| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bin Zhu, Caiping Ren, Ke Du, Hecheng Zhu, Yong Ai, Fenghua Kang, Yi Luo, Weidong Liu, Lei Wang, Yang Xu, Xingjun Jiang, Yihua Zhan. Olean-28,13b-olide 2 plays a role in cisplatin-mediated apoptosis and reverses cisplatin resistance in human lung cancer through multiple signaling pathways. Biochemical pharmacology. vol 170. 2020-07-01. PMID:31541631. |
in the present study, it was demonstrated that a novel synthesized oa family compound, olean-28,13b-olide 2 (olo-2), synergistically enhanced cisplatin (cddp)-mediated apoptosis, led to the activation of caspase-3 and the generation of reactive oxygen species (ros), induced dna damage, and inhibited the activation of the extracellular-signal-regulated kinase (erk), signal transducer and activator of transcription 3 (stat3), akt and nuclear factor-κb (nf-κb) pathways in human multidrug-resistant a549/cddp lung adenocarcinoma cells. |
2020-07-01 |
2023-08-13 |
human |
| Yuki Uchihara, Reiko Komori, Kenji Tago, Hiroomi Tamura, Megumi Funakoshi-Tag. Methotrexate significantly induces apoptosis by inhibiting STAT3 activation in NPM-ALK-positive ALCL cells. Biochemical pharmacology. vol 170. 2020-07-01. PMID:31654627. |
methotrexate significantly induces apoptosis by inhibiting stat3 activation in npm-alk-positive alcl cells. |
2020-07-01 |
2023-08-13 |
Not clear |
| Yuki Uchihara, Reiko Komori, Kenji Tago, Hiroomi Tamura, Megumi Funakoshi-Tag. Methotrexate significantly induces apoptosis by inhibiting STAT3 activation in NPM-ALK-positive ALCL cells. Biochemical pharmacology. vol 170. 2020-07-01. PMID:31654627. |
in the present study, we found that low-dose methotrexate significantly induced apoptosis in transformed ba/f3 cells expressing npm-alk by inhibiting the activation of signal transducer and activator of transcription factor 3 (stat3), a critical downstream molecule of npm-alk. |
2020-07-01 |
2023-08-13 |
Not clear |
| Yuki Uchihara, Reiko Komori, Kenji Tago, Hiroomi Tamura, Megumi Funakoshi-Tag. Methotrexate significantly induces apoptosis by inhibiting STAT3 activation in NPM-ALK-positive ALCL cells. Biochemical pharmacology. vol 170. 2020-07-01. PMID:31654627. |
a co-treatment with folinic acid prevented the methotrexate-induced inhibition of stat3 activation and induction of apoptosis, suggesting that methotrexate exerts its cytotoxic effects by depleting tetrahydrofolate (thf) in transformed cells by npm-alk. |
2020-07-01 |
2023-08-13 |
Not clear |
| Yuki Uchihara, Reiko Komori, Kenji Tago, Hiroomi Tamura, Megumi Funakoshi-Tag. Methotrexate significantly induces apoptosis by inhibiting STAT3 activation in NPM-ALK-positive ALCL cells. Biochemical pharmacology. vol 170. 2020-07-01. PMID:31654627. |
furthermore, methotrexate induced the down-regulation of the anti-apoptotic protein, mcl-1, dna damage, and the activation of a p53 tumor suppressor, leading to apoptosis through the inhibition of stat3. |
2020-07-01 |
2023-08-13 |
Not clear |
| Ammara Riaz, Azhar Rasul, Ghulam Hussain, Muhammad Zubair, Khizar Samiullah, Iqra Sarfraz, Muqaddas Masood, Farhat Jabeen, Tayyaba Sultana, Salma Sultan. Eriocalyxin B induces apoptosis in human triple negative breast cancer cells via inhibiting STAT3 activation and mitochondrial dysfunction. Pakistan journal of pharmaceutical sciences. vol 32. issue 6(Supplementary). 2020-07-01. PMID:32024623. |
eriocalyxin b induces apoptosis in human triple negative breast cancer cells via inhibiting stat3 activation and mitochondrial dysfunction. |
2020-07-01 |
2023-08-13 |
human |
| Ammara Riaz, Azhar Rasul, Ghulam Hussain, Muhammad Zubair, Khizar Samiullah, Iqra Sarfraz, Muqaddas Masood, Farhat Jabeen, Tayyaba Sultana, Salma Sultan. Eriocalyxin B induces apoptosis in human triple negative breast cancer cells via inhibiting STAT3 activation and mitochondrial dysfunction. Pakistan journal of pharmaceutical sciences. vol 32. issue 6(Supplementary). 2020-07-01. PMID:32024623. |
here, we have probed the molecular mechanism of erib-induced apoptosis in tnbc (mda-mb231) cells to check whether its anticancer activity is mediated by modulation of stat3 and nf-ϰb. |
2020-07-01 |
2023-08-13 |
human |
| Ammara Riaz, Azhar Rasul, Ghulam Hussain, Muhammad Zubair, Khizar Samiullah, Iqra Sarfraz, Muqaddas Masood, Farhat Jabeen, Tayyaba Sultana, Salma Sultan. Eriocalyxin B induces apoptosis in human triple negative breast cancer cells via inhibiting STAT3 activation and mitochondrial dysfunction. Pakistan journal of pharmaceutical sciences. vol 32. issue 6(Supplementary). 2020-07-01. PMID:32024623. |
erib induced apoptosis in mda-mb231 cells via inhibiting nf-ϰbp65, stat3 phosphorylation, increasing bax/bcl-2 ratio, mmp dissipation, and activation of caspase-3. |
2020-07-01 |
2023-08-13 |
human |
| Federica Laudisi, Fabio Cherubini, Antonio Di Grazia, Vincenzo Dinallo, Davide Di Fusco, Eleonora Franzè, Angela Ortenzi, Illari Salvatori, Silvia Scaricamazza, Ivan Monteleone, Naoya Sakamoto, Giovanni Monteleone, Carmine Stolf. Progranulin sustains STAT3 hyper-activation and oncogenic function in colorectal cancer cells. Molecular oncology. vol 13. issue 10. 2020-06-29. PMID:31361391. |
progranulin physically interacts with stat3 in crc cells, and its knockdown with a specific antisense oligonucleotide (aso) inhibits stat3 activation and restrains the expression of stat3-related oncogenic proteins, thus causing cell cycle arrest and apoptosis. |
2020-06-29 |
2023-08-13 |
human |
| Muqaddas Masood, Azhar Rasul, Iqra Sarfraz, Faiza Jabeen, Sitong Liu, Xintong Liu, Wei Wei, Jiang Li, Xiaomeng L. Hispolon induces apoptosis against prostate DU145 cancer cells via modulation of mitochondrial and STAT3 pathways. Pakistan journal of pharmaceutical sciences. vol 32. issue 5(Supplementary). 2020-06-29. PMID:31894049. |
hispolon induces apoptosis against prostate du145 cancer cells via modulation of mitochondrial and stat3 pathways. |
2020-06-29 |
2023-08-13 |
Not clear |
| Muqaddas Masood, Azhar Rasul, Iqra Sarfraz, Faiza Jabeen, Sitong Liu, Xintong Liu, Wei Wei, Jiang Li, Xiaomeng L. Hispolon induces apoptosis against prostate DU145 cancer cells via modulation of mitochondrial and STAT3 pathways. Pakistan journal of pharmaceutical sciences. vol 32. issue 5(Supplementary). 2020-06-29. PMID:31894049. |
contemporaneously, these results represent that hispolon's anticancer mechanism of action proceeds via downregulating the phosphorylation of stat3 and induction of apoptosis via mitochondrial pathway. |
2020-06-29 |
2023-08-13 |
Not clear |
| Piyong Ma, Chunmei Zhang, Pengfei Huo, Yan Li, Hailing Yan. A novel role of the miR-152-3p/ERRFI1/STAT3 pathway modulates the apoptosis and inflammatory response after acute kidney injury. Journal of biochemical and molecular toxicology. 2020-06-25. PMID:32583487. |
summarily, our study confirmed that mir-152-3p could promote the expression of stat3 by targeting errfi1, aggravate cell apoptosis and inflammatory response, and thereby aggravate kidney injury in sepsis aki. |
2020-06-25 |
2023-08-13 |
rat |
| Xuehui Sun, Yun Han, Ying Liu, Yanchun Tang, Jibo Wan. Proliferation and apoptosis of rheumatoid arthritis fibroblast-like synoviocytes following signal transducer and activator of transcription 3 RNA interference delivery. Journal of cellular biochemistry. vol 120. issue 3. 2020-06-17. PMID:29236318. |
in this study, we investigated the effects of delivering small interfering rna (sirna) for efficient stat3 downregulation on propagation and apoptosis of rheumatoid arthritis fibroblast-like synoviocytes (ra-fls). |
2020-06-17 |
2023-08-13 |
Not clear |
| Rosie M Butler, Robert C McKenzie, Christine L Jones, Charlotte E Flanagan, Wesley J Woollard, Maria Demontis, Silvia Ferreira, Isabella Tosi, Susan John, Sean J Whittaker, Tracey J Mitchel. Contribution of STAT3 and RAD23B in Primary Sézary Cells to Histone Deacetylase Inhibitor FK228 Resistance. The Journal of investigative dermatology. vol 139. issue 9. 2020-06-15. PMID:30910759. |
critically, sézary cells harboring the common stat3 y640f variant were less sensitive to fk228-induced apoptosis and exogenous expression of stat3 y640f, and d661y conferred partial resistance to stat3 transcriptional inhibition by fk228 (p ≤ 0.0024). |
2020-06-15 |
2023-08-13 |
Not clear |
| Maria Boichuck, Jonathan Zorea, Moshe Elkabets, Marina Wolfson, Vadim E Fraifel. c-Met as a new marker of cellular senescence. Aging. vol 11. issue 9. 2020-06-12. PMID:31085799. |
considering the anti-apoptotic activity of akt and the involvement of stat3 in mediating the effects of proinflammatory cytokines, the findings of this study indicate that c-met could contribute through its downstream targets or partners to at least two major phenotypical features of cs - resistance to apoptosis and senescence-associated secretory phenotype. |
2020-06-12 |
2023-08-13 |
human |
| Yuki Uchihara, Tomoyuki Ohe, Tadahiko Mashino, Takayuki Kidokoro, Kenji Tago, Hiroomi Tamura, Megumi Funakoshi-Tag. N-Acetyl cysteine prevents activities of STAT3 inhibitors, Stattic and BP-1-102 independently of its antioxidant properties. Pharmacological reports : PR. vol 71. issue 6. 2020-06-11. PMID:31627175. |
inhibitors for signal transducer and activator of transcription 3 (stat3), stattic, bp-1-102, and lll12 significantly induce apoptosis in transformed ba/f3 cells expressing an oncogenic fusion protein, nucleophosmin-anaplastic lymphoma kinase (npm-alk) that induces the activation of stat3. |
2020-06-11 |
2023-08-13 |
Not clear |
| Yuki Uchihara, Tomoyuki Ohe, Tadahiko Mashino, Takayuki Kidokoro, Kenji Tago, Hiroomi Tamura, Megumi Funakoshi-Tag. N-Acetyl cysteine prevents activities of STAT3 inhibitors, Stattic and BP-1-102 independently of its antioxidant properties. Pharmacological reports : PR. vol 71. issue 6. 2020-06-11. PMID:31627175. |
we found that the antioxidant reagent, n-acetyl cysteine (nac) prevented the abilities of stattic and bp-1-102, but not lll12 to induce apoptosis in transformed cells expressing npm-alk, providing a novel problem in use of stat3 inhibitors. |
2020-06-11 |
2023-08-13 |
Not clear |
| Zhe Liu, Xianmin Ge, Yuchen Gu, Yingying Huang, Hao Liu, Meiling Yu, Yamin Li. Small molecule STAT3 inhibitor, 6Br-6a suppresses breast cancer growth in vitro and in vivo. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 121. 2020-06-04. PMID:31707351. |
signal transducer and activator of transcription 3 (stat3) protein frequently overexpressed in many malignancies and plays an essential role in regulating proliferation, apoptosis, migration and invasion in cancer cells. |
2020-06-04 |
2023-08-13 |
mouse |
| Zhe Liu, Xianmin Ge, Yuchen Gu, Yingying Huang, Hao Liu, Meiling Yu, Yamin Li. Small molecule STAT3 inhibitor, 6Br-6a suppresses breast cancer growth in vitro and in vivo. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 121. 2020-06-04. PMID:31707351. |
our data demonstrated that 6br-6a significantly induced cell cycle arrest and cell apoptosis in breast cancer via blocking the activation of stat3. |
2020-06-04 |
2023-08-13 |
mouse |
| Zhe Liu, Xianmin Ge, Yuchen Gu, Yingying Huang, Hao Liu, Meiling Yu, Yamin Li. Small molecule STAT3 inhibitor, 6Br-6a suppresses breast cancer growth in vitro and in vivo. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 121. 2020-06-04. PMID:31707351. |
in conclusion, 6br-6a effectively inhibited activation of stat3 and induced cell cycle arrest and apoptosis via regulating cyclin d1 and bcl-2 expression. |
2020-06-04 |
2023-08-13 |
mouse |