| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pengyi Deng, Chen Wang, Liulin Chen, Cheng Wang, Yuhan Du, Xu Yan, Mingjie Chen, Guangxiao Yang, Guangyuan H. Sesamin induces cell cycle arrest and apoptosis through the inhibition of signal transducer and activator of transcription 3 signalling in human hepatocellular carcinoma cell line HepG2. Biological & pharmaceutical bulletin. vol 36. issue 10. 2014-04-28. PMID:24088253. |
our studies showed that stat3 signalling played a key role in sesamin-induced g2/m phase arrest and apoptosis in hepg2 cells. |
2014-04-28 |
2023-08-12 |
human |
| Chunjuan Jiang, Qian Xu, Kai Xu, Haiyang Dai, Zhuiyang Zhang, Wenjuan Wu, Jianming N. Effects of erythropoietin on STAT1 and STAT3 levels following cerebral ischemia-reperfusion in rats. The International journal of neuroscience. vol 123. issue 10. 2014-04-24. PMID:23786492. |
stat1 initiates neuronal apoptosis following cerebral ischemia-reperfusion, while stat3 is neuroprotective. |
2014-04-24 |
2023-08-12 |
rat |
| Qingyuan Jiang, Lei Dai, Lin Cheng, Xiaolei Chen, Yiming Li, Shuang Zhang, Xiaolan Su, Xia Zhao, Yuquan Wei, Hongxin Den. Efficient inhibition of intraperitoneal ovarian cancer growth in nude mice by liposomal delivery of short hairpin RNA against STAT3. The journal of obstetrics and gynaecology research. vol 39. issue 3. 2014-04-22. PMID:23003327. |
our goal was to investigate the effect of silencing stat3 on ovarian cancer cell apoptosis, proliferation, angiogenesis and expression of key targets in vitro and in vivo. |
2014-04-22 |
2023-08-12 |
mouse |
| Robert H Lee, Guillermo Vazque. Evidence for a prosurvival role of alpha-7 nicotinic acetylcholine receptor in alternatively (M2)-activated macrophages. Physiological reports. vol 1. issue 7. 2014-04-18. PMID:24744866. |
our findings show that stimulation of α7nachr results in activation of the stat3 prosurvival pathway and protection of macrophages from endoplasmic reticulum (er) stress-induced apoptosis. |
2014-04-18 |
2023-08-13 |
mouse |
| Haitao Xu, Songyan Zhan. Scutellarin-induced apoptosis in HepG2 hepatocellular carcinoma cells via a STAT3 pathway. Phytotherapy research : PTR. vol 27. issue 10. 2014-04-14. PMID:23192830. |
scutellarin-induced apoptosis in hepg2 hepatocellular carcinoma cells via a stat3 pathway. |
2014-04-14 |
2023-08-12 |
Not clear |
| Haitao Xu, Songyan Zhan. Scutellarin-induced apoptosis in HepG2 hepatocellular carcinoma cells via a STAT3 pathway. Phytotherapy research : PTR. vol 27. issue 10. 2014-04-14. PMID:23192830. |
in summary, we found that scutellarin was able to inhibit the proliferation and induce the apoptosis of hepg2 cells via a stat3 signal pathway, which provided evident support for developing scutellarin as an alternative treatment for liver cancer. |
2014-04-14 |
2023-08-12 |
Not clear |
| Pingping Xue, Yang Zhao, Yang Liu, Qianying Yuan, Chaomei Xiong, Jinlan Rua. A novel compound RY10-4 induces apoptosis and inhibits invasion via inhibiting STAT3 through ERK-, p38-dependent pathways in human lung adenocarcinoma A549 cells. Chemico-biological interactions. vol 209. 2014-04-14. PMID:24300195. |
a novel compound ry10-4 induces apoptosis and inhibits invasion via inhibiting stat3 through erk-, p38-dependent pathways in human lung adenocarcinoma a549 cells. |
2014-04-14 |
2023-08-12 |
human |
| K H Koo, H Kim, Y-K Bae, K Kim, B-K Park, C-H Lee, Y-N Ki. Salinomycin induces cell death via inactivation of Stat3 and downregulation of Skp2. Cell death & disease. vol 4. 2014-02-25. PMID:23807222. |
taken together, our data indicate that salinomycin induces cell cycle arrest and apoptosis via downregulation or inactivation of cell cycle-associated oncogenes, such as stat3, cyclin d1, and skp2, regardless of multidrug resistance. |
2014-02-25 |
2023-08-12 |
Not clear |
| Ming Liu, Fei Wang, Zeqing Wen, Min Shi, Hui Zhan. Blockage of STAT3 signaling pathway with a decoy oligodeoxynucleotide inhibits growth of human ovarian cancer cells. Cancer investigation. vol 32. issue 1. 2014-02-20. PMID:24328557. |
the stat3 decoy odn treatment specifically blocked stat3 signaling, and inhibited cell proliferation by inducing apoptosis and cell cycle arrest. |
2014-02-20 |
2023-08-12 |
human |
| Snehal Dabir, Amy Kluge, Karen McColl, Yu Liu, Minh Lam, Balazs Halmos, Gary Wildey, Afshin Dowlat. PIAS3 activates the intrinsic apoptotic pathway in non-small cell lung cancer cells independent of p53 status. International journal of cancer. vol 134. issue 5. 2014-02-12. PMID:23959540. |
microarray experiments were performed to discover stat3-independent mediators of pias3-induced apoptosis by comparing the apoptotic gene expression signature induced by pias3 overexpression with that induced by stat3 sirna. |
2014-02-12 |
2023-08-12 |
human |
| Jennifer E Kim, Mira Patel, Jacob Ruzevick, Christopher M Jackson, Michael Li. STAT3 Activation in Glioblastoma: Biochemical and Therapeutic Implications. Cancers. vol 6. issue 1. 2014-02-12. PMID:24518612. |
nevertheless, some studies show that stat3 also participates in terminal differentiation and apoptosis of various cell lines and in glioma with phosphatase and tensin homolog (pten)-deficient genetic backgrounds. |
2014-02-12 |
2023-08-12 |
Not clear |
| Ruchi Ghildiyal, Deobrat Dixit, Ellora Se. EGFR inhibitor BIBU induces apoptosis and defective autophagy in glioma cells. Molecular carcinogenesis. vol 52. issue 12. 2014-01-23. PMID:22753156. |
the ability of bibu to abrogate akt and stat3 activation, induce apoptosis and prevent execution of autophagy warrants its investigation as a potent anti-glioma target. |
2014-01-23 |
2023-08-12 |
Not clear |
| Tadashi Ashizawa, Haruo Miyata, Akira Iizuka, Masaru Komiyama, Chie Oshita, Akiko Kume, Masahiro Nogami, Mika Yagoto, Ichiro Ito, Takuma Oishi, Reiko Watanabe, Koichi Mitsuya, Kenji Matsuno, Toshio Furuya, Tadashi Okawara, Masami Otsuka, Naohisa Ogo, Akira Asai, Yoko Nakasu, Ken Yamaguchi, Yasuto Akiyam. Effect of the STAT3 inhibitor STX-0119 on the proliferation of cancer stem-like cells derived from recurrent glioblastoma. International journal of oncology. vol 43. issue 1. 2014-01-07. PMID:23612755. |
notably, stx-0119 demonstrated strong inhibition of the expression of stat3 target genes (c-myc, survivin, cyclin d1, hif-1α and vegf) and stem cell-associated genes (cd44, nanog, nestin and cd133) as well as the induction of apoptosis in one stem-like cell line. |
2014-01-07 |
2023-08-12 |
Not clear |
| Sangkil Nam, Wei Wen, Anne Schroeder, Andreas Herrmann, Hua Yu, Xinlai Cheng, Karl-Heinz Merz, Gerhard Eisenbrand, Hongzhi Li, Yate-Ching Yuan, Richard Jov. Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively-activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells. Molecular oncology. vol 7. issue 3. 2013-12-23. PMID:23206899. |
dual inhibition of janus and src family kinases by novel indirubin derivative blocks constitutively-activated stat3 signaling associated with apoptosis of human pancreatic cancer cells. |
2013-12-23 |
2023-08-12 |
human |
| Sangkil Nam, Wei Wen, Anne Schroeder, Andreas Herrmann, Hua Yu, Xinlai Cheng, Karl-Heinz Merz, Gerhard Eisenbrand, Hongzhi Li, Yate-Ching Yuan, Richard Jov. Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively-activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells. Molecular oncology. vol 7. issue 3. 2013-12-23. PMID:23206899. |
e738 down-regulated expression of the stat3 target proteins mcl-1 and survivin, associated with induction of apoptosis. |
2013-12-23 |
2023-08-12 |
human |
| Chun-Sheng Han, Yan Chen, Xue-Qiang W. [Role of signal transducer and activator of transcription 3 in the development of tumors]. Zhongguo shi yan xue ye xue za zhi. vol 21. issue 2. 2013-12-16. PMID:23628067. |
signal transducer and activator of transcription 3 (stat3) take part in cell proliferation, differentiation, survival, apoptosis, transformation, cellular immunity and some other important physiological and pathological processes. |
2013-12-16 |
2023-08-12 |
Not clear |
| R Kerek, A Geoffroy, A Bison, N Martin, N Akchiche, G Pourié, D Helle, J-L Guéant, C Bossenmeyer-Pourié, J-L Dava. Early methyl donor deficiency may induce persistent brain defects by reducing Stat3 signaling targeted by miR-124. Cell death & disease. vol 4. 2013-12-13. PMID:23928694. |
vitamin shortage also affected upstream kinases of stat3 signaling pathway (phospho-erk1/2, phospho-src, phospho-jnk, and phospho-p38) as well as downstream target gene products (bcl-2 and bcl-xl), thus promoting apoptosis. |
2013-12-13 |
2023-08-12 |
rat |
| Futoshi Matsui, Audrey Rhee, Karen L Hile, Hongji Zhang, Kirstan K Meldru. IL-18 induces profibrotic renal tubular cell injury via STAT3 activation. American journal of physiology. Renal physiology. vol 305. issue 7. 2013-12-11. PMID:23904224. |
in vitro results similarly demonstrate increased p-stat3, socs3, α-sma, and collagen iii expression, and increased collagen production and tec apoptosis in response to il-18 stimulation, but the response was significantly diminished in the presence of stat3 inhibition. |
2013-12-11 |
2023-08-12 |
mouse |
| Jun Liao, Teng Xu, Jia-Xuan Zheng, Jiu-Mao Lin, Qiao-Yan Cai, De-Biao Yu, Jun Pen. Nitidine chloride inhibits hepatocellular carcinoma cell growth in vivo through the suppression of the JAK1/STAT3 signaling pathway. International journal of molecular medicine. vol 32. issue 1. 2013-12-10. PMID:23613111. |
the analysis of the effects of nc on apoptosis in hcc tumor xenografts in mice was carried out by terminal deoxynucleotidyl transferase-mediated dutp nick end-labeling (tunel) assay; the expression of bcl-2, bax, cyclin-dependent kinase (cdk)4, cyclin d1, p21 and proliferating cell nuclear antigen (pcna) was analyzed by immunohistochemistry; and the protein expression of jak1 and stat3 was examined by western blot analysis. |
2013-12-10 |
2023-08-12 |
mouse |
| Philipp Stahl, Volker Ruppert, Thomas Meyer, Jörg Schmidt, Marco A Campos, Ricardo T Gazzinelli, Bernhard Maisch, Ralph T Schwarz, Françoise Debierre-Grockieg. Trypomastigotes and amastigotes of Trypanosoma cruzi induce apoptosis and STAT3 activation in cardiomyocytes in vitro. Apoptosis : an international journal on programmed cell death. vol 18. issue 6. 2013-11-26. PMID:23435997. |
trypomastigotes and amastigotes of trypanosoma cruzi induce apoptosis and stat3 activation in cardiomyocytes in vitro. |
2013-11-26 |
2023-08-12 |
rat |