| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Seulki Lee, Young Youn Cho, Eun Ju Cho, Su Jong Yu, Jeong-Hoon Lee, Jung-Hwan Yoon, Yoon Jun Ki. Synergistic effect of ursodeoxycholic acid on the antitumor activity of sorafenib in hepatocellular carcinoma cells via modulation of STAT3 and ERK. International journal of molecular medicine. vol 42. issue 5. 2019-01-02. PMID:30106087. |
thus, chemotherapy with sorafenib and ursodeoxycholic combination may be efficacious in hepatocellular carcinoma by inhibiting cell proliferation and inducing apoptosis through reactive oxygen species‑dependent activation of erk and dephosphorylation of stat3. |
2019-01-02 |
2023-08-13 |
Not clear |
| Ting Li, Xiuqiong Fu, Anfernee Kai-Wing Tse, Hui Guo, Kin Wah Lee, Bin Liu, Tao Su, Xueyu Wang, Zhiling Y. Inhibiting STAT3 signaling is involved in the anti-melanoma effects of a herbal formula comprising Sophorae Flos and Lonicerae Japonicae Flos. Scientific reports. vol 7. issue 1. 2018-12-31. PMID:28596565. |
in cultured cells, sle dramatically reduced cell viability, induced apoptosis, suppressed migration and invasion, and restrained stat3 activation and nuclear localization. |
2018-12-31 |
2023-08-13 |
mouse |
| Yosuke Matsuno, Takumi Kiwamoto, Yuko Morishima, Yukio Ishii, Nobuyuki Hizawa, Cory M Hogaboa. Notch signaling regulates cell density-dependent apoptosis of NIH 3T3 through an IL-6/STAT3 dependent mechanism. European journal of cell biology. vol 97. issue 7. 2018-12-24. PMID:30249464. |
with the increase in cell density, il-6 expression was induced, which was necessary for stat3 activation as well as apoptosis regulation. |
2018-12-24 |
2023-08-13 |
mouse |
| Yangyang He, Muhammad Khan, Jingbo Yang, Min Yao, Shili Yu, Hongwen Ga. Proscillaridin A induces apoptosis, inhibits STAT3 activation and augments doxorubicin toxicity in prostate cancer cells. International journal of medical sciences. vol 15. issue 8. 2018-12-17. PMID:30008594. |
proscillaridin a induces apoptosis, inhibits stat3 activation and augments doxorubicin toxicity in prostate cancer cells. |
2018-12-17 |
2023-08-13 |
Not clear |
| Li-Wei Ran, Hao Wang, Dong Lan, Hong-Xia Jia, Si-Si Y. Effect of RNA Interference Targeting Chinese medical journal. vol 131. issue 17. 2018-12-12. PMID:30127220. |
the study aimed to investigate the effects of stat3 small interfering rna (sirna) combined with ultrasonic irradiation and sonovue microbubbles on the proliferation and apoptosis in kcs of psoriatic lesions and the relative mechanisms. |
2018-12-12 |
2023-08-13 |
Not clear |
| Chenlin Pei, Qun He, Shuai Liang, Xuejun Gon. Mahanimbine Exerts Anticancer Effects on Human Pancreatic Cancer Cells by Triggering Cell Cycle Arrest, Apoptosis, and Modulation of AKT/Mammalian Target of Rapamycin (mTOR) and Signal Transducer and Activator of Transcription 3 (STAT3) Signalling Pathways. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-12-12. PMID:30273298. |
mahanimbine exerts anticancer effects on human pancreatic cancer cells by triggering cell cycle arrest, apoptosis, and modulation of akt/mammalian target of rapamycin (mtor) and signal transducer and activator of transcription 3 (stat3) signalling pathways. |
2018-12-12 |
2023-08-13 |
human |
| Lingang Cui, Qingjun Meng, Jianguo Wen, Zechen Yan, Zhan Gao, Yudong Tian, Pengchao Xu, Pengchao Lian, Haizhou Y. The effect of a gene associated with retinoid-interferon-induced mortality 19 (GRIM-19) on STAT3-induced gene expression in renal carcinoma. Journal of biochemistry. vol 164. issue 4. 2018-12-11. PMID:29961871. |
overexpression of grim-19, inhibited tumour growth apoptosis by mediating activators of stat3 signal. |
2018-12-11 |
2023-08-13 |
human |
| Radhika S Saraf, Aniruddha Datta, Chao Sima, Jianping Hua, Rosana Lopes, Michael Bittne. An in-silico study examining the induction of apoptosis by Cryptotanshinone in metastatic melanoma cell lines. BMC cancer. vol 18. issue 1. 2018-12-11. PMID:30157799. |
the pro-inflammatory response to melanoma by nf κb and stat3 pathways makes the cancer cells resist trail-induced apoptosis. |
2018-12-11 |
2023-08-13 |
Not clear |
| Feifei Li, Jianni Qi, Chengyong Qin, Zhaoqing Fu, Wanhua Re. Taurolidine promotes cell apoptosis by enhancing GRIM‑19 expression in liver cancer. Oncology reports. vol 40. issue 6. 2018-12-11. PMID:30272302. |
furthermore, following grim‑19 knockdown, the effects of trd on the viability and apoptosis of hepg2 cells, and the expression of downstream target genes (including cyclin d1, stat3, p‑stat3, bcl‑2 and bax) were reversed. |
2018-12-11 |
2023-08-13 |
human |
| Feifei Li, Jianni Qi, Chengyong Qin, Zhaoqing Fu, Wanhua Re. Taurolidine promotes cell apoptosis by enhancing GRIM‑19 expression in liver cancer. Oncology reports. vol 40. issue 6. 2018-12-11. PMID:30272302. |
these results indicated that trd may contribute to cell apoptosis by inducing grim‑19 expression and deactivating the stat3 signaling pathway in liver cancer cells. |
2018-12-11 |
2023-08-13 |
human |
| Fang He, Huibin Liu, Jing Guo, Di Yang, Yang Yu, Jie Yu, Xiuqing Yan, Juan Hu, Zhimin D. Inhibition of MicroRNA-124 Reduces Cardiomyocyte Apoptosis Following Myocardial Infarction via Targeting STAT3. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 51. issue 1. 2018-12-11. PMID:30439699. |
inhibition of microrna-124 reduces cardiomyocyte apoptosis following myocardial infarction via targeting stat3. |
2018-12-11 |
2023-08-13 |
Not clear |
| Nazanin Fathi, Golnaz Rashidi, Ali Khodadadi, Shahriar Shahi, Simin Sharif. STAT3 and apoptosis challenges in cancer. International journal of biological macromolecules. vol 117. 2018-11-16. PMID:29782972. |
stat3 and apoptosis challenges in cancer. |
2018-11-16 |
2023-08-13 |
Not clear |
| Nazanin Fathi, Golnaz Rashidi, Ali Khodadadi, Shahriar Shahi, Simin Sharif. STAT3 and apoptosis challenges in cancer. International journal of biological macromolecules. vol 117. 2018-11-16. PMID:29782972. |
further understanding of the stat3 related signaling and apoptosis pathway can lead to the invention of novel approaches for therapies in unstudied disease. |
2018-11-16 |
2023-08-13 |
Not clear |
| Nazanin Fathi, Golnaz Rashidi, Ali Khodadadi, Shahriar Shahi, Simin Sharif. STAT3 and apoptosis challenges in cancer. International journal of biological macromolecules. vol 117. 2018-11-16. PMID:29782972. |
in this manuscript, review and highlight recent knowledge of the stat3 pathway and its connection with apoptosis process in cancers and discuss stat3-targeting agents to therapeutic developments. |
2018-11-16 |
2023-08-13 |
Not clear |
| Jinshun Xu, Shuai Yuan, Jilai Tian, Kyle A Martin, Jinhua Song, Chenglong Li, Zhigang Wang, Jiayuh Lin, Ting Si, Ronald X X. Ultrasound mediated delivery of oxygen and LLL12 loaded stimuli responsive microdroplets for the treatment of hypoxic cancer cells. Scientific reports. vol 7. 2018-11-14. PMID:28322306. |
lll12 exhibits high specificity for inhibiting stat3 phosphorylation and dimerization, and inducing apoptosis to constitutively activated stat3 cancer cells without cytotoxicity to normal cells with dormant stat3. |
2018-11-14 |
2023-08-13 |
Not clear |
| Duy N Do, Ran Li, Pier-Luc Dudemaine, Eveline M Ibeagha-Awem. MicroRNA roles in signalling during lactation: an insight from differential expression, time course and pathway analyses of deep sequence data. Scientific reports. vol 7. 2018-11-12. PMID:28317898. |
relevant signalling pathways for transition between lactation stages are involved in apoptosis (pten and sapk/jnk), intracellular signalling (protein kinase a, tgf-β and erk5), cell cycle regulation (stat3), cytokines, hormones and growth factors (prolactin, growth hormone and glucocorticoid receptor). |
2018-11-12 |
2023-08-13 |
cattle |
| Flavia M M Paula, Nayara C Leite, Patricia C Borck, Ricardo Freitas-Dias, Miriam Cnop, Mara P T Chacon-Mikahil, Claudia R Cavaglieri, Piero Marchetti, Antonio C Boschero, Claudio C Zoppi, Decio L Eiziri. Exercise training protects human and rodent β cells against endoplasmic reticulum stress and apoptosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 32. issue 3. 2018-11-06. PMID:29133342. |
exposure of human islets or mouse or rat β cells to human or rodent sera, respectively, obtained from trained individuals reduced cytokine (il-1β+ifn-γ)- or chemical er stressor-induced β-cell er stress and apoptosis, at least in part via activation of the transcription factor stat3. |
2018-11-06 |
2023-08-13 |
human |
| Jie Gao, Zhongjun Shao, Min Yan, Ting Fu, Lei Zhang, Yongping Ya. Targeted regulationof STAT3 by miR-29a in mediating Taxol resistance of nasopharyngeal carcinoma cell line CNE-1. Cancer biomarkers : section A of Disease markers. vol 22. issue 4. 2018-11-05. PMID:29914005. |
cne-1/taxol cells were treated with mir-29a mimic and or si-stat3, followed by measuring the expression of mir-29a, stat3, and p-stat3 and cell apoptosis. |
2018-11-05 |
2023-08-13 |
Not clear |
| Jie Gao, Zhongjun Shao, Min Yan, Ting Fu, Lei Zhang, Yongping Ya. Targeted regulationof STAT3 by miR-29a in mediating Taxol resistance of nasopharyngeal carcinoma cell line CNE-1. Cancer biomarkers : section A of Disease markers. vol 22. issue 4. 2018-11-05. PMID:29914005. |
significantly lower rhodamine 123 repository, mir-29a expression and apoptosis and higher expression of stat3, p-stat3 and pcna were observed in cne-2/ taxol cells than those in cne-1 cells. |
2018-11-05 |
2023-08-13 |
Not clear |
| Jie Gao, Zhongjun Shao, Min Yan, Ting Fu, Lei Zhang, Yongping Ya. Targeted regulationof STAT3 by miR-29a in mediating Taxol resistance of nasopharyngeal carcinoma cell line CNE-1. Cancer biomarkers : section A of Disease markers. vol 22. issue 4. 2018-11-05. PMID:29914005. |
transfection of mir-29a mimic and/or si-stat3 decreased stat3, p-stat3 and pcna expression, inhibited proliferation and promoted cell apoptosis. |
2018-11-05 |
2023-08-13 |
Not clear |