| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Craig M Nelson, Ryne A Gorsuch, Travis J Bailey, Kristin M Ackerman, Sean C Kassen, David R Hyd. Stat3 defines three populations of Müller glia and is required for initiating maximal müller glia proliferation in the regenerating zebrafish retina. The Journal of comparative neurology. vol 520. issue 18. 2013-04-18. PMID:22886421. |
knockdown of stat3 protein expression did not affect photoreceptor apoptosis, but significantly reduced, without abolishing, the number of proliferating ascl1a-positive müller glia. |
2013-04-18 |
2023-08-12 |
zebrafish |
| Craig M Nelson, Ryne A Gorsuch, Travis J Bailey, Kristin M Ackerman, Sean C Kassen, David R Hyd. Stat3 defines three populations of Müller glia and is required for initiating maximal müller glia proliferation in the regenerating zebrafish retina. The Journal of comparative neurology. vol 520. issue 18. 2013-04-18. PMID:22886421. |
knockdown of ascl1a protein also did not change the extent of photoreceptor apoptosis, but did yield significantly fewer müller glia that reentered the cell cycle relative to the stat3 morphant and significantly decreased the number and intensity of stat3-expressing müller glia. |
2013-04-18 |
2023-08-12 |
zebrafish |
| Aling Shen, Youqin Chen, Fei Hong, Jiumao Lin, Lihui Wei, Zhenfeng Hong, Thomas J Sferra, Jun Pen. Pien Tze Huang suppresses IL-6-inducible STAT3 activation in human colon carcinoma cells through induction of SOCS3. Oncology reports. vol 28. issue 6. 2013-04-16. PMID:23027374. |
in the present study, we found that pzh could significantly and dose-dependently inhibit il-6-mediated increase of stat3 phosphorylation levels and transcriptional activity in the human colon carcinoma ht-29 cells, resulting in the suppression of cell proliferation and the induction of apoptosis. |
2013-04-16 |
2023-08-12 |
human |
| Eduardo Martinez-Abundis, Venkatesh Rajapurohitam, James V Haist, Xiaohong T Gan, Morris Karmazy. The obesity-related peptide leptin sensitizes cardiac mitochondria to calcium-induced permeability transition pore opening and apoptosis. PloS one. vol 7. issue 7. 2013-04-09. PMID:22848545. |
these effects were associated with increased apoptosis as evidenced by increased tunel staining and caspase 3 activity, both of which were prevented by the transition pore inhibitor sanglifehrin a. leptin enhanced stat3 activation whereas a stat 3 inhibitor peptide prevented leptin-induced mitochondrial transition pore opening as well as the hypertrophic and pro-apoptotic effects of the peptide. |
2013-04-09 |
2023-08-12 |
rat |
| Yanwu Liu, Lingjuan Wang, Yaoping Wu, Changwei Lv, Xinkui Li, Xiaorui Cao, Min Yang, Dapeng Feng, Zhuojing Lu. Pterostilbene exerts antitumor activity against human osteosarcoma cells by inhibiting the JAK2/STAT3 signaling pathway. Toxicology. vol 304. 2013-04-08. PMID:23313376. |
pte also down-regulated the expression of stat3 target genes, including the anti-apoptotic proteins bcl-xl and mcl-1, leading to the up-regulation of mitochondrial apoptosis pathway-related proteins (bax, bak, cytosolic cytochrome c, and cleaved caspase3) and cyclin-dependent kinase inhibitors such as p21 and p27. |
2013-04-08 |
2023-08-12 |
human |
| Xiaoyan Wang, Guozhu Wang, Yi Zhao, Xiaoan Liu, Qiang Ding, Jingping Shi, Yin Ding, Shui Wan. STAT3 mediates resistance of CD44(+)CD24(-/low) breast cancer stem cells to tamoxifen in vitro. Journal of biomedical research. vol 26. issue 5. 2013-04-05. PMID:23554768. |
cell cycle, apoptosis, stat3 and phospho-stat3 changes were observed after treatment with tamoxifen. |
2013-04-05 |
2023-08-12 |
Not clear |
| Zhenzhen Zhang, Tingmei Ye, Xueting Cai, Jie Yang, Wuguang Lu, Chunping Hu, Zhigang Wang, Xiaoning Wang, Peng Ca. 5,7-Dihydroxyflavone Enhances the Apoptosis-Inducing Potential of TRAIL in Human Tumor Cells via Regulation of Apoptosis-Related Proteins. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2013-03-28. PMID:23533482. |
5,7-dihydroxyflavone up-regulated the expression of pro-apoptotic protein bax, attenuated the expression of anti-apoptotic proteins bcl-2, mcl-1, and iaps, and reduced the phosphorylation levels of akt and stat3, weakening the anti-apoptotic signals thus facilitating the process of apoptosis. |
2013-03-28 |
2023-08-12 |
mouse |
| Matthew A Bill, Courtney Nicholas, Thomas A Mace, Jonathan P Etter, Chenglong Li, Eric B Schwartz, James R Fuchs, Gregory S Young, Li Lin, Jiayuh Lin, Lei He, Mitch Phelps, Pui-Kai Li, Gregory B Lesinsk. Structurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines. PloS one. vol 7. issue 8. 2013-03-22. PMID:22899991. |
structurally modified curcumin analogs inhibit stat3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines. |
2013-03-22 |
2023-08-12 |
human |
| Matthew A Bill, Courtney Nicholas, Thomas A Mace, Jonathan P Etter, Chenglong Li, Eric B Schwartz, James R Fuchs, Gregory S Young, Li Lin, Jiayuh Lin, Lei He, Mitch Phelps, Pui-Kai Li, Gregory B Lesinsk. Structurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines. PloS one. vol 7. issue 8. 2013-03-22. PMID:22899991. |
these compounds reduced basal stat3 phosphorylation (pstat3), and induced apoptosis in four separate human rcc cell lines and in human melanoma cell lines as determined by annexin v/pi staining. |
2013-03-22 |
2023-08-12 |
human |
| Olga A Timofeeva, Nadya I Tarasova, Xueping Zhang, Sergey Chasovskikh, Amrita K Cheema, Honghe Wang, Milton L Brown, Anatoly Dritschil. STAT3 suppresses transcription of proapoptotic genes in cancer cells with the involvement of its N-terminal domain. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 4. 2013-03-21. PMID:23288901. |
activation of stat3 in cancers leads to gene expression promoting cell proliferation and resistance to apoptosis, as well as tumor angiogenesis, invasion, and migration. |
2013-03-21 |
2023-08-12 |
human |
| Burçin Tezcanlı Kaymaz, Nur Selvi, Cumhur Gündüz, Cağdaş Aktan, Ayşegül Dalmızrak, Güray Saydam, Buket Kosov. Repression of STAT3, STAT5A, and STAT5B expressions in chronic myelogenous leukemia cell line K-562 with unmodified or chemically modified siRNAs and induction of apoptosis. Annals of hematology. vol 92. issue 2. 2013-03-07. PMID:23053176. |
repression of stat3, stat5a, and stat5b expressions in chronic myelogenous leukemia cell line k-562 with unmodified or chemically modified sirnas and induction of apoptosis. |
2013-03-07 |
2023-08-12 |
Not clear |
| Xiaodong Song, Meirong Wang, Lixia Zhang, Jinjin Zhang, Xiuwen Wang, Wenbo Liu, Xinbin Gu, Changjun L. Changes in cell ultrastructure and inhibition of JAK1/STAT3 signaling pathway in CBRH-7919 cells with astaxanthin. Toxicology mechanisms and methods. vol 22. issue 9. 2013-03-04. PMID:22889354. |
cell apoptosis was evaluated and the expressions of jak1, stat3, non-metastasis23-1 (nm23-1), and apoptotic gene like b-cell lymphoma/leukemia-2 (bcl-2), b-cell lymphoma-extra large (bcl-xl), proto-oncogene proteins c myc (c-myc) and bcl-2- associated x (bax) were also examined. |
2013-03-04 |
2023-08-12 |
rat |
| Chen-Ti Wang, Chen-Si Lin, Chung-Wai Shiau, Pei-Yi Chu, Chung-Ching Hsiao, Yi-Lun Chiang, Wei-Tien Tai, Kuen-Feng Che. SC-1, a sorafenib derivative, shows anti-tumor effects in osteogenic sarcoma cells. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 31. issue 2. 2013-02-28. PMID:22926753. |
ectopic expression of stat3 in 143b cells abolished apoptosis in sc-1-treated cells. |
2013-02-28 |
2023-08-12 |
Not clear |
| Hee Jung Um, Kyoung-Jin Min, Dong Eun Kim, Taeg Kyu Kwo. Withaferin A inhibits JAK/STAT3 signaling and induces apoptosis of human renal carcinoma Caki cells. Biochemical and biophysical research communications. vol 427. issue 1. 2013-02-27. PMID:22982675. |
furthermore, overexpression of stat3 attenuated withaferin a-induced apoptosis. |
2013-02-27 |
2023-08-12 |
human |
| Hee Jung Um, Kyoung-Jin Min, Dong Eun Kim, Taeg Kyu Kwo. Withaferin A inhibits JAK/STAT3 signaling and induces apoptosis of human renal carcinoma Caki cells. Biochemical and biophysical research communications. vol 427. issue 1. 2013-02-27. PMID:22982675. |
taken together, the present study provides strong evidence that down-regulation of the stat3 signaling pathway mediates withaferin a-induced apoptosis. |
2013-02-27 |
2023-08-12 |
human |
| Shu-Ping Wu, Tsui-Chin Huang, Ching-Chun Lin, Cho-Fat Hui, Cheng-Hui Lin, Jyh-Yih Che. Pardaxin, a fish antimicrobial peptide, exhibits antitumor activity toward murine fibrosarcoma in vitro and in vivo. Marine drugs. vol 10. issue 8. 2013-02-20. PMID:23015777. |
a qrt-pcr and elisa showed that pardaxin induced apoptosis, activated caspase-7 and interleukin (il)-7r, and downregulated caspase-9, atf 3, socs3, stat3, cathelicidin, p65, and interferon (ifn)-γ suggesting that pardaxin induces apoptosis through the death receptor/nuclear factor (nf)-κb signaling pathway after 14 days of treatment in tumor-bearing mice. |
2013-02-20 |
2023-08-12 |
mouse |
| Kota Iwahori, Satoshi Serada, Minoru Fujimoto, Barry Ripley, Shintaro Nomura, Hiroyuki Mizuguchi, Kazuki Shimada, Tsuyoshi Takahashi, Ichiro Kawase, Tadamitsu Kishimoto, Tetsuji Nak. SOCS-1 gene delivery cooperates with cisplatin plus pemetrexed to exhibit preclinical antitumor activity against malignant pleural mesothelioma. International journal of cancer. vol 132. issue 2. 2013-02-07. PMID:22532243. |
socs-1 regulated nf-κb and stat3 signaling to induce apoptosis in meso-4 and h226 cells. |
2013-02-07 |
2023-08-12 |
Not clear |
| Haili Lü, Quihang Zhang, Bo Ya. [Mitochondrial mechanisms of antisense oligodeoxynucleotide Stat3 induced apoptosis in laryngeal carcinoma cell]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery. vol 26. issue 7. 2013-02-07. PMID:22737874. |
[mitochondrial mechanisms of antisense oligodeoxynucleotide stat3 induced apoptosis in laryngeal carcinoma cell]. |
2013-02-07 |
2023-08-12 |
Not clear |
| Haili Lü, Quihang Zhang, Bo Ya. [Mitochondrial mechanisms of antisense oligodeoxynucleotide Stat3 induced apoptosis in laryngeal carcinoma cell]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery. vol 26. issue 7. 2013-02-07. PMID:22737874. |
to investigate the changes of mitochondrion by transferring antisense oligodeoxynucleotide stat3 into laryngeal carcinoma hep-2 cell, for elucidating the mechanism of laryngeal carcinoma hep-2 cell apoptosis, for developing more effective treatment for laryngeal cancer. |
2013-02-07 |
2023-08-12 |
Not clear |
| Xing-Hui Shen, Xiang-Shun Cui, Sung-Hyun Lee, Nam-Hyung Ki. Interleukin-6 enhances porcine parthenote development in vitro, through the IL-6/Stat3 signaling pathway. The Journal of reproduction and development. vol 58. issue 4. 2013-02-05. PMID:22522232. |
signal transducer and activator of transcription-3 (stat3) plays a central role in interleukin-6 (il-6)-mediated cell proliferation by inhibiting apoptosis in a variety of cell types. |
2013-02-05 |
2023-08-12 |
Not clear |