| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amara Maryam, Tahir Mehmood, He Zhang, Yongming Li, Muhammad Khan, Tonghui M. Alantolactone induces apoptosis, promotes STAT3 glutathionylation and enhances chemosensitivity of A549 lung adenocarcinoma cells to doxorubicin via oxidative stress. Scientific reports. vol 7. issue 1. 2019-03-06. PMID:28740138. |
taken together; alt induces oxidative stress-dependent apoptosis, inhibits stat3 activation and augments doxorubicin toxicity in a549 lung cancer cells. |
2019-03-06 |
2023-08-13 |
Not clear |
| In-Hyoung Yang, Won Jung, Lee-Han Kim, Ji-Ae Shin, Nam-Pyo Cho, Seong Doo Hong, Kyoung-Ok Hong, Sung-Dae Ch. Nitidine chloride represses Mcl-1 protein via lysosomal degradation in oral squamous cell carcinoma. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. vol 47. issue 9. 2019-03-06. PMID:29924888. |
we have shown previously that nitidine chloride (nc) induces apoptosis via inhibition of signal transducer and activator of transcription 3 (stat3). |
2019-03-06 |
2023-08-13 |
mouse |
| Kalpana Deepa Priya Dorayappan, Ross Wanner, John J Wallbillich, Uksha Saini, Roman Zingarelli, Adrian A Suarez, David E Cohn, Karuppaiyah Selvendira. Hypoxia-induced exosomes contribute to a more aggressive and chemoresistant ovarian cancer phenotype: a novel mechanism linking STAT3/Rab proteins. Oncogene. vol 37. issue 28. 2019-02-25. PMID:29636548. |
blocking exosome release by known inhibitor amiloride or stat3 inhibitor and treating with cisplatin resulted in a significant increase in apoptosis, decreased colony formation, and proliferation. |
2019-02-25 |
2023-08-13 |
mouse |
| Wei Chen, Ping Li, Yi Liu, Yu Yang, Xueting Ye, Fangyi Zhang, Hang Huan. Isoalantolactone induces apoptosis through ROS-mediated ER stress and inhibition of STAT3 in prostate cancer cells. Journal of experimental & clinical cancer research : CR. vol 37. issue 1. 2019-02-20. PMID:30541589. |
isoalantolactone induces apoptosis through ros-mediated er stress and inhibition of stat3 in prostate cancer cells. |
2019-02-20 |
2023-08-13 |
Not clear |
| Feeling YuTing Chen, Eliza Gaylord, Nancy McNamara, Sarah Kno. Deciphering Molecular and Phenotypic Changes Associated with Early Autoimmune Disease in the Aire-Deficient Mouse Model of Sjögren's Syndrome. International journal of molecular sciences. vol 19. issue 11. 2019-02-18. PMID:30453645. |
activated stat3, a blocker of apoptosis, was restricted to the ductal system and also increased with damage, highlighting its potential as a promoter of ductal cell survival. |
2019-02-18 |
2023-08-13 |
mouse |
| Jing Gao, Junling Chen, Mingjun Cai, Haijiao Xu, Junguang Jiang, Ti Tong, Hongda Wan. Clustered localization of STAT3 during the cell cycle detected by super-resolution fluorescence microscopy. Methods and applications in fluorescence. vol 5. issue 2. 2019-02-13. PMID:28367831. |
signal transducer and activator of transcription 3 (stat3) plays a key role in various cellular processes such as cell proliferation, differentiation, apoptosis and immune responses. |
2019-02-13 |
2023-08-13 |
Not clear |
| Mirae Park, Joo Weon Lim, Hyeyoung Ki. Docoxahexaenoic Acid Induces Apoptosis of Pancreatic Cancer Cells by Suppressing Activation of STAT3 and NF-κB. Nutrients. vol 10. issue 11. 2019-02-13. PMID:30400136. |
docoxahexaenoic acid induces apoptosis of pancreatic cancer cells by suppressing activation of stat3 and nf-κb. |
2019-02-13 |
2023-08-13 |
Not clear |
| Mirae Park, Joo Weon Lim, Hyeyoung Ki. Docoxahexaenoic Acid Induces Apoptosis of Pancreatic Cancer Cells by Suppressing Activation of STAT3 and NF-κB. Nutrients. vol 10. issue 11. 2019-02-13. PMID:30400136. |
since the activation of stat3 and nf-κb mediates the expression of survival genes cyclin d1 and survivin, dha induced apoptosis by suppressing the stat3/nf-κb-cyclin d1/survivin axis. |
2019-02-13 |
2023-08-13 |
Not clear |
| Ying Liu, Xinhua Wang, Shuang Zeng, Xiane Zhang, Jimin Zhao, Xiaoyan Zhang, Xinhuan Chen, Wanjing Yang, Yili Yang, Ziming Dong, Jingyu Zhu, Xin Xu, Fang Tia. The natural polyphenol curcumin induces apoptosis by suppressing STAT3 signaling in esophageal squamous cell carcinoma. Journal of experimental & clinical cancer research : CR. vol 37. issue 1. 2019-02-12. PMID:30518397. |
the natural polyphenol curcumin induces apoptosis by suppressing stat3 signaling in esophageal squamous cell carcinoma. |
2019-02-12 |
2023-08-13 |
Not clear |
| Jia-Ru Wang, Gui-Nan Shen, Ying-Hua Luo, Xian-Ji Piao, Meng Shen, Chang Liu, Yue Wang, Ling-Qi Meng, Yi Zhang, Hao Wang, Jin-Qian Li, Wan-Ting Xu, Yang Liu, Hu-Nan Sun, Ying-Hao Han, Mei-Hua Jin, Long-Kui Cao, Cheng-Hao Ji. The compound 2-(naphthalene-2-thio)-5,8-dimethoxy-1,4-naphthoquinone induces apoptosis via reactive oxygen species-regulated mitogen-activated protein kinase, protein kinase B, and signal transducer and activator of transcription 3 signaling in human gastric cancer cells. Drug development research. vol 79. issue 6. 2019-02-05. PMID:30222185. |
taken together, the present findings indicate that ntdmnq-induced gastric cancer cell apoptosis via ros-mediated regulation of the mapk, akt, and stat3 signaling pathways. |
2019-02-05 |
2023-08-13 |
human |
| Ying Wu, Bo Shan, Jianli Dai, Zhixiong Xia, Jie Cai, Tianwei Chen, Songya Lv, Yuxiong Feng, Ling Zheng, Yan Wang, Jianfeng Liu, Jing Fang, Dong Xie, Liangyou Rui, Jianmiao Liu, Yong Li. Dual role for inositol-requiring enzyme 1α in promoting the development of hepatocellular carcinoma during diet-induced obesity in mice. Hepatology (Baltimore, Md.). vol 68. issue 2. 2019-01-31. PMID:29506314. |
irrespective of their adiposity states, lko mice showed decreased hepatocyte proliferation and signal transducer and activator of transcription 3 (stat3) activation, even in the face of increased hepatic apoptosis. |
2019-01-31 |
2023-08-13 |
mouse |
| Eunhye Oh, Yoon-Jae Kim, Hyunsook An, Daeil Sung, Tae-Min Cho, Lee Farrand, Seojin Jang, Jae Hong Seo, Ji Young Ki. Flubendazole elicits anti-metastatic effects in triple-negative breast cancer via STAT3 inhibition. International journal of cancer. vol 143. issue 8. 2019-01-25. PMID:29744876. |
flu treatment caused a significant induction of apoptosis, accompanied by g2/m phase accumulation, caspase-3/-7 activation and the dysregulation of stat3 activation in tnbc cells. |
2019-01-25 |
2023-08-13 |
Not clear |
| Lidia Avalle, Valeria Pol. Nucleus, Mitochondrion, or Reticulum? STAT3 à La Carte. International journal of molecular sciences. vol 19. issue 9. 2019-01-21. PMID:30231582. |
in particular, we focus on the following four features: (i) the distinct properties of the stat3α and β isoforms; (ii) the multiple post-translational modifications (phosphorylation on tyrosine or serine, acetylation and methylation on different residues, and oxidation and glutathionylation) that can affect its activities downstream of multiple different signals; (iii) the non-canonical functions in the mitochondria, contributing to the maintenance of energy homeostasis under stress conditions; and (iv) the recently discovered functions in the endoplasmic reticulum, where stat3 contributes to the regulation of calcium homeostasis, energy production, and apoptosis. |
2019-01-21 |
2023-08-13 |
Not clear |
| Mihwa Kim, Liza D Morales, Ik-Soon Jang, Yong-Yeon Cho, Dae Joon Ki. Protein Tyrosine Phosphatases as Potential Regulators of STAT3 Signaling. International journal of molecular sciences. vol 19. issue 9. 2019-01-11. PMID:30208623. |
the signal transducer and activator of transcription 3 (stat3) protein is a major transcription factor involved in many cellular processes, such as cell growth and proliferation, differentiation, migration, and cell death or cell apoptosis. |
2019-01-11 |
2023-08-13 |
human |
| Xiaohui Yan, Pengfei Li, Yihong Zhan, Miao Qi, Jin Liu, Zhifeng An, Weiwei Yang, Hui Xiao, Hongmei Wu, Yitao Qi, Huanjie Sha. Dihydroartemisinin suppresses STAT3 signaling and Mcl-1 and Survivin expression to potentiate ABT-263-induced apoptosis in Non-small Cell Lung Cancer cells harboring EGFR or RAS mutation. Biochemical pharmacology. vol 150. 2019-01-09. PMID:29360439. |
dihydroartemisinin suppresses stat3 signaling and mcl-1 and survivin expression to potentiate abt-263-induced apoptosis in non-small cell lung cancer cells harboring egfr or ras mutation. |
2019-01-09 |
2023-08-13 |
mouse |
| Xiaohui Yan, Pengfei Li, Yihong Zhan, Miao Qi, Jin Liu, Zhifeng An, Weiwei Yang, Hui Xiao, Hongmei Wu, Yitao Qi, Huanjie Sha. Dihydroartemisinin suppresses STAT3 signaling and Mcl-1 and Survivin expression to potentiate ABT-263-induced apoptosis in Non-small Cell Lung Cancer cells harboring EGFR or RAS mutation. Biochemical pharmacology. vol 150. 2019-01-09. PMID:29360439. |
together, dha effectively inhibits stat3 activity and modulates expression of mcl-1, survivin and bim, thereby synergizing with abt-263 to trigger apoptosis in nsclc cells harboring egfr or ras mutation. |
2019-01-09 |
2023-08-13 |
mouse |
| Hongwei Shen, Yuan Xie, Senlin Ye, Kancheng He, Lu Yi, Rongrong Cu. Spider peptide toxin lycosin-I induces apoptosis and inhibits migration of prostate cancer cells. Experimental biology and medicine (Maywood, N.J.). vol 243. issue 8. 2019-01-09. PMID:29763387. |
it was found that by inactivating stat3 pathway, high concentrations of lycosin-i induce apoptosis in prostate cancer cells and low concentrations of lycosin-i inhibit the migration of prostate cancer cells. |
2019-01-09 |
2023-08-13 |
human |
| Yachong Jiao, Hongmei Ding, Shanshan Huang, Yixin Liu, Xuguo Sun, Wei Wei, Jun Ma, Fang Zhen. Bcl-XL and Mcl-1 upregulation by calreticulin promotes apoptosis resistance of fibroblast-like synoviocytes via activation of PI3K/Akt and STAT3 pathways in rheumatoid arthritis. Clinical and experimental rheumatology. vol 36. issue 5. 2019-01-07. PMID:29652658. |
bcl-xl and mcl-1 upregulation by calreticulin promotes apoptosis resistance of fibroblast-like synoviocytes via activation of pi3k/akt and stat3 pathways in rheumatoid arthritis. |
2019-01-07 |
2023-08-13 |
Not clear |
| Chang Liu, Gui-Nan Shen, Ying-Hua Luo, Xian-Ji Piao, Xue-Yuan Jiang, Ling-Qi Meng, Yue Wang, Yi Zhang, Jia-Ru Wang, Hao Wang, Wan-Ting Xu, Jin-Qian Li, Yang Liu, Yi-Qin Wu, Hu-Nan Sun, Ying-Hao Han, Mei-Hua Jin, Yu-Dong Cui, Nan-Zhu Fang, Cheng-Hao Ji. Novel 1,4-naphthoquinone derivatives induce apoptosis via ROS-mediated p38/MAPK, Akt and STAT3 signaling in human hepatoma Hep3B cells. The international journal of biochemistry & cell biology. vol 96. 2019-01-03. PMID:29326072. |
novel 1,4-naphthoquinone derivatives induce apoptosis via ros-mediated p38/mapk, akt and stat3 signaling in human hepatoma hep3b cells. |
2019-01-03 |
2023-08-13 |
mouse |
| Chang Liu, Gui-Nan Shen, Ying-Hua Luo, Xian-Ji Piao, Xue-Yuan Jiang, Ling-Qi Meng, Yue Wang, Yi Zhang, Jia-Ru Wang, Hao Wang, Wan-Ting Xu, Jin-Qian Li, Yang Liu, Yi-Qin Wu, Hu-Nan Sun, Ying-Hao Han, Mei-Hua Jin, Yu-Dong Cui, Nan-Zhu Fang, Cheng-Hao Ji. Novel 1,4-naphthoquinone derivatives induce apoptosis via ROS-mediated p38/MAPK, Akt and STAT3 signaling in human hepatoma Hep3B cells. The international journal of biochemistry & cell biology. vol 96. 2019-01-03. PMID:29326072. |
these results indicate that bsnq and osnq induce apoptosis in human hepatoma hep3b cells via ros-mediated p38/mapk, akt and stat3 signaling pathways, suggesting that these 1,4-naphthoquinone derivatives may provide promising new anticancer agents to treat hcc. |
2019-01-03 |
2023-08-13 |
mouse |