| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qian-Rong Qi, Zeng-Ming Yan. Regulation and function of signal transducer and activator of transcription 3. World journal of biological chemistry. vol 5. issue 2. 2014-06-24. PMID:24921012. |
recent studies have shown that stat3 can also translocate into mitochondria, participating in aerobic respiration and apoptosis. |
2014-06-24 |
2023-08-13 |
mouse |
| Sam Cross-Knorr, Shaolei Lu, Kimberly Perez, Sara Guevara, Kate Brilliant, Claudio Pisano, Peter J Quesenberry, Murray B Resnick, Devasis Chatterje. RKIP phosphorylation and STAT3 activation is inhibited by oxaliplatin and camptothecin and are associated with poor prognosis in stage II colon cancer patients. BMC cancer. vol 13. 2014-06-23. PMID:24098947. |
in contrast, activated signal transducer and activator of transcription 3 (stat3) is a protein that promotes tumor cell survival by inhibiting apoptosis and has an important role in cancer progression in many of cancer types. |
2014-06-23 |
2023-08-12 |
Not clear |
| Kodappully Sivaraman Siveen, Sakshi Sikka, Rohit Surana, Xiaoyun Dai, Jingwen Zhang, Alan Prem Kumar, Benny K H Tan, Gautam Sethi, Anupam Bishaye. Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors. Biochimica et biophysica acta. vol 1845. issue 2. 2014-06-13. PMID:24388873. |
there is strong evidence to suggest that aberrant stat3 signaling promotes initiation and progression of human cancers by either inhibiting apoptosis or inducing cell proliferation, angiogenesis, invasion, and metastasis. |
2014-06-13 |
2023-08-12 |
human |
| Kodappully Sivaraman Siveen, Sakshi Sikka, Rohit Surana, Xiaoyun Dai, Jingwen Zhang, Alan Prem Kumar, Benny K H Tan, Gautam Sethi, Anupam Bishaye. Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors. Biochimica et biophysica acta. vol 1845. issue 2. 2014-06-13. PMID:24388873. |
suppression of stat3 activation results in the induction of apoptosis in tumor cells, and accordingly its pharmacological modulation by tyrosine kinase inhibitors, antisense oligonucleotides, decoy nucleotides, dominant negative proteins, rna interference and chemopreventive agents have been employed to suppress the proliferation of various human cancer cells in culture and tumorigenicity in vivo. |
2014-06-13 |
2023-08-12 |
human |
| Xiaomei Ren, Lei Duan, Qiang He, Zhang Zhang, Yi Zhou, Donghai Wu, Jingxuan Pan, Duanqing Pei, Ke Din. Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway. ACS medicinal chemistry letters. vol 1. issue 9. 2014-06-05. PMID:24900231. |
this compound potently inhibited the activation and transcriptional function of stat3 and consequently induced cell growth inhibition, apoptosis, and cell cycle arrest of cancer cells with constitutively active stat3. |
2014-06-05 |
2023-08-13 |
human |
| Dae-Seop Shin, Seung Nam Jung, Jieun Yun, Chang Woo Lee, Dong Cho Han, Bumtae Kim, Yong Ki Min, Nam Sook Kang, Byoung-Mog Kwo. Inhibition of STAT3 activation by KT-18618 via the disruption of the interaction between JAK3 and STAT3. Biochemical pharmacology. vol 89. issue 1. 2014-05-29. PMID:24607275. |
the inhibition of stat3 phosphorylation led to the apoptosis of mda-mb-468 cells. |
2014-05-29 |
2023-08-12 |
human |
| Mon-Yuan Yang, Chau-Jong Wang, Nai-Fang Chen, Wen-Hsin Ho, Fung-Jou Lu, Tsui-Hwa Tsen. Luteolin enhances paclitaxel-induced apoptosis in human breast cancer MDA-MB-231 cells by blocking STAT3. Chemico-biological interactions. vol 213. 2014-05-27. PMID:24525192. |
luteolin enhances paclitaxel-induced apoptosis in human breast cancer mda-mb-231 cells by blocking stat3. |
2014-05-27 |
2023-08-12 |
mouse |
| Rui Li, Shuo You, Zhongliang Hu, Zhuo G Chen, Gabriel L Sica, Fadlo R Khuri, Walter J Curran, Dong M Shin, Xingming Den. Inhibition of STAT3 by niclosamide synergizes with erlotinib against head and neck cancer. PloS one. vol 8. issue 9. 2014-05-16. PMID:24019973. |
combined inhibition of egfr and stat3 by erlotinib and niclosamide more effectively induced apoptosis in tumor tissues without toxicity for normal tissues. |
2014-05-16 |
2023-08-12 |
Not clear |
| Mingli Liu, Nana O Wilson, Jacqueline M Hibbert, Jonathan K Stile. STAT3 regulates MMP3 in heme-induced endothelial cell apoptosis. PloS one. vol 8. issue 8. 2014-05-14. PMID:23967200. |
stat3 regulates mmp3 in heme-induced endothelial cell apoptosis. |
2014-05-14 |
2023-08-12 |
mouse |
| Mingli Liu, Nana O Wilson, Jacqueline M Hibbert, Jonathan K Stile. STAT3 regulates MMP3 in heme-induced endothelial cell apoptosis. PloS one. vol 8. issue 8. 2014-05-14. PMID:23967200. |
in the present study, we further tested the hypothesis that heme reduces blood-brain barrier integrity during ecm by induction of apoptosis of brain vascular endothelial cells through stat3 and its target gene matrix metalloproteinase three (mmp3) signaling. |
2014-05-14 |
2023-08-12 |
mouse |
| Yang Wang, Xuequn Ren, Chaoyang Deng, Lu Yang, Erfu Yan, Tao Guo, Yanmin Li, Marvin Xuejun X. Mechanism of the inhibition of the STAT3 signaling pathway by EGCG. Oncology reports. vol 30. issue 6. 2014-05-13. PMID:24065300. |
following treatment of the hepatocellular carcinoma cell lines bel-7402 and qgy-7703 with egcg, in vitro, egcg significantly suppressed cell proliferation as detected by mtt assay, induced apoptosis as detected by flow cytometry, dramatically lowered the expression levels of phosphorylated stat3 proteins (p-stat3) as determined by immunoblot detection, and inhibited the expression of multiple genes including bcl-xl, c-myc, vegf and cyclin d1 as demonstrated by rt-pcr analysis. |
2014-05-13 |
2023-08-12 |
Not clear |
| Jing Zhao, Yaming Xu, Yijia Zong, Shiyun Zhang, Yichao Song, Kangkang Yu, Zhe Li, Yonghua Ji, Yongming Qiu, Fuxue Che. Inhibition of Stat3 expression induces apoptosis and suppresses proliferation in human leukemia HL-60 cells. Hematology (Amsterdam, Netherlands). vol 16. issue 4. 2014-05-12. PMID:21756540. |
inhibition of stat3 expression induces apoptosis and suppresses proliferation in human leukemia hl-60 cells. |
2014-05-12 |
2023-08-12 |
human |
| Jing Zhao, Yaming Xu, Yijia Zong, Shiyun Zhang, Yichao Song, Kangkang Yu, Zhe Li, Yonghua Ji, Yongming Qiu, Fuxue Che. Inhibition of Stat3 expression induces apoptosis and suppresses proliferation in human leukemia HL-60 cells. Hematology (Amsterdam, Netherlands). vol 16. issue 4. 2014-05-12. PMID:21756540. |
the results indicated that constitutively expressed stat3 is present in human leukemia hl-60 cells, and the down-regulation of stat3 expression caused significant induction of apoptosis as well as inhibition of proliferation in hl-60 cells. |
2014-05-12 |
2023-08-12 |
human |
| Jing Zhao, Yaming Xu, Yijia Zong, Shiyun Zhang, Yichao Song, Kangkang Yu, Zhe Li, Yonghua Ji, Yongming Qiu, Fuxue Che. Inhibition of Stat3 expression induces apoptosis and suppresses proliferation in human leukemia HL-60 cells. Hematology (Amsterdam, Netherlands). vol 16. issue 4. 2014-05-12. PMID:21756540. |
these data further demonstrated that stat3 plays a critical role in human leukemia hl-60 cell apoptosis and proliferation. |
2014-05-12 |
2023-08-12 |
human |
| Xiaolei Zhang, Peishu Liu, Bo Zhang, Hongluan Mao, Liang Shen, Yanhui M. Inhibitory effects of STAT3 decoy oligodeoxynucleotides on human epithelial ovarian cancer cell growth in vivo. International journal of molecular medicine. vol 32. issue 3. 2014-05-12. PMID:23828376. |
the results revealed that the stat3 decoy odn inhibited ovarian cancer cell growth and promoted ovarian cancer cell apoptosis in vivo. |
2014-05-12 |
2023-08-12 |
mouse |
| Xiang Li, Feng Xu, Ekapun Karoopongse, A Mario Marcondes, Kayoung Lee, Kris V Kowdley, Carol H Miao, Grant D Trobridge, Jean S Campbell, H Joachim Dee. Allogeneic transplantation, Fas signaling, and dysregulation of hepcidin. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. vol 19. issue 8. 2014-05-09. PMID:23707854. |
inhibition of flipl by rna interference resulted, as expected, not only in enhanced hepatocyte apoptosis in response to fas signals, but also in decreased levels of il-6, stat3, and hamp. |
2014-05-09 |
2023-08-12 |
Not clear |
| Xiang Li, Feng Xu, Ekapun Karoopongse, A Mario Marcondes, Kayoung Lee, Kris V Kowdley, Carol H Miao, Grant D Trobridge, Jean S Campbell, H Joachim Dee. Allogeneic transplantation, Fas signaling, and dysregulation of hepcidin. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. vol 19. issue 8. 2014-05-09. PMID:23707854. |
in contrast, overexpression of flipl protected hepatocytes against agonistic anti-fas antibody-mediated apoptosis and increased the levels of il-6 and stat3, thereby maintaining the expression of hamp in an nf-κb-dependent fashion. |
2014-05-09 |
2023-08-12 |
Not clear |
| Xiang Li, Feng Xu, Ekapun Karoopongse, A Mario Marcondes, Kayoung Lee, Kris V Kowdley, Carol H Miao, Grant D Trobridge, Jean S Campbell, H Joachim Dee. Allogeneic transplantation, Fas signaling, and dysregulation of hepcidin. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. vol 19. issue 8. 2014-05-09. PMID:23707854. |
in vivo overexpression of flipl in the liver via hydrodynamic transfection, similarly, interfered with fas-initiated apoptosis and prevented down-regulation of il-6, stat3, and hamp. |
2014-05-09 |
2023-08-12 |
Not clear |
| Braden C McFarland, G Kenneth Gray, Susan E Nozell, Suk W Hong, Etty N Benvenist. Activation of the NF-κB pathway by the STAT3 inhibitor JSI-124 in human glioblastoma cells. Molecular cancer research : MCR. vol 11. issue 5. 2014-05-02. PMID:23386688. |
in this study, we confirmed that jsi-124 inhibits both constitutive and stimulus-induced janus kinase 2 (jak2) and stat3 phosphorylation, and decreases cell proliferation while inducing apoptosis in cultured gbm cells. |
2014-05-02 |
2023-08-12 |
human |
| Lei Lv, Jiwei Zhang, Lan Zhang, Guanhua Xue, Peng Wang, Qiurong Meng, Wei Lian. Essential role of Pin1 via STAT3 signalling and mitochondria-dependent pathways in restenosis in type 2 diabetes. Journal of cellular and molecular medicine. vol 17. issue 8. 2014-05-01. PMID:23750710. |
we demonstrated that stat3 signalling and mitochondria-dependent pathways played critical roles in the involvement of pin1 in cell cycle regulation and apoptosis of vsmcs in t2d. |
2014-05-01 |
2023-08-12 |
mouse |