| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sun Tae Hwang, Chulwon Kim, Jong Hyun Lee, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Omar H M Shair, Gautam Sethi, Kwang Seok Ah. Cycloastragenol can negate constitutive STAT3 activation and promote paclitaxel-induced apoptosis in human gastric cancer cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 59. 2019-08-29. PMID:30981183. |
cycloastragenol can negate constitutive stat3 activation and promote paclitaxel-induced apoptosis in human gastric cancer cells. |
2019-08-29 |
2023-08-13 |
human |
| Ryota Kondo, Kousuke Ishino, Ryuichi Wada, Hideyuki Takata, Wei-Xia Peng, Mitsuhiro Kudo, Shoko Kure, Yohei Kaneya, Nobuhiko Taniai, Hiroshi Yoshida, Zenya Nait. Downregulation of protein disulfide‑isomerase A3 expression inhibits cell proliferation and induces apoptosis through STAT3 signaling in hepatocellular carcinoma. International journal of oncology. vol 54. issue 4. 2019-08-16. PMID:30720090. |
downregulation of protein disulfide‑isomerase a3 expression inhibits cell proliferation and induces apoptosis through stat3 signaling in hepatocellular carcinoma. |
2019-08-16 |
2023-08-13 |
Not clear |
| Ryota Kondo, Kousuke Ishino, Ryuichi Wada, Hideyuki Takata, Wei-Xia Peng, Mitsuhiro Kudo, Shoko Kure, Yohei Kaneya, Nobuhiko Taniai, Hiroshi Yoshida, Zenya Nait. Downregulation of protein disulfide‑isomerase A3 expression inhibits cell proliferation and induces apoptosis through STAT3 signaling in hepatocellular carcinoma. International journal of oncology. vol 54. issue 4. 2019-08-16. PMID:30720090. |
the knockdown of pdia3 decreased the levels of phosphorylated stat3 (p‑stat3; tyr705) and downstream proteins of the stat3 signaling pathway: the anti‑apoptotic proteins (bcl‑2‑like protein 1, induced myeloid leukemia cell differentiation protein mcl‑1, survivin and x‑linked inhibitor of apoptosis protein). |
2019-08-16 |
2023-08-13 |
Not clear |
| Liwen Fang, Mingming Liu, Linling Ca. [Hederagenin inhibits proliferation and promotes apoptosis of cervical cancer CaSki cells by blocking STAT3 pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 35. issue 2. 2019-08-15. PMID:30975278. |
[hederagenin inhibits proliferation and promotes apoptosis of cervical cancer caski cells by blocking stat3 pathway]. |
2019-08-15 |
2023-08-13 |
Not clear |
| Christian Lis, Stefan Rubner, Martin Roatsch, Angela Berg, Tyler Gilcrest, Darwin Fu, Elizabeth Nguyen, Anne-Marie Schmidt, Harald Krautscheid, Jens Meiler, Thorsten Ber. Development of Erasin: a chromone-based STAT3 inhibitor which induces apoptosis in Erlotinib-resistant lung cancer cells. Scientific reports. vol 7. issue 1. 2019-08-12. PMID:29234062. |
development of erasin: a chromone-based stat3 inhibitor which induces apoptosis in erlotinib-resistant lung cancer cells. |
2019-08-12 |
2023-08-13 |
Not clear |
| Christian Lis, Stefan Rubner, Martin Roatsch, Angela Berg, Tyler Gilcrest, Darwin Fu, Elizabeth Nguyen, Anne-Marie Schmidt, Harald Krautscheid, Jens Meiler, Thorsten Ber. Development of Erasin: a chromone-based STAT3 inhibitor which induces apoptosis in Erlotinib-resistant lung cancer cells. Scientific reports. vol 7. issue 1. 2019-08-12. PMID:29234062. |
our work validates chromone-based acylhydrazones as privileged structures for antagonizing stat sh2 domains, and demonstrates that apoptosis can be induced in nsclc cells with acquired erlotinib resistance by direct inhibition of stat3. |
2019-08-12 |
2023-08-13 |
Not clear |
| Shijun Hu, Daobin Cheng, Dingtian Peng, Jing Tan, Yanlan Huang, Chunyong Che. Leptin attenuates cerebral ischemic injury in rats by modulating the mitochondrial electron transport chain via the mitochondrial STAT3 pathway. Brain and behavior. vol 9. issue 2. 2019-08-12. PMID:30632310. |
during stress, stat3 regulates mitochondrial oxidative stress and reduces apoptosis. |
2019-08-12 |
2023-08-13 |
rat |
| Manoj Kumar Jena, Shalini Jaswal, Sudarshan Kumar, Ashok Kumar Mohant. Molecular mechanism of mammary gland involution: An update. Developmental biology. vol 445. issue 2. 2019-07-30. PMID:30448440. |
the involution stage includes interesting physiological processes such as mec apoptosis, matrix remodeling, and the generation of cells regaining the shape of a virgin mg. signal transducer and activator of transcription 3 (stat3) is the established master regulator of this process and aberrant expression of stat3 leads to subnormal involution and may induce neoplasia. |
2019-07-30 |
2023-08-13 |
Not clear |
| Li Wang, Yuan Wang, Chao Zhang, Jingjing Li, Yuan Meng, Man Dou, Constance Tom Noguchi, Lijun D. Inhibiting Glycogen Synthase Kinase 3 Reverses Obesity-Induced White Adipose Tissue Inflammation by Regulating Apoptosis Inhibitor of Macrophage/CD5L-Mediated Macrophage Migration. Arteriosclerosis, thrombosis, and vascular biology. vol 38. issue 9. 2019-07-19. PMID:30026270. |
these anti-inflammatory effects of gsk3 inhibition were found to be driven, at least in part, by inhibiting production of apoptosis inhibitor of macrophage in macrophages via inactivating stat3 to reduce free fatty acid and chemokine level produced from vat to suppress the migration/chemotaxis of macrophages and monocytes. |
2019-07-19 |
2023-08-13 |
mouse |
| Huilin Liu, Min Wei, Guoxia Wan. [miR-98-5p promotes apoptosis and inhibits migration by reducing the level of STAT3 in A549 cells]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 34. issue 6. 2019-07-08. PMID:30236205. |
[mir-98-5p promotes apoptosis and inhibits migration by reducing the level of stat3 in a549 cells]. |
2019-07-08 |
2023-08-13 |
human |
| Hao Yu, Qun Zhong, Yali Xia, Enchun Li, Shufang Wang, Rong Re. MicroRNA-2861 targets STAT3 and MMP2 to regulate the proliferation and apoptosis of ectopic endometrial cells in endometriosis. Die Pharmazie. vol 74. issue 4. 2019-06-14. PMID:30940310. |
microrna-2861 targets stat3 and mmp2 to regulate the proliferation and apoptosis of ectopic endometrial cells in endometriosis. |
2019-06-14 |
2023-08-13 |
Not clear |
| Hao Yu, Qun Zhong, Yali Xia, Enchun Li, Shufang Wang, Rong Re. MicroRNA-2861 targets STAT3 and MMP2 to regulate the proliferation and apoptosis of ectopic endometrial cells in endometriosis. Die Pharmazie. vol 74. issue 4. 2019-06-14. PMID:30940310. |
additionally, stat3 and mmp2 were confirmed as the targets of mir-2861, and the effects of knockdown of stat3 or mmp2on regulating cell proliferation and apoptosis were opposite with inhibition of mir-2861. |
2019-06-14 |
2023-08-13 |
Not clear |
| Danesh H Sopariwala, Vikas Yadav, Pierre-Marie Badin, Neah Likhite, Megha Sheth, Sabina Lorca, Isabelle K Vila, Eun Ran Kim, Qingchun Tong, Min Sup Song, George G Rodney, Vihang A Narka. Long-term PGC1β overexpression leads to apoptosis, autophagy and muscle wasting. Scientific reports. vol 7. issue 1. 2019-06-11. PMID:28860475. |
concurrently, pgc1β up-regulates apoptosis and/or autophagy transcriptional factors such as e2f1, atf3, stat1, and stat3, which may be facilitating myopathy. |
2019-06-11 |
2023-08-13 |
mouse |
| Jianying Jin, Qunyi Guo, Jingjing Xie, Dan Jin, Yanan Zh. Combination of MEK Inhibitor and the JAK2-STAT3 Pathway Inhibition for the Therapy of Colon Cancer. Pathology oncology research : POR. vol 25. issue 2. 2019-06-10. PMID:30706361. |
in vitro, we examined the hct116 cell viability by cck8, cell apoptosis by flow cytometry; western blot measured p-erk, p-jak2, p-stat3 and stat3 expression. |
2019-06-10 |
2023-08-13 |
mouse |
| Jesse M Mast, Dan Tse, Kevin Shee, M Lakshmi Kuppusamy, Maciej M Kmiec, Tamás Kálai, Periannan Kuppusam. Diarylidenylpiperidones, H-4073 and HO-3867, Induce G2/M Cell-Cycle Arrest, Apoptosis and Inhibit STAT3 Phosphorylation in Human Pancreatic Cancer Cells. Cell biochemistry and biophysics. vol 77. issue 2. 2019-06-10. PMID:31089934. |
diarylidenylpiperidones, h-4073 and ho-3867, induce g2/m cell-cycle arrest, apoptosis and inhibit stat3 phosphorylation in human pancreatic cancer cells. |
2019-06-10 |
2023-08-13 |
human |
| Jesse M Mast, Dan Tse, Kevin Shee, M Lakshmi Kuppusamy, Maciej M Kmiec, Tamás Kálai, Periannan Kuppusam. Diarylidenylpiperidones, H-4073 and HO-3867, Induce G2/M Cell-Cycle Arrest, Apoptosis and Inhibit STAT3 Phosphorylation in Human Pancreatic Cancer Cells. Cell biochemistry and biophysics. vol 77. issue 2. 2019-06-10. PMID:31089934. |
we found that both the compounds exhibited potential cytotoxicity to aspc-1 cells by inducing g2/m cell-cycle arrest, apoptosis, and cell death, by mitochondrial damage and inhibition of stat3 phosphorylation. |
2019-06-10 |
2023-08-13 |
human |
| Jesse M Mast, Dan Tse, Kevin Shee, M Lakshmi Kuppusamy, Maciej M Kmiec, Tamás Kálai, Periannan Kuppusam. Diarylidenylpiperidones, H-4073 and HO-3867, Induce G2/M Cell-Cycle Arrest, Apoptosis and Inhibit STAT3 Phosphorylation in Human Pancreatic Cancer Cells. Cell biochemistry and biophysics. vol 77. issue 2. 2019-06-10. PMID:31089934. |
in summary, h-4073 and ho-3867 are cytotoxic to aspc-1 cells and seem to act through similar mechanisms, including stat3 inhibition, cell-cycle arrest, and apoptosis. |
2019-06-10 |
2023-08-13 |
human |
| Zhi Lan Guo, Jing Zhe Li, Yan Yan Ma, Dan Qian, Ju Ying Zhong, Meng Meng Jin, Peng Huang, Lu Yang Che, Bing Pan, Yi Wang, Zhen Xiao Sun, Chang Zhen Li. Shikonin sensitizes A549 cells to TRAIL-induced apoptosis through the JNK, STAT3 and AKT pathways. BMC cell biology. vol 19. issue 1. 2019-05-31. PMID:30594131. |
shikonin sensitizes a549 cells to trail-induced apoptosis through the jnk, stat3 and akt pathways. |
2019-05-31 |
2023-08-13 |
human |
| Lihua Liu, Linlin Liu, Sijing L. lncRNA H19 promotes viability and epithelial-mesenchymal transition of lung adenocarcinoma cells by targeting miR-29b-3p and modifying STAT3. International journal of oncology. vol 54. issue 3. 2019-05-29. PMID:30747209. |
ultimately, stat3 was identified to decrease lung adenocarcinoma cell viability, survival, apoptosis and emt imposed by mir‑29b‑3p. |
2019-05-29 |
2023-08-13 |
human |
| Ying Zhou, Jing Yang, Qilin Zhang, Qihua Xu, Lihua Lu, Jiening Wang, Wei Xi. P4HB knockdown induces human HT29 colon cancer cell apoptosis through the generation of reactive oxygen species and inactivation of STAT3 signaling. Molecular medicine reports. vol 19. issue 1. 2019-05-28. PMID:30431122. |
p4hb knockdown induces human ht29 colon cancer cell apoptosis through the generation of reactive oxygen species and inactivation of stat3 signaling. |
2019-05-28 |
2023-08-13 |
human |