| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yubao Zhang, Xia Ren, Meiyan Shi, Zheng Jiang, Hengxiao Wang, Qinghong Su, Qinglin Liu, Gang Li, Guosheng Jian. Downregulation of STAT3 and activation of MAPK are involved in the induction of apoptosis by HNK in glioblastoma cell line U87. Oncology reports. vol 32. issue 5. 2015-10-26. PMID:25175884. |
moreover, the inhibition of stat3 signaling, erk1/2 as well as activation of the p38 mapk signaling pathway may be involved in apoptosis induced by hnk in u87 cells. |
2015-10-26 |
2023-08-13 |
human |
| Chengsheng Wu, Ommoleila Molavi, Haifeng Zhang, Nidhi Gupta, Abdulraheem Alshareef, Kathleen M Bone, Keshav Gopal, Fang Wu, Jamie T Lewis, Donna N Douglas, Norman M Kneteman, Raymond La. STAT1 is phosphorylated and downregulated by the oncogenic tyrosine kinase NPM-ALK in ALK-positive anaplastic large-cell lymphoma. Blood. vol 126. issue 3. 2015-10-19. PMID:25921060. |
the importance of the stat1/stat3 functional interaction was further highlighted by the observation that short interfering rna knockdown of stat1 significantly decreased apoptosis induced by stat3 inhibition. |
2015-10-19 |
2023-08-13 |
Not clear |
| Jiumao Lin, Jianheng Zhou, Xiaoyong Zhong, Zhenfeng Hong, Jun Pen. Inhibition of the signal transducer and activator of transcription 3 signaling pathway by Qianliening capsules suppresses the growth and induces the apoptosis of human prostate cells. Molecular medicine reports. vol 11. issue 3. 2015-10-09. PMID:25394909. |
these results suggested that qc effectively inhibited the proliferation and promoted the apoptosis of human prostate cells via modulation of the stat3 signaling pathway and its target genes, which is likely to be one of the mechanisms underlying its activity in bph treatment. |
2015-10-09 |
2023-08-13 |
human |
| Marisa Granato, Barbara Chiozzi, Maria Rosaria Filardi, Lavinia Vittoria Lotti, Livia Di Renzo, Alberto Faggioni, Mara Ciron. Tyrosine kinase inhibitor tyrphostin AG490 triggers both apoptosis and autophagy by reducing HSF1 and Mcl-1 in PEL cells. Cancer letters. vol 366. issue 2. 2015-10-08. PMID:26184999. |
these results suggest that stat3 inhibition, by down-regulating the expression of hsf1/hsp70, reduces mcl-1 and leads to both apoptosis and autophagy induction in pel cells. |
2015-10-08 |
2023-08-13 |
Not clear |
| Ivan Quetier, Nicolas Brezillon, Julien Revaud, James Ahodantin, Lucie DaSilva, Patrick Soussan, Dina Kremsdor. C-terminal-truncated hepatitis B virus X protein enhances the development of diethylnitrosamine-induced hepatocellular carcinogenesis. The Journal of general virology. vol 96. issue Pt 3. 2015-09-30. PMID:25519169. |
furthermore, during den-induced initiation of hcc, ct-hbx- and fl-hbx-transgenic mice showed higher expression of il-6, tnf-α and il-1β transcripts, activation of stat3, erk and jnk proteins and an increase in cell apoptosis. |
2015-09-30 |
2023-08-13 |
mouse |
| Di Xiang, Yunsheng Yuan, Li Chen, Xin Liu, Chandra Belani, Hua Chen. Niclosamide, an anti-helminthic molecule, downregulates the retroviral oncoprotein Tax and pro-survival Bcl-2 proteins in HTLV-1-transformed T lymphocytes. Biochemical and biophysical research communications. vol 464. issue 1. 2015-09-30. PMID:26116531. |
since tax, stat3 and mcl-1 are crucial molecules for promoting survival and growth of htlv-1-transformed t cells, our findings demonstrate a novel mechanism of niclosamide in inducing tax degradation and downregulating various cellular pro-survival molecules, thereby promoting apoptosis of htlv-1-associated leukemia cells. |
2015-09-30 |
2023-08-13 |
human |
| Kang Lu, Na Chen, Xiang-xiang Zhou, Xue-ling Ge, Li-li Feng, Pei-pei Li, Xin-yu Li, Ling-yun Geng, Xin Wan. The STAT3 inhibitor WP1066 synergizes with vorinostat to induce apoptosis of mantle cell lymphoma cells. Biochemical and biophysical research communications. vol 464. issue 1. 2015-09-30. PMID:26116769. |
the stat3 inhibitor wp1066 synergizes with vorinostat to induce apoptosis of mantle cell lymphoma cells. |
2015-09-30 |
2023-08-13 |
Not clear |
| Min-Beom Kim, Chulwon Kim, Won-Seok Chung, Jae-Heung Cho, Dongwoo Nam, Sung-Hoon Kim, Kwang Seok Ah. The hydrolysed products of iridoid glycosides can enhance imatinib mesylate-induced apoptosis in human myeloid leukaemia cells. Phytotherapy research : PTR. vol 29. issue 3. 2015-09-29. PMID:25583173. |
using several leukaemia cell lines, the effect of the hydrolysed-catalpol (h-catalpol) and hydrolysed-aucubin (h-aucubin) products on the stat3 signalling pathway, inhibition of bcr-abl activation, cellular proliferation and potentiation of imatinib mesylate-induced apoptosis was investigated. |
2015-09-29 |
2023-08-13 |
human |
| Min-Beom Kim, Chulwon Kim, Won-Seok Chung, Jae-Heung Cho, Dongwoo Nam, Sung-Hoon Kim, Kwang Seok Ah. The hydrolysed products of iridoid glycosides can enhance imatinib mesylate-induced apoptosis in human myeloid leukaemia cells. Phytotherapy research : PTR. vol 29. issue 3. 2015-09-29. PMID:25583173. |
indeed, h-catalpol and h-aucubin down-regulated bcr-abl phosphorylation and inhibited constitutive stat3 activation through abrogating upstream jak2 and c-src and constitutive stat5 activation leading to apoptosis through caspase-3 activation. |
2015-09-29 |
2023-08-13 |
human |
| Min-Beom Kim, Chulwon Kim, Won-Seok Chung, Jae-Heung Cho, Dongwoo Nam, Sung-Hoon Kim, Kwang Seok Ah. The hydrolysed products of iridoid glycosides can enhance imatinib mesylate-induced apoptosis in human myeloid leukaemia cells. Phytotherapy research : PTR. vol 29. issue 3. 2015-09-29. PMID:25583173. |
hydrolysed-catalpol enhanced the apoptosis induced by imatinib mesylate and this correlated with down-regulation of gene products that mediate cell proliferation (cyclin d1), and cell survival (bcl-2, bcl-xl and survivin); all known to be regulated by the stat3. |
2015-09-29 |
2023-08-13 |
human |
| Yoon Jung Jeon, Seung-Nam Jung, Hyeyoun Chang, Jieun Yun, Chang Woo Lee, Joonku Lee, Sangho Choi, Oyekanmi Nash, Dong Cho Han, Byoung-Mog Kwo. Artocarpus altilis (Parkinson) Fosberg Extracts and Geranyl Dihydrochalcone Inhibit STAT3 Activity in Prostate Cancer DU145 Cells. Phytotherapy research : PTR. vol 29. issue 5. 2015-09-25. PMID:25682949. |
the partially purified fraction and the isolated a geranyl dihydrochalcone, cg901, down-regulated the expression of stat3 target genes, induced apoptosis in du145 prostate cancer cells via caspase-3 and parp degradation, and inhibited tumor growth in human prostate tumor (du145) xenograft initiation model. |
2015-09-25 |
2023-08-13 |
human |
| Tung-Hung Su, Chung-Wai Shiau, Ping Jao, Chen-Hua Liu, Chun-Jen Liu, Wei-Tien Tai, Yung-Ming Jeng, Hung-Chih Yang, Tai-Chung Tseng, Hsiang-Po Huang, Huei-Ru Cheng, Pei-Jer Chen, Kuen-Feng Chen, Jia-Horng Kao, Ding-Shinn Che. Sorafenib and its derivative SC-1 exhibit antifibrotic effects through signal transducer and activator of transcription 3 inhibition. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 23. 2015-09-25. PMID:26039995. |
stat3 overexpression in hsc enhanced cell proliferation and undermined the apoptotic effects of sorafenib and sc-1, whereas stat3-specific inhibition promoted hsc apoptosis. |
2015-09-25 |
2023-08-13 |
mouse |
| Hao-hao Zhang, Shan Kuang, Ying Wang, Xiao-xiao Sun, Yuan Gu, Li-hong Hu, Qiang Y. Bigelovin inhibits STAT3 signaling by inactivating JAK2 and induces apoptosis in human cancer cells. Acta pharmacologica Sinica. vol 36. issue 4. 2015-09-21. PMID:25619393. |
bigelovin inhibits stat3 signaling by inactivating jak2 and induces apoptosis in human cancer cells. |
2015-09-21 |
2023-08-13 |
human |
| Ka-Ho Leung, Li-Juan Liu, Sheng Lin, Lihua Lu, Hai-Jing Zhong, Dewi Susanti, Weidong Rao, Modi Wang, Weng Ian Che, Daniel Shiu-Hin Chan, Chung-Hang Leung, Philip Wai Hong Chan, Dik-Lung M. Discovery of a small-molecule inhibitor of STAT3 by ligand-based pharmacophore screening. Methods (San Diego, Calif.). vol 71. 2015-09-16. PMID:25160651. |
stat3 modulates the transcription of a wide variety of regulatory genes involved in cell proliferation, differentiation, migration, apoptosis, and other critical cellular functions. |
2015-09-16 |
2023-08-13 |
human |
| Min Wang, Xiang-bao Meng, Ying-li Yu, Gui-bo Sun, Xu-dong Xu, Xiao-po Zhang, Xi Dong, Jing-xue Ye, Hui-bo Xu, Yi-fan Sun, Xiao-bo Su. Elatoside C protects against hypoxia/reoxygenation-induced apoptosis in H9c2 cardiomyocytes through the reduction of endoplasmic reticulum stress partially depending on STAT3 activation. Apoptosis : an international journal on programmed cell death. vol 19. issue 12. 2015-09-14. PMID:25326083. |
elatoside c protects against hypoxia/reoxygenation-induced apoptosis in h9c2 cardiomyocytes through the reduction of endoplasmic reticulum stress partially depending on stat3 activation. |
2015-09-14 |
2023-08-13 |
Not clear |
| Min Wang, Xiang-bao Meng, Ying-li Yu, Gui-bo Sun, Xu-dong Xu, Xiao-po Zhang, Xi Dong, Jing-xue Ye, Hui-bo Xu, Yi-fan Sun, Xiao-bo Su. Elatoside C protects against hypoxia/reoxygenation-induced apoptosis in H9c2 cardiomyocytes through the reduction of endoplasmic reticulum stress partially depending on STAT3 activation. Apoptosis : an international journal on programmed cell death. vol 19. issue 12. 2015-09-14. PMID:25326083. |
these changes were associated with the inhibition of er stress-associated apoptosis markers (grp78, chop, caspase-12 and jnk), as well as the increased phosphorylation of stat3 and an increased bcl2/bax ratio. |
2015-09-14 |
2023-08-13 |
Not clear |
| Min Wang, Xiang-bao Meng, Ying-li Yu, Gui-bo Sun, Xu-dong Xu, Xiao-po Zhang, Xi Dong, Jing-xue Ye, Hui-bo Xu, Yi-fan Sun, Xiao-bo Su. Elatoside C protects against hypoxia/reoxygenation-induced apoptosis in H9c2 cardiomyocytes through the reduction of endoplasmic reticulum stress partially depending on STAT3 activation. Apoptosis : an international journal on programmed cell death. vol 19. issue 12. 2015-09-14. PMID:25326083. |
taken together, these results suggested that elatoside c can alleviate h/r-induced cardiomyocyte apoptosis most likely by activating the stat3 pathways and reducing er stress-associated apoptosis. |
2015-09-14 |
2023-08-13 |
Not clear |
| Yaming Xu, Zhe Li, Can Zhang, Shiyun Zhang, Yonghua Ji, Fuxue Che. Knockdown of PKCε expression inhibits growth, induces apoptosis and decreases invasiveness of human glioma cells partially through Stat3. Journal of molecular neuroscience : MN. vol 55. issue 1. 2015-09-10. PMID:24888992. |
knockdown of pkcε expression inhibits growth, induces apoptosis and decreases invasiveness of human glioma cells partially through stat3. |
2015-09-10 |
2023-08-13 |
mouse |
| Yaming Xu, Zhe Li, Can Zhang, Shiyun Zhang, Yonghua Ji, Fuxue Che. Knockdown of PKCε expression inhibits growth, induces apoptosis and decreases invasiveness of human glioma cells partially through Stat3. Journal of molecular neuroscience : MN. vol 55. issue 1. 2015-09-10. PMID:24888992. |
the aim of the study is to investigate whether knockdown of pkcε expression by rna interference (rnai) could affect the growth, apoptosis and invasion of human glioma cells, and the involvement of the signal transducer and activator of transcription 3 (stat3) signaling pathway in these effects. |
2015-09-10 |
2023-08-13 |
mouse |
| Yaming Xu, Zhe Li, Can Zhang, Shiyun Zhang, Yonghua Ji, Fuxue Che. Knockdown of PKCε expression inhibits growth, induces apoptosis and decreases invasiveness of human glioma cells partially through Stat3. Journal of molecular neuroscience : MN. vol 55. issue 1. 2015-09-10. PMID:24888992. |
these results support an important role for pkcε in glioma cell growth, apoptosis and invasion, and pkcε exerting its above effects at least in part through stat3. |
2015-09-10 |
2023-08-13 |
mouse |