| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Zhang, L-M Zheng, C-X Wang, J-M Gu, S Xu. SENP3 protects H9C2 cells from apoptosis triggered by H/R via STAT3 pathway. European review for medical and pharmacological sciences. vol 22. issue 9. 2019-11-06. PMID:29771430. |
to investigate whether senp3 protects h9c2 cells from apoptosis triggered by h/r through the signal transducer and activator of transcription 3 (stat3) pathway. |
2019-11-06 |
2023-08-13 |
Not clear |
| Lingyuan Xu, Sensen Qiu, Lehe Yang, Haitang Xu, Xu Liu, Shiqian Fan, Ri Cui, Weitao Fu, Chengguang Zhao, Liqun Shen, Liangxing Wang, Xiaoying Huan. Aminocyanopyridines as anti-lung cancer agents by inhibiting the STAT3 pathway. Molecular carcinogenesis. vol 58. issue 8. 2019-11-05. PMID:31069881. |
they blocked the constitutive stat3 phosphorylation in a dose- and time-dependent manner and regulated the transcription of stat3 target genes encoding apoptosis factors. |
2019-11-05 |
2023-08-13 |
Not clear |
| Xusheng Xie, Xiaobin Zheng, Zhifen Han, Yufeng Chen, Zhaozhu Zheng, Bin Zheng, Xiaowen He, Yongfeng Wang, David L Kaplan, Yi Li, Gang Li, Xiaoqin Wang, Ping La. A Biodegradable Stent with Surface Functionalization of Combined-Therapy Drugs for Colorectal Cancer. Advanced healthcare materials. vol 7. issue 24. 2019-10-31. PMID:30468567. |
in vitro and in vivo studies on the nanofibrous memembrane-coating demonstrate improved antitumor effects for the cur/5-fu dual drug system which can be attributed to cell cycle arrest in the s phase in association with induced apoptosis in tumor cells by blocking signal transducer and activator of transcription3 (stat3) and nuclear factor kappa beta (nf-kb) signaling pathways, suggesting potential in the treatment of crc in the future. |
2019-10-31 |
2023-08-13 |
mouse |
| Xingxing Chen, Kun Han, Gang Lin, Changxin Liu, Shanghong Wang, Xiao Shi, Zhizhen Hu, Chuxin Wu, Xiaowen Xu, Chengyu H. Ctenopharyngodon Idella STAT3 alleviates autophagy by up-regulating BCL-2 expression. Fish & shellfish immunology. vol 91. 2019-10-29. PMID:31108175. |
as a downstream target gene of stat3, bcl-2 (b-cell lymphoma 2) not only participates in regulating apoptosis, but also responds to autophagy. |
2019-10-29 |
2023-08-13 |
human |
| Young-Il Hahn, Su-Jung Kim, Bu-Young Choi, Kyung-Cho Cho, Raju Bandu, Kwang Pyo Kim, Do-Hee Kim, Wonki Kim, Joon Sung Park, Byung Woo Han, Jeewoo Lee, Hye-Kyung Na, Young-Nam Cha, Young-Joon Sur. Curcumin interacts directly with the Cysteine 259 residue of STAT3 and induces apoptosis in H-Ras transformed human mammary epithelial cells. Scientific reports. vol 8. issue 1. 2019-10-28. PMID:29686295. |
curcumin interacts directly with the cysteine 259 residue of stat3 and induces apoptosis in h-ras transformed human mammary epithelial cells. |
2019-10-28 |
2023-08-13 |
human |
| Young-Il Hahn, Su-Jung Kim, Bu-Young Choi, Kyung-Cho Cho, Raju Bandu, Kwang Pyo Kim, Do-Hee Kim, Wonki Kim, Joon Sung Park, Byung Woo Han, Jeewoo Lee, Hye-Kyung Na, Young-Nam Cha, Young-Joon Sur. Curcumin interacts directly with the Cysteine 259 residue of STAT3 and induces apoptosis in H-Ras transformed human mammary epithelial cells. Scientific reports. vol 8. issue 1. 2019-10-28. PMID:29686295. |
site-directed mutation of this cysteine residue abolished curcumin-induced inactivation of stat3 and apoptosis in h-ras mcf10a cells. |
2019-10-28 |
2023-08-13 |
human |
| Young-Il Hahn, Su-Jung Kim, Bu-Young Choi, Kyung-Cho Cho, Raju Bandu, Kwang Pyo Kim, Do-Hee Kim, Wonki Kim, Joon Sung Park, Byung Woo Han, Jeewoo Lee, Hye-Kyung Na, Young-Nam Cha, Young-Joon Sur. Curcumin interacts directly with the Cysteine 259 residue of STAT3 and induces apoptosis in H-Ras transformed human mammary epithelial cells. Scientific reports. vol 8. issue 1. 2019-10-28. PMID:29686295. |
tetrahydrocurcumin that lacks such electrophilic moiety failed to interact with stat3 and to induce apoptosis in the same cell line. |
2019-10-28 |
2023-08-13 |
human |
| Elli Narvi, Katri Vaparanta, Anna Karrila, Deepankar Chakroborty, Sakari Knuutila, Arto Pulliainen, Maria Sundvall, Klaus Eleniu. Different responses of colorectal cancer cells to alternative sequences of cetuximab and oxaliplatin. Scientific reports. vol 8. issue 1. 2019-10-28. PMID:30410004. |
in contrast, oxaliplatin-enhanced responsiveness to subsequent treatment with cetuximab was associated with increased apoptosis, inhibition of stat3 activity and increased egfr down-regulation. |
2019-10-28 |
2023-08-13 |
Not clear |
| Zhang-Ming Chen, Lei Huang, Miao-Miao Li, Lei Meng, Song-Cheng Ying, A-Man X. Inhibitory effects of isocryptotanshinone on gastric cancer. Scientific reports. vol 8. issue 1. 2019-10-09. PMID:29915371. |
together, these data indicate that icts inhibits gc proliferation by inducing g1/g0 cell cycle arrest and apoptosis via inhibiting the stat3 signaling pathway. |
2019-10-09 |
2023-08-13 |
mouse |
| Ji Eun Park, Do-Hee Kim, Eunyoung Ha, Seung Mi Choi, Joon-Seok Choi, Kyung-Soo Chun, Sang Hoon Jo. Thymoquinone induces apoptosis of human epidermoid carcinoma A431 cells through ROS-mediated suppression of STAT3. Chemico-biological interactions. vol 312. 2019-10-07. PMID:31433961. |
thymoquinone induces apoptosis of human epidermoid carcinoma a431 cells through ros-mediated suppression of stat3. |
2019-10-07 |
2023-08-13 |
mouse |
| Ji Eun Park, Do-Hee Kim, Eunyoung Ha, Seung Mi Choi, Joon-Seok Choi, Kyung-Soo Chun, Sang Hoon Jo. Thymoquinone induces apoptosis of human epidermoid carcinoma A431 cells through ROS-mediated suppression of STAT3. Chemico-biological interactions. vol 312. 2019-10-07. PMID:31433961. |
our results provide the first demonstration that tq induces the apoptosis of a431 cells through generation of ros and inhibition of stat3 signaling. |
2019-10-07 |
2023-08-13 |
mouse |
| Yanlin Song, Lei Gao, Zhongyuan Tang, Hailong Li, Bin Sun, Peng Chu, Eskandar Qaed, Xiaodong Ma, Jinyong Peng, Shisheng Wang, Min Hu, Zeyao Tan. Anticancer effect of SZC015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor κB and STAT3 in vitro and in vivo. Journal of cellular physiology. vol 234. issue 1. 2019-10-02. PMID:30078206. |
anticancer effect of szc015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor κb and stat3 in vitro and in vivo. |
2019-10-02 |
2023-08-13 |
Not clear |
| Haiyan Zhang, Xiao Jin, Yujing Diao, Lijuan Wang, Na Li, Miaomiao Che. Imatinib mesylate inhibits proliferation and promotes apoptosis of chronic myeloid leukemia cells via STAT3 pathway. Panminerva medica. 2019-10-02. PMID:31577092. |
imatinib mesylate inhibits proliferation and promotes apoptosis of chronic myeloid leukemia cells via stat3 pathway. |
2019-10-02 |
2023-08-13 |
Not clear |
| Susann Kleinsimon, Enya Longmuss, Jana Rolff, Sebastian Jäger, Angelika Eggert, Catharina Delebinski, Georg Seifer. GADD45A and CDKN1A are involved in apoptosis and cell cycle modulatory effects of viscumTT with further inactivation of the STAT3 pathway. Scientific reports. vol 8. issue 1. 2019-10-01. PMID:29636527. |
gadd45a and cdkn1a are involved in apoptosis and cell cycle modulatory effects of viscumtt with further inactivation of the stat3 pathway. |
2019-10-01 |
2023-08-13 |
Not clear |
| Aditi Shastri, Gaurav Choudhary, Margarida Teixeira, Shanisha Gordon-Mitchell, Nandini Ramachandra, Lumie Bernard, Sanchari Bhattacharyya, Robert Lopez, Kith Pradhan, Orsolya Giricz, Goutham Ravipati, Li-Fan Wong, Sally Cole, Tushar D Bhagat, Jonathan Feld, Yosman Dhar, Matthias Bartenstein, Victor J Thiruthuvanathan, Amittha Wickrema, B Hilda Ye, David A Frank, Andrea Pellagatti, Jacqueline Boultwood, Tianyuan Zhou, Youngsoo Kim, A Robert MacLeod, P K Epling-Burnette, Minwei Ye, Patricia McCoon, Richard Woessner, Ulrich Steidl, Britta Will, Amit Verm. Antisense STAT3 inhibitor decreases viability of myelodysplastic and leukemic stem cells. The Journal of clinical investigation. vol 128. issue 12. 2019-09-16. PMID:30252677. |
functionally, stat3 inhibition by a clinical, antisense oligonucleotide, azd9150, led to reduced viability and increased apoptosis in leukemic cell lines. |
2019-09-16 |
2023-08-13 |
Not clear |
| PeiPei Wang, Jian Sun, SuJun Lv, Tao Xie, XueDan Wan. Apigenin Alleviates Myocardial Reperfusion Injury in Rats by Downregulating miR-15b. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-09-10. PMID:30983593. |
rat myocardial h9c2 cells were cultured in vitro and divided into 5 treatment groups in vitro; expressions of mir-15b, jak2, p-jak2, stat3, and p-stat3 in h9c2 cells were detected, and the apoptosis and ros content were detected by flow cytometry. |
2019-09-10 |
2023-08-13 |
rat |
| Zhilin Xiao, Meifang Chen, Mei Yang, Xiaobin Che. [STAT3 inhibitor Stattic induced IL-8 production and cell apotosis in THP-1 cells by activating ERK pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 35. issue 6. 2019-09-10. PMID:31292053. |
objective to observe the effect of selectively inhibiting stat3 on the production of il-8 and cell apoptosis of thp-1 cells by stattic, and explore the underlying mechanism. |
2019-09-10 |
2023-08-13 |
Not clear |
| Zhilin Xiao, Meifang Chen, Mei Yang, Xiaobin Che. [STAT3 inhibitor Stattic induced IL-8 production and cell apotosis in THP-1 cells by activating ERK pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 35. issue 6. 2019-09-10. PMID:31292053. |
reverse transcription pcr or real-time pcr was performed to detect the mrna expression of il-8, il-6, il-1β and tumor necrosis factor-α (tnf-α); elisa was used to detect the protein expression of il-8; flow cytometry was applied to evaluate the apoptosis of thp-1 cells; and western blot analysis was performed to detect the phosphorylation of stat3 and extracellular signal-regulated kinase (erk). |
2019-09-10 |
2023-08-13 |
Not clear |
| Zhilin Xiao, Meifang Chen, Mei Yang, Xiaobin Che. [STAT3 inhibitor Stattic induced IL-8 production and cell apotosis in THP-1 cells by activating ERK pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 35. issue 6. 2019-09-10. PMID:31292053. |
conclusion stattic, a selective stat3 inhibitor, can induce the apoptosis and il-8 production by activating erk signaling pathway in thp-1 cells. |
2019-09-10 |
2023-08-13 |
Not clear |
| Lintuo Huang, Zhengxiang Huang, Wenjun Lin, Lu Wang, Xiongbai Zhu, Xin Chen, Shengwu Yang, Chen L. Salidroside suppresses the growth and invasion of human osteosarcoma cell lines MG63 and U2OS in vitro by inhibiting the JAK2/STAT3 signaling pathway. International journal of oncology. vol 54. issue 6. 2019-08-30. PMID:31081055. |
furthermore, our findings demonstrated that salidroside induced the apoptosis, g0/g1 phase arrest and suppressed the invasion of osteosarcoma cells by inhibiting the janus kinase 2 (jak2)/signal transducer and activator of transcription 3 (stat3) signaling pathway, as determined by western blot analysis. |
2019-08-30 |
2023-08-13 |
human |