| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoying Chen, Nanzhen Kuang, Xiaoping Zeng, Zhiqin Zhang, Yanyan Li, Wei Liu, Yingyuan F. Effects of daphnetin combined with Bcl2‑siRNA on antiapoptotic genes in synovial fibroblasts of rats with collagen‑induced arthritis. Molecular medicine reports. vol 17. issue 1. 2018-07-09. PMID:29115552. |
the results suggested that si‑bcl combined with daphnetin may have an enhanced effect in promoting apoptosis of rafls derived from cia rats, and a possible underlying molecular mechanism may function through the downregulation of bcl2 expression and stat3, which is located upstream of bcl2 in the mitochondrial apoptotic pathway. |
2018-07-09 |
2023-08-13 |
rat |
| M Geletu, R Mohan, R Arulanandam, A Berger-Becvar, I R Nabi, P T Gunning, L Rapti. Reciprocal regulation of the Cadherin-11/Stat3 axis by caveolin-1 in mouse fibroblasts and lung carcinoma cells. Biochimica et biophysica acta. Molecular cell research. vol 1865. issue 5. 2018-07-09. PMID:29458077. |
our data reveal the presence of a potent, negative regulatory loop between cav1 and cadherin-11/stat3, leading to stat3 inhibition and apoptosis. |
2018-07-09 |
2023-08-13 |
mouse |
| Weiwei Bao, Yaru Luo, Dan Wang, Jian Li, Xi Wu, Wei Me. Sodium salicylate modulates inflammatory responses through AMP-activated protein kinase activation in LPS-stimulated THP-1 cells. Journal of cellular biochemistry. vol 119. issue 1. 2018-07-06. PMID:28661045. |
we conclude that ampk activation is important for nasal-mediated inflammation by inducing apoptosis, reducing cell proliferation, inhibiting stat3 activity, and producing tnf-α and il-1β. |
2018-07-06 |
2023-08-13 |
Not clear |
| Huiyu Jiang, Lin Wang, Feifei Wang, Jihong Pa. Proprotein convertase subtilisin/kexin type 6 promotes in vitro proliferation, migration and inflammatory cytokine secretion of synovial fibroblast‑like cells from rheumatoid arthritis via nuclear‑κB, signal transducer and activator of transcription 3 and extracellular signal regulated 1/2 pathways. Molecular medicine reports. vol 16. issue 6. 2018-06-26. PMID:28944919. |
the results demonstrated that signaling via nf‑κb and stat3 mediated cell cycle arrest, and signaling through nf‑κb mediated apoptosis in rasf cells stimulated with pcsk6. |
2018-06-26 |
2023-08-13 |
human |
| Minjie Gao, Bo Li, Xi Sun, Yunfei Zhou, Yingcong Wang, Van S Tompkins, Zhijian Xu, Nekitsing Indima, Houcai Wang, Wenqin Xiao, Lu Gao, Gege Chen, Huiqun Wu, Xiaosong Wu, Yuanyuan Kong, Bingqian Xie, Yiwen Zhang, Gaomei Chang, Liangning Hu, Guang Yang, Bojie Dai, Yi Tao, Weiliang Zhu, Jumei Sh. Preclinical activity of DCZ3301, a novel aryl-guanidino compound in the therapy of multiple myeloma. Theranostics. vol 7. issue 15. 2018-06-25. PMID:29109769. |
knockdown of stat3 using sirna in mm cells enhanced dcz3301-induced cytotoxicity, whereas overexpression of stat3 in mm cells partially protected them from apoptosis. |
2018-06-25 |
2023-08-13 |
human |
| Helin Chen, Wenjia Liu, Xiangnan Wu, Min Gou, Jiefei Shen, Hang Wan. Advanced glycation end products induced IL-6 and VEGF-A production and apoptosis in osteocyte-like MLO-Y4 cells by activating RAGE and ERK1/2, P38 and STAT3 signalling pathways. International immunopharmacology. vol 52. 2018-06-12. PMID:28910744. |
advanced glycation end products induced il-6 and vegf-a production and apoptosis in osteocyte-like mlo-y4 cells by activating rage and erk1/2, p38 and stat3 signalling pathways. |
2018-06-12 |
2023-08-13 |
Not clear |
| Helin Chen, Wenjia Liu, Xiangnan Wu, Min Gou, Jiefei Shen, Hang Wan. Advanced glycation end products induced IL-6 and VEGF-A production and apoptosis in osteocyte-like MLO-Y4 cells by activating RAGE and ERK1/2, P38 and STAT3 signalling pathways. International immunopharmacology. vol 52. 2018-06-12. PMID:28910744. |
the erk1/2 inhibitor u0126, the p38 inhibitor sb239063 and the stat3 inhibitor s3i-201 all attenuated the effects of ages on mlo-y4 cell apoptosis and il-6 and vegf-a secretion. |
2018-06-12 |
2023-08-13 |
Not clear |
| Helin Chen, Wenjia Liu, Xiangnan Wu, Min Gou, Jiefei Shen, Hang Wan. Advanced glycation end products induced IL-6 and VEGF-A production and apoptosis in osteocyte-like MLO-Y4 cells by activating RAGE and ERK1/2, P38 and STAT3 signalling pathways. International immunopharmacology. vol 52. 2018-06-12. PMID:28910744. |
together, these data convince us that ages can activate the erk1/2, p38 and stat3 signalling pathways via rage and that their activation involves the ages-induced up-regulation of il-6 and vegf-a production as well as apoptosis in osteocytes. |
2018-06-12 |
2023-08-13 |
Not clear |
| Ying Wang, Hui-Lan Lu, Yong-Dong Liu, Li-Yun Yang, Qing-Kun Jiang, Xiao-Jun Zhu, Hua-Nan Fan, Yong Qia. Cryptotanshinone sensitizes antitumor effect of paclitaxel on tongue squamous cell carcinoma growth by inhibiting the JAK/STAT3 signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 95. 2018-06-11. PMID:28946186. |
furthermore, we found that the combination treatment of cryptotanshinone and paclitaxel more effectively inhibited tscc cell proliferation and migration, and induced apoptosis via the inhibition of stat3 signaling pathway. |
2018-06-11 |
2023-08-13 |
human |
| Kuisheng Liu, Tingting Ren, Yi Huang, Kunkun Sun, Xing Bao, Shidong Wang, Bingxin Zheng, Wei Gu. Apatinib promotes autophagy and apoptosis through VEGFR2/STAT3/BCL-2 signaling in osteosarcoma. Cell death & disease. vol 8. issue 8. 2018-06-05. PMID:28837148. |
stat3 knockdown by sirna reinforced autophagy and apoptosis induced by apatinib. |
2018-06-05 |
2023-08-13 |
human |
| Chun-Yu Liu, Tzu-Ting Huang, Pei-Yi Chu, Chun-Teng Huang, Chia-Han Lee, Wan-Lun Wang, Ka-Yi Lau, Wen-Chun Tsai, Tzu-I Chao, Jung-Chen Su, Ming-Huang Chen, Chung-Wai Shiau, Ling-Ming Tseng, Kuen-Feng Che. The tyrosine kinase inhibitor nintedanib activates SHP-1 and induces apoptosis in triple-negative breast cancer cells. Experimental & molecular medicine. vol 49. issue 8. 2018-05-31. PMID:28798401. |
stat3 overexpression suppressed nintedanib-mediated apoptosis and further increased the activity of purified shp-1 protein. |
2018-05-31 |
2023-08-13 |
Not clear |
| Chun-Yu Liu, Tzu-Ting Huang, Pei-Yi Chu, Chun-Teng Huang, Chia-Han Lee, Wan-Lun Wang, Ka-Yi Lau, Wen-Chun Tsai, Tzu-I Chao, Jung-Chen Su, Ming-Huang Chen, Chung-Wai Shiau, Ling-Ming Tseng, Kuen-Feng Che. The tyrosine kinase inhibitor nintedanib activates SHP-1 and induces apoptosis in triple-negative breast cancer cells. Experimental & molecular medicine. vol 49. issue 8. 2018-05-31. PMID:28798401. |
our findings revealed that nintedanib induces tnbc apoptosis by acting as a shp-1 agonist, suggesting that targeting stat3 by enhancing shp-1 expression could be a viable therapeutic strategy against tnbc. |
2018-05-31 |
2023-08-13 |
Not clear |
| Jing Yu, Yimei Wu, Lu Wang, Wen Zhang, Man Xu, Jiayu Song, Yu Fu, Yiyun Cui, Wei Gong, Shuzhen Li, Weiwei Xia, Songming Huang, Aihua Zhang, Zhanjun Ji. mPGES-1-derived prostaglandin E2 stimulates Stat3 to promote podocyte apoptosis. Apoptosis : an international journal on programmed cell death. vol 22. issue 11. 2018-05-31. PMID:28879567. |
mpges-1-derived prostaglandin e2 stimulates stat3 to promote podocyte apoptosis. |
2018-05-31 |
2023-08-13 |
Not clear |
| Jing Yu, Yimei Wu, Lu Wang, Wen Zhang, Man Xu, Jiayu Song, Yu Fu, Yiyun Cui, Wei Gong, Shuzhen Li, Weiwei Xia, Songming Huang, Aihua Zhang, Zhanjun Ji. mPGES-1-derived prostaglandin E2 stimulates Stat3 to promote podocyte apoptosis. Apoptosis : an international journal on programmed cell death. vol 22. issue 11. 2018-05-31. PMID:28879567. |
here we studied the role of mpges-1/pge2 cascade in activating stat3 signaling and the contribution of stat3 in pge2- and adr-induced podocyte apoptosis. |
2018-05-31 |
2023-08-13 |
Not clear |
| Jing Yu, Yimei Wu, Lu Wang, Wen Zhang, Man Xu, Jiayu Song, Yu Fu, Yiyun Cui, Wei Gong, Shuzhen Li, Weiwei Xia, Songming Huang, Aihua Zhang, Zhanjun Ji. mPGES-1-derived prostaglandin E2 stimulates Stat3 to promote podocyte apoptosis. Apoptosis : an international journal on programmed cell death. vol 22. issue 11. 2018-05-31. PMID:28879567. |
in murine podocytes, pge2 dose- and time-dependently increased the phosphorylation of stat3 in line with the enhanced cell apoptosis and reduced podocyte protein podocin. |
2018-05-31 |
2023-08-13 |
Not clear |
| Jing Yu, Yimei Wu, Lu Wang, Wen Zhang, Man Xu, Jiayu Song, Yu Fu, Yiyun Cui, Wei Gong, Shuzhen Li, Weiwei Xia, Songming Huang, Aihua Zhang, Zhanjun Ji. mPGES-1-derived prostaglandin E2 stimulates Stat3 to promote podocyte apoptosis. Apoptosis : an international journal on programmed cell death. vol 22. issue 11. 2018-05-31. PMID:28879567. |
by application of a specific stat3 inhibitor s3i-201, pge2-induced podocyte apoptosis was largely abolished in parallel with a blockade of podocin reduction. |
2018-05-31 |
2023-08-13 |
Not clear |
| Jing Yu, Yimei Wu, Lu Wang, Wen Zhang, Man Xu, Jiayu Song, Yu Fu, Yiyun Cui, Wei Gong, Shuzhen Li, Weiwei Xia, Songming Huang, Aihua Zhang, Zhanjun Ji. mPGES-1-derived prostaglandin E2 stimulates Stat3 to promote podocyte apoptosis. Apoptosis : an international journal on programmed cell death. vol 22. issue 11. 2018-05-31. PMID:28879567. |
blockade of stat3 by s3i-201 significantly ameliorated adr-induced cell apoptosis and podocin reduction. |
2018-05-31 |
2023-08-13 |
Not clear |
| Jing Yu, Yimei Wu, Lu Wang, Wen Zhang, Man Xu, Jiayu Song, Yu Fu, Yiyun Cui, Wei Gong, Shuzhen Li, Weiwei Xia, Songming Huang, Aihua Zhang, Zhanjun Ji. mPGES-1-derived prostaglandin E2 stimulates Stat3 to promote podocyte apoptosis. Apoptosis : an international journal on programmed cell death. vol 22. issue 11. 2018-05-31. PMID:28879567. |
taken together, this study suggested that mpges-1-derived pge2 could activate stat3 signaling to promote podocyte apoptosis. |
2018-05-31 |
2023-08-13 |
Not clear |
| Kai Li, Han Bao, Panying Zhang, Li Che. Inhibitory Effect of AG490 on STAT3 Signal Transduction Pathway in Nasopharyngeal Carcinoma Cells. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. vol 27. issue 11. 2018-05-28. PMID:29132481. |
to determine the effect of jak kinase inhibitor ag490 on proliferation and apoptosis of nasopharyngeal carcinoma cell line c666-1 and explore the inhibitory effect of ag490 on stat3 signal transduction pathway. |
2018-05-28 |
2023-08-13 |
Not clear |
| Saisai Wang, Yong Shen, Runfeng Qiu, Zhiliang Chen, Zhehang Chen, Wenbin Che. 18 β-glycyrrhetinic acid exhibits potent antitumor effects against colorectal cancer via inhibition of cell proliferation and migration. International journal of oncology. vol 51. issue 2. 2018-05-25. PMID:28656212. |
these results suggest that regulation of the apoptosis, invasion and migration of colorectal cancer cells by gra might be through suppressing pi3k and stat3 signaling pathways. |
2018-05-25 |
2023-08-13 |
Not clear |