| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jian-Guang Yang, Rui Lu, Xiao-Jing Ye, Jing Zhang, Ya-Qin Tan, Gang Zho. Icaritin Reduces Oral Squamous Cell Carcinoma Progression via the Inhibition of STAT3 Signaling. International journal of molecular sciences. vol 18. issue 1. 2017-04-24. PMID:28085115. |
overall, icaritin suppressed proliferation, promoted apoptosis and autophagy, and inhibited stat3 signaling in oscc in vitro and in vivo. |
2017-04-24 |
2023-08-13 |
mouse |
| Xia Bai, Junpeng Luo, Xiaofeng Zhang, Jingjing Han, Zhaoyue Wang, Jingcheng Miao, Yanyan Ba. MicroRNA-126 Reduces Blood-Retina Barrier Breakdown via the Regulation of VCAM-1 and BCL2L11 in Ischemic Retinopathy. Ophthalmic research. vol 57. issue 3. 2017-04-20. PMID:28076855. |
our results suggested that mir-126 may not only regulate the overexpression of vcam-1 or bcl2l11 and lead to the reduction of retinal endothelial cell apoptosis, retinal vascular leakage, or retinal permeability in the oir mouse model, but may also protect hypoxic retinal müller cells via the stat3 signaling pathway. |
2017-04-20 |
2023-08-13 |
mouse |
| Jianheng Wu, Linfan Li, Guangyuan Jiang, Hui Zhan, Nannan Wan. B-cell CLL/lymphoma 3 promotes glioma cell proliferation and inhibits apoptosis through the oncogenic STAT3 pathway. International journal of oncology. vol 49. issue 6. 2017-04-17. PMID:27748795. |
b-cell cll/lymphoma 3 promotes glioma cell proliferation and inhibits apoptosis through the oncogenic stat3 pathway. |
2017-04-17 |
2023-08-13 |
mouse |
| Jianheng Wu, Linfan Li, Guangyuan Jiang, Hui Zhan, Nannan Wan. B-cell CLL/lymphoma 3 promotes glioma cell proliferation and inhibits apoptosis through the oncogenic STAT3 pathway. International journal of oncology. vol 49. issue 6. 2017-04-17. PMID:27748795. |
in conclusion, we suggest that bcl3 serves as an oncogene in glioma by modulating proliferation, cell cycle progression and apoptosis, and its oncogenic effects are mediated by the stat3 signaling pathway. |
2017-04-17 |
2023-08-13 |
mouse |
| Ziwei Miao, Fei Yu, Yahao Ren, Jun Yan. d,l-Sulforaphane Induces ROS-Dependent Apoptosis in Human Gliomablastoma Cells by Inactivating STAT3 Signaling Pathway. International journal of molecular sciences. vol 18. issue 1. 2017-04-13. PMID:28054986. |
d,l-sulforaphane induces ros-dependent apoptosis in human gliomablastoma cells by inactivating stat3 signaling pathway. |
2017-04-13 |
2023-08-13 |
human |
| Toru Oi, Kunihiro Asanuma, Akihiko Matsumine, Takao Matsubara, Tomoki Nakamura, Takahiro Iino, Yumiko Asanuma, Mikinobu Goto, Kazuma Okuno, Takuya Kakimoto, Yuki Yada, Akihiro Sud. STAT3 inhibitor, cucurbitacin I, is a novel therapeutic agent for osteosarcoma. International journal of oncology. vol 49. issue 6. 2017-04-07. PMID:27840900. |
following cucurbitacin i treatment, stat3 was inactivated and analysis of mcl-1, cleaved parp and caspase-3 indicated apoptosis induction. |
2017-04-07 |
2023-08-13 |
mouse |
| Yanli Gu, Jing Wang, Lixin Pen. (-)-Oleocanthal exerts anti-melanoma activities and inhibits STAT3 signaling pathway. Oncology reports. vol 37. issue 1. 2017-04-07. PMID:27878290. |
oc also downregulated stat3 target genes, including mcl-1, bcl-xl, mmp-2, mmp-9, vegf, which are involved in apoptosis, invasion and angiogenesis of melanoma. |
2017-04-07 |
2023-08-13 |
human |
| Xuerong Zhao, Jianping Wang, Lijun Xiao, Qian Xu, Enhong Zhao, Xin Zheng, Huachuan Zheng, Shuang Zhao, Shi Din. Effects of 17-AAG on the cell cycle and apoptosis of H446 cells and the associated mechanisms. Molecular medicine reports. vol 14. issue 2. 2017-04-06. PMID:27279418. |
the results indicated that 17‑aag is able to inhibit the cell proliferation, induce apoptosis and g2/m arrest and downregulate the gene and protein expression levels of stat3, survivin and cyclin d1, and upregulate gene and protein expression of cyt‑c, caspase 9, caspase 3. |
2017-04-06 |
2023-08-13 |
Not clear |
| Jeong-Hyeon Ko, Seung Ho Baek, Dongwoo Nam, Won-Seok Chung, Seok-Geun Lee, Junhee Lee, Woong Mo Yang, Jae-Young Um, Kwang Seok Ah. 3-Formylchromone inhibits proliferation and induces apoptosis of multiple myeloma cells by abrogating STAT3 signaling through the induction of PIAS3. Immunopharmacology and immunotoxicology. vol 38. issue 5. 2017-03-21. PMID:27324722. |
3-formylchromone inhibits proliferation and induces apoptosis of multiple myeloma cells by abrogating stat3 signaling through the induction of pias3. |
2017-03-21 |
2023-08-13 |
Not clear |
| M Ilamathi, V Sivaramakrishna. Artesunate acts as fuel to fire in sensitizing HepG2 cells towards TRAIL mediated apoptosis via STAT3 inhibition and DR4 augmentation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 88. 2017-03-20. PMID:28126677. |
artesunate acts as fuel to fire in sensitizing hepg2 cells towards trail mediated apoptosis via stat3 inhibition and dr4 augmentation. |
2017-03-20 |
2023-08-13 |
Not clear |
| M Ilamathi, V Sivaramakrishna. Artesunate acts as fuel to fire in sensitizing HepG2 cells towards TRAIL mediated apoptosis via STAT3 inhibition and DR4 augmentation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 88. 2017-03-20. PMID:28126677. |
additionally, ats also suppressed the nuclear translocation of activated signal transducers and activators of transcription 3 (stat3) thereby sensitizing the hepg2 cells towards only death receptor 4 (dr4) mediated apoptosis. |
2017-03-20 |
2023-08-13 |
Not clear |
| M Ilamathi, V Sivaramakrishna. Artesunate acts as fuel to fire in sensitizing HepG2 cells towards TRAIL mediated apoptosis via STAT3 inhibition and DR4 augmentation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 88. 2017-03-20. PMID:28126677. |
furthermore, ats exposure in trail resistant cells resulted in significant increase of both dr4/dr5 expression and stat3 inhibition thereby arbitrating trail mediated apoptosis in hepg2 cells. |
2017-03-20 |
2023-08-13 |
Not clear |
| M Ilamathi, V Sivaramakrishna. Artesunate acts as fuel to fire in sensitizing HepG2 cells towards TRAIL mediated apoptosis via STAT3 inhibition and DR4 augmentation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 88. 2017-03-20. PMID:28126677. |
from all the above observations, we conclude that ats up-regulated dr4 expression by targeting stat3, which in turn sensitized hepg2 cells to trail mediated apoptosis. |
2017-03-20 |
2023-08-13 |
Not clear |
| Chi-Hung R Or, Hong-Lin Su, Wee-Chyan Lee, Shu-Yi Yang, Cheesang Ho, Chia-Che Chan. Diphenhydramine induces melanoma cell apoptosis by suppressing STAT3/MCL-1 survival signaling and retards B16-F10 melanoma growth in vivo. Oncology reports. vol 36. issue 6. 2017-03-17. PMID:27779705. |
notably, ectopic expression of constitutively active stat3 mutant reduced dph-induced apoptosis but also protected mcl-1 from downregulation by dph, illustrating that dph impairs stat3 activation to block stat3-mediated induction of mcl-1 in eliciting apoptosis. |
2017-03-17 |
2023-08-13 |
mouse |
| Xiangyu Liu, Kangjian Sun, Handong Wang, Yuyuan Da. Inhibition of Autophagy by Chloroquine Enhances the Antitumor Efficacy of Sorafenib in Glioblastoma. Cellular and molecular neurobiology. vol 36. issue 7. 2017-03-15. PMID:26971793. |
sorafenib, a multi-kinase inhibitor, has been shown to inhibit cell proliferation and induce apoptosis through inhibition of stat3 signaling in glioblastoma cells and in intracranial gliomas. |
2017-03-15 |
2023-08-13 |
Not clear |
| Hye-Sook Seo, Jin Mo Ku, Han-Seok Choi, Youn Kyung Choi, Jong-Kyu Woo, Minsoo Kim, Ilhwan Kim, Chang Hyeok Na, Hansol Hur, Bo-Hyoung Jang, Yong Cheol Shin, Seong-Gyu K. Quercetin induces caspase-dependent extrinsic apoptosis through inhibition of signal transducer and activator of transcription 3 signaling in HER2-overexpressing BT-474 breast cancer cells. Oncology reports. vol 36. issue 1. 2017-03-13. PMID:27175602. |
our study indicates that quercetin induces apoptosis at concentrations >20 µm through inhibition of stat3 signaling and could serve as a useful compound to prevent or treat her2-overexpressing breast cancer. |
2017-03-13 |
2023-08-13 |
Not clear |
| Lingyun Geng, Xinyu Li, Xiangxiang Zhou, Xiaosheng Fang, Dai Yuan, Xin Wan. WP1066 exhibits antitumor efficacy in nasal‑type natural killer/T-cell lymphoma cells through downregulation of the STAT3 signaling pathway. Oncology reports. vol 36. issue 5. 2017-03-10. PMID:27633398. |
furthermore, wp1066 (a novel selective stat3 inhibitor) was able to inhibit proliferation and induce apoptosis of snk6 cells. |
2017-03-10 |
2023-08-13 |
Not clear |
| Yuqing Wang, Dongfei Wang, Lizhi Zhang, Fangyu Ye, Mengmeng Li, Ke We. Role of JAK-STAT pathway in reducing cardiomyocytes hypoxia/reoxygenation injury induced by S1P postconditioning. European journal of pharmacology. vol 784. 2017-03-02. PMID:27215146. |
the data showed that s1p could significantly increase cell viability, lower the rate of apoptosis, decrease the content of lactate dehydrogenase (ldh) and caspase3 activity in the culture medium, increase the activity of total superoxide dismutase (t-sod) and manganese superoxide dismutase (mn-sod), reduce the loss of mitochondrial membrane potential and the fluorescence intensity of intracellular calcium, as well as increase the phosphorylation of jak2 and stat3 in comparison with the h/r group. |
2017-03-02 |
2023-08-13 |
rat |
| Houcai Wang, Bingqian Xie, Yuanyuan Kong, Yi Tao, Guang Yang, Minjie Gao, Hongwei Xu, Fenghuang Zhan, Jumei Shi, Yiwen Zhang, Xiaosong W. Overexpression of RPS27a contributes to enhanced chemoresistance of CML cells to imatinib by the transactivated STAT3. Oncotarget. vol 7. issue 14. 2017-03-01. PMID:26942564. |
by activation of the stat3 pathway, bcr-abl can promote cell cycling, and inhibit differentiation and apoptosis. |
2017-03-01 |
2023-08-13 |
Not clear |
| J Shi, B H Sun, L R Zhou, X S Wan. Role of IL-10 and TNF-α during Mycobacterium tuberculosis infection in murine alveolar macrophages. Genetics and molecular research : GMR. vol 15. issue 3. 2017-02-27. PMID:27706765. |
after mtb infection, tnf-α and il-10 levels, alveolar macrophage apoptosis, and stat3 and p-stat3 expression increased significantly on days 1, 3, and 7 (p < 0.05), with maximum values on day 3. |
2017-02-27 |
2023-08-13 |
mouse |