| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jinxiang Liu, Dan Fei, Jie Xing, Juan D. MicroRNA-29a inhibits proliferation and induces apoptosis in rheumatoid arthritis fibroblast-like synoviocytes by repressing STAT3. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 96. 2018-07-26. PMID:28987940. |
rescue experiments showed that overexpression of stat3 effectively reversed the effect of mir-29a on proliferation and apoptosis in ra-fls. |
2018-07-26 |
2023-08-13 |
Not clear |
| Jinxiang Liu, Dan Fei, Jie Xing, Juan D. MicroRNA-29a inhibits proliferation and induces apoptosis in rheumatoid arthritis fibroblast-like synoviocytes by repressing STAT3. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 96. 2018-07-26. PMID:28987940. |
these data indicate that mir-29a inhibits proliferation and induces apoptosis in ra-fls by targeting stat3, suggesting that promoting mir-29a expression may yield therapeutic benefits in the treatment of ra. |
2018-07-26 |
2023-08-13 |
Not clear |
| Z Wu, W Huang, B Chen, P-D Bai, X-G Wang, J-C Xin. Up-regulation of miR-124 inhibits invasion and proliferation of prostate cancer cells through mediating JAK-STAT3 signaling pathway. European review for medical and pharmacological sciences. vol 21. issue 10. 2018-07-23. PMID:28617558. |
this study aims to investigate the role of mir-124 in regulating stat3 expression and proliferation, cycle, apoptosis and invasion of prostate cancer cells. |
2018-07-23 |
2023-08-13 |
Not clear |
| Mingze Chang, Lin Qiao, Bin Li, Juanhong Wang, Gejuan Zhang, Wenzhen Shi, Zhiqin Liu, Naibing Gu, Zhengli Di, Xinlai Wang, Ye Tia. Suppression of SIRT6 by miR-33a facilitates tumor growth of glioma through apoptosis and oxidative stress resistance. Oncology reports. vol 38. issue 2. 2018-07-23. PMID:28677777. |
in addition, sirt6 restoration led to apoptosis with alterative expression of bax, bcl-2, cleaved caspase-8, and inhibition of janus kinase 2 (jak2)/signal transducer and activator of transcription 3 (stat3) pathway in glioma. |
2018-07-23 |
2023-08-13 |
human |
| Dongbao Jiang, Jingjing Li, Jie Li, Min Wang, Chao Han, Xinru Wang, Chunlin Zhao, Yanwei Y. Combination of FGFR4 inhibitor Blu9931 and 5-fluorouracil effects on the biological characteristics of colorectal cancer cells. International journal of oncology. vol 51. issue 5. 2018-07-23. PMID:29048661. |
western blotting was used to detect the expression of related molecules including signal pathway (stat3), apoptosis (cleaved caspase‑3), cell cycle (cyclin d1 and p27kip1) and epithelial-mesenchymal transition (e-cadherin and vimentin) in hct116 and sw620 cells used as single and combination treatments of 5‑fu and blu9931. |
2018-07-23 |
2023-08-13 |
Not clear |
| Fang Cao, Qiang Zhang, Wei Chen, Feng Zheng, Qishan Ran, Yang He, Yang Gao, Shengtao Ya. Bioscience reports. vol 37. issue 6. 2018-07-18. PMID:29074558. |
gene associated with retinoid-interferon-induced mortality-19 (grim-19) has been recognized as a tumor suppressor protein, which regulates cell growth, apoptosis, and migration by signal transducer and activator of transcription 3 (stat3) signaling pathway and non-stat3 pathway in glioma cells. |
2018-07-18 |
2023-08-13 |
Not clear |
| X-J Wei, X-W Li, J-L Lu, Z-X Long, J-Q Liang, S-B Wei, C-X Lu, W-Z L. MiR-20a regulates fibroblast-like synoviocyte proliferation and apoptosis in rheumatoid arthritis. European review for medical and pharmacological sciences. vol 21. issue 17. 2018-07-17. PMID:28975975. |
this study aimed to investigate the role of mir-20a in the regulation of stat3 expression and synovial cell proliferation as well as apoptosis. |
2018-07-17 |
2023-08-13 |
Not clear |
| Ling-Qi Meng, Chang Liu, Ying-Hua Luo, Xian-Ji Piao, Yue Wang, Yi Zhang, Jia-Ru Wang, Hao Wang, Wan-Ting Xu, Yang Liu, Yi-Qin Wu, Hu-Nan Sun, Ying-Hao Han, Mei-Hua Jin, Gui-Nan Shen, Yan-Qing Zang, Jing Li, Nan-Zhu Fang, Yu-Dong Cui, Cheng-Hao Ji. Quinalizarin exerts an anti-tumour effect on lung cancer A549 cells by modulating the Akt, MAPK, STAT3 and p53 signalling pathways. Molecular medicine reports. vol 17. issue 2. 2018-07-17. PMID:29207064. |
the ros scavenger n‑acetyl‑l‑cysteine restored quinalizarin‑induced cell apoptosis, and inactivated the mapk and stat3 signalling pathways. |
2018-07-17 |
2023-08-13 |
Not clear |
| Ling-Qi Meng, Chang Liu, Ying-Hua Luo, Xian-Ji Piao, Yue Wang, Yi Zhang, Jia-Ru Wang, Hao Wang, Wan-Ting Xu, Yang Liu, Yi-Qin Wu, Hu-Nan Sun, Ying-Hao Han, Mei-Hua Jin, Gui-Nan Shen, Yan-Qing Zang, Jing Li, Nan-Zhu Fang, Yu-Dong Cui, Cheng-Hao Ji. Quinalizarin exerts an anti-tumour effect on lung cancer A549 cells by modulating the Akt, MAPK, STAT3 and p53 signalling pathways. Molecular medicine reports. vol 17. issue 2. 2018-07-17. PMID:29207064. |
the results of the present study demonstrated that quinalizarin induces g0/g1 phase cell cycle arrest and apoptosis via ros mediated‑mapk and stat3 signalling pathways. |
2018-07-17 |
2023-08-13 |
Not clear |
| Ke Wang, Xue Zhu, Kai Zhang, Yongxiang Yin, Yu Chen, Ting Zhan. Interleukin-6 contributes to chemoresistance in MDA-MB-231 cells via targeting HIF-1α. Journal of biochemical and molecular toxicology. vol 32. issue 3. 2018-07-10. PMID:29341321. |
the results showed that il-6 treatment could induce upregulation of hif-1α via the activation of stat3 in mda-mb-231 cells, which consequently contributed to its effect against chemotherapeutic drug-induced cytotoxicity and cell apoptosis. |
2018-07-10 |
2023-08-13 |
Not clear |
| Xiaoying Chen, Nanzhen Kuang, Xiaoping Zeng, Zhiqin Zhang, Yanyan Li, Wei Liu, Yingyuan F. Effects of daphnetin combined with Bcl2‑siRNA on antiapoptotic genes in synovial fibroblasts of rats with collagen‑induced arthritis. Molecular medicine reports. vol 17. issue 1. 2018-07-09. PMID:29115552. |
the results suggested that si‑bcl combined with daphnetin may have an enhanced effect in promoting apoptosis of rafls derived from cia rats, and a possible underlying molecular mechanism may function through the downregulation of bcl2 expression and stat3, which is located upstream of bcl2 in the mitochondrial apoptotic pathway. |
2018-07-09 |
2023-08-13 |
rat |
| M Geletu, R Mohan, R Arulanandam, A Berger-Becvar, I R Nabi, P T Gunning, L Rapti. Reciprocal regulation of the Cadherin-11/Stat3 axis by caveolin-1 in mouse fibroblasts and lung carcinoma cells. Biochimica et biophysica acta. Molecular cell research. vol 1865. issue 5. 2018-07-09. PMID:29458077. |
our data reveal the presence of a potent, negative regulatory loop between cav1 and cadherin-11/stat3, leading to stat3 inhibition and apoptosis. |
2018-07-09 |
2023-08-13 |
mouse |
| Weiwei Bao, Yaru Luo, Dan Wang, Jian Li, Xi Wu, Wei Me. Sodium salicylate modulates inflammatory responses through AMP-activated protein kinase activation in LPS-stimulated THP-1 cells. Journal of cellular biochemistry. vol 119. issue 1. 2018-07-06. PMID:28661045. |
we conclude that ampk activation is important for nasal-mediated inflammation by inducing apoptosis, reducing cell proliferation, inhibiting stat3 activity, and producing tnf-α and il-1β. |
2018-07-06 |
2023-08-13 |
Not clear |
| Huiyu Jiang, Lin Wang, Feifei Wang, Jihong Pa. Proprotein convertase subtilisin/kexin type 6 promotes in vitro proliferation, migration and inflammatory cytokine secretion of synovial fibroblast‑like cells from rheumatoid arthritis via nuclear‑κB, signal transducer and activator of transcription 3 and extracellular signal regulated 1/2 pathways. Molecular medicine reports. vol 16. issue 6. 2018-06-26. PMID:28944919. |
the results demonstrated that signaling via nf‑κb and stat3 mediated cell cycle arrest, and signaling through nf‑κb mediated apoptosis in rasf cells stimulated with pcsk6. |
2018-06-26 |
2023-08-13 |
human |
| Minjie Gao, Bo Li, Xi Sun, Yunfei Zhou, Yingcong Wang, Van S Tompkins, Zhijian Xu, Nekitsing Indima, Houcai Wang, Wenqin Xiao, Lu Gao, Gege Chen, Huiqun Wu, Xiaosong Wu, Yuanyuan Kong, Bingqian Xie, Yiwen Zhang, Gaomei Chang, Liangning Hu, Guang Yang, Bojie Dai, Yi Tao, Weiliang Zhu, Jumei Sh. Preclinical activity of DCZ3301, a novel aryl-guanidino compound in the therapy of multiple myeloma. Theranostics. vol 7. issue 15. 2018-06-25. PMID:29109769. |
knockdown of stat3 using sirna in mm cells enhanced dcz3301-induced cytotoxicity, whereas overexpression of stat3 in mm cells partially protected them from apoptosis. |
2018-06-25 |
2023-08-13 |
human |
| Helin Chen, Wenjia Liu, Xiangnan Wu, Min Gou, Jiefei Shen, Hang Wan. Advanced glycation end products induced IL-6 and VEGF-A production and apoptosis in osteocyte-like MLO-Y4 cells by activating RAGE and ERK1/2, P38 and STAT3 signalling pathways. International immunopharmacology. vol 52. 2018-06-12. PMID:28910744. |
advanced glycation end products induced il-6 and vegf-a production and apoptosis in osteocyte-like mlo-y4 cells by activating rage and erk1/2, p38 and stat3 signalling pathways. |
2018-06-12 |
2023-08-13 |
Not clear |
| Helin Chen, Wenjia Liu, Xiangnan Wu, Min Gou, Jiefei Shen, Hang Wan. Advanced glycation end products induced IL-6 and VEGF-A production and apoptosis in osteocyte-like MLO-Y4 cells by activating RAGE and ERK1/2, P38 and STAT3 signalling pathways. International immunopharmacology. vol 52. 2018-06-12. PMID:28910744. |
the erk1/2 inhibitor u0126, the p38 inhibitor sb239063 and the stat3 inhibitor s3i-201 all attenuated the effects of ages on mlo-y4 cell apoptosis and il-6 and vegf-a secretion. |
2018-06-12 |
2023-08-13 |
Not clear |
| Helin Chen, Wenjia Liu, Xiangnan Wu, Min Gou, Jiefei Shen, Hang Wan. Advanced glycation end products induced IL-6 and VEGF-A production and apoptosis in osteocyte-like MLO-Y4 cells by activating RAGE and ERK1/2, P38 and STAT3 signalling pathways. International immunopharmacology. vol 52. 2018-06-12. PMID:28910744. |
together, these data convince us that ages can activate the erk1/2, p38 and stat3 signalling pathways via rage and that their activation involves the ages-induced up-regulation of il-6 and vegf-a production as well as apoptosis in osteocytes. |
2018-06-12 |
2023-08-13 |
Not clear |
| Ying Wang, Hui-Lan Lu, Yong-Dong Liu, Li-Yun Yang, Qing-Kun Jiang, Xiao-Jun Zhu, Hua-Nan Fan, Yong Qia. Cryptotanshinone sensitizes antitumor effect of paclitaxel on tongue squamous cell carcinoma growth by inhibiting the JAK/STAT3 signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 95. 2018-06-11. PMID:28946186. |
furthermore, we found that the combination treatment of cryptotanshinone and paclitaxel more effectively inhibited tscc cell proliferation and migration, and induced apoptosis via the inhibition of stat3 signaling pathway. |
2018-06-11 |
2023-08-13 |
human |
| Kuisheng Liu, Tingting Ren, Yi Huang, Kunkun Sun, Xing Bao, Shidong Wang, Bingxin Zheng, Wei Gu. Apatinib promotes autophagy and apoptosis through VEGFR2/STAT3/BCL-2 signaling in osteosarcoma. Cell death & disease. vol 8. issue 8. 2018-06-05. PMID:28837148. |
stat3 knockdown by sirna reinforced autophagy and apoptosis induced by apatinib. |
2018-06-05 |
2023-08-13 |
human |