| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Patrick Geraghty, Anne E Wyman, Itsaso Garcia-Arcos, Abdoulaye J Dabo, Sonya Gadhvi, Robert Foronj. STAT3 modulates cigarette smoke-induced inflammation and protease expression. Frontiers in physiology. vol 4. 2013-10-08. PMID:24101903. |
since cigarette smoke activated stat3 in the lung, we then evaluated how the loss of stat3 would impact on smoke-mediated lung inflammation, protease expression, and apoptosis. |
2013-10-08 |
2023-08-12 |
mouse |
| Patrick Geraghty, Anne E Wyman, Itsaso Garcia-Arcos, Abdoulaye J Dabo, Sonya Gadhvi, Robert Foronj. STAT3 modulates cigarette smoke-induced inflammation and protease expression. Frontiers in physiology. vol 4. 2013-10-08. PMID:24101903. |
lastly, apoptosis, as determined by caspase 3/7 activity assay, was increased in the stat3(-/-) at baseline to levels comparable to those observed in the smoke-exposed stat3(+/+) mice. |
2013-10-08 |
2023-08-12 |
mouse |
| Jee-Eun Kim, Dong-Hoon Jin, Wang Jae Lee, Daeyoung Hur, T-C Wu, Daejin Ki. Bortezomib enhances antigen-specific cytotoxic T cell responses against immune-resistant cancer cells generated by STAT3-ablated dendritic cells. Pharmacological research. vol 71. 2013-09-30. PMID:23428347. |
we found that apoptosis via down-regulation of stat3 and nf-κb and up-regulation of fas and death receptor 5 (dr5) expression in tc-1(p3) induced by bortezomib was independent of p53 status. |
2013-09-30 |
2023-08-12 |
mouse |
| Muhammad Khan, Ting Li, Muhammad Khalil Ahmad Khan, Azhar Rasul, Faisal Nawaz, Meiyan Sun, Yongchen Zheng, Tonghui M. Alantolactone induces apoptosis in HepG2 cells through GSH depletion, inhibition of STAT3 activation, and mitochondrial dysfunction. BioMed research international. vol 2013. 2013-09-23. PMID:23533997. |
alantolactone induces apoptosis in hepg2 cells through gsh depletion, inhibition of stat3 activation, and mitochondrial dysfunction. |
2013-09-23 |
2023-08-12 |
human |
| Muhammad Khan, Ting Li, Muhammad Khalil Ahmad Khan, Azhar Rasul, Faisal Nawaz, Meiyan Sun, Yongchen Zheng, Tonghui M. Alantolactone induces apoptosis in HepG2 cells through GSH depletion, inhibition of STAT3 activation, and mitochondrial dysfunction. BioMed research international. vol 2013. 2013-09-23. PMID:23533997. |
signal transducer and activator of transcription 3 (stat3) constitutively expresses in human liver cancer cells and has been implicated in apoptosis resistance and tumorigenesis. |
2013-09-23 |
2023-08-12 |
human |
| Muhammad Khan, Ting Li, Muhammad Khalil Ahmad Khan, Azhar Rasul, Faisal Nawaz, Meiyan Sun, Yongchen Zheng, Tonghui M. Alantolactone induces apoptosis in HepG2 cells through GSH depletion, inhibition of STAT3 activation, and mitochondrial dysfunction. BioMed research international. vol 2013. 2013-09-23. PMID:23533997. |
the present study was conducted to envisage the molecular mechanism of alantolactone-induced apoptosis in hepg2 cells by focusing on the molecular mechanism of gsh depletion and its effect on stat3 activation. |
2013-09-23 |
2023-08-12 |
human |
| Muhammad Khan, Ting Li, Muhammad Khalil Ahmad Khan, Azhar Rasul, Faisal Nawaz, Meiyan Sun, Yongchen Zheng, Tonghui M. Alantolactone induces apoptosis in HepG2 cells through GSH depletion, inhibition of STAT3 activation, and mitochondrial dysfunction. BioMed research international. vol 2013. 2013-09-23. PMID:23533997. |
this alantolactone-induced apoptosis was found to be associated with gsh depletion, inhibition of stat3 activation, ros generation, mitochondrial transmembrane potential dissipation, and increased bax/bcl-2 ratio and caspase-3 activation. |
2013-09-23 |
2023-08-12 |
human |
| Jolyane Meloche, Antony Courchesne, Marjorie Barrier, Sophie Carter, Malik Bisserier, Roxane Paulin, Jean-François Lauzon-Joset, Sandra Breuils-Bonnet, Éve Tremblay, Sabrina Biardel, Christine Racine, Christian Courture, Pierre Bonnet, Susan M Majka, Yves Deshaies, Frédéric Picard, Steeve Provencher, Sébastien Bonne. Critical role for the advanced glycation end-products receptor in pulmonary arterial hypertension etiology. Journal of the American Heart Association. vol 2. issue 1. 2013-09-13. PMID:23525442. |
as rage is one of the most upregulated proteins in pah patients' lungs and a strong stat3 activator, we hypothesized that by activating stat3, rage induces bmpr2 and pparγ downregulation, promoting pah-pasmc proliferation and resistance to apoptosis. |
2013-09-13 |
2023-08-12 |
Not clear |
| Yihui Fan, Renfang Mao, Jianhua Yan. NF-κB and STAT3 signaling pathways collaboratively link inflammation to cancer. Protein & cell. vol 4. issue 3. 2013-09-06. PMID:23483479. |
stat3 regulates the expression of a variety of genes in response to cellular stimuli, and thus plays a key role in cell growth and apoptosis. |
2013-09-06 |
2023-08-12 |
Not clear |
| Tasnim Ara, Rie Nakata, Michael A Sheard, Hiroyuki Shimada, Ralf Buettner, Susan G Groshen, Lingyun Ji, Hua Yu, Richard Jove, Robert C Seeger, Yves A DeClerc. Critical role of STAT3 in IL-6-mediated drug resistance in human neuroblastoma. Cancer research. vol 73. issue 13. 2013-09-04. PMID:23633489. |
treatment of neuroblastoma cells with il-6 protected them from drug-induced apoptosis in a stat3-dependent manner because the protective effect of il-6 was abrogated in the presence of a stat3 inhibitor and upon stat3 knockdown. |
2013-09-04 |
2023-08-12 |
human |
| Stephen A Thacker, Prema Robinson, Adam Abel, David J Tweard. Modulation of the unfolded protein response during hepatocyte and cardiomyocyte apoptosis in trauma/hemorrhagic shock. Scientific reports. vol 3. 2013-08-14. PMID:23378918. |
trauma with hemorrhagic shock (t/hs), has been shown to result in liver injury marked by hepatocyte apoptosis and heart failure marked by cardiomyocyte apoptosis, both of which we have shown to be prevented by il-6 administration at resuscitation, and stat3 largely mediated this. |
2013-08-14 |
2023-08-12 |
Not clear |
| Jason I Couto, Misty D Bear, Jiayuh Lin, Michael Pennel, Samuel K Kulp, William C Kisseberth, Cheryl A Londo. Biologic activity of the novel small molecule STAT3 inhibitor LLL12 against canine osteosarcoma cell lines. BMC veterinary research. vol 8. 2013-08-13. PMID:23244668. |
constitutive activation of stat3, via aberrant phosphorylation, leads to proliferation, cell survival and resistance to apoptosis. |
2013-08-13 |
2023-08-12 |
Not clear |
| Noelle A Hutchins, Chun-Shiang Chung, Joshua N Borgerding, Carol A Ayala, Alfred Ayal. Kupffer cells protect liver sinusoidal endothelial cells from Fas-dependent apoptosis in sepsis by down-regulating gp130. The American journal of pathology. vol 182. issue 3. 2013-08-08. PMID:23306157. |
however, kupffer cell depletion with clodronate liposomes resulted in greater apoptosis and fas expression after clp and a decrease in glycoprotein 130 expression on lsecs, suggesting that stat3 activation may protect these cells from injury. |
2013-08-08 |
2023-08-12 |
Not clear |
| Udo Döbbeling, Ying Waeckerle-Men, Franziska Zabel, Nicole Graf, Thomas M Kündig, Pål Johanse. The antihistamines clemastine and desloratadine inhibit STAT3 and c-Myc activities and induce apoptosis in cutaneous T-cell lymphoma cell lines. Experimental dermatology. vol 22. issue 2. 2013-08-07. PMID:23362870. |
the antihistamines clemastine and desloratadine inhibit stat3 and c-myc activities and induce apoptosis in cutaneous t-cell lymphoma cell lines. |
2013-08-07 |
2023-08-12 |
Not clear |
| Zhiqiang Han, Jing Feng, Zhenya Hong, Lijuan Chen, Wei Li, Shujie Liao, Xiaoli Wang, Teng Ji, Shixuan Wang, Ding Ma, Gang Chen, Qinglei Ga. Silencing of the STAT3 signaling pathway reverses the inherent and induced chemoresistance of human ovarian cancer cells. Biochemical and biophysical research communications. vol 435. issue 2. 2013-08-06. PMID:23665025. |
targeting stat3 by sirna technology markedly enhanced cisplatin-induced apoptosis in cisplatin-resistant ovarian cancer cells that expressed a high level of pstat3. |
2013-08-06 |
2023-08-12 |
human |
| Yunbao Pan, Fuling Zhou, Ronghua Zhang, Francois X Clare. Stat3 inhibitor Stattic exhibits potent antitumor activity and induces chemo- and radio-sensitivity in nasopharyngeal carcinoma. PloS one. vol 8. issue 1. 2013-08-01. PMID:23382914. |
additionally, stat3 transfection attenuated, whereas stat3 knockdown enhanced, the effects of stattic upon cell viability inhibition and apoptosis induction. |
2013-08-01 |
2023-08-12 |
Not clear |
| Yanfei Jia, Dezhi Liu, Dongjie Xiao, Xiaoli Ma, Shuyi Han, Yan Zheng, Shanhui Sun, Maoxiu Zhang, Hongmei Gao, Xia Cui, Yunshan Wan. Expression of AFP and STAT3 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in AFP-producing gastric cancer cells. PloS one. vol 8. issue 1. 2013-08-01. PMID:23382965. |
expression of afp and stat3 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in afp-producing gastric cancer cells. |
2013-08-01 |
2023-08-12 |
Not clear |
| Yanfei Jia, Dezhi Liu, Dongjie Xiao, Xiaoli Ma, Shuyi Han, Yan Zheng, Shanhui Sun, Maoxiu Zhang, Hongmei Gao, Xia Cui, Yunshan Wan. Expression of AFP and STAT3 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in AFP-producing gastric cancer cells. PloS one. vol 8. issue 1. 2013-08-01. PMID:23382965. |
here, we found decreased expression of afp and stat3 after induction of apoptosis by as(2)o(3) in the afpgc fu97 cells. |
2013-08-01 |
2023-08-12 |
Not clear |
| Yanfei Jia, Dezhi Liu, Dongjie Xiao, Xiaoli Ma, Shuyi Han, Yan Zheng, Shanhui Sun, Maoxiu Zhang, Hongmei Gao, Xia Cui, Yunshan Wan. Expression of AFP and STAT3 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in AFP-producing gastric cancer cells. PloS one. vol 8. issue 1. 2013-08-01. PMID:23382965. |
downregulation of afp and stat3 expression plays an important role in as(2)o(3)-induced apoptosis of afpgc cells, which suggests a new mechanism of as(2)o(3)-induced cell apoptosis. |
2013-08-01 |
2023-08-12 |
Not clear |
| Liang Wu, Barbro Ehlin-Henriksson, Hong Zhu, Ingemar Ernberg, George Klei. EBV counteracts IL-21-induced apoptosis in an EBV-positive diffuse large B-cell lymphoma cell line. International journal of cancer. vol 133. issue 3. 2013-07-25. PMID:23364893. |
previously, interleukin (il)-21 has been found to induce apoptosis by activating the signal transducer and activator of transcription 3 (stat3) and concomitant upregulation of c-myc in diffuse large b-cell lymphoma (dlbcl) lines with unknown epstein-barr virus (ebv) status. |
2013-07-25 |
2023-08-12 |
Not clear |