| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei Ren, Zhiwei Wang, Zhiyong Wu, Zhipeng Hu, Feifeng Dai, Jinxing Chang, Bowen Li, Huagang Liu, Yongle Rua. JAK2/STAT3 Pathway Was Associated with the Protective Effects of IL-22 On Aortic Dissection with Acute Lung Injury. Disease markers. vol 2017. 2018-05-02. PMID:28827891. |
il-22 obviously inhibited the apoptosis of pmvecs mediated by angii and downregulated the expression and intranuclear transmission of stat3. |
2018-05-02 |
2023-08-13 |
mouse |
| Wan-Chi Tsai, Li-Yuan Bai, Yi-Jin Chen, Po-Chen Chu, Ya-Wen Hsu, Aaron M Sargeant, Jing-Ru Wen. OSU-A9 inhibits pancreatic cancer cell lines by modulating p38-JAK-STAT3 signaling. Oncotarget. vol 8. issue 17. 2018-04-24. PMID:28418923. |
osu-a9 treatment induced apoptosis, the down-regulation of akt phosphorylation, up-regulation of p38 phosphorylation and decreased phosphorylation of jak and stat3. |
2018-04-24 |
2023-08-13 |
mouse |
| Weixi Shen, Chunhong Chen, Yuanyuan Guan, Xiaowei Song, Yinghua Jin, Jingfang Wang, Yu Hu, Tao Xin, Qiuying Jiang, Li Zhon. A pumpkin polysaccharide induces apoptosis by inhibiting the JAK2/STAT3 pathway in human hepatoma HepG2 cells. International journal of biological macromolecules. vol 104. issue Pt A. 2018-04-23. PMID:28634059. |
the results showed that pppf or stat3 sirna inhibits the cell growth of hepg2 cells via induction of apoptosis. |
2018-04-23 |
2023-08-13 |
mouse |
| Zhiguo Chen, Rujian Zhu, Jiayi Zheng, Chen Chen, Chi Huang, Junjie Ma, Chen Xu, Wei Zhai, Junhua Zhen. Cryptotanshinone inhibits proliferation yet induces apoptosis by suppressing STAT3 signals in renal cell carcinoma. Oncotarget. vol 8. issue 30. 2018-04-23. PMID:28654902. |
cryptotanshinone inhibits proliferation yet induces apoptosis by suppressing stat3 signals in renal cell carcinoma. |
2018-04-23 |
2023-08-13 |
mouse |
| Zhiguo Chen, Rujian Zhu, Jiayi Zheng, Chen Chen, Chi Huang, Junjie Ma, Chen Xu, Wei Zhai, Junhua Zhen. Cryptotanshinone inhibits proliferation yet induces apoptosis by suppressing STAT3 signals in renal cell carcinoma. Oncotarget. vol 8. issue 30. 2018-04-23. PMID:28654902. |
we found that cryptotanshinone substantially suppressed cancer cell growth while it promoted cell apoptosis by inhibiting the phosphorylation of stat3 at tyr705 and its blocking nuclear translocation. |
2018-04-23 |
2023-08-13 |
mouse |
| Eun-Ah Ye, Jena J Steinl. miR-146a suppresses STAT3/VEGF pathways and reduces apoptosis through IL-6 signaling in primary human retinal microvascular endothelial cells in high glucose conditions. Vision research. vol 139. 2018-04-20. PMID:28433754. |
the aim of this study was to investigate our hypothesis that mir-146a plays a role in suppressing pro-inflammatory pathways, involving stat3 and vegf, through regulating il-6 signaling to reduce apoptosis of human retinal endothelial cells (rec) in high glucose conditions. |
2018-04-20 |
2023-08-13 |
human |
| Eun-Ah Ye, Jena J Steinl. miR-146a suppresses STAT3/VEGF pathways and reduces apoptosis through IL-6 signaling in primary human retinal microvascular endothelial cells in high glucose conditions. Vision research. vol 139. 2018-04-20. PMID:28433754. |
overall, we report that mir-146a suppressed il-6 signaling, leading to reduced levels of stat3 and vegf in rec in high glucose conditions, leading to decreased apoptosis. |
2018-04-20 |
2023-08-13 |
human |
| Zuowen Liang, Hongliang Wang, Baofeng Guo, Fubiao Li, Jinsha Liu, Zhewen Liu, Libo Xu, Wenjing Yun, Xuejian Zhao, Ling Zhan. Inhibition of prostate cancer RM1 cell growth in vitro by hydroxyapatite nanoparticle‑delivered short hairpin RNAs against Stat3. Molecular medicine reports. vol 16. issue 1. 2018-03-26. PMID:28534932. |
stat3 mrna expression levels were measured by reverse transcription‑quantitative polymerase chain reaction and stat3, cyclin d1, b cell lymphoma 2 apoptosis regulator (bcl‑2), vascular endothelial growth factor (vegf), bcl‑2 associated x apoptosis regulator (bax) and cleaved‑caspase‑3 protein expression levels were detected using western blot analysis. |
2018-03-26 |
2023-08-13 |
Not clear |
| Do-Hee Kim, Ji Eun Park, In Gyeong Chae, Geumi Park, Sooyeun Lee, Kyung-Soo Chu. Isoliquiritigenin inhibits the proliferation of human renal carcinoma Caki cells through the ROS-mediated regulation of the Jak2/STAT3 pathway. Oncology reports. vol 38. issue 1. 2018-03-26. PMID:28560439. |
taken together, the present study provides the first report that isl induces apoptosis in caki cells via generation of ros, which causes induction of p53 and inhibition of the stat3 signaling pathway. |
2018-03-26 |
2023-08-13 |
human |
| Zhong Wu, Jie Liu, Siyuan Hu, Yuchang Zhu, Shaohua L. Serine/Threonine Kinase 35, a Target Gene of STAT3, Regulates the Proliferation and Apoptosis of Osteosarcoma Cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 45. issue 2. 2018-03-26. PMID:29414823. |
serine/threonine kinase 35, a target gene of stat3, regulates the proliferation and apoptosis of osteosarcoma cells. |
2018-03-26 |
2023-08-13 |
human |
| Ke-Yan Cheng, Min Ha. Mammalian Target of Rapamycin (mTOR) Regulates Transforming Growth Factor-β1 (TGF-β1)-Induced Epithelial-Mesenchymal Transition via Decreased Pyruvate Kinase M2 (PKM2) Expression in Cervical Cancer Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2018-03-22. PMID:28446743. |
cell migration was detected by wound-healing assay; apoptosis was analyzed by flow cytometry; mtor inhibitors inhibited mtor pathway to assess the expression of e-cadherin, vimentin stat3, snail2, p-p70s6k, and pkm2 expression. |
2018-03-22 |
2023-08-13 |
Not clear |
| Jing Li, Jia Li, Guowei Cai, Lin Shen, Furong L. Proapoptotic and Growth-inhibitory Effects of Plumbagin on Human Gastric Cancer Cells Via Suppression of Signal Transducer and Activator of Transcription 3 and Protein Kinase B. Alternative therapies in health and medicine. vol 23. issue 5. 2018-03-21. PMID:28236621. |
conclusions • plumbagin inhibits cell apoptosis in human gc cells, and that effect may be related with its ability to suppress phosphorylation of stat3 and akt. |
2018-03-21 |
2023-08-13 |
human |
| Hui-Long Wen, Guang Yang, Qi-Rong Don. Ellipticine inhibits the proliferation and induces apoptosis in rheumatoid arthritis fibroblast-like synoviocytes via the STAT3 pathway. Immunopharmacology and immunotoxicology. vol 39. issue 4. 2018-03-21. PMID:28555524. |
ellipticine inhibits the proliferation and induces apoptosis in rheumatoid arthritis fibroblast-like synoviocytes via the stat3 pathway. |
2018-03-21 |
2023-08-13 |
Not clear |
| Mengjie Wang, Bi Meng, Yangchen Liu, Jingwen Yu, Qiaoyun Chen, Yangchen Li. MiR-124 Inhibits Growth and Enhances Radiation-Induced Apoptosis in Non-Small Cell Lung Cancer by Inhibiting STAT3. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 44. issue 5. 2018-03-14. PMID:29237164. |
mir-124 inhibits growth and enhances radiation-induced apoptosis in non-small cell lung cancer by inhibiting stat3. |
2018-03-14 |
2023-08-13 |
Not clear |
| Chulwon Kim, Il Ho Lee, Ho Bong Hyun, Jong-Chan Kim, Rajendra Gyawali, Seok-Geun Lee, Junhee Lee, Sung-Hoon Kim, Bum Sang Shim, Somi K Cho, Kwang Seok Ah. Supercritical Fluid Extraction of Citrus iyo Hort. ex Tanaka Pericarp Inhibits Growth and Induces Apoptosis Through Abrogation of STAT3 Regulated Gene Products in Human Prostate Cancer Xenograft Mouse Model. Integrative cancer therapies. vol 16. issue 2. 2018-03-06. PMID:27185319. |
ex tanaka pericarp inhibits growth and induces apoptosis through abrogation of stat3 regulated gene products in human prostate cancer xenograft mouse model. |
2018-03-06 |
2023-08-13 |
mouse |
| Chulwon Kim, Il Ho Lee, Ho Bong Hyun, Jong-Chan Kim, Rajendra Gyawali, Seok-Geun Lee, Junhee Lee, Sung-Hoon Kim, Bum Sang Shim, Somi K Cho, Kwang Seok Ah. Supercritical Fluid Extraction of Citrus iyo Hort. ex Tanaka Pericarp Inhibits Growth and Induces Apoptosis Through Abrogation of STAT3 Regulated Gene Products in Human Prostate Cancer Xenograft Mouse Model. Integrative cancer therapies. vol 16. issue 2. 2018-03-06. PMID:27185319. |
the effect of supercritical extracts of yeagam peel (seyg) on stat3 activation, associated protein kinases, stat3-regulated gene products, cellular proliferation, and apoptosis was examined. |
2018-03-06 |
2023-08-13 |
mouse |
| Yao Yao, Yueyue Sun, Min Shi, Dandan Xia, Kai Zhao, Lingyu Zeng, Ruosi Yao, Ying Zhang, Zhenyu Li, Mingshan Niu, Kailin X. Piperlongumine induces apoptosis and reduces bortezomib resistance by inhibiting STAT3 in multiple myeloma cells. Oncotarget. vol 7. issue 45. 2018-03-05. PMID:27634873. |
piperlongumine induces apoptosis and reduces bortezomib resistance by inhibiting stat3 in multiple myeloma cells. |
2018-03-05 |
2023-08-13 |
mouse |
| Teresa L Ramos, Luis Ignacio Sánchez-Abarca, Alba Redondo, Ángel Hernández-Hernández, Antonio M Almeida, Noemí Puig, Concepción Rodríguez, Rebeca Ortega, Silvia Preciado, Ana Rico, Sandra Muntión, José Ramón González Porras, Consuelo Del Cañizo, Fermín Sánchez-Guij. HDAC8 overexpression in mesenchymal stromal cells from JAK2+ myeloproliferative neoplasms: a new therapeutic target? Oncotarget. vol 8. issue 17. 2018-03-05. PMID:28390197. |
mechanistic studies using different mpn cell lines revealed that pci34051 induced their apoptosis, which is enhanced when were co-cultured with jak2v617f-msc, decreased their colony formation and the phosphorylation of stat3 and stat5. |
2018-03-05 |
2023-08-13 |
Not clear |
| Song Xue, Shu Xiao-Hong, Sha Lin, Bian Jie, Wang Li-Li, Gu Jia-Yao, Shi Shun, Li Pei-Nan, Wu Mo-Li, Wang Qian, Chen Xiao-Yan, Kong Qing-You, Zhang Peng, Li Hong, Liu Ji. Lumbar puncture-administered resveratrol inhibits STAT3 activation, enhancing autophagy and apoptosis in orthotopic rat glioblastomas. Oncotarget. vol 7. issue 46. 2018-02-26. PMID:27716625. |
lumbar puncture-administered resveratrol inhibits stat3 activation, enhancing autophagy and apoptosis in orthotopic rat glioblastomas. |
2018-02-26 |
2023-08-13 |
rat |
| Song Xue, Shu Xiao-Hong, Sha Lin, Bian Jie, Wang Li-Li, Gu Jia-Yao, Shi Shun, Li Pei-Nan, Wu Mo-Li, Wang Qian, Chen Xiao-Yan, Kong Qing-You, Zhang Peng, Li Hong, Liu Ji. Lumbar puncture-administered resveratrol inhibits STAT3 activation, enhancing autophagy and apoptosis in orthotopic rat glioblastomas. Oncotarget. vol 7. issue 46. 2018-02-26. PMID:27716625. |
intracranial drug availabilities, tumor sizes, average life spans and the impacts on stat3 signaling, apoptosis and autophagy rates were evaluated. |
2018-02-26 |
2023-08-13 |
rat |