| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaolong Zhang, Xiaoyi Wu, Fangling Zhang, Shouyong Mo, Yuanyuan Lu, Wei Wei, Xiaoling Chen, Linhua Lan, Bin Lu, Yongzhang Li. Paclitaxel induces apoptosis of esophageal squamous cell carcinoma cells by downregulating STAT3 phosphorylation at Ser727. Oncology reports. vol 37. issue 4. 2017-06-29. PMID:28350087. |
in this study, we found that paclitaxel-induced apoptosis by increasing the relevant apoptosis protein expression and the release of cytochrome c via downregulation of signal transducer and activator of transcription 3 (stat3) and phospho-stat3 (ser727). |
2017-06-29 |
2023-08-13 |
human |
| Xiaolong Zhang, Xiaoyi Wu, Fangling Zhang, Shouyong Mo, Yuanyuan Lu, Wei Wei, Xiaoling Chen, Linhua Lan, Bin Lu, Yongzhang Li. Paclitaxel induces apoptosis of esophageal squamous cell carcinoma cells by downregulating STAT3 phosphorylation at Ser727. Oncology reports. vol 37. issue 4. 2017-06-29. PMID:28350087. |
in conclusion, our findings reveal that paclitaxel induced apoptosis in both ec-1 and eca-109 cells through the reduction of stat3 and phospho‑stat3 (ser727) level, and suggest that paclitaxel may be of therapeutic potential in the treatment of escc through the induction of mitochondrial apoptosis in escc cells. |
2017-06-29 |
2023-08-13 |
human |
| Meng-Hsuan Cheng, Yun-Hong Wong, Chia-Ming Chang, Chun-Chien Yang, Shih-Hua Chen, Chun-Lung Yuan, Hsiao-Mei Kuo, Chun-Yuh Yang, Hui-Fen Chi. B1, a novel HDAC inhibitor, induces apoptosis through the regulation of STAT3 and NF-κB. International journal of molecular medicine. vol 39. issue 5. 2017-06-29. PMID:28393178. |
b1, a novel hdac inhibitor, induces apoptosis through the regulation of stat3 and nf-κb. |
2017-06-29 |
2023-08-13 |
human |
| Jia-Hua Feng, Kyoko Nakagawa-Goto, Kuo-Hsiung Lee, Lie-Fen Shyu. A Novel Plant Sesquiterpene Lactone Derivative, DETD-35, Suppresses BRAFV600E Mutant Melanoma Growth and Overcomes Acquired Vemurafenib Resistance in Mice. Molecular cancer therapeutics. vol 15. issue 6. 2017-06-27. PMID:27048951. |
mechanistic studies suggested that detd-35 overcame acquired vemurafenib resistance at least in part through deregulating mek-erk, akt, and stat3 signaling pathways and promoting apoptosis of cancer cells. |
2017-06-27 |
2023-08-13 |
mouse |
| Sheng-An Su, Du Yang, Wei Zhu, Zhejun Cai, Na Zhang, Lina Zhao, Jian-An Wang, Meixiang Xian. Interleukin-17A mediates cardiomyocyte apoptosis through Stat3-iNOS pathway. Biochimica et biophysica acta. vol 1863. issue 11. 2017-06-26. PMID:27566322. |
in the present study, an in-vitro model of cardiomyocyte apoptosis induced by il-17a stimulation was employed and the roles of inos and stat3 involved were investigated. |
2017-06-26 |
2023-08-13 |
mouse |
| Sheng-An Su, Du Yang, Wei Zhu, Zhejun Cai, Na Zhang, Lina Zhao, Jian-An Wang, Meixiang Xian. Interleukin-17A mediates cardiomyocyte apoptosis through Stat3-iNOS pathway. Biochimica et biophysica acta. vol 1863. issue 11. 2017-06-26. PMID:27566322. |
consistent with these data, silencing of stat3 in fact can aggravate il-17a-triggered cardiomyocyte apoptosis. |
2017-06-26 |
2023-08-13 |
mouse |
| Sheng-An Su, Du Yang, Wei Zhu, Zhejun Cai, Na Zhang, Lina Zhao, Jian-An Wang, Meixiang Xian. Interleukin-17A mediates cardiomyocyte apoptosis through Stat3-iNOS pathway. Biochimica et biophysica acta. vol 1863. issue 11. 2017-06-26. PMID:27566322. |
finally, using an in vivo myocardial ischemia/reperfusion injury model, we verified that stat3 inhibition increased inos expression and exacerbated cardiomyocyte apoptosis. |
2017-06-26 |
2023-08-13 |
mouse |
| Sheng-An Su, Du Yang, Wei Zhu, Zhejun Cai, Na Zhang, Lina Zhao, Jian-An Wang, Meixiang Xian. Interleukin-17A mediates cardiomyocyte apoptosis through Stat3-iNOS pathway. Biochimica et biophysica acta. vol 1863. issue 11. 2017-06-26. PMID:27566322. |
thus, our data strongly support the notion that stat3 plays a compensatory anti-apoptotic role in il-17a/inos-mediated cardiomyocyte apoptosis via inhibiting inos transcription, providing a novel molecular mechanism of apoptosis regulation and complicated interactions between il-17a/inos and il-17a/stat3 signalings. |
2017-06-26 |
2023-08-13 |
mouse |
| Xiaojuan Wu, Yang Cao, Hui Xiao, Chenglong Li, Jiayuh Li. Bazedoxifene as a Novel GP130 Inhibitor for Pancreatic Cancer Therapy. Molecular cancer therapeutics. vol 15. issue 11. 2017-06-15. PMID:27535971. |
here, we observed bazedoxifene inhibited stat3 phosphorylation and stat3 dna binding, induced apoptosis, and suppressed tumor growth in pancreatic cancer cells with persistent il6/gp130/stat3 signaling in vitro and in vivo in addition, il6, but not infγ, rescued bazedoxifene-mediated reduction of cell viability. |
2017-06-15 |
2023-08-13 |
mouse |
| Patrick Geraghty, Eran Hadas, Boe-Hyun Kim, Abdoulaye J Dabo, David J Volsky, Robert Foronj. HIV infection model of chronic obstructive pulmonary disease in mice. American journal of physiology. Lung cellular and molecular physiology. vol 312. issue 4. 2017-06-12. PMID:28104604. |
these changes coincided with enhanced iκbα, erk1/2, p38, and stat3 phosphorylation and lung cell apoptosis. |
2017-06-12 |
2023-08-13 |
mouse |
| Chunwa Jiang, Muqaddas Masood, Azhar Rasul, Wei Wei, Ya Wang, Muhammad Ali, Muhammad Mustaqeem, Jiang Li, Xiaomeng L. Altholactone Inhibits NF-κB and STAT3 Activation and Induces Reactive Oxygen Species-Mediated Apoptosis in Prostate Cancer DU145 Cells. Molecules (Basel, Switzerland). vol 22. issue 2. 2017-06-05. PMID:28178219. |
altholactone inhibits nf-κb and stat3 activation and induces reactive oxygen species-mediated apoptosis in prostate cancer du145 cells. |
2017-06-05 |
2023-08-13 |
Not clear |
| Yinzi Liu, Diane S Sepich, Lilianna Solnica-Kreze. Stat3/Cdc25a-dependent cell proliferation promotes embryonic axis extension during zebrafish gastrulation. PLoS genetics. vol 13. issue 2. 2017-05-26. PMID:28222105. |
zebrafish embryos lacking maternal and zygotic stat3 expression exhibit normal convergence movements and planar cell polarity signaling, but transient axis elongation defect due to insufficient number of cells resulting largely from reduced cell proliferation and increased apoptosis. |
2017-05-26 |
2023-08-13 |
human |
| Do-Hee Kim, Ki-Woong Park, In Gyeong Chae, Juthika Kundu, Eun-Hee Kim, Joydeb Kumar Kundu, Kyung-Soo Chu. Carnosic acid inhibits STAT3 signaling and induces apoptosis through generation of ROS in human colon cancer HCT116 cells. Molecular carcinogenesis. vol 55. issue 6. 2017-05-23. PMID:26152521. |
carnosic acid inhibits stat3 signaling and induces apoptosis through generation of ros in human colon cancer hct116 cells. |
2017-05-23 |
2023-08-13 |
human |
| Do-Hee Kim, Ki-Woong Park, In Gyeong Chae, Juthika Kundu, Eun-Hee Kim, Joydeb Kumar Kundu, Kyung-Soo Chu. Carnosic acid inhibits STAT3 signaling and induces apoptosis through generation of ROS in human colon cancer HCT116 cells. Molecular carcinogenesis. vol 55. issue 6. 2017-05-23. PMID:26152521. |
in conclusion, our study provides the first report that ca induced apoptosis in hct116 cells via generation of ros, induction of p53, activation of caspases, and inhibition of stat3 signaling pathway. |
2017-05-23 |
2023-08-13 |
human |
| Li Qiao, Zhusong Mei, Zhiyong Yang, Xinji Li, Hong Cai, Wei Li. ALA-PDT inhibits proliferation and promotes apoptosis of SCC cells through STAT3 signal pathway. Photodiagnosis and photodynamic therapy. vol 14. 2017-05-17. PMID:26805005. |
ala-pdt inhibits proliferation and promotes apoptosis of scc cells through stat3 signal pathway. |
2017-05-17 |
2023-08-13 |
Not clear |
| Li Qiao, Zhusong Mei, Zhiyong Yang, Xinji Li, Hong Cai, Wei Li. ALA-PDT inhibits proliferation and promotes apoptosis of SCC cells through STAT3 signal pathway. Photodiagnosis and photodynamic therapy. vol 14. 2017-05-17. PMID:26805005. |
ala-pdt could inhibit proliferation of a431 and colo-16 cells, stat3 knock down could enhance ala-pdt's inhibition of cell proliferation, and promote apoptosis induced by ala-pdt. |
2017-05-17 |
2023-08-13 |
Not clear |
| Chunwei Lv, Qunshu Su, Yupei Liang, Jinqing Hu, Sujing Yua. Oncolytic vaccine virus harbouring the IL-24 gene suppresses the growth of lung cancer by inducing apoptosis. Biochemical and biophysical research communications. vol 476. issue 1. 2017-05-16. PMID:27208781. |
interleukin-24 (il-24/mda-7) is an important cytokine that belongs to the activating caspase family and facilitates the inhibition of stat3 when a cell enters the apoptosis pathway. |
2017-05-16 |
2023-08-13 |
human |
| Chunwei Lv, Qunshu Su, Yupei Liang, Jinqing Hu, Sujing Yua. Oncolytic vaccine virus harbouring the IL-24 gene suppresses the growth of lung cancer by inducing apoptosis. Biochemical and biophysical research communications. vol 476. issue 1. 2017-05-16. PMID:27208781. |
our results showed that vv-il-24 efficiently infected and destroyed lung cancer cells via caspase-dependent apoptosis and decreased the expression of stat3. |
2017-05-16 |
2023-08-13 |
human |
| Chunwei Lv, Qunshu Su, Yupei Liang, Jinqing Hu, Sujing Yua. Oncolytic vaccine virus harbouring the IL-24 gene suppresses the growth of lung cancer by inducing apoptosis. Biochemical and biophysical research communications. vol 476. issue 1. 2017-05-16. PMID:27208781. |
in vivo, vv-il-24 expressed il-24 at a high level in the transplanted tumour, reduced stat3 activity, and eventually led to apoptosis. |
2017-05-16 |
2023-08-13 |
human |
| Jiayu Diao, Jin Wei, Rui Yan, Xin Liu, Qing Li, Lin Lin, Yanhe Zhu, Hong L. Rosmarinic Acid suppressed high glucose-induced apoptosis in H9c2 cells by ameliorating the mitochondrial function and activating STAT3. Biochemical and biophysical research communications. vol 477. issue 4. 2017-05-15. PMID:27402269. |
rosmarinic acid suppressed high glucose-induced apoptosis in h9c2 cells by ameliorating the mitochondrial function and activating stat3. |
2017-05-15 |
2023-08-13 |
Not clear |