| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying Wu, Bo Shan, Jianli Dai, Zhixiong Xia, Jie Cai, Tianwei Chen, Songya Lv, Yuxiong Feng, Ling Zheng, Yan Wang, Jianfeng Liu, Jing Fang, Dong Xie, Liangyou Rui, Jianmiao Liu, Yong Li. Dual role for inositol-requiring enzyme 1α in promoting the development of hepatocellular carcinoma during diet-induced obesity in mice. Hepatology (Baltimore, Md.). vol 68. issue 2. 2019-01-31. PMID:29506314. |
irrespective of their adiposity states, lko mice showed decreased hepatocyte proliferation and signal transducer and activator of transcription 3 (stat3) activation, even in the face of increased hepatic apoptosis. |
2019-01-31 |
2023-08-13 |
mouse |
| Eunhye Oh, Yoon-Jae Kim, Hyunsook An, Daeil Sung, Tae-Min Cho, Lee Farrand, Seojin Jang, Jae Hong Seo, Ji Young Ki. Flubendazole elicits anti-metastatic effects in triple-negative breast cancer via STAT3 inhibition. International journal of cancer. vol 143. issue 8. 2019-01-25. PMID:29744876. |
flu treatment caused a significant induction of apoptosis, accompanied by g2/m phase accumulation, caspase-3/-7 activation and the dysregulation of stat3 activation in tnbc cells. |
2019-01-25 |
2023-08-13 |
Not clear |
| Lidia Avalle, Valeria Pol. Nucleus, Mitochondrion, or Reticulum? STAT3 à La Carte. International journal of molecular sciences. vol 19. issue 9. 2019-01-21. PMID:30231582. |
in particular, we focus on the following four features: (i) the distinct properties of the stat3α and β isoforms; (ii) the multiple post-translational modifications (phosphorylation on tyrosine or serine, acetylation and methylation on different residues, and oxidation and glutathionylation) that can affect its activities downstream of multiple different signals; (iii) the non-canonical functions in the mitochondria, contributing to the maintenance of energy homeostasis under stress conditions; and (iv) the recently discovered functions in the endoplasmic reticulum, where stat3 contributes to the regulation of calcium homeostasis, energy production, and apoptosis. |
2019-01-21 |
2023-08-13 |
Not clear |
| Mihwa Kim, Liza D Morales, Ik-Soon Jang, Yong-Yeon Cho, Dae Joon Ki. Protein Tyrosine Phosphatases as Potential Regulators of STAT3 Signaling. International journal of molecular sciences. vol 19. issue 9. 2019-01-11. PMID:30208623. |
the signal transducer and activator of transcription 3 (stat3) protein is a major transcription factor involved in many cellular processes, such as cell growth and proliferation, differentiation, migration, and cell death or cell apoptosis. |
2019-01-11 |
2023-08-13 |
human |
| Xiaohui Yan, Pengfei Li, Yihong Zhan, Miao Qi, Jin Liu, Zhifeng An, Weiwei Yang, Hui Xiao, Hongmei Wu, Yitao Qi, Huanjie Sha. Dihydroartemisinin suppresses STAT3 signaling and Mcl-1 and Survivin expression to potentiate ABT-263-induced apoptosis in Non-small Cell Lung Cancer cells harboring EGFR or RAS mutation. Biochemical pharmacology. vol 150. 2019-01-09. PMID:29360439. |
dihydroartemisinin suppresses stat3 signaling and mcl-1 and survivin expression to potentiate abt-263-induced apoptosis in non-small cell lung cancer cells harboring egfr or ras mutation. |
2019-01-09 |
2023-08-13 |
mouse |
| Xiaohui Yan, Pengfei Li, Yihong Zhan, Miao Qi, Jin Liu, Zhifeng An, Weiwei Yang, Hui Xiao, Hongmei Wu, Yitao Qi, Huanjie Sha. Dihydroartemisinin suppresses STAT3 signaling and Mcl-1 and Survivin expression to potentiate ABT-263-induced apoptosis in Non-small Cell Lung Cancer cells harboring EGFR or RAS mutation. Biochemical pharmacology. vol 150. 2019-01-09. PMID:29360439. |
together, dha effectively inhibits stat3 activity and modulates expression of mcl-1, survivin and bim, thereby synergizing with abt-263 to trigger apoptosis in nsclc cells harboring egfr or ras mutation. |
2019-01-09 |
2023-08-13 |
mouse |
| Hongwei Shen, Yuan Xie, Senlin Ye, Kancheng He, Lu Yi, Rongrong Cu. Spider peptide toxin lycosin-I induces apoptosis and inhibits migration of prostate cancer cells. Experimental biology and medicine (Maywood, N.J.). vol 243. issue 8. 2019-01-09. PMID:29763387. |
it was found that by inactivating stat3 pathway, high concentrations of lycosin-i induce apoptosis in prostate cancer cells and low concentrations of lycosin-i inhibit the migration of prostate cancer cells. |
2019-01-09 |
2023-08-13 |
human |
| Yachong Jiao, Hongmei Ding, Shanshan Huang, Yixin Liu, Xuguo Sun, Wei Wei, Jun Ma, Fang Zhen. Bcl-XL and Mcl-1 upregulation by calreticulin promotes apoptosis resistance of fibroblast-like synoviocytes via activation of PI3K/Akt and STAT3 pathways in rheumatoid arthritis. Clinical and experimental rheumatology. vol 36. issue 5. 2019-01-07. PMID:29652658. |
bcl-xl and mcl-1 upregulation by calreticulin promotes apoptosis resistance of fibroblast-like synoviocytes via activation of pi3k/akt and stat3 pathways in rheumatoid arthritis. |
2019-01-07 |
2023-08-13 |
Not clear |
| Chang Liu, Gui-Nan Shen, Ying-Hua Luo, Xian-Ji Piao, Xue-Yuan Jiang, Ling-Qi Meng, Yue Wang, Yi Zhang, Jia-Ru Wang, Hao Wang, Wan-Ting Xu, Jin-Qian Li, Yang Liu, Yi-Qin Wu, Hu-Nan Sun, Ying-Hao Han, Mei-Hua Jin, Yu-Dong Cui, Nan-Zhu Fang, Cheng-Hao Ji. Novel 1,4-naphthoquinone derivatives induce apoptosis via ROS-mediated p38/MAPK, Akt and STAT3 signaling in human hepatoma Hep3B cells. The international journal of biochemistry & cell biology. vol 96. 2019-01-03. PMID:29326072. |
novel 1,4-naphthoquinone derivatives induce apoptosis via ros-mediated p38/mapk, akt and stat3 signaling in human hepatoma hep3b cells. |
2019-01-03 |
2023-08-13 |
mouse |
| Chang Liu, Gui-Nan Shen, Ying-Hua Luo, Xian-Ji Piao, Xue-Yuan Jiang, Ling-Qi Meng, Yue Wang, Yi Zhang, Jia-Ru Wang, Hao Wang, Wan-Ting Xu, Jin-Qian Li, Yang Liu, Yi-Qin Wu, Hu-Nan Sun, Ying-Hao Han, Mei-Hua Jin, Yu-Dong Cui, Nan-Zhu Fang, Cheng-Hao Ji. Novel 1,4-naphthoquinone derivatives induce apoptosis via ROS-mediated p38/MAPK, Akt and STAT3 signaling in human hepatoma Hep3B cells. The international journal of biochemistry & cell biology. vol 96. 2019-01-03. PMID:29326072. |
these results indicate that bsnq and osnq induce apoptosis in human hepatoma hep3b cells via ros-mediated p38/mapk, akt and stat3 signaling pathways, suggesting that these 1,4-naphthoquinone derivatives may provide promising new anticancer agents to treat hcc. |
2019-01-03 |
2023-08-13 |
mouse |
| Seulki Lee, Young Youn Cho, Eun Ju Cho, Su Jong Yu, Jeong-Hoon Lee, Jung-Hwan Yoon, Yoon Jun Ki. Synergistic effect of ursodeoxycholic acid on the antitumor activity of sorafenib in hepatocellular carcinoma cells via modulation of STAT3 and ERK. International journal of molecular medicine. vol 42. issue 5. 2019-01-02. PMID:30106087. |
thus, chemotherapy with sorafenib and ursodeoxycholic combination may be efficacious in hepatocellular carcinoma by inhibiting cell proliferation and inducing apoptosis through reactive oxygen species‑dependent activation of erk and dephosphorylation of stat3. |
2019-01-02 |
2023-08-13 |
Not clear |
| Ting Li, Xiuqiong Fu, Anfernee Kai-Wing Tse, Hui Guo, Kin Wah Lee, Bin Liu, Tao Su, Xueyu Wang, Zhiling Y. Inhibiting STAT3 signaling is involved in the anti-melanoma effects of a herbal formula comprising Sophorae Flos and Lonicerae Japonicae Flos. Scientific reports. vol 7. issue 1. 2018-12-31. PMID:28596565. |
in cultured cells, sle dramatically reduced cell viability, induced apoptosis, suppressed migration and invasion, and restrained stat3 activation and nuclear localization. |
2018-12-31 |
2023-08-13 |
mouse |
| Yosuke Matsuno, Takumi Kiwamoto, Yuko Morishima, Yukio Ishii, Nobuyuki Hizawa, Cory M Hogaboa. Notch signaling regulates cell density-dependent apoptosis of NIH 3T3 through an IL-6/STAT3 dependent mechanism. European journal of cell biology. vol 97. issue 7. 2018-12-24. PMID:30249464. |
with the increase in cell density, il-6 expression was induced, which was necessary for stat3 activation as well as apoptosis regulation. |
2018-12-24 |
2023-08-13 |
mouse |
| Yangyang He, Muhammad Khan, Jingbo Yang, Min Yao, Shili Yu, Hongwen Ga. Proscillaridin A induces apoptosis, inhibits STAT3 activation and augments doxorubicin toxicity in prostate cancer cells. International journal of medical sciences. vol 15. issue 8. 2018-12-17. PMID:30008594. |
proscillaridin a induces apoptosis, inhibits stat3 activation and augments doxorubicin toxicity in prostate cancer cells. |
2018-12-17 |
2023-08-13 |
Not clear |
| Li-Wei Ran, Hao Wang, Dong Lan, Hong-Xia Jia, Si-Si Y. Effect of RNA Interference Targeting Chinese medical journal. vol 131. issue 17. 2018-12-12. PMID:30127220. |
the study aimed to investigate the effects of stat3 small interfering rna (sirna) combined with ultrasonic irradiation and sonovue microbubbles on the proliferation and apoptosis in kcs of psoriatic lesions and the relative mechanisms. |
2018-12-12 |
2023-08-13 |
Not clear |
| Chenlin Pei, Qun He, Shuai Liang, Xuejun Gon. Mahanimbine Exerts Anticancer Effects on Human Pancreatic Cancer Cells by Triggering Cell Cycle Arrest, Apoptosis, and Modulation of AKT/Mammalian Target of Rapamycin (mTOR) and Signal Transducer and Activator of Transcription 3 (STAT3) Signalling Pathways. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-12-12. PMID:30273298. |
mahanimbine exerts anticancer effects on human pancreatic cancer cells by triggering cell cycle arrest, apoptosis, and modulation of akt/mammalian target of rapamycin (mtor) and signal transducer and activator of transcription 3 (stat3) signalling pathways. |
2018-12-12 |
2023-08-13 |
human |
| Lingang Cui, Qingjun Meng, Jianguo Wen, Zechen Yan, Zhan Gao, Yudong Tian, Pengchao Xu, Pengchao Lian, Haizhou Y. The effect of a gene associated with retinoid-interferon-induced mortality 19 (GRIM-19) on STAT3-induced gene expression in renal carcinoma. Journal of biochemistry. vol 164. issue 4. 2018-12-11. PMID:29961871. |
overexpression of grim-19, inhibited tumour growth apoptosis by mediating activators of stat3 signal. |
2018-12-11 |
2023-08-13 |
human |
| Radhika S Saraf, Aniruddha Datta, Chao Sima, Jianping Hua, Rosana Lopes, Michael Bittne. An in-silico study examining the induction of apoptosis by Cryptotanshinone in metastatic melanoma cell lines. BMC cancer. vol 18. issue 1. 2018-12-11. PMID:30157799. |
the pro-inflammatory response to melanoma by nf κb and stat3 pathways makes the cancer cells resist trail-induced apoptosis. |
2018-12-11 |
2023-08-13 |
Not clear |
| Feifei Li, Jianni Qi, Chengyong Qin, Zhaoqing Fu, Wanhua Re. Taurolidine promotes cell apoptosis by enhancing GRIM‑19 expression in liver cancer. Oncology reports. vol 40. issue 6. 2018-12-11. PMID:30272302. |
furthermore, following grim‑19 knockdown, the effects of trd on the viability and apoptosis of hepg2 cells, and the expression of downstream target genes (including cyclin d1, stat3, p‑stat3, bcl‑2 and bax) were reversed. |
2018-12-11 |
2023-08-13 |
human |
| Feifei Li, Jianni Qi, Chengyong Qin, Zhaoqing Fu, Wanhua Re. Taurolidine promotes cell apoptosis by enhancing GRIM‑19 expression in liver cancer. Oncology reports. vol 40. issue 6. 2018-12-11. PMID:30272302. |
these results indicated that trd may contribute to cell apoptosis by inducing grim‑19 expression and deactivating the stat3 signaling pathway in liver cancer cells. |
2018-12-11 |
2023-08-13 |
human |