| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aiguo Liu, Yan Liu, Zhigang Jin, Qun Hu, Li Lin, David Jou, Jing Yang, Zhenghu Xu, Hong Wang, Chenglong Li, Jiayuh Li. XZH-5 inhibits STAT3 phosphorylation and enhances the cytotoxicity of chemotherapeutic drugs in human breast and pancreatic cancer cells. PloS one. vol 7. issue 10. 2013-05-03. PMID:23056374. |
xzh-5 was found to inhibit stat3 phosphorylation (tyr705) and induce apoptosis in human breast and pancreatic cancer cell lines expressing elevated levels of phosphorylated stat3. |
2013-05-03 |
2023-08-12 |
human |
| Maximilian J Waldner, Sebastian Foersch, Markus F Neurat. Interleukin-6--a key regulator of colorectal cancer development. International journal of biological sciences. vol 8. issue 9. 2013-04-29. PMID:23136553. |
according to experimental studies, these effects are mediated through il-6 trans-signaling promoting tumor cell proliferation and inhibiting apoptosis through gp130 activation on tumor cells with subsequent signaling through janus kinases (jaks) and signal transducer and activator of transcription 3 (stat3). |
2013-04-29 |
2023-08-12 |
Not clear |
| Chulwon Kim, Moo-Chang Kim, Sung-Moo Kim, Dongwoo Nam, Seung-Hoon Choi, Sung-Hoon Kim, Kyoo Seok Ahn, Eun Ha Lee, Sang Hoon Jung, Kwang Seok Ah. Chrysanthemum indicum L. extract induces apoptosis through suppression of constitutive STAT3 activation in human prostate cancer DU145 cells. Phytotherapy research : PTR. vol 27. issue 1. 2013-04-26. PMID:22438130. |
chrysanthemum indicum l. extract induces apoptosis through suppression of constitutive stat3 activation in human prostate cancer du145 cells. |
2013-04-26 |
2023-08-12 |
human |
| Chulwon Kim, Moo-Chang Kim, Sung-Moo Kim, Dongwoo Nam, Seung-Hoon Choi, Sung-Hoon Kim, Kyoo Seok Ahn, Eun Ha Lee, Sang Hoon Jung, Kwang Seok Ah. Chrysanthemum indicum L. extract induces apoptosis through suppression of constitutive STAT3 activation in human prostate cancer DU145 cells. Phytotherapy research : PTR. vol 27. issue 1. 2013-04-26. PMID:22438130. |
sudachitin, chrysoeriol, and acacetin also exerted significantly cytotoxicity, clearly suppressed constitutive stat3 activation, and induced apoptosis, although hesperetin did not show any significant effect in du145 cells. |
2013-04-26 |
2023-08-12 |
human |
| Chulwon Kim, Moo-Chang Kim, Sung-Moo Kim, Dongwoo Nam, Seung-Hoon Choi, Sung-Hoon Kim, Kyoo Seok Ahn, Eun Ha Lee, Sang Hoon Jung, Kwang Seok Ah. Chrysanthemum indicum L. extract induces apoptosis through suppression of constitutive STAT3 activation in human prostate cancer DU145 cells. Phytotherapy research : PTR. vol 27. issue 1. 2013-04-26. PMID:22438130. |
overall, our results demonstrate that mci could induce apoptosis through inhibition of the jak1/2 and stat3 signaling pathways. |
2013-04-26 |
2023-08-12 |
human |
| Zhipeng Wang, Shaojun Zhu, Min Shen, Juanjuan Liu, Meng Wang, Chen Li, Yukun Wang, Anmei Deng, Qibing Me. STAT3 is involved in esophageal carcinogenesis through regulation of Oct-1. Carcinogenesis. vol 34. issue 3. 2013-04-19. PMID:23172665. |
the transcription factor signal transducer and activator of transcription 3 (stat3) contributes to cell proliferation, apoptosis and motility in human cancer cells. |
2013-04-19 |
2023-08-12 |
human |
| Zhipeng Wang, Shaojun Zhu, Min Shen, Juanjuan Liu, Meng Wang, Chen Li, Yukun Wang, Anmei Deng, Qibing Me. STAT3 is involved in esophageal carcinogenesis through regulation of Oct-1. Carcinogenesis. vol 34. issue 3. 2013-04-19. PMID:23172665. |
in conjunction with oct-1, stat3 inhibited apoptosis in esophageal squamous cell carcinoma cells. |
2013-04-19 |
2023-08-12 |
human |
| Zhipeng Wang, Shaojun Zhu, Min Shen, Juanjuan Liu, Meng Wang, Chen Li, Yukun Wang, Anmei Deng, Qibing Me. STAT3 is involved in esophageal carcinogenesis through regulation of Oct-1. Carcinogenesis. vol 34. issue 3. 2013-04-19. PMID:23172665. |
constitutively activated stat3 in normal human esophageal epithelium cells (het-1a) elevated oct-1 expression,and promoted proliferation and decreased apoptosis. |
2013-04-19 |
2023-08-12 |
human |
| Zhipeng Wang, Shaojun Zhu, Min Shen, Juanjuan Liu, Meng Wang, Chen Li, Yukun Wang, Anmei Deng, Qibing Me. STAT3 is involved in esophageal carcinogenesis through regulation of Oct-1. Carcinogenesis. vol 34. issue 3. 2013-04-19. PMID:23172665. |
together, our results indicate that stat3 plays a crucial role in esophageal carcinogenesis by regulating the cell proliferation and apoptosis in conjunction with oct-1. |
2013-04-19 |
2023-08-12 |
human |
| Craig M Nelson, Ryne A Gorsuch, Travis J Bailey, Kristin M Ackerman, Sean C Kassen, David R Hyd. Stat3 defines three populations of Müller glia and is required for initiating maximal müller glia proliferation in the regenerating zebrafish retina. The Journal of comparative neurology. vol 520. issue 18. 2013-04-18. PMID:22886421. |
immunohistochemical analysis was employed to determine the temporal and spatial expression of stat3 and ascl1a proteins following rod and cone photoreceptor cell apoptosis. |
2013-04-18 |
2023-08-12 |
zebrafish |
| Craig M Nelson, Ryne A Gorsuch, Travis J Bailey, Kristin M Ackerman, Sean C Kassen, David R Hyd. Stat3 defines three populations of Müller glia and is required for initiating maximal müller glia proliferation in the regenerating zebrafish retina. The Journal of comparative neurology. vol 520. issue 18. 2013-04-18. PMID:22886421. |
knockdown of stat3 protein expression did not affect photoreceptor apoptosis, but significantly reduced, without abolishing, the number of proliferating ascl1a-positive müller glia. |
2013-04-18 |
2023-08-12 |
zebrafish |
| Craig M Nelson, Ryne A Gorsuch, Travis J Bailey, Kristin M Ackerman, Sean C Kassen, David R Hyd. Stat3 defines three populations of Müller glia and is required for initiating maximal müller glia proliferation in the regenerating zebrafish retina. The Journal of comparative neurology. vol 520. issue 18. 2013-04-18. PMID:22886421. |
knockdown of ascl1a protein also did not change the extent of photoreceptor apoptosis, but did yield significantly fewer müller glia that reentered the cell cycle relative to the stat3 morphant and significantly decreased the number and intensity of stat3-expressing müller glia. |
2013-04-18 |
2023-08-12 |
zebrafish |
| Aling Shen, Youqin Chen, Fei Hong, Jiumao Lin, Lihui Wei, Zhenfeng Hong, Thomas J Sferra, Jun Pen. Pien Tze Huang suppresses IL-6-inducible STAT3 activation in human colon carcinoma cells through induction of SOCS3. Oncology reports. vol 28. issue 6. 2013-04-16. PMID:23027374. |
in the present study, we found that pzh could significantly and dose-dependently inhibit il-6-mediated increase of stat3 phosphorylation levels and transcriptional activity in the human colon carcinoma ht-29 cells, resulting in the suppression of cell proliferation and the induction of apoptosis. |
2013-04-16 |
2023-08-12 |
human |
| Eduardo Martinez-Abundis, Venkatesh Rajapurohitam, James V Haist, Xiaohong T Gan, Morris Karmazy. The obesity-related peptide leptin sensitizes cardiac mitochondria to calcium-induced permeability transition pore opening and apoptosis. PloS one. vol 7. issue 7. 2013-04-09. PMID:22848545. |
these effects were associated with increased apoptosis as evidenced by increased tunel staining and caspase 3 activity, both of which were prevented by the transition pore inhibitor sanglifehrin a. leptin enhanced stat3 activation whereas a stat 3 inhibitor peptide prevented leptin-induced mitochondrial transition pore opening as well as the hypertrophic and pro-apoptotic effects of the peptide. |
2013-04-09 |
2023-08-12 |
rat |
| Yanwu Liu, Lingjuan Wang, Yaoping Wu, Changwei Lv, Xinkui Li, Xiaorui Cao, Min Yang, Dapeng Feng, Zhuojing Lu. Pterostilbene exerts antitumor activity against human osteosarcoma cells by inhibiting the JAK2/STAT3 signaling pathway. Toxicology. vol 304. 2013-04-08. PMID:23313376. |
pte also down-regulated the expression of stat3 target genes, including the anti-apoptotic proteins bcl-xl and mcl-1, leading to the up-regulation of mitochondrial apoptosis pathway-related proteins (bax, bak, cytosolic cytochrome c, and cleaved caspase3) and cyclin-dependent kinase inhibitors such as p21 and p27. |
2013-04-08 |
2023-08-12 |
human |
| Xiaoyan Wang, Guozhu Wang, Yi Zhao, Xiaoan Liu, Qiang Ding, Jingping Shi, Yin Ding, Shui Wan. STAT3 mediates resistance of CD44(+)CD24(-/low) breast cancer stem cells to tamoxifen in vitro. Journal of biomedical research. vol 26. issue 5. 2013-04-05. PMID:23554768. |
cell cycle, apoptosis, stat3 and phospho-stat3 changes were observed after treatment with tamoxifen. |
2013-04-05 |
2023-08-12 |
Not clear |
| Zhenzhen Zhang, Tingmei Ye, Xueting Cai, Jie Yang, Wuguang Lu, Chunping Hu, Zhigang Wang, Xiaoning Wang, Peng Ca. 5,7-Dihydroxyflavone Enhances the Apoptosis-Inducing Potential of TRAIL in Human Tumor Cells via Regulation of Apoptosis-Related Proteins. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2013-03-28. PMID:23533482. |
5,7-dihydroxyflavone up-regulated the expression of pro-apoptotic protein bax, attenuated the expression of anti-apoptotic proteins bcl-2, mcl-1, and iaps, and reduced the phosphorylation levels of akt and stat3, weakening the anti-apoptotic signals thus facilitating the process of apoptosis. |
2013-03-28 |
2023-08-12 |
mouse |
| Matthew A Bill, Courtney Nicholas, Thomas A Mace, Jonathan P Etter, Chenglong Li, Eric B Schwartz, James R Fuchs, Gregory S Young, Li Lin, Jiayuh Lin, Lei He, Mitch Phelps, Pui-Kai Li, Gregory B Lesinsk. Structurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines. PloS one. vol 7. issue 8. 2013-03-22. PMID:22899991. |
structurally modified curcumin analogs inhibit stat3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines. |
2013-03-22 |
2023-08-12 |
human |
| Matthew A Bill, Courtney Nicholas, Thomas A Mace, Jonathan P Etter, Chenglong Li, Eric B Schwartz, James R Fuchs, Gregory S Young, Li Lin, Jiayuh Lin, Lei He, Mitch Phelps, Pui-Kai Li, Gregory B Lesinsk. Structurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines. PloS one. vol 7. issue 8. 2013-03-22. PMID:22899991. |
these compounds reduced basal stat3 phosphorylation (pstat3), and induced apoptosis in four separate human rcc cell lines and in human melanoma cell lines as determined by annexin v/pi staining. |
2013-03-22 |
2023-08-12 |
human |
| Olga A Timofeeva, Nadya I Tarasova, Xueping Zhang, Sergey Chasovskikh, Amrita K Cheema, Honghe Wang, Milton L Brown, Anatoly Dritschil. STAT3 suppresses transcription of proapoptotic genes in cancer cells with the involvement of its N-terminal domain. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 4. 2013-03-21. PMID:23288901. |
activation of stat3 in cancers leads to gene expression promoting cell proliferation and resistance to apoptosis, as well as tumor angiogenesis, invasion, and migration. |
2013-03-21 |
2023-08-12 |
human |