| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jie Mao, Hongbao Yang, Tingting Cui, Pan Pan, Nadia Kabir, Duo Chen, Jinyan Ma, Xingyi Chen, Yijun Chen, Yong Yan. Combined treatment with sorafenib and silibinin synergistically targets both HCC cells and cancer stem cells by enhanced inhibition of the phosphorylation of STAT3/ERK/AKT. European journal of pharmacology. vol 832. 2018-10-08. PMID:29782854. |
as determined by fluorescence staining and western blots, the combination of the two drugs inhibited the phosphorylation of rac-alpha serine/threonine-protein kinase (akt) and signal transducer and activator of transcription 3 (stat3) together with the expression of antiapoptotic proteins including myeloid leukemia cell differentiation protein mcl-1 (mcl-1) and apoptosis regulator bcl-2 (bcl-2), resulting in the death of cancer cells. |
2018-10-08 |
2023-08-13 |
Not clear |
| Yin Shi, Zhen Zhang, Xintao Qu, Xiaoxiao Zhu, Lin Zhao, Ran Wei, Qiang Guo, Linlin Sun, Xunqiang Yin, Yunhong Zhang, Xia L. Roles of STAT3 in leukemia (Review). International journal of oncology. vol 53. issue 1. 2018-10-02. PMID:29749432. |
signal transducer and activator of transcription 3 (stat3) is a vital regulatory factor of signal transduction and transcriptional activation, and once activated, the phosphorylated form of stat3 (p-stat3) is transferred into the nucleus to regulate the transcription of target genes, and plays important roles in cell proliferation, differentiation, apoptosis and other physiological processes. |
2018-10-02 |
2023-08-13 |
Not clear |
| Yin Shi, Zhen Zhang, Xintao Qu, Xiaoxiao Zhu, Lin Zhao, Ran Wei, Qiang Guo, Linlin Sun, Xunqiang Yin, Yunhong Zhang, Xia L. Roles of STAT3 in leukemia (Review). International journal of oncology. vol 53. issue 1. 2018-10-02. PMID:29749432. |
in this review, the roles of stat3 in the pathogenesis, diagnosis, treatment and prognosis of leukemia are discussed in the aspects of cell proliferation, differentiation and apoptosis, with the aim to further clarify the roles of stat3 in leukemia, and shed light into possible novel targets and strategies for clinical diagnosis and treatment. |
2018-10-02 |
2023-08-13 |
Not clear |
| Ming-Yan Hu, Xiong-Bing Du, Hai-Bo Hu, Yan Shi, Gang Chen, Ya-Yun Wan. MiR-410 inhibition induces HUVECs proliferation and represses ox-LDL-triggered apoptosis through activating STAT3. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 101. 2018-09-24. PMID:29518604. |
mir-410 inhibition induces huvecs proliferation and represses ox-ldl-triggered apoptosis through activating stat3. |
2018-09-24 |
2023-08-13 |
Not clear |
| Ming-Yan Hu, Xiong-Bing Du, Hai-Bo Hu, Yan Shi, Gang Chen, Ya-Yun Wan. MiR-410 inhibition induces HUVECs proliferation and represses ox-LDL-triggered apoptosis through activating STAT3. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 101. 2018-09-24. PMID:29518604. |
taken these together, our current study implied that mir-410 silence can inhibit the ox-ldl-induced huvecs proliferation and rescue cell apoptosis through activating stat3 in vitro. |
2018-09-24 |
2023-08-13 |
Not clear |
| T G Shrihari, V Vasudevan, V Manjunath, D Devaraj. Potential Co-Relation Between Chronic Periodontitis And Cancer - An Emerging Concept. The Gulf journal of oncology. vol 1. issue 20. 2018-09-18. PMID:27050175. |
immature myeloid cells such as macrophages, dendritic cells and granulocytes involved in chronic inflammation and tumor progression through immunosuppressive activity against innate and adaptive immunity by factors such as inos, arginase1 and ros, activate major transcriptional factors such as nf-kb and stat3 that could contribute to genetic instability, uncontrolled cell proliferation, angiogenesis, resistance to apoptosis, epithelial to mesenchymal transition, immunosuppression, invasion and metastasis. |
2018-09-18 |
2023-08-13 |
Not clear |
| Amara Maryam, Tahir Mehmood, Qiulong Yan, Yongming Li, Muhammad Khan, Tonghui M. Proscillaridin A Promotes Oxidative Stress and ER Stress, Inhibits STAT3 Activation, and Induces Apoptosis in A549 Lung Adenocarcinoma Cells. Oxidative medicine and cellular longevity. vol 2018. 2018-09-18. PMID:29576846. |
proscillaridin a promotes oxidative stress and er stress, inhibits stat3 activation, and induces apoptosis in a549 lung adenocarcinoma cells. |
2018-09-18 |
2023-08-13 |
Not clear |
| Bin Xiao, Xuan Zhang, Mei-lan Zhang, Xue-wu Zhan. [Apoptosis of human hepatocellular carcinoma HepG-2 cells upon inhibition of STAT3 by 5,2’,4’-trihydroxy-6,7,5’-trimethoxy flavone nanoparticle]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 51. issue 12. 2018-09-17. PMID:29908536. |
[apoptosis of human hepatocellular carcinoma hepg-2 cells upon inhibition of stat3 by 5,2’,4’-trihydroxy-6,7,5’-trimethoxy flavone nanoparticle]. |
2018-09-17 |
2023-08-13 |
human |
| Bin Xiao, Xuan Zhang, Mei-lan Zhang, Xue-wu Zhan. [Apoptosis of human hepatocellular carcinoma HepG-2 cells upon inhibition of STAT3 by 5,2’,4’-trihydroxy-6,7,5’-trimethoxy flavone nanoparticle]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 51. issue 12. 2018-09-17. PMID:29908536. |
taken together, our results showed that ttf1-np induced hepg-2 cell apoptosis through inhibition of the stat3 expression. |
2018-09-17 |
2023-08-13 |
human |
| Sen Wang, Yanyan Lv, Yingting Wang, Peiru Du, Wuhong Tan, Mikko J Lammi, Xiong Gu. Network Analysis of Se-and Zn-related Proteins in the Serum Proteomics Expression Profile of the Endemic Dilated Cardiomyopathy Keshan Disease. Biological trace element research. vol 183. issue 1. 2018-09-11. PMID:28819918. |
the results showed that se-associated proteins stat3 and mapk1 and zn-associated proteins hif1a and parp1, the proteins involved in hif-1 signaling pathway and apoptosis pathway, may play significant roles in the pathogenesis of kd. |
2018-09-11 |
2023-08-13 |
Not clear |
| Jaemoo Chun, Min Kyoung Park, Hyejin Ko, Kyungjin Lee, Yeong Shik Ki. Bioassay-guided isolation of cantharidin from blister beetles and its anticancer activity through inhibition of epidermal growth factor receptor-mediated STAT3 and Akt pathways. Journal of natural medicines. vol 72. issue 4. 2018-09-11. PMID:30043217. |
moreover, cantharidin reduced cell proliferation and induced apoptosis with downregulation of stat3 target genes, such as bcl-2, cox-2, and cyclin d |
2018-09-11 |
2023-08-13 |
human |
| Jun Zou, Yamei Wang, Mingdi Liu, Xiushu Huang, Wenjian Zheng, Qian Gao, Haijing Wan. Euxanthone inhibits glycolysis and triggers mitochondria-mediated apoptosis by targeting hexokinase 2 in epithelial ovarian cancer. Cell biochemistry and function. vol 36. issue 6. 2018-09-04. PMID:29984416. |
apoptosis and glycolysis inhibition was mediated by the downregulation of hk2, which in turn was a result of stat3 inactivation. |
2018-09-04 |
2023-08-13 |
mouse |
| Tomoya Takeda, Masanobu Tsubaki, Yoshika Tomonari, Keishi Kawashima, Tatsuki Itoh, Motohiro Imano, Takao Satou, Shozo Nishid. Bavachin induces the apoptosis of multiple myeloma cell lines by inhibiting the activation of nuclear factor kappa B and signal transducer and activator of transcription 3. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 100. 2018-08-31. PMID:29477912. |
our results suggest that bavachin induces apoptosis through the inhibition of nf-κb and stat3 activation in mm cell lines. |
2018-08-31 |
2023-08-13 |
Not clear |
| Xian-Qun Chu, Jing Wang, Guang-Xiang Chen, Guan-Qi Zhang, De-Yong Zhang, Yong-Yan Ca. Overexpression of microRNA-495 improves the intestinal mucosal barrier function by targeting STAT3 via inhibition of the JAK/STAT3 signaling pathway in a mouse model of ulcerative colitis. Pathology, research and practice. vol 214. issue 1. 2018-08-30. PMID:29129493. |
no significant differences were found in mrna and protein expressions of stat3, jak and claudin-1, cell proliferation, apoptosis and cycle amongst the mir-495 inhibitor+sirna-stat3 groups. |
2018-08-30 |
2023-08-13 |
mouse |
| Hyun-Ju Yu, Chi-Hyun Ahn, In-Hyoung Yang, Dong-Hoon Won, Bohwan Jin, Nam-Pyo Cho, Seong Doo Hong, Ji-Ae Shin, Sung-Dae Ch. Apoptosis induced by methanol extract of Potentilla discolor in human mucoepidermoid carcinoma cells through STAT3/PUMA signaling axis. Molecular medicine reports. vol 17. issue 4. 2018-08-27. PMID:29363716. |
in addition, dephosphorylation of stat3 by cryptotanshinone (a potent stat3 inhibitor) was sufficient to inhibit the growth of mec cells and induce apoptosis via affecting puma protein. |
2018-08-27 |
2023-08-13 |
human |
| Urszula Sulkowska, Andrzej Wincewicz, Luiza Kanczuga-Koda, Mariusz Koda, Stanislaw Sulkowsk. Comparison of E-cadherin with STAT3 and apoptosis regulators: Bak and Bcl-xL in endometrioid adenocarcinomas of different ER-alpha immunoprofile. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. vol 34. issue 2. 2018-08-17. PMID:28937296. |
comparison of e-cadherin with stat3 and apoptosis regulators: bak and bcl-xl in endometrioid adenocarcinomas of different er-alpha immunoprofile. |
2018-08-17 |
2023-08-13 |
human |
| Wei-Qiang Jia, Zhao-Tao Wang, Ming-Ming Zou, Jian-Hao Lin, Ye-Hai Li, Liang Zhang, Ru-Xiang X. Verbascoside Inhibits Glioblastoma Cell Proliferation, Migration and Invasion While Promoting Apoptosis Through Upregulation of Protein Tyrosine Phosphatase SHP-1 and Inhibition of STAT3 Phosphorylation. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 47. issue 5. 2018-08-17. PMID:29961065. |
verbascoside inhibits glioblastoma cell proliferation, migration and invasion while promoting apoptosis through upregulation of protein tyrosine phosphatase shp-1 and inhibition of stat3 phosphorylation. |
2018-08-17 |
2023-08-13 |
Not clear |
| Wei-Qiang Jia, Zhao-Tao Wang, Ming-Ming Zou, Jian-Hao Lin, Ye-Hai Li, Liang Zhang, Ru-Xiang X. Verbascoside Inhibits Glioblastoma Cell Proliferation, Migration and Invasion While Promoting Apoptosis Through Upregulation of Protein Tyrosine Phosphatase SHP-1 and Inhibition of STAT3 Phosphorylation. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 47. issue 5. 2018-08-17. PMID:29961065. |
thus, this study aimed to investigate the effects of vb on glioblastoma cell proliferation, apoptosis, migration, and invasion as well as the mechanism involving signal transducer and activator of transcription 3 (stat3) and src homology 2 domain-containing protein tyrosine phosphatase 1 (shp-1). |
2018-08-17 |
2023-08-13 |
Not clear |
| Valentina Gambini, Martina Tilio, Eunice Wairimu Maina, Cristina Andreani, Caterina Bartolacci, Junbiao Wang, Manuela Iezzi, Stefano Ferraro, Anna Teresa Ramadori, Oumarou Camille Simon, Stefania Pucciarelli, Guojun Wu, Q Ping Dou, Cristina Marchini, Rossana Galassi, Augusto Amic. In vitro and in vivo studies of gold(I) azolate/phosphane complexes for the treatment of basal like breast cancer. European journal of medicinal chemistry. vol 155. 2018-08-13. PMID:29906688. |
this study also provides evidence that both gold(i) complexes inhibited the 19 s proteasome-associated deubiquitinase usp14 and induced apoptosis, while compound 1's mechanism of action depends also on its ability to down-regulate key molecules governing cancer growth and progression, such as stat3 and cox-2. |
2018-08-13 |
2023-08-13 |
mouse |
| Jinxiang Liu, Dan Fei, Jie Xing, Juan D. MicroRNA-29a inhibits proliferation and induces apoptosis in rheumatoid arthritis fibroblast-like synoviocytes by repressing STAT3. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 96. 2018-07-26. PMID:28987940. |
microrna-29a inhibits proliferation and induces apoptosis in rheumatoid arthritis fibroblast-like synoviocytes by repressing stat3. |
2018-07-26 |
2023-08-13 |
Not clear |