| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qunfeng Ma, Bangming Jin, Yao Zhang, Yinan Shi, Chi Zhang, Dan Luo, Pengkun Wang, Cuimi Duan, Heyu Song, Xue Li, Xuefeng Deng, Zhinan Chen, Ziling Wang, Hong Jiang, Yan Li. Secreted recombinant human IL-24 protein inhibits the proliferation of esophageal squamous cell carcinoma Eca-109 cells in vitro and in vivo. Oncology reports. vol 35. issue 5. 2016-12-29. PMID:26935394. |
in vitro, we identified that the purified srhil-24 inhibited proliferation and induced the apoptosis of escc eca-109 cells and activated stat3, which was related with the il-20 receptors. |
2016-12-29 |
2023-08-13 |
human |
| Ji Eun Park, Byoungduck Park, In Gyeong Chae, Do-Hee Kim, Juthika Kundu, Joydeb Kumar Kundu, Kyung-Soo Chu. Carnosic acid induces apoptosis through inactivation of Src/STAT3 signaling pathway in human renal carcinoma Caki cells. Oncology reports. vol 35. issue 5. 2016-12-29. PMID:26936454. |
taken together, the present study revealed that ca induced apoptosis in caki cells by induction of p53 and suppression of stat3 signaling. |
2016-12-29 |
2023-08-13 |
human |
| Zi Ming Zhang, Chao Shen, Hai Li, Qing Fan, Jing Ding, Fang Chun Jin, Lin Sh. Leptin induces the apoptosis of chondrocytes in an in vitro model of osteoarthritis via the JAK2‑STAT3 signaling pathway. Molecular medicine reports. vol 13. issue 4. 2016-12-28. PMID:26936086. |
it has been demonstrated that leptin is associated with the pathogenesis of oa via the janus kinase 2 (jak2)‑signal transducer and activator of transcription 3 (stat3) signaling pathway, and data gathered in the present study demonstrated that suppression of this signaling pathway using a jak2 inhibitor, ag490, significantly ameliorated leptin‑induced apoptosis in damaged chondrocytes in vitro, and reduced the generation of ros. |
2016-12-28 |
2023-08-13 |
Not clear |
| Hasaya Dokduang, Puangrat Yongvanit, Nisana Namwat, Chawalit Pairojkul, Sakkarn Sangkhamanon, Mika Sakurai Yageta, Yoshinori Murakami, Watcharin Loilom. Xanthohumol inhibits STAT3 activation pathway leading to growth suppression and apoptosis induction in human cholangiocarcinoma cells. Oncology reports. vol 35. issue 4. 2016-12-26. PMID:26794001. |
xanthohumol inhibits stat3 activation pathway leading to growth suppression and apoptosis induction in human cholangiocarcinoma cells. |
2016-12-26 |
2023-08-13 |
mouse |
| Hasaya Dokduang, Puangrat Yongvanit, Nisana Namwat, Chawalit Pairojkul, Sakkarn Sangkhamanon, Mika Sakurai Yageta, Yoshinori Murakami, Watcharin Loilom. Xanthohumol inhibits STAT3 activation pathway leading to growth suppression and apoptosis induction in human cholangiocarcinoma cells. Oncology reports. vol 35. issue 4. 2016-12-26. PMID:26794001. |
the reduction in stat3 activity at 20 and 50 µm was associated with a significant reduction of cca cell growth and apoptosis. |
2016-12-26 |
2023-08-13 |
mouse |
| Napapan Kangwan, Yoon-Jae Kim, Young Min Han, Migyeong Jeong, Jong-Min Park, Eun-Jin Go, Ki-Baik Hah. Sonic hedgehog inhibitors prevent colitis-associated cancer via orchestrated mechanisms of IL-6/gp130 inhibition, 15-PGDH induction, Bcl-2 abrogation, and tumorsphere inhibition. Oncotarget. vol 7. issue 7. 2016-12-21. PMID:26716648. |
in the mouse model, shh inhibitors significantly reduced tumor incidence and multiplicity, decreased the expression of il-6, tnf-α, cox-2, stat3, and nf-κb, and significantly induced apoptosis. |
2016-12-21 |
2023-08-13 |
mouse |
| Wenchao Zhou, Aili Cao, Li Wang, Dazheng W. Kurarinone Synergizes TRAIL-Induced Apoptosis in Gastric Cancer Cells. Cell biochemistry and biophysics. vol 72. issue 1. 2016-12-19. PMID:25524636. |
the enhancement of apoptosis trail induced by kurarinone involved downregulation of anti-apoptotic proteins mcl-1 and c-flip as well as inhibition of stat3 signaling. |
2016-12-19 |
2023-08-13 |
human |
| Wenchao Zhou, Aili Cao, Li Wang, Dazheng W. Kurarinone Synergizes TRAIL-Induced Apoptosis in Gastric Cancer Cells. Cell biochemistry and biophysics. vol 72. issue 1. 2016-12-19. PMID:25524636. |
moreover, we found that stat3 inhibitor could synergistically enhanced trail-induced apoptosis, similar to kurarinone. |
2016-12-19 |
2023-08-13 |
human |
| Chulwon Kim, Jin Ho Kim, Eun Young Oh, Dongwoo Nam, Seok Geun Lee, Junhee Lee, Sung-Hoon Kim, Bum Sang Shim, Kwang Seok Ah. Blockage of STAT3 Signaling Pathway by Morusin Induces Apoptosis and Inhibits Invasion in Human Pancreatic Tumor Cells. Pancreas. vol 45. issue 3. 2016-12-13. PMID:26646273. |
blockage of stat3 signaling pathway by morusin induces apoptosis and inhibits invasion in human pancreatic tumor cells. |
2016-12-13 |
2023-08-13 |
human |
| Shanshan Luo, Xianfeng Gu, Fenfen Ma, Chunhua Liu, Yaqi Shen, Ruowen Ge, Yizhun Zh. ZYZ451 protects cardiomyocytes from hypoxia-induced apoptosis via enhancing MnSOD and STAT3 interaction. Free radical biology & medicine. vol 92. 2016-12-13. PMID:26721595. |
zyz451 protects cardiomyocytes from hypoxia-induced apoptosis via enhancing mnsod and stat3 interaction. |
2016-12-13 |
2023-08-13 |
rat |
| Hao Wu, Ning Li, Ronghua Jin, Qinghua Meng, Peng Chen, Guoxian Zhao, Rui Wang, Li Li, Wei L. Cytokine levels contribute to the pathogenesis of minimal hepatic encephalopathy in patients with hepatocellular carcinoma via STAT3 activation. Scientific reports. vol 6. 2016-12-13. PMID:26757951. |
treatment with a stat3 inhibitor protected neurons from cytokine-induced apoptosis in vitro. |
2016-12-13 |
2023-08-13 |
human |
| Hao Wu, Ning Li, Ronghua Jin, Qinghua Meng, Peng Chen, Guoxian Zhao, Rui Wang, Li Li, Wei L. Cytokine levels contribute to the pathogenesis of minimal hepatic encephalopathy in patients with hepatocellular carcinoma via STAT3 activation. Scientific reports. vol 6. 2016-12-13. PMID:26757951. |
the cytokines investigated may induce neural apoptosis via stat3 in the pathogenesis of mhe in hcc. |
2016-12-13 |
2023-08-13 |
human |
| Jing Liu, Hui Fu, Fen Chang, Jinlan Wang, Shangli Zhang, Yi Caudle, Jing Zhao, Deling Yi. Sodium orthovanadate suppresses palmitate-induced cardiomyocyte apoptosis by regulation of the JAK2/STAT3 signaling pathway. Apoptosis : an international journal on programmed cell death. vol 21. issue 5. 2016-12-13. PMID:26921179. |
the data suggested that jnk may be another upstream factor regulating stat3, and verified the important function of p-stat3 (y705) in pa-induced cardiomyocyte apoptosis. |
2016-12-13 |
2023-08-13 |
Not clear |
| Elizabeth Reyes-Zárate, Yesennia Sánchez-Pérez, María Concepción Gutiérrez-Ruiz, Yolanda I Chirino, Álvaro Román Osornio-Vargas, Rocío Morales-Bárcenas, Verónica Souza-Arroyo, Claudia María García-Cuella. Atmospheric particulate matter (PM10) exposure-induced cell cycle arrest and apoptosis evasion through STAT3 activation via PKCζ and Src kinases in lung cells. Environmental pollution (Barking, Essex : 1987). vol 214. 2016-12-13. PMID:27131825. |
atmospheric particulate matter (pm10) exposure-induced cell cycle arrest and apoptosis evasion through stat3 activation via pkcζ and src kinases in lung cells. |
2016-12-13 |
2023-08-13 |
Not clear |
| Elizabeth Reyes-Zárate, Yesennia Sánchez-Pérez, María Concepción Gutiérrez-Ruiz, Yolanda I Chirino, Álvaro Román Osornio-Vargas, Rocío Morales-Bárcenas, Verónica Souza-Arroyo, Claudia María García-Cuella. Atmospheric particulate matter (PM10) exposure-induced cell cycle arrest and apoptosis evasion through STAT3 activation via PKCζ and Src kinases in lung cells. Environmental pollution (Barking, Essex : 1987). vol 214. 2016-12-13. PMID:27131825. |
the inhibition of stat3 phosphorylation prevented cell cycle arrest and triggered apoptosis. |
2016-12-13 |
2023-08-13 |
Not clear |
| Elizabeth Reyes-Zárate, Yesennia Sánchez-Pérez, María Concepción Gutiérrez-Ruiz, Yolanda I Chirino, Álvaro Román Osornio-Vargas, Rocío Morales-Bárcenas, Verónica Souza-Arroyo, Claudia María García-Cuella. Atmospheric particulate matter (PM10) exposure-induced cell cycle arrest and apoptosis evasion through STAT3 activation via PKCζ and Src kinases in lung cells. Environmental pollution (Barking, Essex : 1987). vol 214. 2016-12-13. PMID:27131825. |
these results suggest that pm10 exposure might activate a survival pathway related to stat3 activation, similar to what has been described as part of the immune system and apoptosis evasion during tumor promotion and development. |
2016-12-13 |
2023-08-13 |
Not clear |
| Meng-Chi Yen, Ying-Chu Shih, Ya-Ling Hsu, En-Shyh Lin, Yi-Shiuan Lin, Eing-Mei Tsai, Ya-Wen Ho, Ming-Feng Hou, Po-Lin Ku. Isolinderalactone enhances the inhibition of SOCS3 on STAT3 activity by decreasing miR-30c in breast cancer. Oncology reports. vol 35. issue 3. 2016-10-28. PMID:26707189. |
treatment of isolinderalactone increased the protein level of the suppressor of cytokine signaling 3 (scos3), decreased phosphorylation of the signal transducer and activator of transcription 3 (stat3), and suppressed expression of the down-stream genes of the x-linked inhibitor of apoptosis protein in mda-mb-231 cells. |
2016-10-28 |
2023-08-13 |
mouse |
| Meng-Chi Yen, Ying-Chu Shih, Ya-Ling Hsu, En-Shyh Lin, Yi-Shiuan Lin, Eing-Mei Tsai, Ya-Wen Ho, Ming-Feng Hou, Po-Lin Ku. Isolinderalactone enhances the inhibition of SOCS3 on STAT3 activity by decreasing miR-30c in breast cancer. Oncology reports. vol 35. issue 3. 2016-10-28. PMID:26707189. |
in conclusion, isolinderalactone induces apoptosis in mda-mb‑231 cells and suppresses stat3 signaling pathway through regulation of socs3 and mir-30c. |
2016-10-28 |
2023-08-13 |
mouse |
| Shan Xu, Ning Zhao, Lian Hui, Min Song, Zi-Wei Miao, Xue-Jun Jian. MicroRNA-124-3p inhibits the growth and metastasis of nasopharyngeal carcinoma cells by targeting STAT3. Oncology reports. vol 35. issue 3. 2016-10-28. PMID:26707908. |
to sum up, this study shows that mir-124-3p may negatively regulate the transcription of the stat3 by interfering with its 3'utr, and the degradation of stat3 affects its downstream expression of such as p-stat3, ccnd2 and mmp-2, thereby promoting npc cells apoptosis and inhibiting proliferation, migration and invasion of npc cells. |
2016-10-28 |
2023-08-13 |
mouse |
| Seung Ho Baek, Jeong-Hyeon Ko, Hanwool Lee, Jinhong Jung, Moonkyoo Kong, Jung-woo Lee, Junhee Lee, Arunachalam Chinnathambi, M E Zayed, Sulaiman Ali Alharbi, Seok-Geun Lee, Bum Sang Shim, Gautam Sethi, Sung-Hoon Kim, Woong Mo Yang, Jae-Young Um, Kwang Seok Ah. Resveratrol inhibits STAT3 signaling pathway through the induction of SOCS-1: Role in apoptosis induction and radiosensitization in head and neck tumor cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 23. issue 5. 2016-10-21. PMID:27064016. |
resveratrol inhibits stat3 signaling pathway through the induction of socs-1: role in apoptosis induction and radiosensitization in head and neck tumor cells. |
2016-10-21 |
2023-08-13 |
Not clear |