| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying Huang, Zhe Chen, Yu Wang, Xin Ba, Yao Huang, Pan Shen, Hui Wang, Shenghao T. Triptolide exerts an anti-tumor effect on non‑small cell lung cancer cells by inhibiting activation of the IL‑6/STAT3 axis. International journal of molecular medicine. vol 44. issue 1. 2019-11-27. PMID:31115521. |
tp decreased the phosphorylation of stat3, inhibited stat3 translocation into the nucleus, and reduced the expression of stat3 target genes involved in cell survival, apoptosis and migration, e.g. |
2019-11-27 |
2023-08-13 |
Not clear |
| Yue Chen, Ming Ji, Shen Zhang, Nina Xue, Heng Xu, Songwen Lin, Xiaoguang Che. Bt354 as a new STAT3 signaling pathway inhibitor against triple negative breast cancer. Journal of drug targeting. vol 26. issue 10. 2019-11-25. PMID:29595328. |
furthermore, bt354 inhibited the nuclear translocation of stat3 and consequently induced cell growth inhibition, apoptosis and cell cycle g2/m arrest in triple negative breast cancer cells. |
2019-11-25 |
2023-08-13 |
mouse |
| Jamal Mohammadian, Mehdi Sabzichi, Ommoleila Molavi, Dariush Shanehbandi, Nasser Samad. Combined Treatment with Stattic and Docetaxel Alters the Bax/Bcl-2 Gene Expression Ratio in Human Prostate Cancer Cells Asian Pacific journal of cancer prevention : APJCP. vol 17. issue 11. 2019-11-20. PMID:28032735. |
our results suggest that combination of a stat3 inhibitorwith doctaxel can be considered as a potent strategy for induction of apoptosis via increasing bax mrna expression. |
2019-11-20 |
2023-08-13 |
human |
| Chun-Yu Liu, Ling-Ming Tseng, Jung-Chen Su, Kung-Chi Chang, Pei-Yi Chu, Wei-Tien Tai, Chung-Wai Shiau, Kuen-Feng Che. Erratum to: Novel sorafenib analogues induce apoptosis through SHP-1 dependent STAT3 inactivation in human breast cancer cells. Breast cancer research : BCR. vol 19. issue 1. 2019-11-20. PMID:28077164. |
erratum to: novel sorafenib analogues induce apoptosis through shp-1 dependent stat3 inactivation in human breast cancer cells. |
2019-11-20 |
2023-08-13 |
human |
| Zhong Ren, Wenshuang Zou, Junfeng Cui, Luping Liu, Yang Qing, Yongmei L. Geraniin suppresses tumor cell growth and triggers apoptosis in human glioma via inhibition of STAT3 signaling. Cytotechnology. vol 69. issue 5. 2019-11-20. PMID:28374108. |
geraniin suppresses tumor cell growth and triggers apoptosis in human glioma via inhibition of stat3 signaling. |
2019-11-20 |
2023-08-13 |
mouse |
| Zhong Ren, Wenshuang Zou, Junfeng Cui, Luping Liu, Yang Qing, Yongmei L. Geraniin suppresses tumor cell growth and triggers apoptosis in human glioma via inhibition of STAT3 signaling. Cytotechnology. vol 69. issue 5. 2019-11-20. PMID:28374108. |
overexpression of constitutively active stat3 significantly (p < 0.05) reversed geraniin-mediated growth suppression and apoptosis, which was accompanied by restoration of bcl-xl, mcl-1, bcl-2, and cyclin d1 expression. |
2019-11-20 |
2023-08-13 |
mouse |
| Peng Gao, Na Niu, Tianshu Wei, Hideto Tozawa, Xiaocui Chen, Caiqing Zhang, Jiandong Zhang, Youichiro Wada, Carolyn M Kapron, Ju Li. The roles of signal transducer and activator of transcription factor 3 in tumor angiogenesis. Oncotarget. vol 8. issue 40. 2019-11-20. PMID:28978186. |
signal transducer and activator of transcription factor 3 (stat3) is a transcription factor that regulates a variety of cellular events including proliferation, differentiation and apoptosis. |
2019-11-20 |
2023-08-13 |
Not clear |
| Fang Tian, Xiawen Yang, Ying Liu, Xiao Yuan, Tianli Fan, Fanmiao Zhang, Jimin Zhao, Jing Lu, Yanan Jiang, Ziming Dong, Yili Yan. Constitutive activated STAT3 is an essential regulator and therapeutic target in esophageal squamous cell carcinoma. Oncotarget. vol 8. issue 51. 2019-11-20. PMID:29179470. |
inhibition of stat3 also suppressed the growth and colony formation, and induced apoptosis in the esophageal squamous cell carcinoma cells containing constitutively activated stat3. |
2019-11-20 |
2023-08-13 |
Not clear |
| Mihwa Kim, Liza D Morales, Minwoo Baek, Thomas J Slaga, John DiGiovanni, Dae Joon Ki. UVB-induced nuclear translocation of TC-PTP by AKT/14-3-3σ axis inhibits keratinocyte survival and proliferation. Oncotarget. vol 8. issue 53. 2019-11-20. PMID:29207596. |
overexpression of tc45/t179a in keratinocytes resulted in a decrease of uvb-induced apoptosis which corresponded to an increase in nuclear phosphorylated stat3, and cell proliferation was higher in tc45/t179a-overexpressing keratinocytes compared to control keratinocytes following uvb irradiation. |
2019-11-20 |
2023-08-13 |
Not clear |
| Lee-Han Kim, Sachita Khadka, Ji-Ae Shin, Ji-Youn Jung, Mi-Heon Ryu, Hyun-Ju Yu, Hae Nim Lee, Boonsil Jang, In-Hyoung Yang, Dong-Hoon Won, Hye-Jeong Kwon, Joseph H Jeong, Seong Doo Hong, Nam-Pyo Cho, Sung-Dae Ch. Nitidine chloride acts as an apoptosis inducer in human oral cancer cells and a nude mouse xenograft model via inhibition of STAT3. Oncotarget. vol 8. issue 53. 2019-11-20. PMID:29207645. |
nitidine chloride acts as an apoptosis inducer in human oral cancer cells and a nude mouse xenograft model via inhibition of stat3. |
2019-11-20 |
2023-08-13 |
mouse |
| Yuan Xiang, Xing-Hua Liao, Jia-Peng Li, Hui Li, Huan Qin, Ao Yao, Cheng-Xi Yu, Peng Hu, Wei Guo, Chao-Jiang Gu, Tong-Cun Zhan. Myocardin and Stat3 act synergistically to inhibit cardiomyocyte apoptosis. Oncotarget. vol 8. issue 59. 2019-11-20. PMID:29245928. |
myocardin and stat3 act synergistically to inhibit cardiomyocyte apoptosis. |
2019-11-20 |
2023-08-13 |
rat |
| Yuan Xiang, Xing-Hua Liao, Jia-Peng Li, Hui Li, Huan Qin, Ao Yao, Cheng-Xi Yu, Peng Hu, Wei Guo, Chao-Jiang Gu, Tong-Cun Zhan. Myocardin and Stat3 act synergistically to inhibit cardiomyocyte apoptosis. Oncotarget. vol 8. issue 59. 2019-11-20. PMID:29245928. |
signal transducer and activator of transcription 3 (stat3) and myocardin regulate cardiomyocyte differentiation, proliferation, and apoptosis. |
2019-11-20 |
2023-08-13 |
rat |
| Yuan Xiang, Xing-Hua Liao, Jia-Peng Li, Hui Li, Huan Qin, Ao Yao, Cheng-Xi Yu, Peng Hu, Wei Guo, Chao-Jiang Gu, Tong-Cun Zhan. Myocardin and Stat3 act synergistically to inhibit cardiomyocyte apoptosis. Oncotarget. vol 8. issue 59. 2019-11-20. PMID:29245928. |
we report a novel aspect of the cellular function of myocardin and stat3 in the regulation of cardiomyocyte apoptosis. |
2019-11-20 |
2023-08-13 |
rat |
| Yuan Xiang, Xing-Hua Liao, Jia-Peng Li, Hui Li, Huan Qin, Ao Yao, Cheng-Xi Yu, Peng Hu, Wei Guo, Chao-Jiang Gu, Tong-Cun Zhan. Myocardin and Stat3 act synergistically to inhibit cardiomyocyte apoptosis. Oncotarget. vol 8. issue 59. 2019-11-20. PMID:29245928. |
myocardin and stat3 synergistically inhibited staurosporine-induced cardiomyocyte apoptosis by up-regulating expression of anti-apoptotic bcl-2 and mcl-1 in neonatal rat cardiomyocytes. |
2019-11-20 |
2023-08-13 |
rat |
| Vinothkumar Rajamanickam, Heping Zhu, Chen Feng, Xi Chen, Hailun Zheng, Xiaohong Xu, Qianqian Zhang, Peng Zou, Guodong He, Xuanxuan Dai, Xi Yang, Yi Wang, Zhiguo Liu, Guang Liang, Guilong Gu. Novel allylated monocarbonyl analogs of curcumin induce mitotic arrest and apoptosis by reactive oxygen species-mediated endoplasmic reticulum stress and inhibition of STAT3. Oncotarget. vol 8. issue 60. 2019-11-20. PMID:29254150. |
novel allylated monocarbonyl analogs of curcumin induce mitotic arrest and apoptosis by reactive oxygen species-mediated endoplasmic reticulum stress and inhibition of stat3. |
2019-11-20 |
2023-08-13 |
mouse |
| Retraction: Gambogic Acid Inhibits STAT3 Phosphorylation through Activation of Protein Tyrosine Phosphatase SHP-1: Potential Role in Proliferation and Apoptosis. Cancer prevention research (Philadelphia, Pa.). vol 11. issue 9. 2019-11-20. PMID:30181122. |
retraction: gambogic acid inhibits stat3 phosphorylation through activation of protein tyrosine phosphatase shp-1: potential role in proliferation and apoptosis. |
2019-11-20 |
2023-08-13 |
Not clear |
| Seyung S Chung, Pranabananda Dutta, David Austin, Piwen Wang, Adam Awad, Jaydutt V Vadgam. Combination of resveratrol and 5-flurouracil enhanced anti-telomerase activity and apoptosis by inhibiting STAT3 and Akt signaling pathways in human colorectal cancer cells. Oncotarget. vol 9. issue 68. 2019-11-20. PMID:30250641. |
combination of resveratrol and 5-flurouracil enhanced anti-telomerase activity and apoptosis by inhibiting stat3 and akt signaling pathways in human colorectal cancer cells. |
2019-11-20 |
2023-08-13 |
human |
| Li Li, Yi Ji, Yan-Xia Ma, Liang-Qin Gao, Hong-Guang Zhou, Mian-Hua W. 6-Gingerol inhibits proliferation in gastric cancer via the STAT3 pathway in vitro. Cellular and molecular biology (Noisy-le-Grand, France). vol 65. issue 3. 2019-11-20. PMID:30942163. |
and a study on further pathways by western blot shows that gi brings about cell apoptosis by inhibiting the activation of stat3. |
2019-11-20 |
2023-08-13 |
human |
| L-L Huang, W Ra. SiRNA interfering STAT3 enhances DDP sensitivity in cervical cancer cells. European review for medical and pharmacological sciences. vol 22. issue 13. 2019-11-12. PMID:30024597. |
signal transducer and activator of transcription 3 (stat3) is an important regulatory protein in the janus kinase (jak)-signal transducer and activator of transcription (stat) pathway, which regulates cell proliferation, apoptosis, and other biological processes. |
2019-11-12 |
2023-08-13 |
Not clear |
| Y Zhang, L-M Zheng, C-X Wang, J-M Gu, S Xu. SENP3 protects H9C2 cells from apoptosis triggered by H/R via STAT3 pathway. European review for medical and pharmacological sciences. vol 22. issue 9. 2019-11-06. PMID:29771430. |
senp3 protects h9c2 cells from apoptosis triggered by h/r via stat3 pathway. |
2019-11-06 |
2023-08-13 |
Not clear |