| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wan-Ting Xu, Gui-Nan Shen, Ying-Hua Luo, Xian-Ji Piao, Jia-Ru Wang, Hao Wang, Yi Zhang, Jin-Qian Li, Yu-Chao Feng, Yu Zhang, Tong Zhang, Shi-Nong Wang, Chang-Yuan Wang, Cheng-Hao Ji. New naphthalene derivatives induce human lung cancer A549 cell apoptosis via ROS-mediated MAPKs, Akt, and STAT3 signaling pathways. Chemico-biological interactions. vol 304. 2019-05-13. PMID:30871965. |
new naphthalene derivatives induce human lung cancer a549 cell apoptosis via ros-mediated mapks, akt, and stat3 signaling pathways. |
2019-05-13 |
2023-08-13 |
human |
| Wan-Ting Xu, Gui-Nan Shen, Ying-Hua Luo, Xian-Ji Piao, Jia-Ru Wang, Hao Wang, Yi Zhang, Jin-Qian Li, Yu-Chao Feng, Yu Zhang, Tong Zhang, Shi-Nong Wang, Chang-Yuan Wang, Cheng-Hao Ji. New naphthalene derivatives induce human lung cancer A549 cell apoptosis via ROS-mediated MAPKs, Akt, and STAT3 signaling pathways. Chemico-biological interactions. vol 304. 2019-05-13. PMID:30871965. |
in conclusion, bsq and osq induce human lung cancer a549 cell apoptosis by ros-mediated mapks, akt, and stat3 signaling pathways. |
2019-05-13 |
2023-08-13 |
human |
| Elena Butturini, Flora Cozzolino, Diana Boriero, Alessandra Carcereri de Prati, Maria Monti, Michele Rossin, Diana Canetti, Barbara Cellini, Piero Pucci, Sofia Mariott. S-glutathionylation exerts opposing roles in the regulation of STAT1 and STAT3 signaling in reactive microglia. Free radical biology & medicine. vol 117. 2019-05-08. PMID:29427792. |
stat1 and stat3 are two transcription factors involved in a lot of cellular functions such as immune response, proliferation, apoptosis, and cell survival. |
2019-05-08 |
2023-08-13 |
Not clear |
| Elena Butturini, Flora Cozzolino, Diana Boriero, Alessandra Carcereri de Prati, Maria Monti, Michele Rossin, Diana Canetti, Barbara Cellini, Piero Pucci, Sofia Mariott. S-glutathionylation exerts opposing roles in the regulation of STAT1 and STAT3 signaling in reactive microglia. Free radical biology & medicine. vol 117. 2019-05-08. PMID:29427792. |
a number of literature evidences described a yin-yang relationship between activation of stat1 and stat3 in neurodegenerative disorders where stat1 exerts a pro-apoptotic effect whereas stat3 shows neuroprotective properties through the inhibition of apoptosis. |
2019-05-08 |
2023-08-13 |
Not clear |
| Zhe Liu, Huan Wang, Lingnan Guan, Siyi Chen, Maode La. A novel small molecular STAT3 inhibitor, 5Br-6b, induces apoptosis and inhibits migration in colorectal cancer cells. Anti-cancer drugs. vol 29. issue 5. 2019-05-08. PMID:29438179. |
a novel small molecular stat3 inhibitor, 5br-6b, induces apoptosis and inhibits migration in colorectal cancer cells. |
2019-05-08 |
2023-08-13 |
Not clear |
| Zhe Liu, Huan Wang, Lingnan Guan, Siyi Chen, Maode La. A novel small molecular STAT3 inhibitor, 5Br-6b, induces apoptosis and inhibits migration in colorectal cancer cells. Anti-cancer drugs. vol 29. issue 5. 2019-05-08. PMID:29438179. |
the results show that 5br-6b inhibits the activation of stat3, and decreases the expression of its target genes that regulate cell proliferation, migration, and apoptosis. |
2019-05-08 |
2023-08-13 |
Not clear |
| Prajna Guha, Jillian Gardell, Josephine Darpolor, Marissa Cunetta, Matthew Lima, George Miller, N Joseph Espat, Richard P Junghans, Steven C Kat. STAT3 inhibition induces Bax-dependent apoptosis in liver tumor myeloid-derived suppressor cells. Oncogene. vol 38. issue 4. 2019-05-08. PMID:30158673. |
stat3 inhibition induces bax-dependent apoptosis in liver tumor myeloid-derived suppressor cells. |
2019-05-08 |
2023-08-13 |
mouse |
| Prajna Guha, Jillian Gardell, Josephine Darpolor, Marissa Cunetta, Matthew Lima, George Miller, N Joseph Espat, Richard P Junghans, Steven C Kat. STAT3 inhibition induces Bax-dependent apoptosis in liver tumor myeloid-derived suppressor cells. Oncogene. vol 38. issue 4. 2019-05-08. PMID:30158673. |
these findings represent a previously unrecognized link between stat3 inhibition and fas-induced apoptosis of mdscs. |
2019-05-08 |
2023-08-13 |
mouse |
| Xiuli Ding, Jiadong Chi, Xue Yang, Jian Hao, Chang Liu, Cuihong Zhu, Xiaodong Wang, Xiaohui Liu, Yangyang Niu, Wei Ji, Dan Chen, Xiongzhi W. Cucurbitacin B synergistically enhances the apoptosis-inducing effect of arsenic trioxide by inhibiting STAT3 phosphorylation in lymphoma Ramos cells. Leukemia & lymphoma. vol 58. issue 10. 2019-04-26. PMID:28278714. |
however, the therapeutic effect of ato is limited in lymphoma, which resists apoptosis possibly due to inappropriate activation of stat3. |
2019-04-26 |
2023-08-13 |
Not clear |
| Xiuli Ding, Jiadong Chi, Xue Yang, Jian Hao, Chang Liu, Cuihong Zhu, Xiaodong Wang, Xiaohui Liu, Yangyang Niu, Wei Ji, Dan Chen, Xiongzhi W. Cucurbitacin B synergistically enhances the apoptosis-inducing effect of arsenic trioxide by inhibiting STAT3 phosphorylation in lymphoma Ramos cells. Leukemia & lymphoma. vol 58. issue 10. 2019-04-26. PMID:28278714. |
dramatically, cucurbitacin b (cub), an effective component of the dichloromethane extraction from trichosanthes kirilowii maxim, synergistically eliminated the apoptosis resistance of burkitt's lymphoma ramos cells to ato by inhibiting the phosphorylation of stat3, followed in turn by downregulation of bcl-2 and upregulation of bax. |
2019-04-26 |
2023-08-13 |
Not clear |
| Gaowu Hu, Wei Pen, Ming Wan. TRIM14 Promotes Breast Cancer Cell Proliferation by Inhibiting Apoptosis. Oncology research. vol 27. issue 4. 2019-04-23. PMID:29562956. |
additionally, cryptotanshinone, a stat3 inhibitor, inhibited cell proliferation but increased cell apoptosis in the bt474 and mda-mb-231 cell lines. |
2019-04-23 |
2023-08-13 |
human |
| Naveen A Mallangada, Joselin M Vargas, Swaroopa Thomas, Matthew G DiGiovanni, Brandon M Vaeth, Matthew D Nemesure, Ruixue Wang, Joseph F LaComb, Jennie L Williams, Lorne M Golub, Francis Johnson, Gerardo G Mackenzi. A novel tricarbonylmethane agent (CMC2.24) reduces human pancreatic tumor growth in mice by targeting Ras. Molecular carcinogenesis. vol 57. issue 9. 2019-04-22. PMID:29683208. |
in addition, downstream of erk, cmc2.24 inhibited stat3 phosphorylation levels at the serine 727 residue, enhanced the levels of superoxide anion in mitochondria, and induced intrinsic apoptosis as shown by the release of cytochrome c from the mitochondria to the cytosol and the further cleavage of caspase 9 in pc cells. |
2019-04-22 |
2023-08-13 |
mouse |
| You Lang Zhou, Luzhong Zhang, Zhou Zhou, Wei Liu, Yang Lu, Shumin He, Yajuan Cui, Yongwei Qin, Minhui Hu. Antibody Modified Nanoparticle-Mediated Delivery of miR-124 Regulates Apoptosis via Repression the Stat3 Signal in Mycobacterial-Infected Microglia. Journal of biomedical nanotechnology. vol 14. issue 12. 2019-04-16. PMID:30305225. |
antibody modified nanoparticle-mediated delivery of mir-124 regulates apoptosis via repression the stat3 signal in mycobacterial-infected microglia. |
2019-04-16 |
2023-08-13 |
Not clear |
| Fatemeh Khaki-Khatibi, Marjan Ghorbani, Mehdi Sabzichi, Fatemeh Ramezani, Jamal Mohammadia. Adjuvant therapy with stattic enriches the anti-proliferative effect of doxorubicin in human ZR-75-1 breast cancer cells via arresting cell cycle and inducing apoptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 109. 2019-03-28. PMID:30551374. |
cell viability was investigated by mtt assay, the percentage of apoptosis by dapi staining, and annexin v. real time-pcr was applied to find out the correlation between mechanistic roles of the stat3 pathway and apoptotic signal in the modulation of bcl-2 and bax gene expressions axis. |
2019-03-28 |
2023-08-13 |
human |
| Maria L Valle, Janine Dworshak, Ashok Sharma, Ahmed S Ibrahim, Mohamed Al-Shabrawey, Shruti Sharm. Inhibition of interleukin-6 trans-signaling prevents inflammation and endothelial barrier disruption in retinal endothelial cells. Experimental eye research. vol 178. 2019-03-25. PMID:30240585. |
il-6 trans-signaling activation caused a significant increase in stat3 phosphorylation, expression of adhesion molecules, ros production and apoptosis in hrecs whereas a significant decrease in mitochondrial membrane potential and no production was observed in il-6 trans-signaling activated cells. |
2019-03-25 |
2023-08-13 |
human |
| Qi Yang, Wenyu Chen, Yufeng Xu, Xiaodong Lv, Ming Zhang, Hao Jian. Polyphyllin I modulates MALAT1/STAT3 signaling to induce apoptosis in gefitinib-resistant non-small cell lung cancer. Toxicology and applied pharmacology. vol 356. 2019-03-21. PMID:30076870. |
these findings suggest that, in vitro and in vivo, pp i inhibits the viability and induces apoptosis of gefitinib-resistant nsclc by down-regulating malat1 and inactivating stat3 signaling pathway. |
2019-03-21 |
2023-08-13 |
Not clear |
| Rubashruti Kanna, Gaurav Choudhary, Nandini Ramachandra, Ulrich Steidl, Amit Verma, Aditi Shastr. STAT3 inhibition as a therapeutic strategy for leukemia. Leukemia & lymphoma. vol 59. issue 9. 2019-03-18. PMID:29164994. |
stat3 is an important transcription factor that regulates cell growth, proliferation, and inhibits apoptosis. |
2019-03-18 |
2023-08-13 |
Not clear |
| Wuguo Li, Qing Zhang, Kaotan Chen, Zhenhua Sima, Jingli Liu, Qiang Yu, Jiawei Li. 2-Ethoxystypandrone, a novel small-molecule STAT3 signaling inhibitor from Polygonum cuspidatum, inhibits cell growth and induces apoptosis of HCC cells and HCC Cancer stem cells. BMC complementary and alternative medicine. vol 19. issue 1. 2019-03-18. PMID:30709346. |
2-ethoxystypandrone, a novel small-molecule stat3 signaling inhibitor from polygonum cuspidatum, inhibits cell growth and induces apoptosis of hcc cells and hcc cancer stem cells. |
2019-03-18 |
2023-08-13 |
Not clear |
| Haiyan Ma, Dan Yan, Yina Wang, Wei Shi, Tianshu Liu, Chongqiang Zhao, Shengqi Huo, Jialin Duan, Jingwen Tao, Maocai Zhai, Pengcheng Luo, Junyi Guo, Lei Tian, Lulu Mageta, David Jou, Cuntai Zhang, Chenglong Li, Jiayuh Lin, Jiagao Lv, Sheng Li, Li Li. Bazedoxifene exhibits growth suppressive activity by targeting interleukin-6/glycoprotein 130/signal transducer and activator of transcription 3 signaling in hepatocellular carcinoma. Cancer science. vol 110. issue 3. 2019-03-08. PMID:30648776. |
our data showed that baz inhibited stat3 phosphorylation (p-stat3) and expression of stat3 downstream genes, inducing apoptosis in liver cancer cells. |
2019-03-08 |
2023-08-13 |
mouse |
| Amara Maryam, Tahir Mehmood, He Zhang, Yongming Li, Muhammad Khan, Tonghui M. Alantolactone induces apoptosis, promotes STAT3 glutathionylation and enhances chemosensitivity of A549 lung adenocarcinoma cells to doxorubicin via oxidative stress. Scientific reports. vol 7. issue 1. 2019-03-06. PMID:28740138. |
alantolactone induces apoptosis, promotes stat3 glutathionylation and enhances chemosensitivity of a549 lung adenocarcinoma cells to doxorubicin via oxidative stress. |
2019-03-06 |
2023-08-13 |
Not clear |