| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rebeca Fernandez-Ruiz, Elaine Vieira, Pablo M Garcia-Roves, Ramon Gomi. Protein tyrosine phosphatase-1B modulates pancreatic β-cell mass. PloS one. vol 9. issue 2. 2014-10-28. PMID:24587334. |
furthermore, the ablation of ptp1b is able to regulate key proteins involved in the proliferation and/or apoptosis pathways, such as stat3, akt, erk1/2 and p53 in isolated islets from ptp1b knockout (ptp1b (-)/(-)) mice. |
2014-10-28 |
2023-08-12 |
mouse |
| Nagarjuna Vasagiri, Vijay Kumar Kutal. Molecular mechanism of interaction of mitocurcumin-1 with Akt1 and STAT3: an in silico approach. Indian journal of biochemistry & biophysics. vol 51. issue 4. 2014-10-23. PMID:25296502. |
we found that such conjugation significantly increased the uptake of curcumin in various cancer cells and caused cancer cell death by inducing apoptosis by decreasing the phosphorylation of akt1 (thr308) and stat3 (tyr705). |
2014-10-23 |
2023-08-13 |
Not clear |
| Yunyun Li, Zhongzu Zhang, Xiuxia Liu, Tingting Huang, Wenfeng He, Yang Shen, Xin Liu, Kui Hong, Qing Ca. miR-124 functions as a tumor suppressor in the endometrial carcinoma cell line HEC-1B partly by suppressing STAT3. Molecular and cellular biochemistry. vol 388. issue 1-2. 2014-10-21. PMID:24287565. |
restored stat3 expression through treatment with il-6 cytokine partly abolished mir-124-mediated cell cycle arrest and apoptosis induction. |
2014-10-21 |
2023-08-12 |
human |
| Y Feng, C Ke, Q Tang, H Dong, X Zheng, W Lin, J Ke, J Huang, S-C J Yeung, H Zhan. Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling. Cell death & disease. vol 5. 2014-10-21. PMID:24577086. |
metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating stat3 signaling. |
2014-10-21 |
2023-08-12 |
Not clear |
| Y Feng, C Ke, Q Tang, H Dong, X Zheng, W Lin, J Ke, J Huang, S-C J Yeung, H Zhan. Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling. Cell death & disease. vol 5. 2014-10-21. PMID:24577086. |
accordingly, small interfering rna (sirna)-mediated stat3 knockdown enhanced metformin-induced autophagy and apoptosis, and concomitantly enhanced the inhibitory effect of metformin on cell viability. |
2014-10-21 |
2023-08-12 |
Not clear |
| Y Feng, C Ke, Q Tang, H Dong, X Zheng, W Lin, J Ke, J Huang, S-C J Yeung, H Zhan. Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling. Cell death & disease. vol 5. 2014-10-21. PMID:24577086. |
in vivo, metformin downregulated stat3 activity and bcl-2 expression, induced apoptosis and autophagy, and inhibited tumor growth. |
2014-10-21 |
2023-08-12 |
Not clear |
| Malvika H Solanki, Prodyot K Chatterjee, Madhu Gupta, Xiangying Xue, Andrei Plagov, Margot H Metz, Rachel Mintz, Pravin C Singhal, Christine N Met. Magnesium protects against cisplatin-induced acute kidney injury by regulating platinum accumulation. American journal of physiology. Renal physiology. vol 307. issue 4. 2014-10-21. PMID:24944268. |
magnesium deficiency significantly increased cisplatin-associated weight loss and markers of renal damage (plasma blood urea nitrogen and creatinine), histological changes, inflammation, and renal cell apoptosis and modulated signaling pathways (e.g., erk1/2, p53, and stat3). |
2014-10-21 |
2023-08-13 |
mouse |
| Nicholas Don-Doncow, Zilma Escobar, Martin Johansson, Sven Kjellström, Victor Garcia, Eduardo Munoz, Olov Sterner, Anders Bjartell, Rebecka Hellste. Galiellalactone is a direct inhibitor of the transcription factor STAT3 in prostate cancer cells. The Journal of biological chemistry. vol 289. issue 23. 2014-10-07. PMID:24755219. |
the fungal metabolite galiellalactone, a stat3 signaling inhibitor, inhibits the growth, both in vitro and in vivo, of prostate cancer cells expressing active stat3 and induces apoptosis of prostate cancer stem cell-like cells expressing phosphorylated stat3 (pstat3). |
2014-10-07 |
2023-08-13 |
Not clear |
| Wei Lin, Liangpu Zheng, Qunchuan Zhuang, Jinyan Zhao, Zhiyun Cao, Jianwei Zeng, Shan Lin, Wei Xu, Jun Pen. Spica prunellae promotes cancer cell apoptosis, inhibits cell proliferation and tumor angiogenesis in a mouse model of colorectal cancer via suppression of stat3 pathway. BMC complementary and alternative medicine. vol 13. 2014-10-06. PMID:23800091. |
spica prunellae promotes cancer cell apoptosis, inhibits cell proliferation and tumor angiogenesis in a mouse model of colorectal cancer via suppression of stat3 pathway. |
2014-10-06 |
2023-08-12 |
mouse |
| Claudia Bello, Dania Vazquez-Blomquist, Jamilet Miranda, Yanelda Garcia, Lidia Ines Novoa, Daniel Palenzuela, Iraldo Bell. Regulation by IFN-α/IFN-γ co-formulation (HerberPAG®) of genes involved in interferon-STAT-pathways and apoptosis in U87MG. Current topics in medicinal chemistry. vol 14. issue 3. 2014-10-04. PMID:24304312. |
some of the genes involved in the first steps of ifns signaling pathways (stat1 and stat3) and apoptosis events (tp53, bax, bcl-2, bad, caspase3 (casp3), caspase8 (casp8) and caspase9 (casp9)) were studied. |
2014-10-04 |
2023-08-12 |
Not clear |
| Dan Hu, Lei Wan, Michael Chen, Yi Caudle, Gene LeSage, Qinchuan Li, Deling Yi. Essential role of IL-10/STAT3 in chronic stress-induced immune suppression. Brain, behavior, and immunity. vol 36. 2014-10-02. PMID:24513872. |
interestingly, blocking antibody against il-10 receptor and inhibition of stat3 by stat3 inhibitor s3i-201 attenuates stress-induced lymphocyte apoptosis. |
2014-10-02 |
2023-08-12 |
mouse |
| Han Chen, Yongli Guan, Gu Yuan, Qiang Zhang, Naijie Jin. A perylene derivative regulates HIF-1α and Stat3 signaling pathways. Bioorganic & medicinal chemistry. vol 22. issue 4. 2014-09-29. PMID:24485121. |
tel03 blocks the expression of both hif-1α and stat3, regulated oncogenes (e.g., bcl-2, vegf, glut1, and others) in cancer cells, and induces cancer cell apoptosis. |
2014-09-29 |
2023-08-12 |
Not clear |
| Yang Xu, Ying Shi, Qi Yuan, Xuli Liu, Bin Yan, Ling Chen, Yongguang Tao, Ya Ca. Epstein-Barr Virus encoded LMP1 regulates cyclin D1 promoter activity by nuclear EGFR and STAT3 in CNE1 cells. Journal of experimental & clinical cancer research : CR. vol 32. 2014-09-26. PMID:24499623. |
signal transducer and activator of transcription 3 (stat3) is a master transcriptional regulator in proliferation and apoptosis. |
2014-09-26 |
2023-08-12 |
Not clear |
| Shruti Chowdhari, Neeru Sain. hsa-miR-4516 mediated downregulation of STAT3/CDK6/UBE2N plays a role in PUVA induced apoptosis in keratinocytes. Journal of cellular physiology. vol 229. issue 11. 2014-09-25. PMID:24610393. |
we further show that overexpression of hsa-mir-4516 downregulates stat3, p-stat3, cdk6, and ube2n proteins that are consistently upregulated in psoriasis and induces apoptosis in hacat cells. |
2014-09-25 |
2023-08-12 |
human |
| Jian-Ping Wang, Zhi-Tang Yang, Cong Liu, Yuan-Hong He, Shan-Shan Zha. L-carnosine inhibits neuronal cell apoptosis through signal transducer and activator of transcription 3 signaling pathway after acute focal cerebral ischemia. Brain research. vol 1507. 2014-09-18. PMID:23454231. |
these results indicate that l-carnosine plays an important role in inhibiting neuronal cell apoptosis through stat3 signaling pathway after acute cerebral ischemia. |
2014-09-18 |
2023-08-12 |
rat |
| Yong-Qian Jiang, Zhi-Xiang Zhou, You-Lin J. Suppression of EGFR-STAT3 signaling inhibits tumorigenesis in a lung cancer cell line. International journal of clinical and experimental medicine. vol 7. issue 8. 2014-09-18. PMID:25232393. |
egfr and stat3 protein expression, cell apoptosis rate, cell proliferation, cell invasion, and cell division were analyzed and compared. |
2014-09-18 |
2023-08-13 |
Not clear |
| Qian Li, Chunling Pan, Di Teng, Li Lin, Yurong Kou, Elaine M Haase, Frank A Scannapieco, Yaping Pa. Porphyromonas gingivalis modulates Pseudomonas aeruginosa-induced apoptosis of respiratory epithelial cells through the STAT3 signaling pathway. Microbes and infection. vol 16. issue 1. 2014-09-11. PMID:24140557. |
porphyromonas gingivalis modulates pseudomonas aeruginosa-induced apoptosis of respiratory epithelial cells through the stat3 signaling pathway. |
2014-09-11 |
2023-08-12 |
Not clear |
| Qian Li, Chunling Pan, Di Teng, Li Lin, Yurong Kou, Elaine M Haase, Frank A Scannapieco, Yaping Pa. Porphyromonas gingivalis modulates Pseudomonas aeruginosa-induced apoptosis of respiratory epithelial cells through the STAT3 signaling pathway. Microbes and infection. vol 16. issue 1. 2014-09-11. PMID:24140557. |
p. gingivalis invasion transiently inhibited p. aeruginosa-induced apoptosis in respiratory epithelial cells via the signal transducer and activator of transcription 3 (stat3) signaling pathway. |
2014-09-11 |
2023-08-12 |
Not clear |
| Shasha Li, Saul J Priceman, Hong Xin, Wang Zhang, Jiehui Deng, Yong Liu, Jiabin Huang, Wenshan Zhu, Mingjie Chen, Wei Hu, Xiaomin Deng, Jian Zhang, Hua Yu, Guangyuan H. Icaritin inhibits JAK/STAT3 signaling and growth of renal cell carcinoma. PloS one. vol 8. issue 12. 2014-09-11. PMID:24324713. |
expression of the constitutively active form of stat3 blocked icaritin-induced apoptosis, while sirna directed against stat3 potentiated apoptosis. |
2014-09-11 |
2023-08-12 |
mouse |
| Xubin Wei, Gang Wang, Wei Li, Xupang Hu, Qinghong Huang, Ke Xu, Wenjia Lou, Jia Wu, Chen Liang, Qibin Lou, Chen Qian, Li Li. Activation of the JAK-STAT3 pathway is associated with the growth of colorectal carcinoma cells. Oncology reports. vol 31. issue 1. 2014-09-05. PMID:24253664. |
our data revealed that i) in crc cells, stat3 was continuously activated by phosphorylation, and socs3 was at a relative low expression level; and ii) adcn305-cppsocs3 inhibited the continuous activation of the jak/stat3 pathway, suppressed crc cell growth and induced apoptosis, in vitro and in vivo. |
2014-09-05 |
2023-08-12 |
Not clear |