| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Wei, Zhenhua Fan, Zhuo Yang, Yujie Zhou, Fan Da, Linyan Zhou, Wenjing Tao, Deshou Wan. Leukemia Inhibitory Factor Is Essential for the Self-Renewal of Embryonic Stem Cells from Nile Tilapia (Oreochromis niloticus) Through Stat3 Signaling. Stem cells and development. vol 27. issue 2. 2018-11-01. PMID:29161958. |
notably, it mediated stat3 phosphorylation, whose inhibitor treatment could lead to apoptosis. |
2018-11-01 |
2023-08-13 |
mouse |
| Wei Wen, Gina Lowe, Cai M Roberts, James Finlay, Ernest S Han, Carlotta A Glackin, Thanh Hue Dellinge. Pterostilbene Suppresses Ovarian Cancer Growth via Induction of Apoptosis and Blockade of Cell Cycle Progression Involving Inhibition of the STAT3 Pathway. International journal of molecular sciences. vol 19. issue 7. 2018-10-24. PMID:29986501. |
pterostilbene suppresses ovarian cancer growth via induction of apoptosis and blockade of cell cycle progression involving inhibition of the stat3 pathway. |
2018-10-24 |
2023-08-13 |
Not clear |
| Wei Wen, Gina Lowe, Cai M Roberts, James Finlay, Ernest S Han, Carlotta A Glackin, Thanh Hue Dellinge. Pterostilbene Suppresses Ovarian Cancer Growth via Induction of Apoptosis and Blockade of Cell Cycle Progression Involving Inhibition of the STAT3 Pathway. International journal of molecular sciences. vol 19. issue 7. 2018-10-24. PMID:29986501. |
further molecular study has shown that pterostilbene effectively suppressed phosphorylation of stat3, as well as stat3 downstream genes that regulate cell cycle and apoptosis, indicating that inhibition of stat3 pathway may be involved in its anti-tumor activity. |
2018-10-24 |
2023-08-13 |
Not clear |
| Zhibo Dai, Ligang Wang, Xiaoxiong Wang, Boxian Zhao, Wenyang Zhao, Shashank Singh Bhardwaj, Junyi Ye, Zhiqin Yin, Jun Zhang, Shiguang Zha. Oxymatrine induces cell cycle arrest and apoptosis and suppresses the invasion of human glioblastoma cells through the EGFR/PI3K/Akt/mTOR signaling pathway and STAT3. Oncology reports. vol 40. issue 2. 2018-10-24. PMID:29989652. |
oxymatrine induces cell cycle arrest and apoptosis and suppresses the invasion of human glioblastoma cells through the egfr/pi3k/akt/mtor signaling pathway and stat3. |
2018-10-24 |
2023-08-13 |
human |
| Yibin Lin, Jiahui Li, Shazhou Ye, Jiayi Chen, Yanru Zhang, Liu Wang, Yang Xi, Shizhong Bu, Xiaohui Qi. LncRNA GACAT3 acts as a competing endogenous RNA of HMGA1 and alleviates cucurbitacin B-induced apoptosis of gastric cancer cells. Gene. vol 678. 2018-10-22. PMID:30098426. |
mechanistically, gacat3 amplified stat3 expression and decreased the level of the apoptosis gene bcl-2-associated x protein (bax). |
2018-10-22 |
2023-08-13 |
Not clear |
| Wei Huang, Yuan Liu, Jun Wang, Xia Yuan, Hong-Wei Jin, Liang-Ren Zhang, Jian-Ting Zhang, Zhen-Ming Liu, Jing-Rong Cu. Small-molecule compounds targeting the STAT3 DNA-binding domain suppress survival of cisplatin-resistant human ovarian cancer cells by inducing apoptosis. European journal of medicinal chemistry. vol 157. 2018-10-22. PMID:30145375. |
small-molecule compounds targeting the stat3 dna-binding domain suppress survival of cisplatin-resistant human ovarian cancer cells by inducing apoptosis. |
2018-10-22 |
2023-08-13 |
human |
| Ling-Qi Meng, Yue Wang, Ying-Hua Luo, Xian-Ji Piao, Chang Liu, Yue Wang, Yi Zhang, Jia-Ru Wang, Hao Wang, Wan-Ting Xu, Yang Liu, Yi-Qin Wu, Hu-Nan Sun, Ying-Hao Han, Mei-Hua Jin, Gui-Nan Shen, Nan-Zhu Fang, Cheng-Hao Ji. Quinalizarin Induces Apoptosis through Reactive Oxygen Species (ROS)-Mediated Mitogen-Activated Protein Kinase (MAPK) and Signal Transducer and Activator of Transcription 3 (STAT3) Signaling Pathways in Colorectal Cancer Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-10-16. PMID:29860266. |
quinalizarin induces apoptosis through reactive oxygen species (ros)-mediated mitogen-activated protein kinase (mapk) and signal transducer and activator of transcription 3 (stat3) signaling pathways in colorectal cancer cells. |
2018-10-16 |
2023-08-13 |
Not clear |
| Ling-Qi Meng, Yue Wang, Ying-Hua Luo, Xian-Ji Piao, Chang Liu, Yue Wang, Yi Zhang, Jia-Ru Wang, Hao Wang, Wan-Ting Xu, Yang Liu, Yi-Qin Wu, Hu-Nan Sun, Ying-Hao Han, Mei-Hua Jin, Gui-Nan Shen, Nan-Zhu Fang, Cheng-Hao Ji. Quinalizarin Induces Apoptosis through Reactive Oxygen Species (ROS)-Mediated Mitogen-Activated Protein Kinase (MAPK) and Signal Transducer and Activator of Transcription 3 (STAT3) Signaling Pathways in Colorectal Cancer Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-10-16. PMID:29860266. |
quinalizarin induced apoptosis in colorectal cancer cells by regulating mapk and stat3 signaling pathways via ros generation. |
2018-10-16 |
2023-08-13 |
Not clear |
| Xuan Zhang, Silin Zhang, Qitong Sun, Wenjun Jiao, Yan Yan, Xuewu Zhan. Compound K Induces Endoplasmic Reticulum Stress and Apoptosis in Human Liver Cancer Cells by Regulating STAT3. Molecules (Basel, Switzerland). vol 23. issue 6. 2018-10-09. PMID:29921768. |
compound k induces endoplasmic reticulum stress and apoptosis in human liver cancer cells by regulating stat3. |
2018-10-09 |
2023-08-13 |
human |
| Xiqing Li, Zunlan Zhao, Ming Li, Mingyue Liu, Andres Bahena, Yaping Zhang, Yuwei Zhang, Chetan Nambiar, Guangzhi Li. Sulforaphane promotes apoptosis, and inhibits proliferation and self-renewal of nasopharyngeal cancer cells by targeting STAT signal through miRNA-124-3p. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 103. 2018-10-08. PMID:29677532. |
moreover, sf inhibits proliferation and induces apoptosis decreasing the stemness of nasopharyngeal cancer cells through a mechanism related to stat3 signaling in vitro. |
2018-10-08 |
2023-08-13 |
Not clear |
| Jie Mao, Hongbao Yang, Tingting Cui, Pan Pan, Nadia Kabir, Duo Chen, Jinyan Ma, Xingyi Chen, Yijun Chen, Yong Yan. Combined treatment with sorafenib and silibinin synergistically targets both HCC cells and cancer stem cells by enhanced inhibition of the phosphorylation of STAT3/ERK/AKT. European journal of pharmacology. vol 832. 2018-10-08. PMID:29782854. |
as determined by fluorescence staining and western blots, the combination of the two drugs inhibited the phosphorylation of rac-alpha serine/threonine-protein kinase (akt) and signal transducer and activator of transcription 3 (stat3) together with the expression of antiapoptotic proteins including myeloid leukemia cell differentiation protein mcl-1 (mcl-1) and apoptosis regulator bcl-2 (bcl-2), resulting in the death of cancer cells. |
2018-10-08 |
2023-08-13 |
Not clear |
| Yin Shi, Zhen Zhang, Xintao Qu, Xiaoxiao Zhu, Lin Zhao, Ran Wei, Qiang Guo, Linlin Sun, Xunqiang Yin, Yunhong Zhang, Xia L. Roles of STAT3 in leukemia (Review). International journal of oncology. vol 53. issue 1. 2018-10-02. PMID:29749432. |
signal transducer and activator of transcription 3 (stat3) is a vital regulatory factor of signal transduction and transcriptional activation, and once activated, the phosphorylated form of stat3 (p-stat3) is transferred into the nucleus to regulate the transcription of target genes, and plays important roles in cell proliferation, differentiation, apoptosis and other physiological processes. |
2018-10-02 |
2023-08-13 |
Not clear |
| Yin Shi, Zhen Zhang, Xintao Qu, Xiaoxiao Zhu, Lin Zhao, Ran Wei, Qiang Guo, Linlin Sun, Xunqiang Yin, Yunhong Zhang, Xia L. Roles of STAT3 in leukemia (Review). International journal of oncology. vol 53. issue 1. 2018-10-02. PMID:29749432. |
in this review, the roles of stat3 in the pathogenesis, diagnosis, treatment and prognosis of leukemia are discussed in the aspects of cell proliferation, differentiation and apoptosis, with the aim to further clarify the roles of stat3 in leukemia, and shed light into possible novel targets and strategies for clinical diagnosis and treatment. |
2018-10-02 |
2023-08-13 |
Not clear |
| Ming-Yan Hu, Xiong-Bing Du, Hai-Bo Hu, Yan Shi, Gang Chen, Ya-Yun Wan. MiR-410 inhibition induces HUVECs proliferation and represses ox-LDL-triggered apoptosis through activating STAT3. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 101. 2018-09-24. PMID:29518604. |
mir-410 inhibition induces huvecs proliferation and represses ox-ldl-triggered apoptosis through activating stat3. |
2018-09-24 |
2023-08-13 |
Not clear |
| Ming-Yan Hu, Xiong-Bing Du, Hai-Bo Hu, Yan Shi, Gang Chen, Ya-Yun Wan. MiR-410 inhibition induces HUVECs proliferation and represses ox-LDL-triggered apoptosis through activating STAT3. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 101. 2018-09-24. PMID:29518604. |
taken these together, our current study implied that mir-410 silence can inhibit the ox-ldl-induced huvecs proliferation and rescue cell apoptosis through activating stat3 in vitro. |
2018-09-24 |
2023-08-13 |
Not clear |
| T G Shrihari, V Vasudevan, V Manjunath, D Devaraj. Potential Co-Relation Between Chronic Periodontitis And Cancer - An Emerging Concept. The Gulf journal of oncology. vol 1. issue 20. 2018-09-18. PMID:27050175. |
immature myeloid cells such as macrophages, dendritic cells and granulocytes involved in chronic inflammation and tumor progression through immunosuppressive activity against innate and adaptive immunity by factors such as inos, arginase1 and ros, activate major transcriptional factors such as nf-kb and stat3 that could contribute to genetic instability, uncontrolled cell proliferation, angiogenesis, resistance to apoptosis, epithelial to mesenchymal transition, immunosuppression, invasion and metastasis. |
2018-09-18 |
2023-08-13 |
Not clear |
| Amara Maryam, Tahir Mehmood, Qiulong Yan, Yongming Li, Muhammad Khan, Tonghui M. Proscillaridin A Promotes Oxidative Stress and ER Stress, Inhibits STAT3 Activation, and Induces Apoptosis in A549 Lung Adenocarcinoma Cells. Oxidative medicine and cellular longevity. vol 2018. 2018-09-18. PMID:29576846. |
proscillaridin a promotes oxidative stress and er stress, inhibits stat3 activation, and induces apoptosis in a549 lung adenocarcinoma cells. |
2018-09-18 |
2023-08-13 |
Not clear |
| Bin Xiao, Xuan Zhang, Mei-lan Zhang, Xue-wu Zhan. [Apoptosis of human hepatocellular carcinoma HepG-2 cells upon inhibition of STAT3 by 5,2’,4’-trihydroxy-6,7,5’-trimethoxy flavone nanoparticle]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 51. issue 12. 2018-09-17. PMID:29908536. |
[apoptosis of human hepatocellular carcinoma hepg-2 cells upon inhibition of stat3 by 5,2’,4’-trihydroxy-6,7,5’-trimethoxy flavone nanoparticle]. |
2018-09-17 |
2023-08-13 |
human |
| Bin Xiao, Xuan Zhang, Mei-lan Zhang, Xue-wu Zhan. [Apoptosis of human hepatocellular carcinoma HepG-2 cells upon inhibition of STAT3 by 5,2’,4’-trihydroxy-6,7,5’-trimethoxy flavone nanoparticle]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 51. issue 12. 2018-09-17. PMID:29908536. |
taken together, our results showed that ttf1-np induced hepg-2 cell apoptosis through inhibition of the stat3 expression. |
2018-09-17 |
2023-08-13 |
human |
| Sen Wang, Yanyan Lv, Yingting Wang, Peiru Du, Wuhong Tan, Mikko J Lammi, Xiong Gu. Network Analysis of Se-and Zn-related Proteins in the Serum Proteomics Expression Profile of the Endemic Dilated Cardiomyopathy Keshan Disease. Biological trace element research. vol 183. issue 1. 2018-09-11. PMID:28819918. |
the results showed that se-associated proteins stat3 and mapk1 and zn-associated proteins hif1a and parp1, the proteins involved in hif-1 signaling pathway and apoptosis pathway, may play significant roles in the pathogenesis of kd. |
2018-09-11 |
2023-08-13 |
Not clear |