| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kazuhiro Yamamoto, Hiroaki Shichiri, Takahiro Ishida, Kenta Kaku, Tatsuya Nishioka, Manabu Kume, Hiroo Makimoto, Tsutomu Nakagawa, Takeshi Hirano, Toshinori Bito, Chikako Nishigori, Ikuko Yano, Midori Hira. Effects of Ascorbyl-2-phosphate Magnesium on Human Keratinocyte Toxicity and Pathological Changes by Sorafenib. Biological & pharmaceutical bulletin. vol 40. issue 9. 2018-05-24. PMID:28867735. |
moreover, p-vc-mg inhibited the decrease of signal transducer and activator of transcription 3 (stat3) phosphorylation and the expression of apoptosis suppressors treated by sorafenib. |
2018-05-24 |
2023-08-13 |
human |
| Kazuhiro Yamamoto, Hiroaki Shichiri, Takahiro Ishida, Kenta Kaku, Tatsuya Nishioka, Manabu Kume, Hiroo Makimoto, Tsutomu Nakagawa, Takeshi Hirano, Toshinori Bito, Chikako Nishigori, Ikuko Yano, Midori Hira. Effects of Ascorbyl-2-phosphate Magnesium on Human Keratinocyte Toxicity and Pathological Changes by Sorafenib. Biological & pharmaceutical bulletin. vol 40. issue 9. 2018-05-24. PMID:28867735. |
these findings suggest that p-vc-mg attenuates sorafenib-induced apoptosis and pathological changes in human keratinocyte cells and in the 3d skin model mediated by the maintenance of stat3 activity. |
2018-05-24 |
2023-08-13 |
human |
| Jian Wang, Jie Xu, Guoqiang Xin. Lycorine inhibits the growth and metastasis of breast cancer through the blockage of STAT3 signaling pathway. Acta biochimica et biophysica Sinica. vol 49. issue 9. 2018-05-23. PMID:28910973. |
lycorine also downregulated the expressions of stat3 target genes, including mcl-1, bcl-xl, mmp-2, mmp-9, which are involved in apoptosis and invasion of breast cancer. |
2018-05-23 |
2023-08-13 |
mouse |
| Bong Hee Park, Joung Eun Lim, Hwang Gyun Jeon, Seong Il Seo, Hyun Moo Lee, Han Yong Choi, Seong Soo Jeon, Byong Chang Jeon. Curcumin potentiates antitumor activity of cisplatin in bladder cancer cell lines via ROS-mediated activation of ERK1/2. Oncotarget. vol 7. issue 39. 2018-05-22. PMID:27564099. |
unlike 253j-bv cells, t24 cells were co-treated with curcumin and cisplatin revealed an induction of apoptosis through decreased p-signal transducer and activator of transcription 3(stat3) expression. |
2018-05-22 |
2023-08-13 |
Not clear |
| Xiaoni Liu, Jianji Xu, Shuang Wang, Xiaoxiao Yu, Boxin Kou, Mengyin Chai, Yunjin Zang, Dexi Che. Synergistic inhibitory effects on hepatocellular carcinoma with recombinant human adenovirus Aspp2 and oxaliplatin via p53-independent pathway in vitro and in vivo. International journal of oncology. vol 51. issue 4. 2018-05-14. PMID:28902369. |
in conclusion, aspp2-ad, in p53-independent manner, regulated erk and stat3 signal moleculars to inhibit hepatocarcinoma in coordination with oxaliplatin by influencing the protein expression of proliferation, apoptosis, autophagy and vascular growth. |
2018-05-14 |
2023-08-13 |
human |
| JingJing Duan, Wen Yue, JianYu E, Jyoti Malhotra, Shou-En Lu, Jun Gu, Feng Xu, Xiang-Lin Ta. In vitro comparative studies of resveratrol and triacetylresveratrol on cell proliferation, apoptosis, and STAT3 and NFκB signaling in pancreatic cancer cells. Scientific reports. vol 6. 2018-05-09. PMID:27539371. |
in vitro comparative studies of resveratrol and triacetylresveratrol on cell proliferation, apoptosis, and stat3 and nfκb signaling in pancreatic cancer cells. |
2018-05-09 |
2023-08-13 |
mouse |
| JingJing Duan, Wen Yue, JianYu E, Jyoti Malhotra, Shou-En Lu, Jun Gu, Feng Xu, Xiang-Lin Ta. In vitro comparative studies of resveratrol and triacetylresveratrol on cell proliferation, apoptosis, and STAT3 and NFκB signaling in pancreatic cancer cells. Scientific reports. vol 6. 2018-05-09. PMID:27539371. |
we comparatively evaluated their effects on cell proliferation, apoptosis and the molecular changes in stat3, nfκb and apoptotic signaling pathways in pancreatic cancer cells. |
2018-05-09 |
2023-08-13 |
mouse |
| Kenrie P Y Hui, Hung Sing Li, Man Chun Cheung, Renee W Y Chan, Kit M Yuen, Chris K P Mok, John M Nicholls, J S Malik Peiris, Michael C W Cha. Highly pathogenic avian influenza H5N1 virus delays apoptotic responses via activation of STAT3. Scientific reports. vol 6. 2018-05-08. PMID:27344974. |
more importantly, stat3 knock-down increased apoptosis by h5n1 infection suggesting that h5n1 virus delays apoptosis through activation of stat3. |
2018-05-08 |
2023-08-13 |
human |
| Kenrie P Y Hui, Hung Sing Li, Man Chun Cheung, Renee W Y Chan, Kit M Yuen, Chris K P Mok, John M Nicholls, J S Malik Peiris, Michael C W Cha. Highly pathogenic avian influenza H5N1 virus delays apoptotic responses via activation of STAT3. Scientific reports. vol 6. 2018-05-08. PMID:27344974. |
taken together, we demonstrate that stat3 is involved in h5n1-delayed apoptosis compared to h1n1. |
2018-05-08 |
2023-08-13 |
human |
| Kenrie P Y Hui, Hung Sing Li, Man Chun Cheung, Renee W Y Chan, Kit M Yuen, Chris K P Mok, John M Nicholls, J S Malik Peiris, Michael C W Cha. Highly pathogenic avian influenza H5N1 virus delays apoptotic responses via activation of STAT3. Scientific reports. vol 6. 2018-05-08. PMID:27344974. |
since delay in apoptosis prolongs the duration of virus replication and production of pro-inflammatory cytokines and trail from h5n1-infected cells, which contribute to orchestrate cytokine storm and tissue damage, our results suggest that stat3 may play a previously unsuspected role in h5n1 pathogenesis. |
2018-05-08 |
2023-08-13 |
human |
| Wei Ren, Zhiwei Wang, Zhiyong Wu, Zhipeng Hu, Feifeng Dai, Jinxing Chang, Bowen Li, Huagang Liu, Yongle Rua. JAK2/STAT3 Pathway Was Associated with the Protective Effects of IL-22 On Aortic Dissection with Acute Lung Injury. Disease markers. vol 2017. 2018-05-02. PMID:28827891. |
il-22 obviously inhibited the apoptosis of pmvecs mediated by angii and downregulated the expression and intranuclear transmission of stat3. |
2018-05-02 |
2023-08-13 |
mouse |
| Wan-Chi Tsai, Li-Yuan Bai, Yi-Jin Chen, Po-Chen Chu, Ya-Wen Hsu, Aaron M Sargeant, Jing-Ru Wen. OSU-A9 inhibits pancreatic cancer cell lines by modulating p38-JAK-STAT3 signaling. Oncotarget. vol 8. issue 17. 2018-04-24. PMID:28418923. |
osu-a9 treatment induced apoptosis, the down-regulation of akt phosphorylation, up-regulation of p38 phosphorylation and decreased phosphorylation of jak and stat3. |
2018-04-24 |
2023-08-13 |
mouse |
| Weixi Shen, Chunhong Chen, Yuanyuan Guan, Xiaowei Song, Yinghua Jin, Jingfang Wang, Yu Hu, Tao Xin, Qiuying Jiang, Li Zhon. A pumpkin polysaccharide induces apoptosis by inhibiting the JAK2/STAT3 pathway in human hepatoma HepG2 cells. International journal of biological macromolecules. vol 104. issue Pt A. 2018-04-23. PMID:28634059. |
the results showed that pppf or stat3 sirna inhibits the cell growth of hepg2 cells via induction of apoptosis. |
2018-04-23 |
2023-08-13 |
mouse |
| Zhiguo Chen, Rujian Zhu, Jiayi Zheng, Chen Chen, Chi Huang, Junjie Ma, Chen Xu, Wei Zhai, Junhua Zhen. Cryptotanshinone inhibits proliferation yet induces apoptosis by suppressing STAT3 signals in renal cell carcinoma. Oncotarget. vol 8. issue 30. 2018-04-23. PMID:28654902. |
cryptotanshinone inhibits proliferation yet induces apoptosis by suppressing stat3 signals in renal cell carcinoma. |
2018-04-23 |
2023-08-13 |
mouse |
| Zhiguo Chen, Rujian Zhu, Jiayi Zheng, Chen Chen, Chi Huang, Junjie Ma, Chen Xu, Wei Zhai, Junhua Zhen. Cryptotanshinone inhibits proliferation yet induces apoptosis by suppressing STAT3 signals in renal cell carcinoma. Oncotarget. vol 8. issue 30. 2018-04-23. PMID:28654902. |
we found that cryptotanshinone substantially suppressed cancer cell growth while it promoted cell apoptosis by inhibiting the phosphorylation of stat3 at tyr705 and its blocking nuclear translocation. |
2018-04-23 |
2023-08-13 |
mouse |
| Eun-Ah Ye, Jena J Steinl. miR-146a suppresses STAT3/VEGF pathways and reduces apoptosis through IL-6 signaling in primary human retinal microvascular endothelial cells in high glucose conditions. Vision research. vol 139. 2018-04-20. PMID:28433754. |
the aim of this study was to investigate our hypothesis that mir-146a plays a role in suppressing pro-inflammatory pathways, involving stat3 and vegf, through regulating il-6 signaling to reduce apoptosis of human retinal endothelial cells (rec) in high glucose conditions. |
2018-04-20 |
2023-08-13 |
human |
| Eun-Ah Ye, Jena J Steinl. miR-146a suppresses STAT3/VEGF pathways and reduces apoptosis through IL-6 signaling in primary human retinal microvascular endothelial cells in high glucose conditions. Vision research. vol 139. 2018-04-20. PMID:28433754. |
overall, we report that mir-146a suppressed il-6 signaling, leading to reduced levels of stat3 and vegf in rec in high glucose conditions, leading to decreased apoptosis. |
2018-04-20 |
2023-08-13 |
human |
| Zuowen Liang, Hongliang Wang, Baofeng Guo, Fubiao Li, Jinsha Liu, Zhewen Liu, Libo Xu, Wenjing Yun, Xuejian Zhao, Ling Zhan. Inhibition of prostate cancer RM1 cell growth in vitro by hydroxyapatite nanoparticle‑delivered short hairpin RNAs against Stat3. Molecular medicine reports. vol 16. issue 1. 2018-03-26. PMID:28534932. |
stat3 mrna expression levels were measured by reverse transcription‑quantitative polymerase chain reaction and stat3, cyclin d1, b cell lymphoma 2 apoptosis regulator (bcl‑2), vascular endothelial growth factor (vegf), bcl‑2 associated x apoptosis regulator (bax) and cleaved‑caspase‑3 protein expression levels were detected using western blot analysis. |
2018-03-26 |
2023-08-13 |
Not clear |
| Do-Hee Kim, Ji Eun Park, In Gyeong Chae, Geumi Park, Sooyeun Lee, Kyung-Soo Chu. Isoliquiritigenin inhibits the proliferation of human renal carcinoma Caki cells through the ROS-mediated regulation of the Jak2/STAT3 pathway. Oncology reports. vol 38. issue 1. 2018-03-26. PMID:28560439. |
taken together, the present study provides the first report that isl induces apoptosis in caki cells via generation of ros, which causes induction of p53 and inhibition of the stat3 signaling pathway. |
2018-03-26 |
2023-08-13 |
human |
| Zhong Wu, Jie Liu, Siyuan Hu, Yuchang Zhu, Shaohua L. Serine/Threonine Kinase 35, a Target Gene of STAT3, Regulates the Proliferation and Apoptosis of Osteosarcoma Cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 45. issue 2. 2018-03-26. PMID:29414823. |
serine/threonine kinase 35, a target gene of stat3, regulates the proliferation and apoptosis of osteosarcoma cells. |
2018-03-26 |
2023-08-13 |
human |