| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying Zhou, Jing Yang, Qilin Zhang, Qihua Xu, Lihua Lu, Jiening Wang, Wei Xi. P4HB knockdown induces human HT29 colon cancer cell apoptosis through the generation of reactive oxygen species and inactivation of STAT3 signaling. Molecular medicine reports. vol 19. issue 1. 2019-05-28. PMID:30431122. |
in conclusion, these findings suggested that p4hb knockdown may induce ht29 human colon cancer cell apoptosis through the generation of ros and inactivation of the stat3 signaling pathway. |
2019-05-28 |
2023-08-13 |
human |
| Kilmer S McCull. Homocysteine, Thioretinaco Ozonide, and Oxidative Phosphorylation in Cancer and Aging: A Proposed Clinical Trial Protocol. Methods in molecular biology (Clifton, N.J.). vol 1866. 2019-05-27. PMID:30725425. |
a deficiency of dietary sulfur amino acids downregulates cystathionine synthase, causing hyperhomocysteinemia.the organic sulfur compound diallyl trisulfide increases hydrogen sulfide production from homocysteine in animal models, inhibits stat3 signaling in cancer stem cells, and produces apoptosis of malignant cells. |
2019-05-27 |
2023-08-13 |
human |
| Kilmer S McCull. Homocysteine, Thioretinaco Ozonide, and Oxidative Phosphorylation in Cancer and Aging: A Proposed Clinical Trial Protocol. Methods in molecular biology (Clifton, N.J.). vol 1866. 2019-05-27. PMID:30725425. |
the furanonaphthoquinone compound napabucasin inhibits stat3 signaling and causes mitochondrial dysfunction, decreased oxidative phosphorylation, and apoptosis of malignant cells. |
2019-05-27 |
2023-08-13 |
human |
| Yue Wang, Ying-Hua Luo, Xian-Ji Piao, Gui-Nan Shen, Ling-Qi Meng, Yi Zhang, Jia-Ru Wang, Jin-Qian Li, Hao Wang, Wan-Ting Xu, Yang Liu, Yu Zhang, Tong Zhang, Shi-Nong Wang, Hu-Nan Sun, Ying-Hao Han, Mei-Hua Jin, Yan-Qing Zang, Dong-Jie Zhang, Cheng-Hao Ji. Novel 1,4‑naphthoquinone derivatives induce reactive oxygen species‑mediated apoptosis in liver cancer cells. Molecular medicine reports. vol 19. issue 3. 2019-05-24. PMID:30592276. |
epdmnq and endmnq induced apoptosis by upregulating the protein expression of p38 mapk and c‑jun n‑terminal kinase and downregulating extracellular signal‑regulated kinase and stat3; these effects were inhibited by nac. |
2019-05-24 |
2023-08-13 |
Not clear |
| Yue Wang, Ying-Hua Luo, Xian-Ji Piao, Gui-Nan Shen, Ling-Qi Meng, Yi Zhang, Jia-Ru Wang, Jin-Qian Li, Hao Wang, Wan-Ting Xu, Yang Liu, Yu Zhang, Tong Zhang, Shi-Nong Wang, Hu-Nan Sun, Ying-Hao Han, Mei-Hua Jin, Yan-Qing Zang, Dong-Jie Zhang, Cheng-Hao Ji. Novel 1,4‑naphthoquinone derivatives induce reactive oxygen species‑mediated apoptosis in liver cancer cells. Molecular medicine reports. vol 19. issue 3. 2019-05-24. PMID:30592276. |
the results of the present study demonstrated that epdmnq and endmnq induced apoptosis through ros‑modulated mapk and stat3 signaling pathways in hep3b cells. |
2019-05-24 |
2023-08-13 |
Not clear |
| Sneha Dhapare, Hua Li, Masahiro Sakagam. Salvianolic acid B as an anti-emphysema agent II: In vivo reversal activities in two rat models of emphysema. Pulmonary pharmacology & therapeutics. vol 53. 2019-05-20. PMID:30193865. |
functional treadmill exercise endurance; morphological airspace enlargement and alveolar destruction; apoptosis, cell proliferation and tissue matrix proteins; phosphorylated stat3 (pstat3) and vegf expressions; neutrophil accumulation; and lipid peroxidation were determined. |
2019-05-20 |
2023-08-13 |
rat |
| Hu-Nan Sun, Ying-Hua Luo, Ling-Qi Meng, Xian-Ji Piao, Yue Wang, Jia-Ru Wang, Hao Wang, Yi Zhang, Jin-Qian Li, Wan-Ting Xu, Yang Liu, Yu Zhang, Tong Zhang, Ying-Hao Han, Mei-Hua Jin, Gui-Nan Shen, Yan-Qing Zang, Long-Kui Cao, Dong-Jie Zhang, Cheng-Hao Ji. Cryptotanshinone induces reactive oxygen species‑mediated apoptosis in human rheumatoid arthritis fibroblast‑like synoviocytes. International journal of molecular medicine. vol 43. issue 2. 2019-05-20. PMID:30535477. |
western blotting was used to assess the expression levels of proteins associated with apoptosis and with the mitogen‑activated protein kinase (mapk), protein kinase b (akt), and signal transducer and activator of transcription‑3 (stat3) signaling pathways. |
2019-05-20 |
2023-08-13 |
human |
| Hu-Nan Sun, Ying-Hua Luo, Ling-Qi Meng, Xian-Ji Piao, Yue Wang, Jia-Ru Wang, Hao Wang, Yi Zhang, Jin-Qian Li, Wan-Ting Xu, Yang Liu, Yu Zhang, Tong Zhang, Ying-Hao Han, Mei-Hua Jin, Gui-Nan Shen, Yan-Qing Zang, Long-Kui Cao, Dong-Jie Zhang, Cheng-Hao Ji. Cryptotanshinone induces reactive oxygen species‑mediated apoptosis in human rheumatoid arthritis fibroblast‑like synoviocytes. International journal of molecular medicine. vol 43. issue 2. 2019-05-20. PMID:30535477. |
these results suggest that ros‑mediated akt, mapk and stat3 signaling pathways serve important roles in the ct‑induced apoptosis of ra‑flss. |
2019-05-20 |
2023-08-13 |
human |
| Zhuoying Wang, Jiakang Shen, Wei Sun, Tao Zhang, Dongqing Zuo, Hongsheng Wang, Gangyang Wang, Jing Xu, Fei Yin, Min Mao, Zifei Zhou, Yingqi Hua, Zhengdong Ca. Antitumor activity of Raddeanin A is mediated by Jun amino-terminal kinase activation and signal transducer and activator of transcription 3 inhibition in human osteosarcoma. Cancer science. vol 110. issue 5. 2019-05-17. PMID:30907478. |
taken together, our results show that ra suppresses proliferation and induces apoptosis by modulating the jnk/c-jun and stat3 signaling pathways in human osteosarcoma. |
2019-05-17 |
2023-08-13 |
human |
| Yanqiang Chen, Jianzhen Liu, Pei Lv, Jiangyan Gao, Mingzheng Wang, Yongjun Wan. IL-6 is involved in malignancy and doxorubicin sensitivity of renal carcinoma cells. Cell adhesion & migration. vol 12. issue 1. 2019-05-16. PMID:28328292. |
various survival factors such as the pleiotropic cytokine interleukin-6 (il-6), a major mediator of inflammation and activator of signal transducer and activator of transcription 3 (stat3), serve to block apoptosis in cancer cells. |
2019-05-16 |
2023-08-13 |
human |
| Wan-Ting Xu, Gui-Nan Shen, Ying-Hua Luo, Xian-Ji Piao, Jia-Ru Wang, Hao Wang, Yi Zhang, Jin-Qian Li, Yu-Chao Feng, Yu Zhang, Tong Zhang, Shi-Nong Wang, Chang-Yuan Wang, Cheng-Hao Ji. New naphthalene derivatives induce human lung cancer A549 cell apoptosis via ROS-mediated MAPKs, Akt, and STAT3 signaling pathways. Chemico-biological interactions. vol 304. 2019-05-13. PMID:30871965. |
new naphthalene derivatives induce human lung cancer a549 cell apoptosis via ros-mediated mapks, akt, and stat3 signaling pathways. |
2019-05-13 |
2023-08-13 |
human |
| Wan-Ting Xu, Gui-Nan Shen, Ying-Hua Luo, Xian-Ji Piao, Jia-Ru Wang, Hao Wang, Yi Zhang, Jin-Qian Li, Yu-Chao Feng, Yu Zhang, Tong Zhang, Shi-Nong Wang, Chang-Yuan Wang, Cheng-Hao Ji. New naphthalene derivatives induce human lung cancer A549 cell apoptosis via ROS-mediated MAPKs, Akt, and STAT3 signaling pathways. Chemico-biological interactions. vol 304. 2019-05-13. PMID:30871965. |
in conclusion, bsq and osq induce human lung cancer a549 cell apoptosis by ros-mediated mapks, akt, and stat3 signaling pathways. |
2019-05-13 |
2023-08-13 |
human |
| Elena Butturini, Flora Cozzolino, Diana Boriero, Alessandra Carcereri de Prati, Maria Monti, Michele Rossin, Diana Canetti, Barbara Cellini, Piero Pucci, Sofia Mariott. S-glutathionylation exerts opposing roles in the regulation of STAT1 and STAT3 signaling in reactive microglia. Free radical biology & medicine. vol 117. 2019-05-08. PMID:29427792. |
stat1 and stat3 are two transcription factors involved in a lot of cellular functions such as immune response, proliferation, apoptosis, and cell survival. |
2019-05-08 |
2023-08-13 |
Not clear |
| Elena Butturini, Flora Cozzolino, Diana Boriero, Alessandra Carcereri de Prati, Maria Monti, Michele Rossin, Diana Canetti, Barbara Cellini, Piero Pucci, Sofia Mariott. S-glutathionylation exerts opposing roles in the regulation of STAT1 and STAT3 signaling in reactive microglia. Free radical biology & medicine. vol 117. 2019-05-08. PMID:29427792. |
a number of literature evidences described a yin-yang relationship between activation of stat1 and stat3 in neurodegenerative disorders where stat1 exerts a pro-apoptotic effect whereas stat3 shows neuroprotective properties through the inhibition of apoptosis. |
2019-05-08 |
2023-08-13 |
Not clear |
| Zhe Liu, Huan Wang, Lingnan Guan, Siyi Chen, Maode La. A novel small molecular STAT3 inhibitor, 5Br-6b, induces apoptosis and inhibits migration in colorectal cancer cells. Anti-cancer drugs. vol 29. issue 5. 2019-05-08. PMID:29438179. |
a novel small molecular stat3 inhibitor, 5br-6b, induces apoptosis and inhibits migration in colorectal cancer cells. |
2019-05-08 |
2023-08-13 |
Not clear |
| Zhe Liu, Huan Wang, Lingnan Guan, Siyi Chen, Maode La. A novel small molecular STAT3 inhibitor, 5Br-6b, induces apoptosis and inhibits migration in colorectal cancer cells. Anti-cancer drugs. vol 29. issue 5. 2019-05-08. PMID:29438179. |
the results show that 5br-6b inhibits the activation of stat3, and decreases the expression of its target genes that regulate cell proliferation, migration, and apoptosis. |
2019-05-08 |
2023-08-13 |
Not clear |
| Prajna Guha, Jillian Gardell, Josephine Darpolor, Marissa Cunetta, Matthew Lima, George Miller, N Joseph Espat, Richard P Junghans, Steven C Kat. STAT3 inhibition induces Bax-dependent apoptosis in liver tumor myeloid-derived suppressor cells. Oncogene. vol 38. issue 4. 2019-05-08. PMID:30158673. |
stat3 inhibition induces bax-dependent apoptosis in liver tumor myeloid-derived suppressor cells. |
2019-05-08 |
2023-08-13 |
mouse |
| Prajna Guha, Jillian Gardell, Josephine Darpolor, Marissa Cunetta, Matthew Lima, George Miller, N Joseph Espat, Richard P Junghans, Steven C Kat. STAT3 inhibition induces Bax-dependent apoptosis in liver tumor myeloid-derived suppressor cells. Oncogene. vol 38. issue 4. 2019-05-08. PMID:30158673. |
these findings represent a previously unrecognized link between stat3 inhibition and fas-induced apoptosis of mdscs. |
2019-05-08 |
2023-08-13 |
mouse |
| Xiuli Ding, Jiadong Chi, Xue Yang, Jian Hao, Chang Liu, Cuihong Zhu, Xiaodong Wang, Xiaohui Liu, Yangyang Niu, Wei Ji, Dan Chen, Xiongzhi W. Cucurbitacin B synergistically enhances the apoptosis-inducing effect of arsenic trioxide by inhibiting STAT3 phosphorylation in lymphoma Ramos cells. Leukemia & lymphoma. vol 58. issue 10. 2019-04-26. PMID:28278714. |
however, the therapeutic effect of ato is limited in lymphoma, which resists apoptosis possibly due to inappropriate activation of stat3. |
2019-04-26 |
2023-08-13 |
Not clear |
| Xiuli Ding, Jiadong Chi, Xue Yang, Jian Hao, Chang Liu, Cuihong Zhu, Xiaodong Wang, Xiaohui Liu, Yangyang Niu, Wei Ji, Dan Chen, Xiongzhi W. Cucurbitacin B synergistically enhances the apoptosis-inducing effect of arsenic trioxide by inhibiting STAT3 phosphorylation in lymphoma Ramos cells. Leukemia & lymphoma. vol 58. issue 10. 2019-04-26. PMID:28278714. |
dramatically, cucurbitacin b (cub), an effective component of the dichloromethane extraction from trichosanthes kirilowii maxim, synergistically eliminated the apoptosis resistance of burkitt's lymphoma ramos cells to ato by inhibiting the phosphorylation of stat3, followed in turn by downregulation of bcl-2 and upregulation of bax. |
2019-04-26 |
2023-08-13 |
Not clear |