancer cell apoptosis through the generation of reactive oxygen species and inactivation of STAT3 signaling. Molecular medicine reports. vol 19. issue 1. 2019-05-28. PMID:30431122. |
in conclusion, these findings suggested that p4hb knockdown may induce ht29 human colon cancer cell apoptosis through the generation of ros and inactivation of the stat3 signaling pathway. |
2019-05-28 |
2023-08-13 |
human |
| Kilmer S McCull. Homocysteine, Thioretinaco Ozonide, and Oxidative Phosphorylation in Cancer and Aging: A Proposed Clinical Trial Protocol. Methods in molecular biology (Clifton, N.J.). vol 1866. 2019-05-27. PMID:30725425. |
a deficiency of dietary sulfur amino acids downregulates cystathionine synthase, causing hyperhomocysteinemia.the organic sulfur compound diallyl trisulfide increases hydrogen sulfide production from homocysteine in animal models, inhibits stat3 signaling in cancer stem cells, and produces apoptosis of malignant cells. |
2019-05-27 |
2023-08-13 |
human |
| Kilmer S McCull. Homocysteine, Thioretinaco Ozonide, and Oxidative Phosphorylation in Cancer and Aging: A Proposed Clinical Trial Protocol. Methods in molecular biology (Clifton, N.J.). vol 1866. 2019-05-27. PMID:30725425. |
the furanonaphthoquinone compound napabucasin inhibits stat3 signaling and causes mitochondrial dysfunction, decreased oxidative phosphorylation, and apoptosis of malignant cells. |
2019-05-27 |
2023-08-13 |
human |
| Yue Wang, Ying-Hua Luo, Xian-Ji Piao, Gui-Nan Shen, Ling-Qi Meng, Yi Zhang, Jia-Ru Wang, Jin-Qian Li, Hao Wang, Wan-Ting Xu, Yang Liu, Yu Zhang, Tong Zhang, Shi-Nong Wang, Hu-Nan Sun, Ying-Hao Han, Mei-Hua Jin, Yan-Qing Zang, Dong-Jie Zhang, Cheng-Hao Ji. Novel 1,4‑naphthoquinone derivatives induce reactive oxygen species‑mediated apoptosis in liver cancer cells. Molecular medicine reports. vol 19. issue 3. 2019-05-24. PMID:30592276. |
epdmnq and endmnq induced apoptosis by upregulating the protein expression of p38 mapk and c‑jun n‑terminal kinase and downregulating extracellular signal‑regulated kinase and stat3; these effects were inhibited by nac. |
2019-05-24 |
2023-08-13 |
Not clear |
| Yue Wang, Ying-Hua Luo, Xian-Ji Piao, Gui-Nan Shen, Ling-Qi Meng, Yi Zhang, Jia-Ru Wang, Jin-Qian Li, Hao Wang, Wan-Ting Xu, Yang Liu, Yu Zhang, Tong Zhang, Shi-Nong Wang, Hu-Nan Sun, Ying-Hao Han, Mei-Hua Jin, Yan-Qing Zang, Dong-Jie Zhang, Cheng-Hao Ji. Novel 1,4‑naphthoquinone derivatives induce reactive oxygen species‑mediated apoptosis in liver cancer cells. Molecular medicine reports. vol 19. issue 3. 2019-05-24. PMID:30592276. |
the results of the present study demonstrated that epdmnq and endmnq induced apoptosis through ros‑modulated mapk and stat3 signaling pathways in hep3b cells. |
2019-05-24 |
2023-08-13 |
Not clear |
| Sneha Dhapare, Hua Li, Masahiro Sakagam. Salvianolic acid B as an anti-emphysema agent II: In vivo reversal activities in two rat models of emphysema. Pulmonary pharmacology & therapeutics. vol 53. 2019-05-20. PMID:30193865. |
functional treadmill exercise endurance; morphological airspace enlargement and alveolar destruction; apoptosis, cell proliferation and tissue matrix proteins; phosphorylated stat3 (pstat3) and vegf expressions; neutrophil accumulation; and lipid peroxidation were determined. |
2019-05-20 |
2023-08-13 |
rat |
| Hu-Nan Sun, Ying-Hua Luo, Ling-Qi Meng, Xian-Ji Piao, Yue Wang, Jia-Ru Wang, Hao Wang, Yi Zhang, Jin-Qian Li, Wan-Ting Xu, Yang Liu, Yu Zhang, Tong Zhang, Ying-Hao Han, Mei-Hua Jin, Gui-Nan Shen, Yan-Qing Zang, Long-Kui Cao, Dong-Jie Zhang, Cheng-Hao Ji. Cryptotanshinone induces reactive oxygen species‑mediated apoptosis in human rheumatoid arthritis fibroblast‑like synoviocytes. International journal of molecular medicine. vol 43. issue 2. 2019-05-20. PMID:30535477. |
western blotting was used to assess the expression levels of proteins associated with apoptosis and with the mitogen‑activated protein kinase (mapk), protein kinase b (akt), and signal transducer and activator of transcription‑3 (stat3) signaling pathways. |
2019-05-20 |
2023-08-13 |
human |
| Hu-Nan Sun, Ying-Hua Luo, Ling-Qi Meng, Xian-Ji Piao, Yue Wang, Jia-Ru Wang, Hao Wang, Yi Zhang, Jin-Qian Li, Wan-Ting Xu, Yang Liu, Yu Zhang, Tong Zhang, Ying-Hao Han, Mei-Hua Jin, Gui-Nan Shen, Yan-Qing Zang, Long-Kui Cao, Dong-Jie Zhang, Cheng-Hao Ji. Cryptotanshinone induces reactive oxygen species‑mediated apoptosis in human rheumatoid arthritis fibroblast‑like synoviocytes. International journal of molecular medicine. vol 43. issue 2. 2019-05-20. PMID:30535477. |
these results suggest that ros‑mediated akt, mapk and stat3 signaling pathways serve important roles in the ct‑induced apoptosis of ra‑flss. |
2019-05-20 |
2023-08-13 |
human |
| Zhuoying Wang, Jiakang Shen, Wei Sun, Tao Zhang, Dongqing Zuo, Hongsheng Wang, Gangyang Wang, Jing Xu, Fei Yin, Min Mao, Zifei Zhou, Yingqi Hua, Zhengdong Ca. Antitumor activity of Raddeanin A is mediated by Jun amino-terminal kinase activation and signal transducer and activator of transcription 3 inhibition in human osteosarcoma. Cancer science. vol 110. issue 5. 2019-05-17. PMID:30907478. |
taken together, our results show that ra suppresses proliferation and induces apoptosis by modulating the jnk/c-jun and stat3 signaling pathways in human osteosarcoma. |
2019-05-17 |
2023-08-13 |
human |
| Yanqiang Chen, Jianzhen Liu, Pei Lv, Jiangyan Gao, Mingzheng Wang, Yongjun Wan. IL-6 is involved in malignancy and doxorubicin sensitivity of renal carcinoma cells. Cell adhesion & migration. vol 12. issue 1. 2019-05-16. PMID:28328292. |
various survival factors such as the pleiotropic cytokine interleukin-6 (il-6), a major mediator of inflammation and activator of signal transducer and activator of transcription 3 (stat3), serve to block apoptosis in cancer cells. |
2019-05-16 |
2023-08-13 |
human |