| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Muhammad Khan, Amara Maryam, Javed Iqbal Qazi, Tonghui M. Targeting Apoptosis and Multiple Signaling Pathways with Icariside II in Cancer Cells. International journal of biological sciences. vol 11. issue 9. 2016-05-27. PMID:26221076. |
icariside ii has been found to induce apoptosis in various human cancer cell lines of different origin by targeting multiple signaling pathways including stat3, pi3k/akt, mapk/erk, cox-2/pge2 and β-catenin which are frequently deregulated in cancers, suggesting that this collective activity rather than just a single effect may play an important role in developing icariside ii into a potential lead compound for anticancer therapy. |
2016-05-27 |
2023-08-13 |
human |
| Ji Hoon Jung, Miyong Yun, Eun-Jeong Choo, Sun-Hee Kim, Myoung-Seok Jeong, Deok-Beom Jung, Hyemin Lee, Eun-Ok Kim, Nobuo Kato, Bonglee Kim, Sanjay K Srivastava, Kunihiro Kaihatsu, Sung-Hoon Ki. A derivative of epigallocatechin-3-gallate induces apoptosis via SHP-1-mediated suppression of BCR-ABL and STAT3 signalling in chronic myelogenous leukaemia. British journal of pharmacology. vol 172. issue 14. 2016-05-17. PMID:25825203. |
a derivative of epigallocatechin-3-gallate induces apoptosis via shp-1-mediated suppression of bcr-abl and stat3 signalling in chronic myelogenous leukaemia. |
2016-05-17 |
2023-08-13 |
Not clear |
| Napapan Kangwan, Yoon-Jae Kim, Young-Min Han, Migyeong Jeong, Jong-Min Park, Ki-Baik Hah. Concerted actions of ameliorated colitis, aberrant crypt foci inhibition and 15-hydroxyprostaglandin dehydrogenase induction by sonic hedgehog inhibitor led to prevention of colitis-associated cancer. International journal of cancer. vol 138. issue 6. 2016-05-13. PMID:26476372. |
among inflammatory mediators, significantly decreased levels of il-6 and tnf-α, regulated with repressed nf-κb and stat3, were prominent with shh inhibitor, whereas significant inductions of apoptosis were noted with shh inhibitors. |
2016-05-13 |
2023-08-13 |
mouse |
| Napapan Kangwan, Yoon-Jae Kim, Young-Min Han, Migyeong Jeong, Jong-Min Park, Ki-Baik Hah. Concerted actions of ameliorated colitis, aberrant crypt foci inhibition and 15-hydroxyprostaglandin dehydrogenase induction by sonic hedgehog inhibitor led to prevention of colitis-associated cancer. International journal of cancer. vol 138. issue 6. 2016-05-13. PMID:26476372. |
in conclusion, shh inhibitors significantly prevented cac covering either ameliorating oncogenic inflammation or suppressing tumor proliferation, especially supported with significant inhibition of il-6 and stat3 signaling, 15-pgdh preservation and apoptosis induction. |
2016-05-13 |
2023-08-13 |
mouse |
| Jean-René Pallandre, Christophe Borg, Didier Rognan, Thibault Boibessot, Vincent Luzet, Semen Yesylevskyy, Christophe Ramseyer, Marc Pudl. Novel aminotetrazole derivatives as selective STAT3 non-peptide inhibitors. European journal of medicinal chemistry. vol 103. 2016-05-09. PMID:26352675. |
in this context, the selectivity of inhibitors against the stat1 transcription factor is crucial as stat3 and stat1 play opposite roles in the apoptosis of tumor cells and polarization of the immune response. |
2016-05-09 |
2023-08-13 |
Not clear |
| Weiliang Jiang, Senlin Zhao, Ling Xu, Yingying Lu, Zhanjun Lu, Congying Chen, Jianbo Ni, Rong Wan, Lijuan Yan. The inhibitory effects of xanthohumol, a prenylated chalcone derived from hops, on cell growth and tumorigenesis in human pancreatic cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 73. 2016-05-02. PMID:26211581. |
xn treatment was found to induce cell cycle arrest and apoptosis of pc cells (panc-1, bxpc-3) by inhibiting phosphorylation of signal transducer and activator of transcription 3 (stat3) and expression of its downstream targeted genes cyclind1, survivin, and bcl-xl at the messenger rna level, which involved in regulation of apoptosis and the cell cycle. |
2016-05-02 |
2023-08-13 |
human |
| Elena Ciaglia, Giovanni Torelli, Simona Pisanti, Paola Picardi, Alba D'Alessandro, Chiara Laezza, Anna Maria Malfitano, Donatella Fiore, Antonio Christian Pagano Zottola, Maria Chiara Proto, Giuseppe Catapano, Patrizia Gazzerro, Maurizio Bifulc. Cannabinoid receptor CB1 regulates STAT3 activity and its expression dictates the responsiveness to SR141716 treatment in human glioma patients' cells. Oncotarget. vol 6. issue 17. 2016-04-29. PMID:26008966. |
functional studies, using u251mg glioma cells and primary tumor cell lines derived from glioma patients expressing different levels of cb1, highlighted sr141716 efficacy in inducing apoptosis via g1 phase stasis and block of tgf-β1 secretion through a mechanism that involves stat3 inhibition. |
2016-04-29 |
2023-08-13 |
human |
| Xiaokui Yu, Li He, Peng Cao, Qiang Y. Eriocalyxin B Inhibits STAT3 Signaling by Covalently Targeting STAT3 and Blocking Phosphorylation and Activation of STAT3. PloS one. vol 10. issue 5. 2016-04-27. PMID:26010889. |
activated stat3 plays an important role in oncogenesis by stimulating cell proliferation and resisting apoptosis. |
2016-04-27 |
2023-08-13 |
Not clear |
| Xiaokui Yu, Li He, Peng Cao, Qiang Y. Eriocalyxin B Inhibits STAT3 Signaling by Covalently Targeting STAT3 and Blocking Phosphorylation and Activation of STAT3. PloS one. vol 10. issue 5. 2016-04-27. PMID:26010889. |
eb selectively inhibited constitutive as well as il-6-induced phosphorylation of stat3 and induced apoptosis of stat3-dependent tumor cells. |
2016-04-27 |
2023-08-13 |
Not clear |
| Xiaokui Yu, Li He, Peng Cao, Qiang Y. Eriocalyxin B Inhibits STAT3 Signaling by Covalently Targeting STAT3 and Blocking Phosphorylation and Activation of STAT3. PloS one. vol 10. issue 5. 2016-04-27. PMID:26010889. |
these data strongly suggest that eb directly targets stat3 through a covalent linkage to inhibit the phosphorylation and activation of stat3 and induces apoptosis of stat3-dependent tumor cells. |
2016-04-27 |
2023-08-13 |
Not clear |
| Ning Wu, Jia Liu, Xiangzhong Zhao, Zhiyong Yan, Bo Jiang, Lijun Wang, Shousong Cao, Dayong Shi, Xiukun Li. Cardamonin induces apoptosis by suppressing STAT3 signaling pathway in glioblastoma stem cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 12. 2016-04-26. PMID:26150336. |
cardamonin induces apoptosis by suppressing stat3 signaling pathway in glioblastoma stem cells. |
2016-04-26 |
2023-08-13 |
mouse |
| Ning Wu, Jia Liu, Xiangzhong Zhao, Zhiyong Yan, Bo Jiang, Lijun Wang, Shousong Cao, Dayong Shi, Xiukun Li. Cardamonin induces apoptosis by suppressing STAT3 signaling pathway in glioblastoma stem cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 12. 2016-04-26. PMID:26150336. |
in the present study, we investigated the effects of cardamonin (3,4,2,4-tetrahydroxychalcone) on the self-renewal and apoptosis of gscs, and if its action is associated with signal transducer and activator of transcription 3 (stat3) pathway. |
2016-04-26 |
2023-08-13 |
mouse |
| Jijun You, Xuejun He, Haibing Ding, Tingrong Zhan. BRMS1 regulates apoptosis in non-small cell lung cancer cells. Cell biochemistry and biophysics. vol 71. issue 1. 2016-04-25. PMID:25182004. |
we identified that brms1 regulate apoptosis in nsclc cells by modulating stat3 activation. |
2016-04-25 |
2023-08-13 |
human |
| Jijun You, Xuejun He, Haibing Ding, Tingrong Zhan. BRMS1 regulates apoptosis in non-small cell lung cancer cells. Cell biochemistry and biophysics. vol 71. issue 1. 2016-04-25. PMID:25182004. |
taken together, our results show that brms1 sensitizes nsclc cells to apoptosis through stat3 signaling pathway, suggesting a potential role of brms1 in regulating nsclc apoptosis and metastasis. |
2016-04-25 |
2023-08-13 |
human |
| Concetta Paola Ilisso, Luigi Sapio, Donatella Delle Cave, Michela Illiano, Annamaria Spina, Giovanna Cacciapuoti, Silvio Naviglio, Marina Porcell. S-Adenosylmethionine Affects ERK1/2 and Stat3 Pathways and Induces Apotosis in Osteosarcoma Cells. Journal of cellular physiology. vol 231. issue 2. 2016-04-22. PMID:26174106. |
altogether, our data enforce the evidence of adomet acting as a biomolecule with antiproliferative action in osteosarcoma cells, capable of down-regulating erk1/2 and stat3 pathways leading to cell cycle inhibition and apoptosis, and provide a rationale for the possible use of adomet in osteosarcoma therapy. |
2016-04-22 |
2023-08-13 |
Not clear |
| Takanobu Nagata, Hideo Yasukawa, Sachiko Kyogoku, Toyoharu Oba, Jinya Takahashi, Shoichiro Nohara, Tomoko Minami, Kazutoshi Mawatari, Yusuke Sugi, Koutatsu Shimozono, Sylvain Pradervand, Masahiko Hoshijima, Hiroki Aoki, Yoshihiro Fukumoto, Tsutomu Imaizum. Cardiac-Specific SOCS3 Deletion Prevents In Vivo Myocardial Ischemia Reperfusion Injury through Sustained Activation of Cardioprotective Signaling Molecules. PloS one. vol 10. issue 5. 2016-04-21. PMID:26010537. |
in socs3-cko mice, stat3, akt, and erk1/2 phosphorylation was sustained, myocardial apoptosis was prevented, and the expression of anti-apoptotic bcl-2 family member myeloid cell leukemia-1 (mcl-1) was augmented. |
2016-04-21 |
2023-08-13 |
mouse |
| Aiping Shi, Jie Dong, Susan Hilsenbeck, Lirong Bi, Hong Zhang, Yi L. The Status of STAT3 and STAT5 in Human Breast Atypical Ductal Hyperplasia. PloS one. vol 10. issue 7. 2016-04-18. PMID:26146825. |
signal transducer and activation of transcription factors (stat3 and stat5) play important roles in breast epithelial cell differentiation, proliferation, and apoptosis. |
2016-04-18 |
2023-08-13 |
human |
| Xiaoli Yao, Hua Liu, Xinghua Zhang, Liang Zhang, Xiang Li, Changhua Wang, Shengrong Su. Cell Surface GRP78 Accelerated Breast Cancer Cell Proliferation and Migration by Activating STAT3. PloS one. vol 10. issue 5. 2016-04-13. PMID:25973748. |
furthermore, genetic and pharmacological inhibition of stat3 reversed the impacts of grp78 on cell proliferation, apoptosis, and migration. |
2016-04-13 |
2023-08-13 |
human |
| X Song, C T Wang, X H Gen. MicroRNA-29a promotes apoptosis of monocytes by targeting STAT3 during sepsis. Genetics and molecular research : GMR. vol 14. issue 4. 2016-04-13. PMID:26535690. |
microrna-29a promotes apoptosis of monocytes by targeting stat3 during sepsis. |
2016-04-13 |
2023-08-13 |
human |
| C Liu, L-H Dai, D-Q Dou, L-Q Ma, Y-X Su. A natural food sweetener with anti-pancreatic cancer properties. Oncogenesis. vol 5. 2016-04-12. PMID:27065453. |
herein, we found that mogroside v possesses tumor growth inhibitory activity in in vitro and in vivo models of pancreatic cancer by promoting apoptosis and cell cycle arrest of pancreatic cancer cells (panc-1 cells), which may in part be mediated through regulating the stat3 signaling pathway. |
2016-04-12 |
2023-08-13 |
mouse |