Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Hye-Sook Seo, Han-Seok Choi, Soon-Re Kim, Youn Kyung Choi, Sang-Mi Woo, Incheol Shin, Jong-Kyu Woo, Sang-Yoon Park, Yong Cheol Shin, Seong-Gyu Ko, Seong-Kyu K. Apigenin induces apoptosis via extrinsic pathway, inducing p53 and inhibiting STAT3 and NFκB signaling in HER2-overexpressing breast cancer cells. Molecular and cellular biochemistry. vol 366. issue 1-2. 2012-10-09. PMID:22527937. |
apigenin induces apoptosis via extrinsic pathway, inducing p53 and inhibiting stat3 and nfκb signaling in her2-overexpressing breast cancer cells. |
2012-10-09 |
2023-08-12 |
Not clear |
Andrzej Wincewicz, Mariola Sulkowska, Ryszard Rutkowski, Stanislaw Sulkowski, Boguslaw Musiatowicz, Tomasz Hirnle, Waldemar Famulski, Mariusz Koda, Grzegorz Sokol, Przemyslaw Szarejk. STAT1 and STAT3 as intracellular regulators of vascular remodeling. European journal of internal medicine. vol 18. issue 4. 2012-10-02. PMID:17574099. |
stat3 can contribute to counteracting apoptosis by eventual cooperation with c-fos and the bcl-xl gene. |
2012-10-02 |
2023-08-12 |
Not clear |
Guotai Xu, Cai Zhang, Jian Zhan. Dominant negative STAT3 suppresses the growth and invasion capability of human lung cancer cells. Molecular medicine reports. vol 2. issue 5. 2012-10-02. PMID:21475907. |
overexpressed stat3β specifically blocked stat3 transcriptional activation, inhibiting the proliferation and augmenting the apoptosis of human lung cancer cells. |
2012-10-02 |
2023-08-12 |
human |
Adetola L Shodeinde, Beverly E Barto. Potential use of STAT3 inhibitors in targeted prostate cancer therapy: future prospects. OncoTargets and therapy. vol 5. 2012-10-02. PMID:22815644. |
more important, inhibition of stat3 has been shown to induce apoptosis in prostate cancer cells. |
2012-10-02 |
2023-08-12 |
Not clear |
P K Kandala, S K Srivastav. Regulation of Janus-activated kinase-2 (JAK2) by diindolylmethane in ovarian cancer in vitro and in vivo. Drug discoveries & therapeutics. vol 6. issue 2. 2012-09-25. PMID:22622019. |
we have reported previously that diindolylmethane (dim) induces apoptosis in ovarian cancer cells by inhibiting stat3. |
2012-09-25 |
2023-08-12 |
mouse |
Grace-Ifeyinwa Onimoe, Aiguo Liu, Li Lin, Chang-Ching Wei, Eric B Schwartz, Deepak Bhasin, Chenglong Li, James R Fuchs, Pui-kai Li, Peter Houghton, Amanda Termuhlen, Thomas Gross, Jiayuh Li. Small molecules, LLL12 and FLLL32, inhibit STAT3 and exhibit potent growth suppressive activity in osteosarcoma cells and tumor growth in mice. Investigational new drugs. vol 30. issue 3. 2012-09-20. PMID:21340507. |
the inhibition of stat3 by lll12 and flll32 resulted in the induction of apoptosis, reduction of plating efficiency, and migration in osteosarcoma cells. |
2012-09-20 |
2023-08-12 |
mouse |
Ping Liu, Xin Wang, Chunhong Hu, Tiehui H. Inhibition of proliferation and induction of apoptosis by trimethoxyl stilbene (TMS) in a lung cancer cell line. Asian Pacific journal of cancer prevention : APJCP. vol 12. issue 9. 2012-09-18. PMID:22296367. |
tms inhibited proliferation (ic50 8.6 μmol/l) and induced apoptosis of the cells in a concentration-dependent manner., also inducing apoptosis accompanied by up-regulated expression and cleavage activation of caspase-3, up-regulation of iκb and down-regulation of nfκb, stat3, stat5b, and jak2 signal transduction. |
2012-09-18 |
2023-08-12 |
Not clear |
M Zhao, B Jiang, F-H Ga. Small molecule inhibitors of STAT3 for cancer therapy. Current medicinal chemistry. vol 18. issue 26. 2012-09-17. PMID:21824090. |
constitutive stat3 activity induces specific target genes that stimulate cell proliferation, prevent apoptosis, promote angiogenesis and facilitate tumor immune evasion. |
2012-09-17 |
2023-08-12 |
human |
Shoichi Ihara, Hiroshi Kida, Hisashi Arase, Lokesh P Tripathi, Yi-An Chen, Tetsuya Kimura, Mitsuhiro Yoshida, Yozo Kashiwa, Haruhiko Hirata, Reiko Fukamizu, Ruriko Inoue, Kana Hasegawa, Sho Goya, Ryo Takahashi, Toshiyuki Minami, Kazuyuki Tsujino, Mayumi Suzuki, Satoshi Kohmo, Koji Inoue, Izumi Nagatomo, Yoshito Takeda, Takashi Kijima, Kenji Mizuguchi, Isao Tachibana, Atsushi Kumanogo. Inhibitory roles of signal transducer and activator of transcription 3 in antitumor immunity during carcinogen-induced lung tumorigenesis. Cancer research. vol 72. issue 12. 2012-09-04. PMID:22659452. |
stat3 mediates a complex spectrum of cellular responses, including inflammation, cell proliferation, and apoptosis. |
2012-09-04 |
2023-08-12 |
mouse |
Shoichi Ihara, Hiroshi Kida, Hisashi Arase, Lokesh P Tripathi, Yi-An Chen, Tetsuya Kimura, Mitsuhiro Yoshida, Yozo Kashiwa, Haruhiko Hirata, Reiko Fukamizu, Ruriko Inoue, Kana Hasegawa, Sho Goya, Ryo Takahashi, Toshiyuki Minami, Kazuyuki Tsujino, Mayumi Suzuki, Satoshi Kohmo, Koji Inoue, Izumi Nagatomo, Yoshito Takeda, Takashi Kijima, Kenji Mizuguchi, Isao Tachibana, Atsushi Kumanogo. Inhibitory roles of signal transducer and activator of transcription 3 in antitumor immunity during carcinogen-induced lung tumorigenesis. Cancer research. vol 72. issue 12. 2012-09-04. PMID:22659452. |
although stat3(Δ/Δ) mice did not show any lung defects in terms of proliferation, apoptosis, or angiogenesis, they exhibited reduced urethane-induced tumorigenesis and increased antitumor inflammation and natural killer (nk) cell immunity. |
2012-09-04 |
2023-08-12 |
mouse |
Eunju Park, Jinah Park, Sae-Won Han, Seock-Ah Im, Tae-You Kim, Do-Youn Oh, Yung-Jue Ban. NVP-BKM120, a novel PI3K inhibitor, shows synergism with a STAT3 inhibitor in human gastric cancer cells harboring KRAS mutations. International journal of oncology. vol 40. issue 4. 2012-08-31. PMID:22159814. |
the synergistic efficacy study demonstrated that dual pi3k and stat3 blockade showed a synergism in cells harboring mutated kras by inducing apoptosis. |
2012-08-31 |
2023-08-12 |
human |
Xiaofei Wang, Yan Zhang, Xiwen Zhang, Wenxia Tian, Wenli Feng, Tingmei Che. The curcumin analogue hydrazinocurcumin exhibits potent suppressive activity on carcinogenicity of breast cancer cells via STAT3 inhibition. International journal of oncology. vol 40. issue 4. 2012-08-31. PMID:22179587. |
the results demonstrated that compared to curcumin, hc was more effective in inhibiting stat3 phosphorylation and downregulation of an array of stat3 downstream targets which contributed to suppression of cell proliferation, loss of colony formation, depression of cell migration and invasion as well as induction of cell apoptosis. |
2012-08-31 |
2023-08-12 |
human |
Seiji Umehara, Hitoshi Fujiwara, Atsushi Shiozaki, Momoko Todo, Akinobu Furutani, Masayuki Yoneda, Atsushi Ikai, Hiroyuki Tada, Shuhei Komatsu, Daisuke Ichikawa, Kazuma Okamoto, Toshiya Ochiai, Yukihito Kokuba, Eigo Otsuj. PSK induces apoptosis through the inhibition of activated STAT3 in human esophageal carcinoma cells. International journal of oncology. vol 41. issue 1. 2012-08-31. PMID:22552778. |
psk induces apoptosis through the inhibition of activated stat3 in human esophageal carcinoma cells. |
2012-08-31 |
2023-08-12 |
human |
Seiji Umehara, Hitoshi Fujiwara, Atsushi Shiozaki, Momoko Todo, Akinobu Furutani, Masayuki Yoneda, Atsushi Ikai, Hiroyuki Tada, Shuhei Komatsu, Daisuke Ichikawa, Kazuma Okamoto, Toshiya Ochiai, Yukihito Kokuba, Eigo Otsuj. PSK induces apoptosis through the inhibition of activated STAT3 in human esophageal carcinoma cells. International journal of oncology. vol 41. issue 1. 2012-08-31. PMID:22552778. |
in the present study, stat3 was constitutively activated in kyse170 and te13 esophageal carcinoma cells, and psk inhibited proliferation and induced apoptosis in these cells in a dose-dependent manner. |
2012-08-31 |
2023-08-12 |
human |
Seiji Umehara, Hitoshi Fujiwara, Atsushi Shiozaki, Momoko Todo, Akinobu Furutani, Masayuki Yoneda, Atsushi Ikai, Hiroyuki Tada, Shuhei Komatsu, Daisuke Ichikawa, Kazuma Okamoto, Toshiya Ochiai, Yukihito Kokuba, Eigo Otsuj. PSK induces apoptosis through the inhibition of activated STAT3 in human esophageal carcinoma cells. International journal of oncology. vol 41. issue 1. 2012-08-31. PMID:22552778. |
based on these findings, the relationship between stat3 and apoptosis in these cells was investigated. |
2012-08-31 |
2023-08-12 |
human |
Seiji Umehara, Hitoshi Fujiwara, Atsushi Shiozaki, Momoko Todo, Akinobu Furutani, Masayuki Yoneda, Atsushi Ikai, Hiroyuki Tada, Shuhei Komatsu, Daisuke Ichikawa, Kazuma Okamoto, Toshiya Ochiai, Yukihito Kokuba, Eigo Otsuj. PSK induces apoptosis through the inhibition of activated STAT3 in human esophageal carcinoma cells. International journal of oncology. vol 41. issue 1. 2012-08-31. PMID:22552778. |
these results indicate that psk may induce apoptosis in esophageal carcinoma cells by inhibiting the expression of activated stat3. |
2012-08-31 |
2023-08-12 |
human |
Xin-Sheng Deng, Shuiliang Wang, Anlong Deng, Bolin Liu, Susan M Edgerton, Stuart E Lind, Reema Wahdan-Alaswad, Ann D Tho. Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers. Cell cycle (Georgetown, Tex.). vol 11. issue 2. 2012-08-30. PMID:22189713. |
metformin targets stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers. |
2012-08-30 |
2023-08-12 |
human |
Xin-Sheng Deng, Shuiliang Wang, Anlong Deng, Bolin Liu, Susan M Edgerton, Stuart E Lind, Reema Wahdan-Alaswad, Ann D Tho. Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers. Cell cycle (Georgetown, Tex.). vol 11. issue 2. 2012-08-30. PMID:22189713. |
ca-stat3 transfection attenuated, whereas stat3 knockdown enhanced, the effects of metformin upon growth inhibition and apoptosis induction. |
2012-08-30 |
2023-08-12 |
human |
Xin-Sheng Deng, Shuiliang Wang, Anlong Deng, Bolin Liu, Susan M Edgerton, Stuart E Lind, Reema Wahdan-Alaswad, Ann D Tho. Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers. Cell cycle (Georgetown, Tex.). vol 11. issue 2. 2012-08-30. PMID:22189713. |
a stat3 specific inhibitor acted synergistically with metformin in reducing cell growth and inducing apoptosis. |
2012-08-30 |
2023-08-12 |
human |
Dong-bo Liu, Guang-yuan Hu, Guo-xian Long, Hong Qiu, Qi Mei, Guo-qing H. Celecoxib induces apoptosis and cell-cycle arrest in nasopharyngeal carcinoma cell lines via inhibition of STAT3 phosphorylation. Acta pharmacologica Sinica. vol 33. issue 5. 2012-08-28. PMID:22504904. |
celecoxib induces apoptosis and cell-cycle arrest in nasopharyngeal carcinoma cell lines via inhibition of stat3 phosphorylation. |
2012-08-28 |
2023-08-12 |
Not clear |