| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ruth Herrmann, Joseph Skaf, Jeanette Roller, Christine Polednik, Ulrike Holzgrabe, Marianne Schmid. Anticancer effects of NSC‑631570 (Ukrain) in head and neck cancer cells: In vitro analysis of growth, invasion, angiogenesis and gene expression. Oncology reports. vol 43. issue 1. 2020-06-01. PMID:31789425. |
microarray analysis revealed the downregulation of genes encoding key regulators, including egfr, akt2, jak1, stat3 and ß‑catenin (ctnnb1), all of which are involved in cell proliferation, migration, angiogenesis, apoptosis as well as the radiation‑ and chemo‑resistance of hnscc. |
2020-06-01 |
2023-08-13 |
human |
| Wan-Ting Xu, Tian-Zhu Li, Shu-Mei Li, Cheng Wang, Hao Wang, Ying-Hua Luo, Xian-Ji Piao, Jia-Ru Wang, Yu Zhang, Tong Zhang, Hui Xue, Long-Kui Cao, Cheng-Hao Ji. Cytisine exerts anti-tumour effects on lung cancer cells by modulating reactive oxygen species-mediated signalling pathways. Artificial cells, nanomedicine, and biotechnology. vol 48. issue 1. 2020-06-01. PMID:31852250. |
during apoptosis, cytisine increased the phosphorylation levels of jnk, p38, and i-κb, and decreased the phosphorylation levels of erk, stat3, and nf-κb. |
2020-06-01 |
2023-08-13 |
human |
| Dingyuan Luo, Magdalena Fraga-Lauhirat, Jonathan Millings, Cristella Ho, Emily M Villarreal, Teresa C Fletchinger, James V Bonfiglio, Leyda Mata, Matthew D Nemesure, Lauren E Bartels, Ruixue Wang, Basil Rigas, Gerardo G Mackenzi. Phospho-valproic acid (MDC-1112) suppresses glioblastoma growth in preclinical models through the inhibition of STAT3 phosphorylation. Carcinogenesis. vol 40. issue 12. 2020-05-27. PMID:30994173. |
in addition, mdc-1112 reduced stat3 levels in the mitochondria and enhanced mitochondrial levels of reactive oxygen species, which triggered apoptosis. |
2020-05-27 |
2023-08-13 |
mouse |
| Fang Gan, Xuan Zhou, Yajiao Zhou, Lili Hou, Xingxiang Chen, Cuiling Pan, Kehe Huan. Nephrotoxicity instead of immunotoxicity of OTA is induced through DNMT1-dependent activation of JAK2/STAT3 signaling pathway by targeting SOCS3. Archives of toxicology. vol 93. issue 4. 2020-05-22. PMID:30923867. |
dnmt inhibitor (5-aza-2-dc), promoted socs3 expression, inhibited jak2 and stat3 expression, alleviated cytotoxicity, apoptosis and dna damage induced by ota at 4.0 µg/ml in pk15 cells. |
2020-05-22 |
2023-08-13 |
Not clear |
| Fang Gan, Xuan Zhou, Yajiao Zhou, Lili Hou, Xingxiang Chen, Cuiling Pan, Kehe Huan. Nephrotoxicity instead of immunotoxicity of OTA is induced through DNMT1-dependent activation of JAK2/STAT3 signaling pathway by targeting SOCS3. Archives of toxicology. vol 93. issue 4. 2020-05-22. PMID:30923867. |
while, in pams, 5-aza-2-dc had no effects on socs3 expression induced by ota at 4.0 µg/ml, but inhibited jak2 and stat3 expression, and alleviated cytotoxicity, apoptosis and dna damage induced by ota. |
2020-05-22 |
2023-08-13 |
Not clear |
| Fangfang Li, Haiping Zhao, Ziping Han, Rongliang Wang, Zhen Tao, Zhibin Fan, Sijia Zhang, Guangwen Li, Zhigang Chen, Yumin Lu. Xuesaitong May Protect Against Ischemic Stroke by Modulating Microglial Phenotypes and Inhibiting Neuronal Cell Apoptosis via the STAT3 Signaling Pathway. CNS & neurological disorders drug targets. vol 18. issue 2. 2020-05-13. PMID:30426907. |
xuesaitong may protect against ischemic stroke by modulating microglial phenotypes and inhibiting neuronal cell apoptosis via the stat3 signaling pathway. |
2020-05-13 |
2023-08-13 |
Not clear |
| Ying-Hua Luo, Jin-Qian Li, Yi Zhang, Jia-Ru Wang, Wan-Ting Xu, Yu Zhang, Yu-Chao Feng, Shi-Ze Li, Cheng-Hao Ji. Quinalizarin induces cycle arrest and apoptosis via reactive oxygen species-mediated signaling pathways in human melanoma A375 cells. Drug development research. vol 80. issue 8. 2020-05-07. PMID:31432559. |
quinalizarin treatment led to apoptosis of a375 cells via activation of mapk and inhibition of stat3 signaling pathways. |
2020-05-07 |
2023-08-13 |
human |
| Ying-Hua Luo, Jin-Qian Li, Yi Zhang, Jia-Ru Wang, Wan-Ting Xu, Yu Zhang, Yu-Chao Feng, Shi-Ze Li, Cheng-Hao Ji. Quinalizarin induces cycle arrest and apoptosis via reactive oxygen species-mediated signaling pathways in human melanoma A375 cells. Drug development research. vol 80. issue 8. 2020-05-07. PMID:31432559. |
in addition, quinalizarin increased the level of ros, but ros scavenger nac inhibited quinalizarin-induced apoptosis by regulating mapk and stat3 signaling pathways. |
2020-05-07 |
2023-08-13 |
human |
| Ying-Hua Luo, Jin-Qian Li, Yi Zhang, Jia-Ru Wang, Wan-Ting Xu, Yu Zhang, Yu-Chao Feng, Shi-Ze Li, Cheng-Hao Ji. Quinalizarin induces cycle arrest and apoptosis via reactive oxygen species-mediated signaling pathways in human melanoma A375 cells. Drug development research. vol 80. issue 8. 2020-05-07. PMID:31432559. |
in summary, quinalizarin induces cell cycle arrest and apoptosis via ros-mediated mapk and stat3 signaling pathways in human melanoma a375 cells, and quinalizarin may be used as a novel and effective antimelanoma therapeutic. |
2020-05-07 |
2023-08-13 |
human |
| Zongye Cai, Jian Li, Qi Zhuang, Xueming Zhang, Ancai Yuan, Lan Shen, Kang Kang, Bo Qu, Yuanjia Tang, Jun Pu, Deming Gou, Jieyan She. MiR-125a-5p ameliorates monocrotaline-induced pulmonary arterial hypertension by targeting the TGF-β1 and IL-6/STAT3 signaling pathways. Experimental & molecular medicine. vol 50. issue 4. 2020-04-20. PMID:29700287. |
taken together, these findings suggest that mir-125a-5p ameliorates mct-pah in rats, has a negative feedback regulation with tgf-β1 and il-6, and regulates the proliferation and apoptosis of pasmcs by directly targeting stat3. |
2020-04-20 |
2023-08-13 |
rat |
| Tingting Yao, Rongbiao Lu, Jun Zhang, Xingyu Fang, Li Fan, Chunxian Huang, Rongchun Lin, Zhongqiu Li. Growth arrest-specific 5 attenuates cisplatin-induced apoptosis in cervical cancer by regulating STAT3 signaling via miR-21. Journal of cellular physiology. vol 234. issue 6. 2020-04-13. PMID:30352127. |
growth arrest-specific 5 attenuates cisplatin-induced apoptosis in cervical cancer by regulating stat3 signaling via mir-21. |
2020-04-13 |
2023-08-13 |
human |
| Patrycja Kurowska, Ewa Mlyczyńska, Monika Dawid, Małgorzata Opydo-Chanek, Joelle Dupont, Agnieszka Ra. In Vitro Effects of Vaspin on Porcine Granulosa Cell Proliferation, Cell Cycle Progression, and Apoptosis by Activation of GRP78 Receptor and Several Kinase Signaling Pathways Including MAP3/1, AKT, and STAT3. International journal of molecular sciences. vol 20. issue 22. 2020-04-07. PMID:31752432. |
in vitro effects of vaspin on porcine granulosa cell proliferation, cell cycle progression, and apoptosis by activation of grp78 receptor and several kinase signaling pathways including map3/1, akt, and stat3. |
2020-04-07 |
2023-08-13 |
Not clear |
| Zi-Fei Zhou, Tuan-Wei Sun, Yun-Hao Qin, Ying-Jie Zhu, Ying-Ying Jiang, Yang Zhang, Jun-Jian Liu, Jin Wu, Shi-Sheng He, Feng Che. Selenium-doped hydroxyapatite biopapers with an anti-bone tumor effect by inducing apoptosis. Biomaterials science. vol 7. issue 12. 2020-04-01. PMID:31552923. |
the results demonstrate that se-ha/cs biopapers may inhibit the growth of hcs 2/8 and sjsa cells by synchronously inducing jnk activation and stat3 inhibition and consequently promote the apoptosis of these cells. |
2020-04-01 |
2023-08-13 |
human |
| Jianchu Wang, Libai Lu, Zongjiang Luo, Wenchuan Li, Yuan Lu, Qianli Tang, Jian P. miR-383 inhibits cell growth and promotes cell apoptosis in hepatocellular carcinoma by targeting IL-17 via STAT3 signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 120. 2020-03-31. PMID:31648164. |
mir-383 inhibits cell growth and promotes cell apoptosis in hepatocellular carcinoma by targeting il-17 via stat3 signaling pathway. |
2020-03-31 |
2023-08-13 |
Not clear |
| Yan-Qing Zang, Yan-Yu Feng, Ying-Hua Luo, Yu-Qing Zhai, Xue-Ying Ju, Yu-Chao Feng, Ya-Nan Sheng, Jia-Ru Wang, Chang-Qing Yu, Cheng-Hao Ji. Quinalizarin induces ROS‑mediated apoptosis via the MAPK, STAT3 and NF‑κB signaling pathways in human breast cancer cells. Molecular medicine reports. vol 20. issue 5. 2020-03-31. PMID:31702038. |
quinalizarin induces ros‑mediated apoptosis via the mapk, stat3 and nf‑κb signaling pathways in human breast cancer cells. |
2020-03-31 |
2023-08-13 |
human |
| Yan-Qing Zang, Yan-Yu Feng, Ying-Hua Luo, Yu-Qing Zhai, Xue-Ying Ju, Yu-Chao Feng, Ya-Nan Sheng, Jia-Ru Wang, Chang-Qing Yu, Cheng-Hao Ji. Quinalizarin induces ROS‑mediated apoptosis via the MAPK, STAT3 and NF‑κB signaling pathways in human breast cancer cells. Molecular medicine reports. vol 20. issue 5. 2020-03-31. PMID:31702038. |
the results from the present study suggested that quinalizarin induced g2/m phase cell cycle arrest and apoptosis in mcf‑7 cells through ros‑mediated mapk, stat3 and nf‑κb signaling pathways. |
2020-03-31 |
2023-08-13 |
human |
| Pei-Jun Chen, An-Quan Shang, Jian-Ping Yang, Wei-Wei Wan. microRNA-874 inhibition targeting STAT3 protects the heart from ischemia-reperfusion injury by attenuating cardiomyocyte apoptosis in a mouse model. Journal of cellular physiology. vol 234. issue 5. 2020-03-27. PMID:30370578. |
microrna-874 inhibition targeting stat3 protects the heart from ischemia-reperfusion injury by attenuating cardiomyocyte apoptosis in a mouse model. |
2020-03-27 |
2023-08-13 |
mouse |
| Pei-Jun Chen, An-Quan Shang, Jian-Ping Yang, Wei-Wei Wan. microRNA-874 inhibition targeting STAT3 protects the heart from ischemia-reperfusion injury by attenuating cardiomyocyte apoptosis in a mouse model. Journal of cellular physiology. vol 234. issue 5. 2020-03-27. PMID:30370578. |
terminal deoxynucleotidyl transferase (tdt)-mediated dutp biotin nick-end labeling (tunel) staining was used to detect cardiomyocyte apoptosis and dual luciferase reporter gene assay to identify the targeting relationship between mir-874 and stat3. |
2020-03-27 |
2023-08-13 |
mouse |
| Shengli Li, Song Yang, Bin Sun, Chunhua Han. Melatonin attenuates early brain injury after subarachnoid hemorrhage by the JAK-STAT signaling pathway. International journal of clinical and experimental pathology. vol 12. issue 3. 2020-03-25. PMID:31933900. |
mortality, neurological scores, brain edema, cell apoptosis, and the expression of jak1, stat3, and cleaved caspase-3 proteins were assayed after 24 h sah. |
2020-03-25 |
2023-08-13 |
rat |
| Jinghua Jiao, Yuheng Wang, Xiaofeng Sun, Xiaojing Jian. Midazolam induces A549 cell apoptosis International journal of clinical and experimental pathology. vol 11. issue 3. 2020-03-25. PMID:31938232. |
thus, midazolam can induce apoptosis of a549 cells by targeting stat3 via mir-520d-5p. |
2020-03-25 |
2023-08-13 |
Not clear |