| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuzo Maeda, Hiroki Takahashi, Nozomu Nakai, Takeshi Yanagita, Nanako Ando, Tomotaka Okubo, Kenta Saito, Kazuyoshi Shiga, Takahisa Hirokawa, Masayasu Hara, Hideyuki Ishiguro, Yoichi Matsuo, Shuji Takiguch. Apigenin induces apoptosis by suppressing Bcl-xl and Mcl-1 simultaneously via signal transducer and activator of transcription 3 signaling in colon cancer. International journal of oncology. vol 52. issue 5. 2020-02-24. PMID:29512707. |
the results of the current study therefore determined that apigenin induces the apoptosis of colon cancer cells by inhibiting the phosphorylation of stat3 and consequently downregulates the anti-apoptotic proteins bcl-xl and mcl-1. |
2020-02-24 |
2023-08-13 |
Not clear |
| Hanli Fan, Jianbo Li, Jiwu Wang, Zange H. Long Non-Coding RNAs (lncRNAs) Tumor-Suppressive Role of lncRNA on Chromosome 8p12 (TSLNC8) Inhibits Tumor Metastasis and Promotes Apoptosis by Regulating Interleukin 6 (IL-6)/Signal Transducer and Activator of Transcription 3 (STAT3)/Hypoxia-Inducible Factor 1-alpha (HIF-1α) Signaling Pathway in Non-Small Cell Lung Cancer. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-02-20. PMID:31601776. |
long non-coding rnas (lncrnas) tumor-suppressive role of lncrna on chromosome 8p12 (tslnc8) inhibits tumor metastasis and promotes apoptosis by regulating interleukin 6 (il-6)/signal transducer and activator of transcription 3 (stat3)/hypoxia-inducible factor 1-alpha (hif-1α) signaling pathway in non-small cell lung cancer. |
2020-02-20 |
2023-08-13 |
human |
| Lina Liu, Haoran Zhang, Hongyu Mao, Xiaohong Li, Yamin H. Exosomal miR-320d derived from adipose tissue-derived MSCs inhibits apoptosis in cardiomyocytes with atrial fibrillation (AF). Artificial cells, nanomedicine, and biotechnology. vol 47. issue 1. 2020-02-19. PMID:31591913. |
inhibition of stat3 abolished the effect of modified exosomes in cardiomyocytes, causing decreased apoptosis and increased cell viability. |
2020-02-19 |
2023-08-13 |
Not clear |
| Mengqiu Dang, Xiangjun Zeng, Buxing Chen, Hongxia Wang, Huihua Li, Yu Liu, Xiuling Zhang, Xianxian Cao, Fenghe Du, Caixia Gu. Soluble receptor for advance glycation end-products inhibits ischemia/reperfusion-induced myocardial autophagy via the STAT3 pathway. Free radical biology & medicine. vol 130. 2020-02-17. PMID:30367996. |
soluble receptor for advanced glycation end-products (srage) exerts protective effects during i/r by decreasing cardiac apoptosis, which is mediated via increasing the ubiquitin proteasome system (ups) and signal transducer and activator of transcription 3 (stat3). |
2020-02-17 |
2023-08-13 |
mouse |
| Raquel Santana da Cruz, Fabia de Oliveira Andrade, Vivian Montes de Oca Carioni, Mariana Papaléo Rosim, Mayara Lilian Paulino Miranda, Camile Castilho Fontelles, Pedro Vitoriano de Oliveira, Luis Fernando Barbisan, Inar Alves Castro, Thomas Prates On. Dietary zinc deficiency or supplementation during gestation increases breast cancer susceptibility in adult female mice offspring following a J-shaped pattern and through distinct mechanisms. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 134. 2020-02-17. PMID:31505237. |
this was accompanied by a decreased number of terminal end buds, increased cell proliferation and apoptosis, and increased tumor suppressors p21, p53 and rassf1, zfp382 and stat3 expression in mammary glands, as well as increased zinc status. |
2020-02-17 |
2023-08-13 |
mouse |
| Karolina Swiatek-Machado, Bozena Kaminsk. STAT Signaling in Glioma Cells. Advances in experimental medicine and biology. vol 1202. 2020-02-11. PMID:32034715. |
while stat1 is believed to play an important role in growth arrest and apoptosis, and to act as a tumor suppressor, stat3 and 5 are involved in promoting cell cycle progression, cellular transformation, and preventing apoptosis. |
2020-02-11 |
2023-08-13 |
human |
| Yan Liu, Yingru Zhi, Haizhu Song, Mingzhu Zong, Jun Yi, Guoxin Mao, Longbang Chen, Guichun Huan. S1PR1 promotes proliferation and inhibits apoptosis of esophageal squamous cell carcinoma through activating STAT3 pathway. Journal of experimental & clinical cancer research : CR. vol 38. issue 1. 2020-02-10. PMID:31438989. |
s1pr1 promotes proliferation and inhibits apoptosis of esophageal squamous cell carcinoma through activating stat3 pathway. |
2020-02-10 |
2023-08-13 |
Not clear |
| Haeri Lee, Ae Jin Jeong, Sang-Kyu Y. Highlighted STAT3 as a potential drug target for cancer therapy. BMB reports. vol 52. issue 7. 2020-02-04. PMID:31186087. |
signal transducer and activator of transcription 3 (stat3) is a cytoplasmic transcription factor that regulates cell proliferation, differentiation, apoptosis, angiogenesis, inflammation and immune responses. |
2020-02-04 |
2023-08-13 |
human |
| Hyejin Ko, Jong Hyun Lee, Hyun Su Kim, Taewoo Kim, Young Taek Han, Young-Ger Suh, Jaemoo Chun, Yeong Shik Kim, Kwang Seok Ah. Novel Galiellalactone Analogues Can Target STAT3 Phosphorylation and Cause Apoptosis in Triple-Negative Breast Cancer. Biomolecules. vol 9. issue 5. 2020-01-30. PMID:31058868. |
novel galiellalactone analogues can target stat3 phosphorylation and cause apoptosis in triple-negative breast cancer. |
2020-01-30 |
2023-08-13 |
Not clear |
| Hyejin Ko, Jong Hyun Lee, Hyun Su Kim, Taewoo Kim, Young Taek Han, Young-Ger Suh, Jaemoo Chun, Yeong Shik Kim, Kwang Seok Ah. Novel Galiellalactone Analogues Can Target STAT3 Phosphorylation and Cause Apoptosis in Triple-Negative Breast Cancer. Biomolecules. vol 9. issue 5. 2020-01-30. PMID:31058868. |
moreover, sg-1721 not only inhibited nuclear translocation and dna binding of stat3 but also induced apoptosis, and decreased expression of diverse oncogenic proteins. |
2020-01-30 |
2023-08-13 |
Not clear |
| Haijing Liang, Guifang Wang, Yuanyuan Liu, Guiqiu Zhao, Jiangdong Du, Xue Zha. Targeting STAT3 induces apoptosis and suppresses cell growth and invasion by inactivation of Slug signaling in retinoblastoma. International journal of clinical and experimental pathology. vol 11. issue 1. 2020-01-19. PMID:31938117. |
targeting stat3 induces apoptosis and suppresses cell growth and invasion by inactivation of slug signaling in retinoblastoma. |
2020-01-19 |
2023-08-13 |
human |
| Jia-Ru Wang, Ying-Hua Luo, Xian-Ji Piao, Yi Zhang, Yu-Chao Feng, Jin-Qian Li, Wan-Ting Xu, Yu Zhang, Tong Zhang, Shi-Nong Wang, Hui Xue, Wen-Zhong Wang, Long-Kui Cao, Cheng-Hao Ji. Mechanisms underlying isoliquiritigenin-induced apoptosis and cell cycle arrest via ROS-mediated MAPK/STAT3/NF-κB pathways in human hepatocellular carcinoma cells. Drug development research. vol 80. issue 4. 2020-01-17. PMID:30698296. |
taken together, the findings of this study indicate that isl induced hepg2 cell apoptosis via ros-mediated mapk, stat3, and nf-κb signaling pathways. |
2020-01-17 |
2023-08-13 |
human |
| T Lei, S Zhou, Q Meng, M Zhan. STAT3 signaling pathway in drug-resistant bladder cancer cell line. Journal of biological regulators and homeostatic agents. vol 33. issue 5. 2020-01-14. PMID:31912690. |
stat3 signaling pathway is related to the proliferation, apoptosis and metastasis of tumor cells. |
2020-01-14 |
2023-08-13 |
Not clear |
| Zhuoying Wang, Chongren Wang, Dongqing Zuo, Tao Zhang, Fei Yin, Zifei Zhou, Hongsheng Wang, Jing Xu, Min Mao, Gangyang Wang, Yingqi Hua, Wei Sun, Zhengdong Ca. Attenuation of STAT3 Phosphorylation Promotes Apoptosis and Chemosensitivity in Human Osteosarcoma Induced by Raddeanin A. International journal of biological sciences. vol 15. issue 3. 2020-01-13. PMID:30745853. |
attenuation of stat3 phosphorylation promotes apoptosis and chemosensitivity in human osteosarcoma induced by raddeanin a. osteosarcoma (os) is the most common primary bone malignancy in adolescents. |
2020-01-13 |
2023-08-13 |
human |
| Narjes Hendouei, Fatemeh Saghafi, Faezeh Shadfar, Seyed Jalal Hosseinimeh. Molecular mechanisms of anti-psychotic drugs for improvement of cancer treatment. European journal of pharmacology. vol 856. 2020-01-13. PMID:31108054. |
besides their medical applications, anti-psychotic drugs have other pharmacological properties which are involved in multiple intracellular functions including metabolism, cell stress, cell-cycle regulation, survival and apoptosis through modulation of cellular signaling pathways such as pi3k/akt/gsk-3β, stat3 and wingless (wnt)-related intracellular signaling. |
2020-01-13 |
2023-08-13 |
Not clear |
| Hao Wang, Ying-Hua Luo, Gui-Nan Shen, Xian-Ji Piao, Wan-Ting Xu, Yi Zhang, Jia-Ru Wang, Yu-Chao Feng, Jin-Qian Li, Yu Zhang, Tong Zhang, Shi-Nong Wang, Hui Xue, Hong-Xing Wang, Chang-Yuan Wang, Cheng-Hao Ji. Two novel 1,4‑naphthoquinone derivatives induce human gastric cancer cell apoptosis and cell cycle arrest by regulating reactive oxygen species‑mediated MAPK/Akt/STAT3 signaling pathways. Molecular medicine reports. vol 20. issue 3. 2020-01-13. PMID:31322207. |
bq and oq induced apoptosis by upregulating the protein expression of p38 and jnk and downregulating the levels of erk and stat3. |
2020-01-13 |
2023-08-13 |
human |
| Hao Wang, Ying-Hua Luo, Gui-Nan Shen, Xian-Ji Piao, Wan-Ting Xu, Yi Zhang, Jia-Ru Wang, Yu-Chao Feng, Jin-Qian Li, Yu Zhang, Tong Zhang, Shi-Nong Wang, Hui Xue, Hong-Xing Wang, Chang-Yuan Wang, Cheng-Hao Ji. Two novel 1,4‑naphthoquinone derivatives induce human gastric cancer cell apoptosis and cell cycle arrest by regulating reactive oxygen species‑mediated MAPK/Akt/STAT3 signaling pathways. Molecular medicine reports. vol 20. issue 3. 2020-01-13. PMID:31322207. |
these results demonstrated that bq and oq induced apoptosis and cell cycle arrest at the g2/m phase in ags cells by stimulating ros generation, which caused subsequent activation of mapk, akt and stat3 signaling pathways. |
2020-01-13 |
2023-08-13 |
human |
| Yen-Po Cheng, Shiming Li, Wan-Ling Chuang, Chia-Hsuan Li, Guan-Jun Chen, Ching-Chin Chang, Chi-Hung R Or, Ping-Yi Lin, Chia-Che Chan. Blockade of STAT3 Signaling Contributes to Anticancer Effect of 5-Acetyloxy-6,7,8,4'-Tetra-Methoxyflavone, a Tangeretin Derivative, on Human Glioblastoma Multiforme Cells. International journal of molecular sciences. vol 20. issue 13. 2020-01-13. PMID:31323961. |
notably, ectopic expression of dominant-active stat3 impeded 5-actmf-induced suppression of viability and clonogenicity plus apoptosis induction in gbm cells, confirming the prerequisite of stat3 blockage for the inhibitory action of 5-actmf on gbm cell survival and growth. |
2020-01-13 |
2023-08-13 |
human |
| Gui-Xiang Tan, Xin-Ning Wang, Yun-Yun Tang, Wan-Jing Cen, Zhen-Hua Li, Guo-Cai Wang, Jian-Wei Jiang, Xi-Cheng Wan. PP-22 promotes autophagy and apoptosis in the nasopharyngeal carcinoma cell line CNE-2 by inducing endoplasmic reticulum stress, downregulating STAT3 signaling, and modulating the MAPK pathway. Journal of cellular physiology. vol 234. issue 3. 2020-01-09. PMID:30191969. |
pp-22 promotes autophagy and apoptosis in the nasopharyngeal carcinoma cell line cne-2 by inducing endoplasmic reticulum stress, downregulating stat3 signaling, and modulating the mapk pathway. |
2020-01-09 |
2023-08-13 |
Not clear |
| Gui-Xiang Tan, Xin-Ning Wang, Yun-Yun Tang, Wan-Jing Cen, Zhen-Hua Li, Guo-Cai Wang, Jian-Wei Jiang, Xi-Cheng Wan. PP-22 promotes autophagy and apoptosis in the nasopharyngeal carcinoma cell line CNE-2 by inducing endoplasmic reticulum stress, downregulating STAT3 signaling, and modulating the MAPK pathway. Journal of cellular physiology. vol 234. issue 3. 2020-01-09. PMID:30191969. |
a further study showed that pp-22 also induced apoptosis by downregulating the signal transducers and activators of transcription 3 (stat3) pathway, and the inhibitory effect was also confirmed by stat3 small interfering rna. |
2020-01-09 |
2023-08-13 |
Not clear |