| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ji Eun Park, Do-Hee Kim, Eunyoung Ha, Seung Mi Choi, Joon-Seok Choi, Kyung-Soo Chun, Sang Hoon Jo. Thymoquinone induces apoptosis of human epidermoid carcinoma A431 cells through ROS-mediated suppression of STAT3. Chemico-biological interactions. vol 312. 2019-10-07. PMID:31433961. |
our results provide the first demonstration that tq induces the apoptosis of a431 cells through generation of ros and inhibition of stat3 signaling. |
2019-10-07 |
2023-08-13 |
mouse |
| Yanlin Song, Lei Gao, Zhongyuan Tang, Hailong Li, Bin Sun, Peng Chu, Eskandar Qaed, Xiaodong Ma, Jinyong Peng, Shisheng Wang, Min Hu, Zeyao Tan. Anticancer effect of SZC015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor κB and STAT3 in vitro and in vivo. Journal of cellular physiology. vol 234. issue 1. 2019-10-02. PMID:30078206. |
anticancer effect of szc015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor κb and stat3 in vitro and in vivo. |
2019-10-02 |
2023-08-13 |
Not clear |
| Haiyan Zhang, Xiao Jin, Yujing Diao, Lijuan Wang, Na Li, Miaomiao Che. Imatinib mesylate inhibits proliferation and promotes apoptosis of chronic myeloid leukemia cells via STAT3 pathway. Panminerva medica. 2019-10-02. PMID:31577092. |
imatinib mesylate inhibits proliferation and promotes apoptosis of chronic myeloid leukemia cells via stat3 pathway. |
2019-10-02 |
2023-08-13 |
Not clear |
| Susann Kleinsimon, Enya Longmuss, Jana Rolff, Sebastian Jäger, Angelika Eggert, Catharina Delebinski, Georg Seifer. GADD45A and CDKN1A are involved in apoptosis and cell cycle modulatory effects of viscumTT with further inactivation of the STAT3 pathway. Scientific reports. vol 8. issue 1. 2019-10-01. PMID:29636527. |
gadd45a and cdkn1a are involved in apoptosis and cell cycle modulatory effects of viscumtt with further inactivation of the stat3 pathway. |
2019-10-01 |
2023-08-13 |
Not clear |
| Aditi Shastri, Gaurav Choudhary, Margarida Teixeira, Shanisha Gordon-Mitchell, Nandini Ramachandra, Lumie Bernard, Sanchari Bhattacharyya, Robert Lopez, Kith Pradhan, Orsolya Giricz, Goutham Ravipati, Li-Fan Wong, Sally Cole, Tushar D Bhagat, Jonathan Feld, Yosman Dhar, Matthias Bartenstein, Victor J Thiruthuvanathan, Amittha Wickrema, B Hilda Ye, David A Frank, Andrea Pellagatti, Jacqueline Boultwood, Tianyuan Zhou, Youngsoo Kim, A Robert MacLeod, P K Epling-Burnette, Minwei Ye, Patricia McCoon, Richard Woessner, Ulrich Steidl, Britta Will, Amit Verm. Antisense STAT3 inhibitor decreases viability of myelodysplastic and leukemic stem cells. The Journal of clinical investigation. vol 128. issue 12. 2019-09-16. PMID:30252677. |
functionally, stat3 inhibition by a clinical, antisense oligonucleotide, azd9150, led to reduced viability and increased apoptosis in leukemic cell lines. |
2019-09-16 |
2023-08-13 |
Not clear |
| PeiPei Wang, Jian Sun, SuJun Lv, Tao Xie, XueDan Wan. Apigenin Alleviates Myocardial Reperfusion Injury in Rats by Downregulating miR-15b. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-09-10. PMID:30983593. |
rat myocardial h9c2 cells were cultured in vitro and divided into 5 treatment groups in vitro; expressions of mir-15b, jak2, p-jak2, stat3, and p-stat3 in h9c2 cells were detected, and the apoptosis and ros content were detected by flow cytometry. |
2019-09-10 |
2023-08-13 |
rat |
| Zhilin Xiao, Meifang Chen, Mei Yang, Xiaobin Che. [STAT3 inhibitor Stattic induced IL-8 production and cell apotosis in THP-1 cells by activating ERK pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 35. issue 6. 2019-09-10. PMID:31292053. |
objective to observe the effect of selectively inhibiting stat3 on the production of il-8 and cell apoptosis of thp-1 cells by stattic, and explore the underlying mechanism. |
2019-09-10 |
2023-08-13 |
Not clear |
| Zhilin Xiao, Meifang Chen, Mei Yang, Xiaobin Che. [STAT3 inhibitor Stattic induced IL-8 production and cell apotosis in THP-1 cells by activating ERK pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 35. issue 6. 2019-09-10. PMID:31292053. |
reverse transcription pcr or real-time pcr was performed to detect the mrna expression of il-8, il-6, il-1β and tumor necrosis factor-α (tnf-α); elisa was used to detect the protein expression of il-8; flow cytometry was applied to evaluate the apoptosis of thp-1 cells; and western blot analysis was performed to detect the phosphorylation of stat3 and extracellular signal-regulated kinase (erk). |
2019-09-10 |
2023-08-13 |
Not clear |
| Zhilin Xiao, Meifang Chen, Mei Yang, Xiaobin Che. [STAT3 inhibitor Stattic induced IL-8 production and cell apotosis in THP-1 cells by activating ERK pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 35. issue 6. 2019-09-10. PMID:31292053. |
conclusion stattic, a selective stat3 inhibitor, can induce the apoptosis and il-8 production by activating erk signaling pathway in thp-1 cells. |
2019-09-10 |
2023-08-13 |
Not clear |
| Lintuo Huang, Zhengxiang Huang, Wenjun Lin, Lu Wang, Xiongbai Zhu, Xin Chen, Shengwu Yang, Chen L. Salidroside suppresses the growth and invasion of human osteosarcoma cell lines MG63 and U2OS in vitro by inhibiting the JAK2/STAT3 signaling pathway. International journal of oncology. vol 54. issue 6. 2019-08-30. PMID:31081055. |
furthermore, our findings demonstrated that salidroside induced the apoptosis, g0/g1 phase arrest and suppressed the invasion of osteosarcoma cells by inhibiting the janus kinase 2 (jak2)/signal transducer and activator of transcription 3 (stat3) signaling pathway, as determined by western blot analysis. |
2019-08-30 |
2023-08-13 |
human |
| Sun Tae Hwang, Chulwon Kim, Jong Hyun Lee, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Omar H M Shair, Gautam Sethi, Kwang Seok Ah. Cycloastragenol can negate constitutive STAT3 activation and promote paclitaxel-induced apoptosis in human gastric cancer cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 59. 2019-08-29. PMID:30981183. |
cycloastragenol can negate constitutive stat3 activation and promote paclitaxel-induced apoptosis in human gastric cancer cells. |
2019-08-29 |
2023-08-13 |
human |
| Ryota Kondo, Kousuke Ishino, Ryuichi Wada, Hideyuki Takata, Wei-Xia Peng, Mitsuhiro Kudo, Shoko Kure, Yohei Kaneya, Nobuhiko Taniai, Hiroshi Yoshida, Zenya Nait. Downregulation of protein disulfide‑isomerase A3 expression inhibits cell proliferation and induces apoptosis through STAT3 signaling in hepatocellular carcinoma. International journal of oncology. vol 54. issue 4. 2019-08-16. PMID:30720090. |
downregulation of protein disulfide‑isomerase a3 expression inhibits cell proliferation and induces apoptosis through stat3 signaling in hepatocellular carcinoma. |
2019-08-16 |
2023-08-13 |
Not clear |
| Ryota Kondo, Kousuke Ishino, Ryuichi Wada, Hideyuki Takata, Wei-Xia Peng, Mitsuhiro Kudo, Shoko Kure, Yohei Kaneya, Nobuhiko Taniai, Hiroshi Yoshida, Zenya Nait. Downregulation of protein disulfide‑isomerase A3 expression inhibits cell proliferation and induces apoptosis through STAT3 signaling in hepatocellular carcinoma. International journal of oncology. vol 54. issue 4. 2019-08-16. PMID:30720090. |
the knockdown of pdia3 decreased the levels of phosphorylated stat3 (p‑stat3; tyr705) and downstream proteins of the stat3 signaling pathway: the anti‑apoptotic proteins (bcl‑2‑like protein 1, induced myeloid leukemia cell differentiation protein mcl‑1, survivin and x‑linked inhibitor of apoptosis protein). |
2019-08-16 |
2023-08-13 |
Not clear |
| Liwen Fang, Mingming Liu, Linling Ca. [Hederagenin inhibits proliferation and promotes apoptosis of cervical cancer CaSki cells by blocking STAT3 pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 35. issue 2. 2019-08-15. PMID:30975278. |
[hederagenin inhibits proliferation and promotes apoptosis of cervical cancer caski cells by blocking stat3 pathway]. |
2019-08-15 |
2023-08-13 |
Not clear |
| Christian Lis, Stefan Rubner, Martin Roatsch, Angela Berg, Tyler Gilcrest, Darwin Fu, Elizabeth Nguyen, Anne-Marie Schmidt, Harald Krautscheid, Jens Meiler, Thorsten Ber. Development of Erasin: a chromone-based STAT3 inhibitor which induces apoptosis in Erlotinib-resistant lung cancer cells. Scientific reports. vol 7. issue 1. 2019-08-12. PMID:29234062. |
development of erasin: a chromone-based stat3 inhibitor which induces apoptosis in erlotinib-resistant lung cancer cells. |
2019-08-12 |
2023-08-13 |
Not clear |
| Christian Lis, Stefan Rubner, Martin Roatsch, Angela Berg, Tyler Gilcrest, Darwin Fu, Elizabeth Nguyen, Anne-Marie Schmidt, Harald Krautscheid, Jens Meiler, Thorsten Ber. Development of Erasin: a chromone-based STAT3 inhibitor which induces apoptosis in Erlotinib-resistant lung cancer cells. Scientific reports. vol 7. issue 1. 2019-08-12. PMID:29234062. |
our work validates chromone-based acylhydrazones as privileged structures for antagonizing stat sh2 domains, and demonstrates that apoptosis can be induced in nsclc cells with acquired erlotinib resistance by direct inhibition of stat3. |
2019-08-12 |
2023-08-13 |
Not clear |
| Shijun Hu, Daobin Cheng, Dingtian Peng, Jing Tan, Yanlan Huang, Chunyong Che. Leptin attenuates cerebral ischemic injury in rats by modulating the mitochondrial electron transport chain via the mitochondrial STAT3 pathway. Brain and behavior. vol 9. issue 2. 2019-08-12. PMID:30632310. |
during stress, stat3 regulates mitochondrial oxidative stress and reduces apoptosis. |
2019-08-12 |
2023-08-13 |
rat |
| Manoj Kumar Jena, Shalini Jaswal, Sudarshan Kumar, Ashok Kumar Mohant. Molecular mechanism of mammary gland involution: An update. Developmental biology. vol 445. issue 2. 2019-07-30. PMID:30448440. |
the involution stage includes interesting physiological processes such as mec apoptosis, matrix remodeling, and the generation of cells regaining the shape of a virgin mg. signal transducer and activator of transcription 3 (stat3) is the established master regulator of this process and aberrant expression of stat3 leads to subnormal involution and may induce neoplasia. |
2019-07-30 |
2023-08-13 |
Not clear |
| Li Wang, Yuan Wang, Chao Zhang, Jingjing Li, Yuan Meng, Man Dou, Constance Tom Noguchi, Lijun D. Inhibiting Glycogen Synthase Kinase 3 Reverses Obesity-Induced White Adipose Tissue Inflammation by Regulating Apoptosis Inhibitor of Macrophage/CD5L-Mediated Macrophage Migration. Arteriosclerosis, thrombosis, and vascular biology. vol 38. issue 9. 2019-07-19. PMID:30026270. |
these anti-inflammatory effects of gsk3 inhibition were found to be driven, at least in part, by inhibiting production of apoptosis inhibitor of macrophage in macrophages via inactivating stat3 to reduce free fatty acid and chemokine level produced from vat to suppress the migration/chemotaxis of macrophages and monocytes. |
2019-07-19 |
2023-08-13 |
mouse |
| Huilin Liu, Min Wei, Guoxia Wan. [miR-98-5p promotes apoptosis and inhibits migration by reducing the level of STAT3 in A549 cells]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 34. issue 6. 2019-07-08. PMID:30236205. |
[mir-98-5p promotes apoptosis and inhibits migration by reducing the level of stat3 in a549 cells]. |
2019-07-08 |
2023-08-13 |
human |