| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paul Den. HDACIs and the inhibition of invasive potential. Cancer biology & therapy. vol 14. issue 9. 2015-05-12. PMID:23974427. |
inhibition of src, erk, or stat3 can all suppress tumor cell migration and reduce the threshold at which tumor cells undergo apoptosis. |
2015-05-12 |
2023-08-12 |
Not clear |
| Hui Xiao, Hemant Kumar Bid, David Jou, Xiaojuan Wu, Wenying Yu, Chenglong Li, Peter J Houghton, Jiayuh Li. A novel small molecular STAT3 inhibitor, LY5, inhibits cell viability, cell migration, and angiogenesis in medulloblastoma cells. The Journal of biological chemistry. vol 290. issue 6. 2015-05-05. PMID:25313399. |
numerous studies have demonstrated that inhibition of the persistent stat3 signaling pathway results in decreased proliferation and increased apoptosis in human cancer cells, indicating that stat3 is a viable molecular target for cancer therapy. |
2015-05-05 |
2023-08-13 |
human |
| Hui Xiao, Hemant Kumar Bid, David Jou, Xiaojuan Wu, Wenying Yu, Chenglong Li, Peter J Houghton, Jiayuh Li. A novel small molecular STAT3 inhibitor, LY5, inhibits cell viability, cell migration, and angiogenesis in medulloblastoma cells. The Journal of biological chemistry. vol 290. issue 6. 2015-05-05. PMID:25313399. |
ly5 inhibited persistent stat3 phosphorylation and induced apoptosis in human medulloblastoma cell lines expressing constitutive stat3 phosphorylation. |
2015-05-05 |
2023-08-13 |
human |
| Li Chu, Huaxin Zhao, Juemin Fang, Chunyan Li, Zhuqing Liu, Ran Cui, Fei Hu, Xi Zhang, Yijing Chen, Hui Han, Chuanhai Cao, Qing X. The traditional Chinese medicinal formula BDL301 suppresses tumor growth by inhibiting STAT3 pathway and inducing apoptosis in colorectal cancer cells. DNA and cell biology. vol 34. issue 3. 2015-04-21. PMID:25607688. |
the traditional chinese medicinal formula bdl301 suppresses tumor growth by inhibiting stat3 pathway and inducing apoptosis in colorectal cancer cells. |
2015-04-21 |
2023-08-13 |
Not clear |
| Li Chu, Huaxin Zhao, Juemin Fang, Chunyan Li, Zhuqing Liu, Ran Cui, Fei Hu, Xi Zhang, Yijing Chen, Hui Han, Chuanhai Cao, Qing X. The traditional Chinese medicinal formula BDL301 suppresses tumor growth by inhibiting STAT3 pathway and inducing apoptosis in colorectal cancer cells. DNA and cell biology. vol 34. issue 3. 2015-04-21. PMID:25607688. |
in addition, apoptosis was induced and the signal transducer and activator of transcription-3 (stat3) pathway were suppressed in the colorectal cancer cells in vitro and in vivo by bdl301. |
2015-04-21 |
2023-08-13 |
Not clear |
| Li Chu, Huaxin Zhao, Juemin Fang, Chunyan Li, Zhuqing Liu, Ran Cui, Fei Hu, Xi Zhang, Yijing Chen, Hui Han, Chuanhai Cao, Qing X. The traditional Chinese medicinal formula BDL301 suppresses tumor growth by inhibiting STAT3 pathway and inducing apoptosis in colorectal cancer cells. DNA and cell biology. vol 34. issue 3. 2015-04-21. PMID:25607688. |
this study demonstrates that bdl301 exerted significant anticancer activity by inhibiting the stat3 pathways and inducing apoptosis in colorectal cancer cells. |
2015-04-21 |
2023-08-13 |
Not clear |
| Kang Lu, Xiao-sheng Fang, Li-li Feng, Yu-jie Jiang, Xiang-xiang Zhou, Xin Liu, Pei-pei Li, Na Chen, Mei Ding, Na Wang, Jie Zhang, Xin Wan. The STAT3 inhibitor WP1066 reverses the resistance of chronic lymphocytic leukemia cells to histone deacetylase inhibitors induced by interleukin-6. Cancer letters. vol 359. issue 2. 2015-04-20. PMID:25636517. |
co-culture of cll cells with bmscs could also facilitate the activation of stat3 and protected cll cells from apoptosis when treated with hdac inhibitors, and this cytoprotection was reversed by wp1066. |
2015-04-20 |
2023-08-13 |
Not clear |
| Achinto Saha, Jorge Blando, Eric Silver, Linda Beltran, Jonathan Sessler, John DiGiovann. 6-Shogaol from dried ginger inhibits growth of prostate cancer cells both in vitro and in vivo through inhibition of STAT3 and NF-κB signaling. Cancer prevention research (Philadelphia, Pa.). vol 7. issue 6. 2015-04-16. PMID:24691500. |
in addition, 6-sho decreased the level of several stat3 and nf-κb-regulated target genes at the protein level, including cyclin d1, survivin, and cmyc and modulated mrna levels of chemokine, cytokine, cell cycle, and apoptosis regulatory genes (il-7, ccl5, bax, bcl2, p21, and p27). |
2015-04-16 |
2023-08-13 |
mouse |
| Alexandra Papoudou-Bai, Alexandra Barbouti, Vassiliki Galani, Kalliopi Stefanaki, Panagiotis Kanavaro. Immunohistological analysis of the jun family and the signal transducers and activators of transcription in thymus. Anatomy research international. vol 2015. 2015-04-13. PMID:25866678. |
moreover, c-jun and stat3 cooperate to regulate apoptosis. |
2015-04-13 |
2023-08-13 |
human |
| Yu-Qing Ge, Xiao-Feng Xu, Bo Yang, Zhe Chen, Ru-Bin Chen. Saponins from Rubus parvifolius L. induce apoptosis in human chronic myeloid leukemia cells through AMPK activation and STAT3 inhibition. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 13. 2015-04-07. PMID:25041018. |
saponins from rubus parvifolius l. induce apoptosis in human chronic myeloid leukemia cells through ampk activation and stat3 inhibition. |
2015-04-07 |
2023-08-13 |
human |
| Murali M Yallapu, Sheema Khan, Diane M Maher, Mara C Ebeling, Vasudha Sundram, Neeraj Chauhan, Aditya Ganju, Swathi Balakrishna, Brij K Gupta, Nadeem Zafar, Meena Jaggi, Subhash C Chauha. Anti-cancer activity of curcumin loaded nanoparticles in prostate cancer. Biomaterials. vol 35. issue 30. 2015-03-30. PMID:25028336. |
it also suppresses stat3 and akt phosphorylation and leads to apoptosis via inhibition of key anti-apoptotic proteins, mcl-1, bcl-xl and caused induction of parp cleavage. |
2015-03-30 |
2023-08-13 |
mouse |
| Fang Tian, Lijie Dong, Yu Zhou, Yan Shao, Wenbo Li, Hong Zhang, Fei Wan. Rapamycin-Induced apoptosis in HGF-stimulated lens epithelial cells by AKT/mTOR, ERK and JAK2/STAT3 pathways. International journal of molecular sciences. vol 15. issue 8. 2015-03-30. PMID:25116684. |
moreover, the forced expression of akt, erk and stat3 could induce a significant suppression of apoptosis in these cells after treatment of rapamycin. |
2015-03-30 |
2023-08-13 |
Not clear |
| Meiyu Peng, Bingqing Huang, Qi Zhang, Shuyu Fu, Dan Wang, Xixi Cheng, Xi Wu, Zhenyi Xue, Lijuan Zhang, Da Zhang, Yurong Da, Yun Dai, Qing Yang, Zhi Yao, Liang Qiao, Rongxin Zhan. Embelin inhibits pancreatic cancer progression by directly inducing cancer cell apoptosis and indirectly restricting IL-6 associated inflammatory and immune suppressive cells. Cancer letters. vol 354. issue 2. 2015-03-13. PMID:25128650. |
embelin significantly attenuated cells invasion, proliferation and induced apoptosis through inhibition of stat3 and activation of p53 signaling pathways. |
2015-03-13 |
2023-08-13 |
Not clear |
| Kazuhiro Yamamoto, Atsushi Mizumoto, Kohji Nishimura, Atsushi Uda, Akira Mukai, Kazuhiko Yamashita, Manabu Kume, Hiroo Makimoto, Toshinori Bito, Chikako Nishigori, Tsutomu Nakagawa, Takeshi Hirano, Midori Hira. Association of toxicity of sorafenib and sunitinib for human keratinocytes with inhibition of signal transduction and activator of transcription 3 (STAT3). PloS one. vol 9. issue 7. 2015-03-04. PMID:25013907. |
thus, stat3 activation mediating apoptosis suppressors may be a key factor in sorafenib and sunitinib-induced keratinocyte cytotoxicity. |
2015-03-04 |
2023-08-13 |
human |
| Ying-Chao Wang, Ji-Lin Wang, Xuan Kong, Tian-Tian Sun, Hao-Yan Chen, Jie Hong, Jing-Yuan Fan. CD24 mediates gastric carcinogenesis and promotes gastric cancer progression via STAT3 activation. Apoptosis : an international journal on programmed cell death. vol 19. issue 4. 2015-02-26. PMID:24327257. |
taken together, our results indicate that cd24 mediates gastric carcinogenesis and may promote gc progression by suppressing apoptosis and promoting invasion, with the activation of stat3 playing a critical role. |
2015-02-26 |
2023-08-12 |
Not clear |
| Qinchuan Liang, Chenkai Ma, Yang Zhao, Guodong Gao, Jie M. Inhibition of STAT3 reduces astrocytoma cell invasion and constitutive activation of STAT3 predicts poor prognosis in human astrocytoma. PloS one. vol 8. issue 12. 2015-02-23. PMID:24386409. |
recent studies have revealed that knockdown of signal transducers and activators of transcription 3 (stat3) expression by rnai induces apoptosis in astrocytoma cell. |
2015-02-23 |
2023-08-12 |
human |
| Emma Stuart, Michael Buchert, Tracy Putoczki, Stefan Thiem, Ryan Farid, Joachim Elzer, Dennis Huszar, Paul M Waring, Toby J Phesse, Matthias Erns. Therapeutic inhibition of Jak activity inhibits progression of gastrointestinal tumors in mice. Molecular cancer therapeutics. vol 13. issue 2. 2015-02-19. PMID:24398427. |
we find that systemic administration of azd1480 readily replicates this effect, which is associated with reduced stat3 activation and correlates with diminished tumor cell proliferation and increased apoptosis. |
2015-02-19 |
2023-08-12 |
mouse |
| Juthika Kundu, Bu Young Choi, Chul-Ho Jeong, Joydeb Kumar Kundu, Kyung-Soo Chu. Thymoquinone induces apoptosis in human colon cancer HCT116 cells through inactivation of STAT3 by blocking JAK2- and Src‑mediated phosphorylation of EGF receptor tyrosine kinase. Oncology reports. vol 32. issue 2. 2015-02-12. PMID:24890449. |
thymoquinone induces apoptosis in human colon cancer hct116 cells through inactivation of stat3 by blocking jak2- and src‑mediated phosphorylation of egf receptor tyrosine kinase. |
2015-02-12 |
2023-08-13 |
human |
| Juthika Kundu, Bu Young Choi, Chul-Ho Jeong, Joydeb Kumar Kundu, Kyung-Soo Chu. Thymoquinone induces apoptosis in human colon cancer HCT116 cells through inactivation of STAT3 by blocking JAK2- and Src‑mediated phosphorylation of EGF receptor tyrosine kinase. Oncology reports. vol 32. issue 2. 2015-02-12. PMID:24890449. |
collectively, our study revealed that tq induced apoptosis in hct116 cells by blocking stat3 signaling via inhibition of jak2- and src-mediated phosphorylation of egfr tyrosine kinase. |
2015-02-12 |
2023-08-13 |
human |
| Gui-Min Wang, Zhong-Xi Ren, Pei-Song Wang, Chang Su, Wen-Xin Zhang, Zeng-Guang Liu, Ling Zhang, Xue-Jian Zhao, Guang Che. Plasmid-based Stat3-specific siRNA and GRIM-19 inhibit the growth of thyroid cancer cells in vitro and in vivo. Oncology reports. vol 32. issue 2. 2015-02-12. PMID:24899100. |
gene associated with retinoid-ifn-induced mortality 19 (grim-19), a stat3-inhibitory protein, was identified as a potential tumor suppressor associated with growth inhibition and cell apoptosis by targeting the transcription factor stat3 for inhibition. |
2015-02-12 |
2023-08-13 |
Not clear |