| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W-J Teng, P Chen, F-Y Zhu, K Di, C Zhou, J Zhuang, X-J Cao, J Yang, L-J Deng, C-G Su. Effect of Rhizoma paridis total saponins on apoptosis of colorectal cancer cells and imbalance of the JAK/STAT3 molecular pathway induced by IL-6 suppression. Genetics and molecular research : GMR. vol 14. issue 2. 2016-04-11. PMID:26125778. |
we determined whether rpts influences the interleukin-6 (il-6)/janus kinase (jak)-signal transducer and activator of transcription-3 (stat3) apoptosis molecular pathway and looked for colon cancer-related signal transduction pathways or targets inducing apoptosis. |
2016-04-11 |
2023-08-13 |
Not clear |
| E Yu Moskaleva, V G Perevozchikova, A S Zhirnik, S E Severi. [Molecular mechanisms of niclosamide antitumor activity]. Biomeditsinskaia khimiia. vol 61. issue 6. 2016-04-08. PMID:26716739. |
niclosamide not only inhibits the wnt/β-catenin, mtorc1, stat3, nf-κb and notch signaling pathways, but also targets mitochondria in cancer cells to induce growth inhibition and apoptosis. |
2016-04-08 |
2023-08-13 |
mouse |
| C F Chang, J Yang, W M Zhao, Y Li, P J Guo, M H Li, Y Zhou, C S X. Gene expression profiling analysis of 5-hydroxytryptamine signaling pathway in rat regenerating liver and different types of liver cells. Genetics and molecular research : GMR. vol 14. issue 2. 2016-04-05. PMID:25966107. |
based on the gene expression profiles of the 8 types of liver cells, 5-hydroxytryptamine promoted hepatocyte proliferation through the ras and stat3 signaling pathways, proliferation and differentiation of sinusoidal endothelial cells through the stat3 signaling pathway, and proliferation and apoptosis of pit cells through the akt3 signaling pathway. |
2016-04-05 |
2023-08-13 |
rat |
| Hephzibah Rani S Tagaram, Dhimant Desai, Guangfu Li, Dai Liu, C Bart Rountree, Kavitha Gowda, Arthur Berg, Shantu Amin, Kevin F Staveley-O'Carroll, Eric T Kimch. A Selenium Containing Inhibitor for the Treatment of Hepatocellular Cancer. Pharmaceuticals (Basel, Switzerland). vol 9. issue 2. 2016-03-30. PMID:27023566. |
pbise promoted apoptosis by inhibiting pi3k, mapk, and stat3 signaling with significant reduction in the tumor sizes (p < 0.007). |
2016-03-30 |
2023-08-13 |
mouse |
| Suresh V Kuchipud. The Complex Role of STAT3 in Viral Infections. Journal of immunology research. vol 2015. 2016-03-24. PMID:26199948. |
signal transducer and activators of transcription-3 (stat3) regulates diverse biological functions including cell growth, differentiation, and apoptosis. |
2016-03-24 |
2023-08-13 |
Not clear |
| Hye-Sook Seo, Jin Mo Ku, Han-Seok Choi, Jong-Kyu Woo, Bo-Hyoung Jang, Hoyeon Go, Yong Cheol Shin, Seong-Gyu K. Apigenin induces caspase-dependent apoptosis by inhibiting signal transducer and activator of transcription 3 signaling in HER2-overexpressing SKBR3 breast cancer cells. Molecular medicine reports. vol 12. issue 2. 2016-03-10. PMID:25936427. |
therefore, these results suggested that apigenin induced apoptosis via the inhibition of stat3 signaling in skbr3 cells. |
2016-03-10 |
2023-08-13 |
human |
| Samson Jamesdanie. Downstream targets of Lmo4 are modulated by cisplatin in the inner ear of Wistar rats. PloS one. vol 9. issue 12. 2016-03-09. PMID:25501662. |
these results suggest that cisplatin-induced decreases in the cochlear lmo4 upon nitration, and associated modulation in the cochlear expression of its binding partners esr1 and jak1, probably facilitates the repression of stat3, a downstream target of lmo4 implicated in drug mediated apoptosis. |
2016-03-09 |
2023-08-13 |
rat |
| San-Qiang Li, Sha Zhu, Hong-Mei Han, Hua-Jie Lu, Hong-Ye Men. IL-6 trans-signaling plays important protective roles in acute liver injury induced by acetaminophen in mice. Journal of biochemical and molecular toxicology. vol 29. issue 6. 2016-03-08. PMID:25914167. |
blockade of il-6 trans-signaling during aap-induced liver injury remarkably increased the levels of serum aspartate aminotransferase and alanine aminotransferase; lowered the level of serum sil-6r; aggravated liver injury; inhibited the expression of phosphorylation of stat3 (pstat3), proliferating cell nuclear antigen, vascular endothelial growth factor, and glycogen synthesis; and induced the expression of caspase3, cytochrome p450 2e1 (cyp2e1), and hepatocyte apoptosis in the liver of mice. |
2016-03-08 |
2023-08-13 |
mouse |
| Meng Qin, Yun Luo, Xiang-bao Meng, Min Wang, Hong-wei Wang, Shi-yu Song, Jing-xue Ye, Rui-le Pan, Fan Yao, Ping Wu, Gui-bo Sun, Xiao-bo Su. Myricitrin attenuates endothelial cell apoptosis to prevent atherosclerosis: An insight into PI3K/Akt activation and STAT3 signaling pathways. Vascular pharmacology. vol 70. 2016-03-04. PMID:25849952. |
myricitrin attenuates endothelial cell apoptosis to prevent atherosclerosis: an insight into pi3k/akt activation and stat3 signaling pathways. |
2016-03-04 |
2023-08-13 |
mouse |
| Meng Qin, Yun Luo, Xiang-bao Meng, Min Wang, Hong-wei Wang, Shi-yu Song, Jing-xue Ye, Rui-le Pan, Fan Yao, Ping Wu, Gui-bo Sun, Xiao-bo Su. Myricitrin attenuates endothelial cell apoptosis to prevent atherosclerosis: An insight into PI3K/Akt activation and STAT3 signaling pathways. Vascular pharmacology. vol 70. 2016-03-04. PMID:25849952. |
treatment with myricitrin significantly attenuated ox-ldl-induced endothelial cell apoptosis by inhibiting lox-1 expression and by increasing the activation of the stat3 and pi3k/akt/enos signaling pathways. |
2016-03-04 |
2023-08-13 |
mouse |
| Zhongmian Zhang, Ping Liu, Jian Wang, Tianxiao Gong, Fang Zhang, Jun Ma, Na Ha. Ubiquitin-conjugating enzyme E2C regulates apoptosis-dependent tumor progression of non-small cell lung cancer via ERK pathway. Medical oncology (Northwood, London, England). vol 32. issue 5. 2016-03-02. PMID:25832867. |
furthermore, ube2c could regulate phospho-erk1/2 level but not stat3, yap, or akt pathway, which was accompanied with the classic function of erk pathway in cell growth and apoptosis. |
2016-03-02 |
2023-08-13 |
human |
| Qiang Meng, Xinli Chen, Changyuan Wang, Qi Liu, Huijun Sun, Pengyuan Sun, Xiaokui Huo, Zhihao Liu, Kexin Li. Protective effects of alisol B 23-acetate from edible botanical Rhizoma alismatis against carbon tetrachloride-induced hepatotoxicity in mice. Food & function. vol 6. issue 4. 2016-03-01. PMID:25747392. |
in addition, ab23a induced the expression of stat3 phosphorylation, and stat3 target genes bcl-xl and socs3, resulting in decreased hepatocyte apoptosis. |
2016-03-01 |
2023-08-13 |
mouse |
| Xin-Hong Wang, Ming-Na Liu, Ping Huang, Jun Xu, Ai-Yun Liu, Jing Chen, Cheng-Qian Lv, Rui-Ling X. Simultaneous silencing of β-catenin and signal transducer and activator of transcription 3 synergistically induces apoptosis and inhibits cell proliferation in HepG2 liver cancer cells. Molecular medicine reports. vol 12. issue 2. 2016-03-01. PMID:25845340. |
following sirna transfection, β-catenin and stat3 protein levels decreased at 72 h. hepg2 cell growth inhibition and early apoptosis in the β-catenin and stat3 sirna co-transfection group were significantly greater than those in the groups transfected with β-catenin or stat3 sirna alone. |
2016-03-01 |
2023-08-13 |
Not clear |
| Xin-Hong Wang, Ming-Na Liu, Ping Huang, Jun Xu, Ai-Yun Liu, Jing Chen, Cheng-Qian Lv, Rui-Ling X. Simultaneous silencing of β-catenin and signal transducer and activator of transcription 3 synergistically induces apoptosis and inhibits cell proliferation in HepG2 liver cancer cells. Molecular medicine reports. vol 12. issue 2. 2016-03-01. PMID:25845340. |
simultaneous silencing of β-catenin and stat3 using sirnas resulted in an enhanced loss of cell viability and induction of apoptosis in hepg2 liver cancer cells, suggesting that these genes are promising targets for the further preclinical and clinical development of anti-cancer therapeutic strategies, which target several cancer signaling pathways simultaneously. |
2016-03-01 |
2023-08-13 |
Not clear |
| Na Zhou, Yizhuang Zhang, Xuehui Zhang, Zhen Lei, Ruobi Hu, Hui Li, Yiqing Mao, Xi Wang, David M Irwin, Gang Niu, Huanran Ta. Exposure of tumor-associated macrophages to apoptotic MCF-7 cells promotes breast cancer growth and metastasis. International journal of molecular sciences. vol 16. issue 6. 2016-02-29. PMID:26016502. |
our results indicate that when cancer cells endure chemotherapy induced apoptosis, macrophages in their microenvironment can then activate cancer stem cells to promote cancer growth and metastasis by secreting il-6, which activates stat3 phosphorylation to regulate the transcription of its downstream target genes. |
2016-02-29 |
2023-08-13 |
mouse |
| Nadine Wittkopf, Geethanjali Pickert, Ulrike Billmeier, Mousumi Mahapatro, Stefan Wirtz, Eva Martini, Moritz Leppkes, Markus Friedrich Neurath, Christoph Becke. Activation of intestinal epithelial Stat3 orchestrates tissue defense during gastrointestinal infection. PloS one. vol 10. issue 3. 2016-02-25. PMID:25799189. |
stat3 concerts the host response to bacterial infection by controlling bacterial growth and suppression of apoptosis to maintain intestinal epithelial barrier function. |
2016-02-25 |
2023-08-13 |
mouse |
| Jun-Ru Liu, Wen-Juan Wu, Shu-Xia Liu, Lian-Fu Zuo, Yuan Wang, Jian-Zhu Yang, Yue-Min Na. Nimesulide inhibits the growth of human esophageal carcinoma cells by inactivating the JAK2/STAT3 pathway. Pathology, research and practice. vol 211. issue 6. 2016-02-22. PMID:25724470. |
nimesulide downregulated the phosphorylation levels of jak2 and stat3, and jak2 inhibition by ag490 significantly augmented both nimesulide-induced apoptosis and the downregulation of cox-2 and survivin (p<0.05). |
2016-02-22 |
2023-08-13 |
mouse |
| Tian-xiao Wang, Xiao-yan Shi, Yue Cong, Zhong-qing Zhang, Ying-hua Li. [Prosapogenin A inhibits cell growth of MCF7 via downregulating STAT3 and glycometabolism-related gene]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 48. issue 9. 2016-02-02. PMID:24358789. |
the results suggested that psa could inhibit cell growth and promote cell apoptosis of mcf7 via inhibition of stat3 and glycometabolism-related gene. |
2016-02-02 |
2023-08-12 |
Not clear |
| Y J Tang, Z L Sun, W G Wu, J Xing, Y F He, D M Xin, P Ha. Inhibitor of signal transducer and activator of transcription 3 (STAT3) suppresses ovarian cancer growth, migration and invasion and enhances the effect of cisplatin in vitro. Genetics and molecular research : GMR. vol 14. issue 1. 2016-01-27. PMID:25867391. |
in conclusion, inhibition of stat3 may suppress the proliferation, migration and invasion, induce apoptosis and enhance the chemosensitivity of ovarian cancer cells, indicating that stat3 is a new therapeutic target of ovarian cancer. |
2016-01-27 |
2023-08-13 |
Not clear |
| Moon Kyung Joo, Jong-Jae Park, Sung Ho Kim, Hyo Soon Yoo, Beom Jae Lee, Hoon Jai Chun, Sang Woo Lee, Young-Tae Ba. Antitumorigenic effect of plumbagin by induction of SH2-containing protein tyrosine phosphatase 1 in human gastric cancer cells. International journal of oncology. vol 46. issue 6. 2016-01-26. PMID:25815436. |
collectively, our findings suggest that plumbagin is a potential regulator of cellular growth, migration, invasion and apoptosis by inhibiting both constitutive and inducible stat3 activity through induction of shp1 in gastric cancer cells. |
2016-01-26 |
2023-08-13 |
human |