| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chunhua Yu, Qiuyang Zhang, Hui Ying Zhang, Xi Zhang, Xiaofang Huo, Edaire Cheng, David H Wang, Jack L Arbiser, Stuart Jon Spechler, Rhonda F Souz. Targeting the intrinsic inflammatory pathway: honokiol exerts proapoptotic effects through STAT3 inhibition in transformed Barrett's cells. American journal of physiology. Gastrointestinal and liver physiology. vol 303. issue 5. 2012-12-11. PMID:22744336. |
we used human barrett's epithelial and esophageal adenocarcinoma cell lines to determine effects of honokiol on cell number, necrosis, apoptosis, and anchorage-independent growth and to explore stat3's role in those effects. |
2012-12-11 |
2023-08-12 |
human |
| Chunhua Yu, Qiuyang Zhang, Hui Ying Zhang, Xi Zhang, Xiaofang Huo, Edaire Cheng, David H Wang, Jack L Arbiser, Stuart Jon Spechler, Rhonda F Souz. Targeting the intrinsic inflammatory pathway: honokiol exerts proapoptotic effects through STAT3 inhibition in transformed Barrett's cells. American journal of physiology. Gastrointestinal and liver physiology. vol 303. issue 5. 2012-12-11. PMID:22744336. |
cells were infected with constitutively active stat3-c to assess effects of honokiol-induced stat3 inhibition on apoptosis. |
2012-12-11 |
2023-08-12 |
human |
| Chunhua Yu, Qiuyang Zhang, Hui Ying Zhang, Xi Zhang, Xiaofang Huo, Edaire Cheng, David H Wang, Jack L Arbiser, Stuart Jon Spechler, Rhonda F Souz. Targeting the intrinsic inflammatory pathway: honokiol exerts proapoptotic effects through STAT3 inhibition in transformed Barrett's cells. American journal of physiology. Gastrointestinal and liver physiology. vol 303. issue 5. 2012-12-11. PMID:22744336. |
within 30 min of honokiol treatment, transformed barrett's cells decreased expression of phosphorylated stat3; decreases in ras activity and phosphorylated erk1/2 expression were detected at 24 h. infection with stat3-c significantly reduced apoptosis after honokiol treatment. |
2012-12-11 |
2023-08-12 |
human |
| Chunhua Yu, Qiuyang Zhang, Hui Ying Zhang, Xi Zhang, Xiaofang Huo, Edaire Cheng, David H Wang, Jack L Arbiser, Stuart Jon Spechler, Rhonda F Souz. Targeting the intrinsic inflammatory pathway: honokiol exerts proapoptotic effects through STAT3 inhibition in transformed Barrett's cells. American journal of physiology. Gastrointestinal and liver physiology. vol 303. issue 5. 2012-12-11. PMID:22744336. |
honokiol causes necrosis and apoptosis in transformed barrett's and esophageal adenocarcinoma cells, but not in nontransformed barrett's cells, and the proapoptotic effects of honokiol are mediated by its inhibition of stat3 signaling. |
2012-12-11 |
2023-08-12 |
human |
| Wan Du, Jie Hong, Ying-Chao Wang, Yan-Jie Zhang, Ping Wang, Wen-Yu Su, Yan-Wei Lin, Rong Lu, Wei-Ping Zou, Hua Xiong, Jing-Yuan Fan. Inhibition of JAK2/STAT3 signalling induces colorectal cancer cell apoptosis via mitochondrial pathway. Journal of cellular and molecular medicine. vol 16. issue 8. 2012-12-03. PMID:22050790. |
to investigate the role of both jak2 and stat3 in the mechanism underlying crc apoptosis, we inhibited jak2 with ag490 and depleted stat3 with a small interfering rna. |
2012-12-03 |
2023-08-12 |
Not clear |
| Karolina Swiatek-Machado, Bozena Kaminsk. STAT signaling in glioma cells. Advances in experimental medicine and biology. vol 986. 2012-11-29. PMID:22879070. |
while stat1 is believed to play an important role in growth arrest and apoptosis, and to act as a tumor suppressor, stat3 and 5 are involved in promoting cell cycle progression, cellular transformation, and preventing apoptosis. |
2012-11-29 |
2023-08-12 |
human |
| Brent J Tierney, Georgia A McCann, David E Cohn, Eric Eisenhauer, Meryl Sudhakar, Periannan Kuppusamy, Kálmán Hideg, Karuppaiyah Selvendira. HO-3867, a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1-mutated ovarian cancer cells. Cancer biology & therapy. vol 13. issue 9. 2012-11-26. PMID:22801507. |
ho-3867, a stat3 inhibitor induces apoptosis by inactivation of stat3 activity in brca1-mutated ovarian cancer cells. |
2012-11-26 |
2023-08-12 |
Not clear |
| Brent J Tierney, Georgia A McCann, David E Cohn, Eric Eisenhauer, Meryl Sudhakar, Periannan Kuppusamy, Kálmán Hideg, Karuppaiyah Selvendira. HO-3867, a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1-mutated ovarian cancer cells. Cancer biology & therapy. vol 13. issue 9. 2012-11-26. PMID:22801507. |
in addition, overexpression of stat3 cdna provided resistance to ho-3867-induced apoptosis. |
2012-11-26 |
2023-08-12 |
Not clear |
| J L Ríos, I Andújar, J M Escandell, R M Giner, M C Reci. Cucurbitacins as inducers of cell death and a rich source of potential anticancer compounds. Current pharmaceutical design. vol 18. issue 12. 2012-10-17. PMID:22443631. |
in general, cucurbitacins are considered to be selective inhibitors of the jak/stat pathways; however, other mechanisms may be implicated in their apoptotic effects, including the mapk pathway (known to be important for cancer cell proliferation and survival), parp cleavage, expression of active caspase-3, decreased pstat3 and jak3 levels, as well as decreases in various downstream stat3 targets such as mcl-1, bcl-2, bcl-xl, and cyclin d3, all of which are implicated in apoptosis and the cell cycle. |
2012-10-17 |
2023-08-12 |
Not clear |
| Mercedes Tkach, Lorena Coria, Cinthia Rosemblit, Martín A Rivas, Cecilia J Proietti, María Celeste Díaz Flaqué, Wendy Beguelin, Isabel Frahm, Eduardo H Charreau, Juliana Cassataro, Patricia V Elizalde, Roxana Schillac. Targeting Stat3 induces senescence in tumor cells and elicits prophylactic and therapeutic immune responses against breast cancer growth mediated by NK cells and CD4+ T cells. Journal of immunology (Baltimore, Md. : 1950). vol 189. issue 3. 2012-10-15. PMID:22753933. |
aberrant stat3 activation and signaling contribute to malignant transformation by promoting cell cycle progression, inhibiting apoptosis, and mediating tumor immune evasion. |
2012-10-15 |
2023-08-12 |
mouse |
| Hye-Sook Seo, Han-Seok Choi, Soon-Re Kim, Youn Kyung Choi, Sang-Mi Woo, Incheol Shin, Jong-Kyu Woo, Sang-Yoon Park, Yong Cheol Shin, Seong-Gyu Ko, Seong-Kyu K. Apigenin induces apoptosis via extrinsic pathway, inducing p53 and inhibiting STAT3 and NFκB signaling in HER2-overexpressing breast cancer cells. Molecular and cellular biochemistry. vol 366. issue 1-2. 2012-10-09. PMID:22527937. |
apigenin induces apoptosis via extrinsic pathway, inducing p53 and inhibiting stat3 and nfκb signaling in her2-overexpressing breast cancer cells. |
2012-10-09 |
2023-08-12 |
Not clear |
| Andrzej Wincewicz, Mariola Sulkowska, Ryszard Rutkowski, Stanislaw Sulkowski, Boguslaw Musiatowicz, Tomasz Hirnle, Waldemar Famulski, Mariusz Koda, Grzegorz Sokol, Przemyslaw Szarejk. STAT1 and STAT3 as intracellular regulators of vascular remodeling. European journal of internal medicine. vol 18. issue 4. 2012-10-02. PMID:17574099. |
stat3 can contribute to counteracting apoptosis by eventual cooperation with c-fos and the bcl-xl gene. |
2012-10-02 |
2023-08-12 |
Not clear |
| Guotai Xu, Cai Zhang, Jian Zhan. Dominant negative STAT3 suppresses the growth and invasion capability of human lung cancer cells. Molecular medicine reports. vol 2. issue 5. 2012-10-02. PMID:21475907. |
overexpressed stat3β specifically blocked stat3 transcriptional activation, inhibiting the proliferation and augmenting the apoptosis of human lung cancer cells. |
2012-10-02 |
2023-08-12 |
human |
| Adetola L Shodeinde, Beverly E Barto. Potential use of STAT3 inhibitors in targeted prostate cancer therapy: future prospects. OncoTargets and therapy. vol 5. 2012-10-02. PMID:22815644. |
more important, inhibition of stat3 has been shown to induce apoptosis in prostate cancer cells. |
2012-10-02 |
2023-08-12 |
Not clear |
| P K Kandala, S K Srivastav. Regulation of Janus-activated kinase-2 (JAK2) by diindolylmethane in ovarian cancer in vitro and in vivo. Drug discoveries & therapeutics. vol 6. issue 2. 2012-09-25. PMID:22622019. |
we have reported previously that diindolylmethane (dim) induces apoptosis in ovarian cancer cells by inhibiting stat3. |
2012-09-25 |
2023-08-12 |
mouse |
| Grace-Ifeyinwa Onimoe, Aiguo Liu, Li Lin, Chang-Ching Wei, Eric B Schwartz, Deepak Bhasin, Chenglong Li, James R Fuchs, Pui-kai Li, Peter Houghton, Amanda Termuhlen, Thomas Gross, Jiayuh Li. Small molecules, LLL12 and FLLL32, inhibit STAT3 and exhibit potent growth suppressive activity in osteosarcoma cells and tumor growth in mice. Investigational new drugs. vol 30. issue 3. 2012-09-20. PMID:21340507. |
the inhibition of stat3 by lll12 and flll32 resulted in the induction of apoptosis, reduction of plating efficiency, and migration in osteosarcoma cells. |
2012-09-20 |
2023-08-12 |
mouse |
| Ping Liu, Xin Wang, Chunhong Hu, Tiehui H. Inhibition of proliferation and induction of apoptosis by trimethoxyl stilbene (TMS) in a lung cancer cell line. Asian Pacific journal of cancer prevention : APJCP. vol 12. issue 9. 2012-09-18. PMID:22296367. |
tms inhibited proliferation (ic50 8.6 μmol/l) and induced apoptosis of the cells in a concentration-dependent manner., also inducing apoptosis accompanied by up-regulated expression and cleavage activation of caspase-3, up-regulation of iκb and down-regulation of nfκb, stat3, stat5b, and jak2 signal transduction. |
2012-09-18 |
2023-08-12 |
Not clear |
| M Zhao, B Jiang, F-H Ga. Small molecule inhibitors of STAT3 for cancer therapy. Current medicinal chemistry. vol 18. issue 26. 2012-09-17. PMID:21824090. |
constitutive stat3 activity induces specific target genes that stimulate cell proliferation, prevent apoptosis, promote angiogenesis and facilitate tumor immune evasion. |
2012-09-17 |
2023-08-12 |
human |
| Shoichi Ihara, Hiroshi Kida, Hisashi Arase, Lokesh P Tripathi, Yi-An Chen, Tetsuya Kimura, Mitsuhiro Yoshida, Yozo Kashiwa, Haruhiko Hirata, Reiko Fukamizu, Ruriko Inoue, Kana Hasegawa, Sho Goya, Ryo Takahashi, Toshiyuki Minami, Kazuyuki Tsujino, Mayumi Suzuki, Satoshi Kohmo, Koji Inoue, Izumi Nagatomo, Yoshito Takeda, Takashi Kijima, Kenji Mizuguchi, Isao Tachibana, Atsushi Kumanogo. Inhibitory roles of signal transducer and activator of transcription 3 in antitumor immunity during carcinogen-induced lung tumorigenesis. Cancer research. vol 72. issue 12. 2012-09-04. PMID:22659452. |
stat3 mediates a complex spectrum of cellular responses, including inflammation, cell proliferation, and apoptosis. |
2012-09-04 |
2023-08-12 |
mouse |
| Shoichi Ihara, Hiroshi Kida, Hisashi Arase, Lokesh P Tripathi, Yi-An Chen, Tetsuya Kimura, Mitsuhiro Yoshida, Yozo Kashiwa, Haruhiko Hirata, Reiko Fukamizu, Ruriko Inoue, Kana Hasegawa, Sho Goya, Ryo Takahashi, Toshiyuki Minami, Kazuyuki Tsujino, Mayumi Suzuki, Satoshi Kohmo, Koji Inoue, Izumi Nagatomo, Yoshito Takeda, Takashi Kijima, Kenji Mizuguchi, Isao Tachibana, Atsushi Kumanogo. Inhibitory roles of signal transducer and activator of transcription 3 in antitumor immunity during carcinogen-induced lung tumorigenesis. Cancer research. vol 72. issue 12. 2012-09-04. PMID:22659452. |
although stat3(Δ/Δ) mice did not show any lung defects in terms of proliferation, apoptosis, or angiogenesis, they exhibited reduced urethane-induced tumorigenesis and increased antitumor inflammation and natural killer (nk) cell immunity. |
2012-09-04 |
2023-08-12 |
mouse |