| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yanmin Zhang, Zhaoxiao Du, Zirong Zhuang, Yanjun Wang, Fen Wang, Shuai Liu, Han Wang, Hairong Feng, Haoyuan Li, Liyan Wang, Xianghong Zhang, Aijun Ha. E804 induces growth arrest, differentiation and apoptosis of glioblastoma cells by blocking Stat3 signaling. Journal of neuro-oncology. vol 125. issue 2. 2016-07-25. PMID:26386687. |
taken together, our results indicate that e804 can effectively suppress tumor cell growth, induce tumor cell differentiation and apoptosis mediated partially by stat3 signaling pathway, suggesting that e804 could be useful for a potential anti-glioblastoma therapeutic approach. |
2016-07-25 |
2023-08-13 |
human |
| Jin Mo Ku, Soon Re Kim, Se Hyang Hong, Han-Seok Choi, Hye Sook Seo, Yong Cheol Shin, Seong-Gyu K. Cucurbitacin D induces cell cycle arrest and apoptosis by inhibiting STAT3 and NF-κB signaling in doxorubicin-resistant human breast carcinoma (MCF7/ADR) cells. Molecular and cellular biochemistry. vol 409. issue 1-2. 2016-07-22. PMID:26169986. |
cucurbitacin d induces cell cycle arrest and apoptosis by inhibiting stat3 and nf-κb signaling in doxorubicin-resistant human breast carcinoma (mcf7/adr) cells. |
2016-07-22 |
2023-08-13 |
human |
| Jin Mo Ku, Soon Re Kim, Se Hyang Hong, Han-Seok Choi, Hye Sook Seo, Yong Cheol Shin, Seong-Gyu K. Cucurbitacin D induces cell cycle arrest and apoptosis by inhibiting STAT3 and NF-κB signaling in doxorubicin-resistant human breast carcinoma (MCF7/ADR) cells. Molecular and cellular biochemistry. vol 409. issue 1-2. 2016-07-22. PMID:26169986. |
co-administration of cucurbitacin d and doxorubicin induced apoptosis, and g2/m cell cycle arrest, and inhibited upregulated stat3 by doxorubicin on mcf7/adr cells. |
2016-07-22 |
2023-08-13 |
human |
| Jin Mo Ku, Soon Re Kim, Se Hyang Hong, Han-Seok Choi, Hye Sook Seo, Yong Cheol Shin, Seong-Gyu K. Cucurbitacin D induces cell cycle arrest and apoptosis by inhibiting STAT3 and NF-κB signaling in doxorubicin-resistant human breast carcinoma (MCF7/ADR) cells. Molecular and cellular biochemistry. vol 409. issue 1-2. 2016-07-22. PMID:26169986. |
cucurbitacin d decreases cell proliferation and induces apoptosis by inhibiting stat3 and nf-κb signaling in doxorubicin-resistant breast cancer cells. |
2016-07-22 |
2023-08-13 |
human |
| Andrea M Griesinger, Rebecca J Josephson, Andrew M Donson, Jean M Mulcahy Levy, Vladimir Amani, Diane K Birks, Lindsey M Hoffman, Steffanie L Furtek, Phillip Reigan, Michael H Handler, Rajeev Vibhakar, Nicholas K Forema. Interleukin-6/STAT3 Pathway Signaling Drives an Inflammatory Phenotype in Group A Ependymoma. Cancer immunology research. vol 3. issue 10. 2016-07-19. PMID:25968456. |
epn tumor cell growth was shown to be dependent on stat3 activity, as demonstrated using shrna knockdown and pharmacologic inhibition of stat3 that blocked proliferation and induced apoptosis. |
2016-07-19 |
2023-08-13 |
Not clear |
| Charlotte E Egan, Chhinder P Sodhi, Misty Good, Joyce Lin, Hongpeng Jia, Yukihiro Yamaguchi, Peng Lu, Congrong Ma, Maria F Branca, Samantha Weyandt, William B Fulton, Diego F Niño, Thomas Prindle, John A Ozolek, David J Hacka. Toll-like receptor 4-mediated lymphocyte influx induces neonatal necrotizing enterocolitis. The Journal of clinical investigation. vol 126. issue 2. 2016-07-08. PMID:26690704. |
th17 lymphocytes were required for nec development, as inhibition of stat3 or il-17 receptor signaling attenuated nec in mice, while il-17 release impaired enterocyte tight junctions, increased enterocyte apoptosis, and reduced enterocyte proliferation, leading to nec. |
2016-07-08 |
2023-08-13 |
mouse |
| Xiao-hu Nie, Jia Ou-yang, Ying Xing, Dan-yan Li, Xing-yu Dong, Ru-en Liu, Ru-xiang X. Paeoniflorin inhibits human glioma cells via STAT3 degradation by the ubiquitin-proteasome pathway. Drug design, development and therapy. vol 9. 2016-07-06. PMID:26508835. |
these findings indicated that pf-induced growth suppression and apoptosis in human glioma cells through the proteasome-dependent degradation of stat3. |
2016-07-06 |
2023-08-13 |
human |
| Xing-Hua Liao, Li Zheng, Hong-Peng He, De-Liang Zheng, Zhao-Qiang Wei, Nan Wang, Jian Dong, Wen-Jian Ma, Tong-Cun Zhan. STAT3 regulated ATR via microRNA-383 to control DNA damage to affect apoptosis in A431 cells. Cellular signalling. vol 27. issue 11. 2016-06-30. PMID:26261078. |
stat3 regulated atr via microrna-383 to control dna damage to affect apoptosis in a431 cells. |
2016-06-30 |
2023-08-13 |
human |
| Yoon Mee Yang, Chan Gyu Lee, Ja Hyun Koo, Tae Hyun Kim, Jung Min Lee, Jihyun An, Kang Mo Kim, Sang Geon Ki. Gα12 overexpressed in hepatocellular carcinoma reduces microRNA-122 expression via HNF4α inactivation, which causes c-Met induction. Oncotarget. vol 6. issue 22. 2016-06-28. PMID:25965999. |
mir-122 mimic transfection diminished the ability of gα12 to increase c-met and to activate erk, stat3, and akt/mtor, suppressing cell proliferation with augmented apoptosis. |
2016-06-28 |
2023-08-13 |
human |
| Rong-Jing Zhou, Xiong-Ying Xu, Bu-Xing Liu, Wen-Zhen Dai, Mei-Qin Cai, Chun-Feng Bai, Xian-Fei Zhang, Li-Min Wang, Li Lin, Shu-Zhen Jia, Wen-Hua Wan. Growth-inhibitory and chemosensitizing effects of microRNA-31 in human glioblastoma multiforme cells. International journal of molecular medicine. vol 36. issue 4. 2016-06-20. PMID:26310668. |
for this purpose, the human gbm cell lines, u251 and u87, were transfected with a mir-31 precursor (pre-mir-31), and cell proliferation, apoptosis and stat3 phosphorylation were then assessed. |
2016-06-20 |
2023-08-13 |
human |
| Rong-Jing Zhou, Xiong-Ying Xu, Bu-Xing Liu, Wen-Zhen Dai, Mei-Qin Cai, Chun-Feng Bai, Xian-Fei Zhang, Li-Min Wang, Li Lin, Shu-Zhen Jia, Wen-Hua Wan. Growth-inhibitory and chemosensitizing effects of microRNA-31 in human glioblastoma multiforme cells. International journal of molecular medicine. vol 36. issue 4. 2016-06-20. PMID:26310668. |
taken together, our results indicate that mir-31 triggers mitochondrial apoptosis and potentiates tmz cytotoxicity in gbm cells largely through the suppression of stat3 activation. |
2016-06-20 |
2023-08-13 |
human |
| Huan Yan, Bi-Ying Guo, Shu Zhan. Cancer-associated fibroblasts attenuate Cisplatin-induced apoptosis in ovarian cancer cells by promoting STAT3 signaling. Biochemical and biophysical research communications. vol 470. issue 4. 2016-06-20. PMID:26826383. |
cancer-associated fibroblasts attenuate cisplatin-induced apoptosis in ovarian cancer cells by promoting stat3 signaling. |
2016-06-20 |
2023-08-13 |
human |
| Huan Yan, Bi-Ying Guo, Shu Zhan. Cancer-associated fibroblasts attenuate Cisplatin-induced apoptosis in ovarian cancer cells by promoting STAT3 signaling. Biochemical and biophysical research communications. vol 470. issue 4. 2016-06-20. PMID:26826383. |
in conclusion, our data suggested that cafs could activate the anti-apoptotic stat3 signaling, thereby decrease the cisplatin-induced apoptosis and promote chemoresistance in ovarian cancer. |
2016-06-20 |
2023-08-13 |
human |
| Xian-Jie Zheng, Zhong-Xin Yang, Yan-Jun Dong, Guo-Yu Zhang, Ming-Fei Sun, Xiao-Kang An, Li-Hong Pan, Shuang-Lin Zhan. Downregulation of leptin inhibits growth and induces apoptosis of lung cancer cells via the Notch and JAK/STAT3 signaling pathways. Biology open. vol 5. issue 6. 2016-06-16. PMID:27185268. |
furthermore, gene silencing of notch signaling with notch-1 sirna or inhibition of jak/stat3 signaling by jsi-124, an inhibitor of stat3, resulted in proliferation inhibition and apoptosis induction in nsclc a549 cells. |
2016-06-16 |
2023-08-13 |
human |
| Wen Yue, Xi Zheng, Yong Lin, Chung S Yang, Qing Xu, Darren Carpizo, Huarong Huang, Robert S DiPaola, Xiang-Lin Ta. Metformin combined with aspirin significantly inhibit pancreatic cancer cell growth in vitro and in vivo by suppressing anti-apoptotic proteins Mcl-1 and Bcl-2. Oncotarget. vol 6. issue 25. 2016-06-15. PMID:26056043. |
herein, we evaluated the effects of metformin and aspirin, alone or in combination, on cell viability, migration, and apoptosis as well as the molecular changes in mtor, stat3 and apoptotic signaling pathways in panc-1 and bxpc3 cells. |
2016-06-15 |
2023-08-13 |
mouse |
| Wen Yue, Xi Zheng, Yong Lin, Chung S Yang, Qing Xu, Darren Carpizo, Huarong Huang, Robert S DiPaola, Xiang-Lin Ta. Metformin combined with aspirin significantly inhibit pancreatic cancer cell growth in vitro and in vivo by suppressing anti-apoptotic proteins Mcl-1 and Bcl-2. Oncotarget. vol 6. issue 25. 2016-06-15. PMID:26056043. |
metformin combined with aspirin significantly inhibited the phosphorylation of mtor and stat3, and induced apoptosis as measured by caspase-3 and parp cleavage. |
2016-06-15 |
2023-08-13 |
mouse |
| Irina Kiprianova, Janina Remy, Nelli Milosch, Isabelle V Mohrenz, Volker Seifert, Achim Aigner, Donat Köge. Sorafenib Sensitizes Glioma Cells to the BH3 Mimetic ABT-737 by Targeting MCL1 in a STAT3-Dependent Manner. Neoplasia (New York, N.Y.). vol 17. issue 7. 2016-06-09. PMID:26297434. |
the oncogenic transcription factor signal transducer and activator of transcription 3 (stat3) is overactivated in malignant glioma and plays a key role in promoting cell survival, thereby increasing the acquired apoptosis resistance of these tumors. |
2016-06-09 |
2023-08-13 |
Not clear |
| Irina Kiprianova, Janina Remy, Nelli Milosch, Isabelle V Mohrenz, Volker Seifert, Achim Aigner, Donat Köge. Sorafenib Sensitizes Glioma Cells to the BH3 Mimetic ABT-737 by Targeting MCL1 in a STAT3-Dependent Manner. Neoplasia (New York, N.Y.). vol 17. issue 7. 2016-06-09. PMID:26297434. |
they also suggest that targeting stat3 in combination with inducers of the intrinsic pathway of apoptosis may be a promising novel strategy for the treatment of malignant glioma. |
2016-06-09 |
2023-08-13 |
Not clear |
| Minhua Hu, Wenfeng Ye, Jiaming Li, Peng Zhou, Zhaoxin Chu, Weijun Huan. The salicylanilide derivatives inhibit signal transducer and activator of transcription 3 pathways in A549 lung cancer cells. Anti-cancer drugs. vol 27. issue 1. 2016-05-31. PMID:26469835. |
these studies further validate stat3 as a drug discovery target and provide evidence that pharmacological agents that can selectively reduce the phospho-stat3 levels in human cancer cells result in tumor apoptosis and growth inhibition. |
2016-05-31 |
2023-08-13 |
human |
| Ya-Ju Hsieh, Sung-Pin Tseng, Yu-Hsuan Kuo, Tain-Lu Cheng, Chiao-Yu Chiang, Yew-Min Tzeng, Wan-Chi Tsa. Ovatodiolide of Anisomeles indica Exerts the Anticancer Potential on Pancreatic Cancer Cell Lines through STAT3 and NF-κB Regulation. Evidence-based complementary and alternative medicine : eCAM. vol 2016. 2016-05-31. PMID:27242913. |
these results demonstrated that ov could potentially inhibit mia-paca2 cancer cells proliferation and induce apoptosis through modulation of nf-κb and stat3 pathway. |
2016-05-31 |
2023-08-13 |
Not clear |