| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jaemoo Chun, Min Kyoung Park, Hyejin Ko, Kyungjin Lee, Yeong Shik Ki. Bioassay-guided isolation of cantharidin from blister beetles and its anticancer activity through inhibition of epidermal growth factor receptor-mediated STAT3 and Akt pathways. Journal of natural medicines. vol 72. issue 4. 2018-09-11. PMID:30043217. |
moreover, cantharidin reduced cell proliferation and induced apoptosis with downregulation of stat3 target genes, such as bcl-2, cox-2, and cyclin d |
2018-09-11 |
2023-08-13 |
human |
| Jun Zou, Yamei Wang, Mingdi Liu, Xiushu Huang, Wenjian Zheng, Qian Gao, Haijing Wan. Euxanthone inhibits glycolysis and triggers mitochondria-mediated apoptosis by targeting hexokinase 2 in epithelial ovarian cancer. Cell biochemistry and function. vol 36. issue 6. 2018-09-04. PMID:29984416. |
apoptosis and glycolysis inhibition was mediated by the downregulation of hk2, which in turn was a result of stat3 inactivation. |
2018-09-04 |
2023-08-13 |
mouse |
| Tomoya Takeda, Masanobu Tsubaki, Yoshika Tomonari, Keishi Kawashima, Tatsuki Itoh, Motohiro Imano, Takao Satou, Shozo Nishid. Bavachin induces the apoptosis of multiple myeloma cell lines by inhibiting the activation of nuclear factor kappa B and signal transducer and activator of transcription 3. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 100. 2018-08-31. PMID:29477912. |
our results suggest that bavachin induces apoptosis through the inhibition of nf-κb and stat3 activation in mm cell lines. |
2018-08-31 |
2023-08-13 |
Not clear |
| Xian-Qun Chu, Jing Wang, Guang-Xiang Chen, Guan-Qi Zhang, De-Yong Zhang, Yong-Yan Ca. Overexpression of microRNA-495 improves the intestinal mucosal barrier function by targeting STAT3 via inhibition of the JAK/STAT3 signaling pathway in a mouse model of ulcerative colitis. Pathology, research and practice. vol 214. issue 1. 2018-08-30. PMID:29129493. |
no significant differences were found in mrna and protein expressions of stat3, jak and claudin-1, cell proliferation, apoptosis and cycle amongst the mir-495 inhibitor+sirna-stat3 groups. |
2018-08-30 |
2023-08-13 |
mouse |
| Hyun-Ju Yu, Chi-Hyun Ahn, In-Hyoung Yang, Dong-Hoon Won, Bohwan Jin, Nam-Pyo Cho, Seong Doo Hong, Ji-Ae Shin, Sung-Dae Ch. Apoptosis induced by methanol extract of Potentilla discolor in human mucoepidermoid carcinoma cells through STAT3/PUMA signaling axis. Molecular medicine reports. vol 17. issue 4. 2018-08-27. PMID:29363716. |
in addition, dephosphorylation of stat3 by cryptotanshinone (a potent stat3 inhibitor) was sufficient to inhibit the growth of mec cells and induce apoptosis via affecting puma protein. |
2018-08-27 |
2023-08-13 |
human |
| Urszula Sulkowska, Andrzej Wincewicz, Luiza Kanczuga-Koda, Mariusz Koda, Stanislaw Sulkowsk. Comparison of E-cadherin with STAT3 and apoptosis regulators: Bak and Bcl-xL in endometrioid adenocarcinomas of different ER-alpha immunoprofile. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. vol 34. issue 2. 2018-08-17. PMID:28937296. |
comparison of e-cadherin with stat3 and apoptosis regulators: bak and bcl-xl in endometrioid adenocarcinomas of different er-alpha immunoprofile. |
2018-08-17 |
2023-08-13 |
human |
| Wei-Qiang Jia, Zhao-Tao Wang, Ming-Ming Zou, Jian-Hao Lin, Ye-Hai Li, Liang Zhang, Ru-Xiang X. Verbascoside Inhibits Glioblastoma Cell Proliferation, Migration and Invasion While Promoting Apoptosis Through Upregulation of Protein Tyrosine Phosphatase SHP-1 and Inhibition of STAT3 Phosphorylation. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 47. issue 5. 2018-08-17. PMID:29961065. |
verbascoside inhibits glioblastoma cell proliferation, migration and invasion while promoting apoptosis through upregulation of protein tyrosine phosphatase shp-1 and inhibition of stat3 phosphorylation. |
2018-08-17 |
2023-08-13 |
Not clear |
| Wei-Qiang Jia, Zhao-Tao Wang, Ming-Ming Zou, Jian-Hao Lin, Ye-Hai Li, Liang Zhang, Ru-Xiang X. Verbascoside Inhibits Glioblastoma Cell Proliferation, Migration and Invasion While Promoting Apoptosis Through Upregulation of Protein Tyrosine Phosphatase SHP-1 and Inhibition of STAT3 Phosphorylation. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 47. issue 5. 2018-08-17. PMID:29961065. |
thus, this study aimed to investigate the effects of vb on glioblastoma cell proliferation, apoptosis, migration, and invasion as well as the mechanism involving signal transducer and activator of transcription 3 (stat3) and src homology 2 domain-containing protein tyrosine phosphatase 1 (shp-1). |
2018-08-17 |
2023-08-13 |
Not clear |
| Valentina Gambini, Martina Tilio, Eunice Wairimu Maina, Cristina Andreani, Caterina Bartolacci, Junbiao Wang, Manuela Iezzi, Stefano Ferraro, Anna Teresa Ramadori, Oumarou Camille Simon, Stefania Pucciarelli, Guojun Wu, Q Ping Dou, Cristina Marchini, Rossana Galassi, Augusto Amic. In vitro and in vivo studies of gold(I) azolate/phosphane complexes for the treatment of basal like breast cancer. European journal of medicinal chemistry. vol 155. 2018-08-13. PMID:29906688. |
this study also provides evidence that both gold(i) complexes inhibited the 19 s proteasome-associated deubiquitinase usp14 and induced apoptosis, while compound 1's mechanism of action depends also on its ability to down-regulate key molecules governing cancer growth and progression, such as stat3 and cox-2. |
2018-08-13 |
2023-08-13 |
mouse |
| Jinxiang Liu, Dan Fei, Jie Xing, Juan D. MicroRNA-29a inhibits proliferation and induces apoptosis in rheumatoid arthritis fibroblast-like synoviocytes by repressing STAT3. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 96. 2018-07-26. PMID:28987940. |
microrna-29a inhibits proliferation and induces apoptosis in rheumatoid arthritis fibroblast-like synoviocytes by repressing stat3. |
2018-07-26 |
2023-08-13 |
Not clear |
| Jinxiang Liu, Dan Fei, Jie Xing, Juan D. MicroRNA-29a inhibits proliferation and induces apoptosis in rheumatoid arthritis fibroblast-like synoviocytes by repressing STAT3. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 96. 2018-07-26. PMID:28987940. |
rescue experiments showed that overexpression of stat3 effectively reversed the effect of mir-29a on proliferation and apoptosis in ra-fls. |
2018-07-26 |
2023-08-13 |
Not clear |
| Jinxiang Liu, Dan Fei, Jie Xing, Juan D. MicroRNA-29a inhibits proliferation and induces apoptosis in rheumatoid arthritis fibroblast-like synoviocytes by repressing STAT3. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 96. 2018-07-26. PMID:28987940. |
these data indicate that mir-29a inhibits proliferation and induces apoptosis in ra-fls by targeting stat3, suggesting that promoting mir-29a expression may yield therapeutic benefits in the treatment of ra. |
2018-07-26 |
2023-08-13 |
Not clear |
| Z Wu, W Huang, B Chen, P-D Bai, X-G Wang, J-C Xin. Up-regulation of miR-124 inhibits invasion and proliferation of prostate cancer cells through mediating JAK-STAT3 signaling pathway. European review for medical and pharmacological sciences. vol 21. issue 10. 2018-07-23. PMID:28617558. |
this study aims to investigate the role of mir-124 in regulating stat3 expression and proliferation, cycle, apoptosis and invasion of prostate cancer cells. |
2018-07-23 |
2023-08-13 |
Not clear |
| Mingze Chang, Lin Qiao, Bin Li, Juanhong Wang, Gejuan Zhang, Wenzhen Shi, Zhiqin Liu, Naibing Gu, Zhengli Di, Xinlai Wang, Ye Tia. Suppression of SIRT6 by miR-33a facilitates tumor growth of glioma through apoptosis and oxidative stress resistance. Oncology reports. vol 38. issue 2. 2018-07-23. PMID:28677777. |
in addition, sirt6 restoration led to apoptosis with alterative expression of bax, bcl-2, cleaved caspase-8, and inhibition of janus kinase 2 (jak2)/signal transducer and activator of transcription 3 (stat3) pathway in glioma. |
2018-07-23 |
2023-08-13 |
human |
| Dongbao Jiang, Jingjing Li, Jie Li, Min Wang, Chao Han, Xinru Wang, Chunlin Zhao, Yanwei Y. Combination of FGFR4 inhibitor Blu9931 and 5-fluorouracil effects on the biological characteristics of colorectal cancer cells. International journal of oncology. vol 51. issue 5. 2018-07-23. PMID:29048661. |
western blotting was used to detect the expression of related molecules including signal pathway (stat3), apoptosis (cleaved caspase‑3), cell cycle (cyclin d1 and p27kip1) and epithelial-mesenchymal transition (e-cadherin and vimentin) in hct116 and sw620 cells used as single and combination treatments of 5‑fu and blu9931. |
2018-07-23 |
2023-08-13 |
Not clear |
| Fang Cao, Qiang Zhang, Wei Chen, Feng Zheng, Qishan Ran, Yang He, Yang Gao, Shengtao Ya. Bioscience reports. vol 37. issue 6. 2018-07-18. PMID:29074558. |
gene associated with retinoid-interferon-induced mortality-19 (grim-19) has been recognized as a tumor suppressor protein, which regulates cell growth, apoptosis, and migration by signal transducer and activator of transcription 3 (stat3) signaling pathway and non-stat3 pathway in glioma cells. |
2018-07-18 |
2023-08-13 |
Not clear |
| X-J Wei, X-W Li, J-L Lu, Z-X Long, J-Q Liang, S-B Wei, C-X Lu, W-Z L. MiR-20a regulates fibroblast-like synoviocyte proliferation and apoptosis in rheumatoid arthritis. European review for medical and pharmacological sciences. vol 21. issue 17. 2018-07-17. PMID:28975975. |
this study aimed to investigate the role of mir-20a in the regulation of stat3 expression and synovial cell proliferation as well as apoptosis. |
2018-07-17 |
2023-08-13 |
Not clear |
| Ling-Qi Meng, Chang Liu, Ying-Hua Luo, Xian-Ji Piao, Yue Wang, Yi Zhang, Jia-Ru Wang, Hao Wang, Wan-Ting Xu, Yang Liu, Yi-Qin Wu, Hu-Nan Sun, Ying-Hao Han, Mei-Hua Jin, Gui-Nan Shen, Yan-Qing Zang, Jing Li, Nan-Zhu Fang, Yu-Dong Cui, Cheng-Hao Ji. Quinalizarin exerts an anti-tumour effect on lung cancer A549 cells by modulating the Akt, MAPK, STAT3 and p53 signalling pathways. Molecular medicine reports. vol 17. issue 2. 2018-07-17. PMID:29207064. |
the ros scavenger n‑acetyl‑l‑cysteine restored quinalizarin‑induced cell apoptosis, and inactivated the mapk and stat3 signalling pathways. |
2018-07-17 |
2023-08-13 |
Not clear |
| Ling-Qi Meng, Chang Liu, Ying-Hua Luo, Xian-Ji Piao, Yue Wang, Yi Zhang, Jia-Ru Wang, Hao Wang, Wan-Ting Xu, Yang Liu, Yi-Qin Wu, Hu-Nan Sun, Ying-Hao Han, Mei-Hua Jin, Gui-Nan Shen, Yan-Qing Zang, Jing Li, Nan-Zhu Fang, Yu-Dong Cui, Cheng-Hao Ji. Quinalizarin exerts an anti-tumour effect on lung cancer A549 cells by modulating the Akt, MAPK, STAT3 and p53 signalling pathways. Molecular medicine reports. vol 17. issue 2. 2018-07-17. PMID:29207064. |
the results of the present study demonstrated that quinalizarin induces g0/g1 phase cell cycle arrest and apoptosis via ros mediated‑mapk and stat3 signalling pathways. |
2018-07-17 |
2023-08-13 |
Not clear |
| Ke Wang, Xue Zhu, Kai Zhang, Yongxiang Yin, Yu Chen, Ting Zhan. Interleukin-6 contributes to chemoresistance in MDA-MB-231 cells via targeting HIF-1α. Journal of biochemical and molecular toxicology. vol 32. issue 3. 2018-07-10. PMID:29341321. |
the results showed that il-6 treatment could induce upregulation of hif-1α via the activation of stat3 in mda-mb-231 cells, which consequently contributed to its effect against chemotherapeutic drug-induced cytotoxicity and cell apoptosis. |
2018-07-10 |
2023-08-13 |
Not clear |