| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jee-Eun Kim, Ji-In Lee, Dong-Hoon Jin, Wang Jae Lee, Ga Bin Park, Seonghan Kim, Yeong Seok Kim, T-C Wu, Dae Young Hur, Daejin Ki. Sequential treatment of HPV E6 and E7-expressing TC-1 cells with bortezomib and celecoxib promotes apoptosis through p-p38 MAPK-mediated downregulation of cyclin D1 and CDK2. Oncology reports. vol 31. issue 5. 2015-01-12. PMID:24627094. |
in tc-1 cells sequentially treated with bortezomib and celecoxib, apoptosis was induced through decreased expression of signal transducer and activator of transcription-3 (stat3), cyclin d1 and cyclin-dependent kinase (cdk) 2, which are major regulators of the g0/g1 cell cycle checkpoint. |
2015-01-12 |
2023-08-12 |
human |
| Sutapa Ray, Yingxin Zhao, Mohammad Jamaluddin, Chukwudi B Edeh, Chang Lee, Allan R Brasie. Inducible STAT3 NH2 terminal mono-ubiquitination promotes BRD4 complex formation to regulate apoptosis. Cellular signalling. vol 26. issue 7. 2015-01-10. PMID:24657799. |
inducible stat3 nh2 terminal mono-ubiquitination promotes brd4 complex formation to regulate apoptosis. |
2015-01-10 |
2023-08-12 |
Not clear |
| Sutapa Ray, Yingxin Zhao, Mohammad Jamaluddin, Chukwudi B Edeh, Chang Lee, Allan R Brasie. Inducible STAT3 NH2 terminal mono-ubiquitination promotes BRD4 complex formation to regulate apoptosis. Cellular signalling. vol 26. issue 7. 2015-01-10. PMID:24657799. |
signal transducers and activator of transcription-3 (stat3) are latent transcription factors that are regulated by post-translational modifications (ptms) in response to cellular activation by the il-6 superfamily of cytokines to regulate cell cycle progression and/or apoptosis. |
2015-01-10 |
2023-08-12 |
Not clear |
| Lin Yang, Guangchao Li, Likun Zhao, Fei Pan, Jiankun Qiang, Siqi Ha. Blocking the PI3K pathway enhances the efficacy of ALK-targeted therapy in EML4-ALK-positive nonsmall-cell lung cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 10. 2015-01-05. PMID:24972969. |
we found that genetic or pharmacological inhibition of alk markedly abrogated phosphorylated stat3 and erk, but it failed to suppress akt activity or induce apoptosis, in eml4-alk-positive h2228 cells. |
2015-01-05 |
2023-08-13 |
Not clear |
| Burçin Tezcanlı Kaymaz, Vildan Bozok Cetintaş, Cağdaş Aktan, Buket Kosov. MicroRNA-520a-5p displays a therapeutic effect upon chronic myelogenous leukemia cells by targeting STAT3 and enhances the anticarcinogenic role of capsaicin. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 9. 2014-12-29. PMID:24870597. |
finally, we observed the effects of capsaicin following mir-520a-5p inhibitor transfection upon cell proliferation, apoptosis, and stat3 expression levels. |
2014-12-29 |
2023-08-13 |
Not clear |
| Burçin Tezcanlı Kaymaz, Vildan Bozok Cetintaş, Cağdaş Aktan, Buket Kosov. MicroRNA-520a-5p displays a therapeutic effect upon chronic myelogenous leukemia cells by targeting STAT3 and enhances the anticarcinogenic role of capsaicin. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 9. 2014-12-29. PMID:24870597. |
in summary, mir-520a-5p displays a therapeutic effect by targeting stat3 and impacting the anticancer effects of capsaicin; whereas capsaicin, potentially through the mir-520a-5p/stat3 interaction, induces apoptosis and inhibits k562 leukemic cell proliferation with need of further investigation. |
2014-12-29 |
2023-08-13 |
Not clear |
| Alpna Tyagi, Komal Raina, Suraj Prakash Shrestha, Bettina Miller, John A Thompson, Michael F Wempe, Rajesh Agarwal, Chapla Agarwa. Procyanidin B2 3,3(″)-di-O-gallate, a biologically active constituent of grape seed extract, induces apoptosis in human prostate cancer cells via targeting NF-κB, Stat3, and AP1 transcription factors. Nutrition and cancer. vol 66. issue 4. 2014-12-22. PMID:24191894. |
procyanidin b2 3,3(″)-di-o-gallate, a biologically active constituent of grape seed extract, induces apoptosis in human prostate cancer cells via targeting nf-κb, stat3, and ap1 transcription factors. |
2014-12-22 |
2023-08-12 |
human |
| Xu Wang, Jonathan J Beitler, Hong Wang, Michael J Lee, Wen Huang, Lydia Koenig, Sreenivas Nannapaneni, A R M Ruhul Amin, Michael Bonner, Hyung Ju C Shin, Zhuo Georgia Chen, Jack L Arbiser, Dong M Shi. Honokiol enhances paclitaxel efficacy in multi-drug resistant human cancer model through the induction of apoptosis. PloS one. vol 9. issue 2. 2014-12-22. PMID:24586249. |
honokiol induced mitochondria-dependent and death receptor-mediated apoptosis in mdr kb cells, which was associated with inhibition of egfr-stat3 signaling and downregulation of stat3 target genes. |
2014-12-22 |
2023-08-12 |
human |
| Prasun Guha, Gargi Bandyopadhyaya, Swamy K Polumuri, Saranya Chumsri, Padmaja Gade, Dhananjaya V Kalvakolanu, Hafiz Ahme. Nicotine promotes apoptosis resistance of breast cancer cells and enrichment of side population cells with cancer stem cell-like properties via a signaling cascade involving galectin-3, α9 nicotinic acetylcholine receptor and STAT3. Breast cancer research and treatment. vol 145. issue 1. 2014-12-22. PMID:24668500. |
nicotine promotes apoptosis resistance of breast cancer cells and enrichment of side population cells with cancer stem cell-like properties via a signaling cascade involving galectin-3, α9 nicotinic acetylcholine receptor and stat3. |
2014-12-22 |
2023-08-12 |
Not clear |
| Huaxiang Liu, Guixiang Liu, Yanwen B. CNTF regulates neurite outgrowth and neuronal migration through JAK2/STAT3 and PI3K/Akt signaling pathways of DRG explants with gp120-induced neurotoxicity in vitro. Neuroscience letters. vol 569. 2014-12-09. PMID:24708926. |
these data imply that cntf improved neuronal status by promoting gap-43 expression and inhibiting apoptosis through jak2/signal transducer and activator of transcription 3 (stat3) and pi3k/akt signaling pathways of drg neurons with gp120-induced neurotoxicity. |
2014-12-09 |
2023-08-13 |
Not clear |
| Chun-Yu Liu, Ling-Ming Tseng, Jung-Chen Su, Kung-Chi Chang, Pei-Yi Chu, Wei-Tien Tai, Chung-Wai Shiau, Kuen-Feng Che. Novel sorafenib analogues induce apoptosis through SHP-1 dependent STAT3 inactivation in human breast cancer cells. Breast cancer research : BCR. vol 15. issue 4. 2014-12-08. PMID:23938089. |
novel sorafenib analogues induce apoptosis through shp-1 dependent stat3 inactivation in human breast cancer cells. |
2014-12-08 |
2023-08-12 |
human |
| A P Renjini, Shiny Titus, Prashanth Narayan, Megha Murali, Rajesh Kumar Jha, Malini Laloray. STAT3 and MCL-1 associate to cause a mesenchymal epithelial transition. Journal of cell science. vol 127. issue Pt 8. 2014-12-05. PMID:24481815. |
stat3 functionally associates with mcl-1 in the mammalian breast cancer cell line mcf7 that overexpresses stat3 and mcl-1, which leads to an increased rate of apoptosis and decreased cellular invasion, disrupting the emt. |
2014-12-05 |
2023-08-12 |
Not clear |
| Laura Mack, Boris Brill, Natalia Delis, Corina Borghouts, Axel Weber, Bernd Grone. Stat3 is activated in skin lesions by the local application of imiquimod, a ligand of TLR7, and inhibited by the recombinant peptide aptamer rS3-PA. Hormone molecular biology and clinical investigation. vol 10. issue 2. 2014-12-03. PMID:25436683. |
stat3 is activated in skin lesions by the local application of imiquimod, a ligand of tlr7, and inhibited by the recombinant peptide aptamer rs3-pa. abstract signal transducer and activator of transcription 3 (stat3) assumes central functions in the regulation of apoptosis, proliferation, angiogenesis, and immune responses in normal cells. |
2014-12-03 |
2023-08-13 |
mouse |
| Ki-Woong Park, Juthika Kundu, In-Gyeong Chae, Do-Hee Kim, Mi-Hee Yu, Joydeb Kumar Kundu, Kyung-Soo Chu. Carnosol induces apoptosis through generation of ROS and inactivation of STAT3 signaling in human colon cancer HCT116 cells. International journal of oncology. vol 44. issue 4. 2014-11-26. PMID:24481553. |
carnosol induces apoptosis through generation of ros and inactivation of stat3 signaling in human colon cancer hct116 cells. |
2014-11-26 |
2023-08-12 |
human |
| Ki-Woong Park, Juthika Kundu, In-Gyeong Chae, Do-Hee Kim, Mi-Hee Yu, Joydeb Kumar Kundu, Kyung-Soo Chu. Carnosol induces apoptosis through generation of ROS and inactivation of STAT3 signaling in human colon cancer HCT116 cells. International journal of oncology. vol 44. issue 4. 2014-11-26. PMID:24481553. |
taken together, our study provides the first report that carnosol induced apoptosis in hct116 cells via generation of ros, induction of p53, activation of caspases and inhibition of stat3 signaling pathway. |
2014-11-26 |
2023-08-12 |
human |
| Dongwoo Nam, Junho Song, Sung-Moo Kim, Shu Yuan Chiang, Ji-Sung Kim, Won-Seok Chung, Hyeung-Jin Jang, Sang Hoon Jung, Young-Soon Na, Sung-Hoon Kim, Bum Sang Shim, Kwang Seok Ah. 8-hydrocalamenene, derived from Reynoutria elliptica, suppresses constitutive STAT3 activation, inhibiting proliferation and enhancing chemosensitization of human multiple myeloma cells. Journal of medicinal food. vol 17. issue 3. 2014-11-17. PMID:24476219. |
based on the evidence that anti-inflammatory agents frequently exert antiproliferative activity, we tested two sesquiterpene derivatives, 8-hydrocalamenene (hc) and 8,14-dihydrocalamenene (dhc), for their ability to induce apoptosis and suppress signal transducer and activator of transcription 3 (stat3) activation in multiple myeloma (mm) u266 cells. |
2014-11-17 |
2023-08-12 |
human |
| Sung-Moo Kim, Jong Hyun Lee, Gautam Sethi, Chulwon Kim, Seung Ho Baek, Dongwoo Nam, Won-Seok Chung, Sung-Hoon Kim, Bum Sang Shim, Kwang Seok Ah. Bergamottin, a natural furanocoumarin obtained from grapefruit juice induces chemosensitization and apoptosis through the inhibition of STAT3 signaling pathway in tumor cells. Cancer letters. vol 354. issue 1. 2014-11-17. PMID:25130169. |
bergamottin, a natural furanocoumarin obtained from grapefruit juice induces chemosensitization and apoptosis through the inhibition of stat3 signaling pathway in tumor cells. |
2014-11-17 |
2023-08-13 |
Not clear |
| Jing Nan, Yuping Du, Xing Chen, Qifeng Bai, Yuxin Wang, Xinxin Zhang, Ning Zhu, Jing Zhang, Jianwen Hou, Qin Wang, Jinbo Yan. TPCA-1 is a direct dual inhibitor of STAT3 and NF-κB and regresses mutant EGFR-associated human non-small cell lung cancers. Molecular cancer therapeutics. vol 13. issue 3. 2014-11-12. PMID:24401319. |
inhibiting egfr, stat3, and nf-κb by combination of tkis with tpca-1 showed increased sensitivity and enhanced apoptosis induced by gefitinib. |
2014-11-12 |
2023-08-12 |
human |
| Chulwon Kim, Somi K Cho, Shweta Kapoor, Ansu Kumar, Shireen Vali, Taher Abbasi, Sung-Hoon Kim, Gautam Sethi, Kwang Seok Ah. β-Caryophyllene oxide inhibits constitutive and inducible STAT3 signaling pathway through induction of the SHP-1 protein tyrosine phosphatase. Molecular carcinogenesis. vol 53. issue 10. 2014-11-03. PMID:23765383. |
the effect of cpo on stat3 activation, associated protein kinases and phosphatase, stat3-regulated gene products and apoptosis was investigated using both functional proteomics tumor pathway technology platform and different tumor cell lines. |
2014-11-03 |
2023-08-12 |
Not clear |
| Chulwon Kim, Somi K Cho, Shweta Kapoor, Ansu Kumar, Shireen Vali, Taher Abbasi, Sung-Hoon Kim, Gautam Sethi, Kwang Seok Ah. β-Caryophyllene oxide inhibits constitutive and inducible STAT3 signaling pathway through induction of the SHP-1 protein tyrosine phosphatase. Molecular carcinogenesis. vol 53. issue 10. 2014-11-03. PMID:23765383. |
the inhibition of stat3 activation by cpo inhibited proliferation, induced apoptosis and abrogated the invasive potential of tumor cells. |
2014-11-03 |
2023-08-12 |
Not clear |