| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Junwei Zhang, Jiajun Du, Qi Liu, Yi Zhan. Down-regulation of STAT3 expression using vector-based RNA interference promotes apoptosis in Hepatocarcinoma cells. Artificial cells, nanomedicine, and biotechnology. vol 44. issue 5. 2017-01-12. PMID:26134753. |
down-regulation of stat3 expression using vector-based rna interference promotes apoptosis in hepatocarcinoma cells. |
2017-01-12 |
2023-08-13 |
Not clear |
| Junwei Zhang, Jiajun Du, Qi Liu, Yi Zhan. Down-regulation of STAT3 expression using vector-based RNA interference promotes apoptosis in Hepatocarcinoma cells. Artificial cells, nanomedicine, and biotechnology. vol 44. issue 5. 2017-01-12. PMID:26134753. |
in this study, we followed a dna vector-based rnai approach to silence the signal transducer and activator of transcription 3 (stat3) expression in bel-7402 cells, to explore how the janus kinase (jak)/stat3 signaling pathway influences the apoptosis of hepatocarcinoma cells. |
2017-01-12 |
2023-08-13 |
Not clear |
| Zubin Zhang, Hongwu Mao, Xiaolin Du, Jingyu Zhu, Yujia Xu, Siyu Wang, Xin Xu, Peng Ji, Yang Yu, Biyin Cao, Kunkun Han, Tingjun Hou, Zhuan Xu, Yan Kong, Gaofeng Jiang, Xiaowen Tang, Chunhua Qiao, Xinliang Ma. A novel small molecule agent displays potent anti-myeloma activity by inhibiting the JAK2-STAT3 signaling pathway. Oncotarget. vol 7. issue 8. 2017-01-06. PMID:26814430. |
by inhibiting the stat3 signaling, sc99 induced mm cell apoptosis which could be partly abolished by the ectopic expression of stat3. |
2017-01-06 |
2023-08-13 |
mouse |
| Chuntao Wu, Jinji Zhang, Tienan Liu, Guimei Jiao, Changzai Li, Baoshan H. [Astaxanthin inhibits proliferation and promotes apoptosis of A549 lung cancer cells via blocking JAK1/STAT3 pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 32. issue 6. 2017-01-06. PMID:27371847. |
the viability of a549 cells was detected by cck-8 assay; cell cycle and apoptosis were observed by flow cytometry; and the expressions of b-cell lymphoma-2 (bcl-2), bcl-2 associated x protein (bax), signal transducers and activators of transcription 3 (stat3), and janus kinase 1 (jak1) were evaluated by western blotting. |
2017-01-06 |
2023-08-13 |
Not clear |
| Lei Wang, Yanbo Liu, Xinli Zhao, Weigao She. [Knockdown of STAT3 reduces the level of survivin and promotes the apoptosis of U87MG glioma cells]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 32. issue 6. 2017-01-06. PMID:27371848. |
[knockdown of stat3 reduces the level of survivin and promotes the apoptosis of u87mg glioma cells]. |
2017-01-06 |
2023-08-13 |
human |
| Lei Wang, Yanbo Liu, Xinli Zhao, Weigao She. [Knockdown of STAT3 reduces the level of survivin and promotes the apoptosis of U87MG glioma cells]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 32. issue 6. 2017-01-06. PMID:27371848. |
objective to investigate the effect of signal transducer and activator of transcription (stat3)-specific sirna (sistat3) on the apoptosis of u87mg human glioma cells and its mechanism. |
2017-01-06 |
2023-08-13 |
human |
| Lei Wang, Yanbo Liu, Xinli Zhao, Weigao She. [Knockdown of STAT3 reduces the level of survivin and promotes the apoptosis of U87MG glioma cells]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 32. issue 6. 2017-01-06. PMID:27371848. |
conclusion knockdown of stat3 in u87mg cells can downregulate the level of survivin and remarkably promote the apoptosis of glioma cells. |
2017-01-06 |
2023-08-13 |
human |
| Shengjun Ji, Yeliang Wen, Qiting Lai, Minjing Li, Peifang Zhan. [Hypoxia combined with TNF-α induces apoptosis of cultured human pulmonary microvascular endothelial cells via activation of the STAT3 rather than ERK1/2 signaling pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 32. issue 7. 2017-01-03. PMID:27363268. |
[hypoxia combined with tnf-α induces apoptosis of cultured human pulmonary microvascular endothelial cells via activation of the stat3 rather than erk1/2 signaling pathway]. |
2017-01-03 |
2023-08-13 |
human |
| Shengjun Ji, Yeliang Wen, Qiting Lai, Minjing Li, Peifang Zhan. [Hypoxia combined with TNF-α induces apoptosis of cultured human pulmonary microvascular endothelial cells via activation of the STAT3 rather than ERK1/2 signaling pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 32. issue 7. 2017-01-03. PMID:27363268. |
moreover, the stat3 inhibitor s3i-201 reduced the apoptosis rate in the combined treatment group. |
2017-01-03 |
2023-08-13 |
human |
| Shengjun Ji, Yeliang Wen, Qiting Lai, Minjing Li, Peifang Zhan. [Hypoxia combined with TNF-α induces apoptosis of cultured human pulmonary microvascular endothelial cells via activation of the STAT3 rather than ERK1/2 signaling pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 32. issue 7. 2017-01-03. PMID:27363268. |
conclusion combined hypoxia and tnf-α could promote hpmvec apoptosis by activating stat3 rather than erk1/2. |
2017-01-03 |
2023-08-13 |
human |
| Qunfeng Ma, Bangming Jin, Yao Zhang, Yinan Shi, Chi Zhang, Dan Luo, Pengkun Wang, Cuimi Duan, Heyu Song, Xue Li, Xuefeng Deng, Zhinan Chen, Ziling Wang, Hong Jiang, Yan Li. Secreted recombinant human IL-24 protein inhibits the proliferation of esophageal squamous cell carcinoma Eca-109 cells in vitro and in vivo. Oncology reports. vol 35. issue 5. 2016-12-29. PMID:26935394. |
in vitro, we identified that the purified srhil-24 inhibited proliferation and induced the apoptosis of escc eca-109 cells and activated stat3, which was related with the il-20 receptors. |
2016-12-29 |
2023-08-13 |
human |
| Ji Eun Park, Byoungduck Park, In Gyeong Chae, Do-Hee Kim, Juthika Kundu, Joydeb Kumar Kundu, Kyung-Soo Chu. Carnosic acid induces apoptosis through inactivation of Src/STAT3 signaling pathway in human renal carcinoma Caki cells. Oncology reports. vol 35. issue 5. 2016-12-29. PMID:26936454. |
taken together, the present study revealed that ca induced apoptosis in caki cells by induction of p53 and suppression of stat3 signaling. |
2016-12-29 |
2023-08-13 |
human |
| Zi Ming Zhang, Chao Shen, Hai Li, Qing Fan, Jing Ding, Fang Chun Jin, Lin Sh. Leptin induces the apoptosis of chondrocytes in an in vitro model of osteoarthritis via the JAK2‑STAT3 signaling pathway. Molecular medicine reports. vol 13. issue 4. 2016-12-28. PMID:26936086. |
it has been demonstrated that leptin is associated with the pathogenesis of oa via the janus kinase 2 (jak2)‑signal transducer and activator of transcription 3 (stat3) signaling pathway, and data gathered in the present study demonstrated that suppression of this signaling pathway using a jak2 inhibitor, ag490, significantly ameliorated leptin‑induced apoptosis in damaged chondrocytes in vitro, and reduced the generation of ros. |
2016-12-28 |
2023-08-13 |
Not clear |
| Hasaya Dokduang, Puangrat Yongvanit, Nisana Namwat, Chawalit Pairojkul, Sakkarn Sangkhamanon, Mika Sakurai Yageta, Yoshinori Murakami, Watcharin Loilom. Xanthohumol inhibits STAT3 activation pathway leading to growth suppression and apoptosis induction in human cholangiocarcinoma cells. Oncology reports. vol 35. issue 4. 2016-12-26. PMID:26794001. |
xanthohumol inhibits stat3 activation pathway leading to growth suppression and apoptosis induction in human cholangiocarcinoma cells. |
2016-12-26 |
2023-08-13 |
mouse |
| Hasaya Dokduang, Puangrat Yongvanit, Nisana Namwat, Chawalit Pairojkul, Sakkarn Sangkhamanon, Mika Sakurai Yageta, Yoshinori Murakami, Watcharin Loilom. Xanthohumol inhibits STAT3 activation pathway leading to growth suppression and apoptosis induction in human cholangiocarcinoma cells. Oncology reports. vol 35. issue 4. 2016-12-26. PMID:26794001. |
the reduction in stat3 activity at 20 and 50 µm was associated with a significant reduction of cca cell growth and apoptosis. |
2016-12-26 |
2023-08-13 |
mouse |
| Napapan Kangwan, Yoon-Jae Kim, Young Min Han, Migyeong Jeong, Jong-Min Park, Eun-Jin Go, Ki-Baik Hah. Sonic hedgehog inhibitors prevent colitis-associated cancer via orchestrated mechanisms of IL-6/gp130 inhibition, 15-PGDH induction, Bcl-2 abrogation, and tumorsphere inhibition. Oncotarget. vol 7. issue 7. 2016-12-21. PMID:26716648. |
in the mouse model, shh inhibitors significantly reduced tumor incidence and multiplicity, decreased the expression of il-6, tnf-α, cox-2, stat3, and nf-κb, and significantly induced apoptosis. |
2016-12-21 |
2023-08-13 |
mouse |
| Wenchao Zhou, Aili Cao, Li Wang, Dazheng W. Kurarinone Synergizes TRAIL-Induced Apoptosis in Gastric Cancer Cells. Cell biochemistry and biophysics. vol 72. issue 1. 2016-12-19. PMID:25524636. |
the enhancement of apoptosis trail induced by kurarinone involved downregulation of anti-apoptotic proteins mcl-1 and c-flip as well as inhibition of stat3 signaling. |
2016-12-19 |
2023-08-13 |
human |
| Wenchao Zhou, Aili Cao, Li Wang, Dazheng W. Kurarinone Synergizes TRAIL-Induced Apoptosis in Gastric Cancer Cells. Cell biochemistry and biophysics. vol 72. issue 1. 2016-12-19. PMID:25524636. |
moreover, we found that stat3 inhibitor could synergistically enhanced trail-induced apoptosis, similar to kurarinone. |
2016-12-19 |
2023-08-13 |
human |
| Chulwon Kim, Jin Ho Kim, Eun Young Oh, Dongwoo Nam, Seok Geun Lee, Junhee Lee, Sung-Hoon Kim, Bum Sang Shim, Kwang Seok Ah. Blockage of STAT3 Signaling Pathway by Morusin Induces Apoptosis and Inhibits Invasion in Human Pancreatic Tumor Cells. Pancreas. vol 45. issue 3. 2016-12-13. PMID:26646273. |
blockage of stat3 signaling pathway by morusin induces apoptosis and inhibits invasion in human pancreatic tumor cells. |
2016-12-13 |
2023-08-13 |
human |
| Shanshan Luo, Xianfeng Gu, Fenfen Ma, Chunhua Liu, Yaqi Shen, Ruowen Ge, Yizhun Zh. ZYZ451 protects cardiomyocytes from hypoxia-induced apoptosis via enhancing MnSOD and STAT3 interaction. Free radical biology & medicine. vol 92. 2016-12-13. PMID:26721595. |
zyz451 protects cardiomyocytes from hypoxia-induced apoptosis via enhancing mnsod and stat3 interaction. |
2016-12-13 |
2023-08-13 |
rat |