| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qunchuan Zhuang, Fei Hong, Aling Shen, Liangpu Zheng, Jianwei Zeng, Wei Lin, Youqin Chen, Thomas J Sferra, Zhenfeng Hong, Jun Pen. Pien Tze Huang inhibits tumor cell proliferation and promotes apoptosis via suppressing the STAT3 pathway in a colorectal cancer mouse model. International journal of oncology. vol 40. issue 5. 2012-06-29. PMID:22218594. |
consequently, the inhibitory effect of pzh on stat3 activation resulted in the up-regulation of bax/bcl-2 ratio as well as down-regulation of cyclin d1 and cdk4 expression, leading to the induction of apoptosis as well as the inhibition of cell proliferation. |
2012-06-29 |
2023-08-12 |
mouse |
| Qunchuan Zhuang, Fei Hong, Aling Shen, Liangpu Zheng, Jianwei Zeng, Wei Lin, Youqin Chen, Thomas J Sferra, Zhenfeng Hong, Jun Pen. Pien Tze Huang inhibits tumor cell proliferation and promotes apoptosis via suppressing the STAT3 pathway in a colorectal cancer mouse model. International journal of oncology. vol 40. issue 5. 2012-06-29. PMID:22218594. |
these results suggest that promotion of cancer cell apoptosis and inhibition of proliferation via suppression of stat3 pathway might be one of the mechanisms by which pzh treats colorectal cancer. |
2012-06-29 |
2023-08-12 |
mouse |
| Karen A Nahmod, Thomas Walther, Nadia Cambados, Natalia Fernandez, Roberto Meiss, Nils Tappenbeck, Yong Wang, Diego Raffo, Marina Simian, Anja Schwiebs, Roberto G Pozner, Juan I Fuxman Bass, Andrea G Pozzi, Jorge R Geffner, Edith C Kordon, Carolina Schere-Lev. AT1 receptor blockade delays postlactational mammary gland involution: a novel role for the renin angiotensin system. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 26. issue 5. 2012-06-29. PMID:22286690. |
we found that exogenous administration of angii in mammary glands of lactating balb/c mice induced epithelium apoptosis [2.9±0.5% (control) vs. 9.6±1.1% (angii); p < 0.001] and activation of the proapoptotic factor stat3, an effect inhibited by irbesartan, an at(1) receptor blocker. |
2012-06-29 |
2023-08-12 |
mouse |
| Sumit Kumar Hira, Partha Pratim Mann. Down regulation of CD24 and HER-2/neu in breast carcinoma cells by activated human dendritic cell. Role of STAT3. Cellular immunology. vol 275. issue 1-2. 2012-06-29. PMID:22480875. |
pretreatment of tumor cells with stat3 specific inhibitors or knocking down of stat3 by sirna makes the tumor cell more susceptible to apoptosis and dc mediated inhibition of both cd24 and her-2/neu. |
2012-06-29 |
2023-08-12 |
human |
| Yi Zhang, Jun-Wei Zhang, Guo-Yue Lv, Shu-Li Xie, Guang-Yi Wan. Effects of STAT3 gene silencing and rapamycin on apoptosis in hepatocarcinoma cells. International journal of medical sciences. vol 9. issue 3. 2012-06-25. PMID:22408571. |
effects of stat3 gene silencing and rapamycin on apoptosis in hepatocarcinoma cells. |
2012-06-25 |
2023-08-12 |
human |
| Yi Zhang, Jun-Wei Zhang, Guo-Yue Lv, Shu-Li Xie, Guang-Yi Wan. Effects of STAT3 gene silencing and rapamycin on apoptosis in hepatocarcinoma cells. International journal of medical sciences. vol 9. issue 3. 2012-06-25. PMID:22408571. |
in this study, we targeted stat3 and mtor in human hepatocellular carcinoma bel-7402 cells and examined the subsequent alterations in cellular apoptosis. |
2012-06-25 |
2023-08-12 |
human |
| Yi Zhang, Jun-Wei Zhang, Guo-Yue Lv, Shu-Li Xie, Guang-Yi Wan. Effects of STAT3 gene silencing and rapamycin on apoptosis in hepatocarcinoma cells. International journal of medical sciences. vol 9. issue 3. 2012-06-25. PMID:22408571. |
combined treatments using rapamycin and stat3 gene silencing significantly increases apoptosis in bel-7402 cells, displaying more dramatic effect than any single treatment. |
2012-06-25 |
2023-08-12 |
human |
| Kuen-Feng Chen, Jung-Chen Su, Chun-Yu Liu, Jui-Wen Huang, Kuei-Chiu Chen, Wei-Lin Chen, Wei-Tien Tai, Chung-Wai Shia. A novel obatoclax derivative, SC-2001, induces apoptosis in hepatocellular carcinoma cells through SHP-1-dependent STAT3 inactivation. Cancer letters. vol 321. issue 1. 2012-06-22. PMID:22465052. |
a novel obatoclax derivative, sc-2001, induces apoptosis in hepatocellular carcinoma cells through shp-1-dependent stat3 inactivation. |
2012-06-22 |
2023-08-12 |
Not clear |
| Kuen-Feng Chen, Jung-Chen Su, Chun-Yu Liu, Jui-Wen Huang, Kuei-Chiu Chen, Wei-Lin Chen, Wei-Tien Tai, Chung-Wai Shia. A novel obatoclax derivative, SC-2001, induces apoptosis in hepatocellular carcinoma cells through SHP-1-dependent STAT3 inactivation. Cancer letters. vol 321. issue 1. 2012-06-22. PMID:22465052. |
in conclusion, our results suggest that sc-2001 induces apoptosis in hcc, and that this effect is mediated through shp-1-dependent stat3 inactivation. |
2012-06-22 |
2023-08-12 |
Not clear |
| Hyun-Jin Nam, Keith A Ching, Julie Kan, Hwang-Phill Kim, Sae-Won Han, Seock-Ah Im, Tae-You Kim, James G Christensen, Do-Youn Oh, Yung-Jue Ban. Evaluation of the antitumor effects and mechanisms of PF00299804, a pan-HER inhibitor, alone or in combination with chemotherapy or targeted agents in gastric cancer. Molecular cancer therapeutics. vol 11. issue 2. 2012-06-18. PMID:22135232. |
pf00299804 induced apoptosis and g(1) arrest and inhibited phosphorylation of receptors in the her family and downstream signaling pathways including stat3, akt, and extracellular signal-regulated kinases (erk) in her2-amplified gastric cancer cells. |
2012-06-18 |
2023-08-12 |
Not clear |
| Wei-Tien Tai, Ann-Lii Cheng, Chung-Wai Shiau, Chun-Yu Liu, Ching-Huai Ko, Mai-Wei Lin, Pei-Jer Chen, Kuen-Feng Che. Dovitinib induces apoptosis and overcomes sorafenib resistance in hepatocellular carcinoma through SHP-1-mediated inhibition of STAT3. Molecular cancer therapeutics. vol 11. issue 2. 2012-06-18. PMID:22180308. |
dovitinib induces apoptosis and overcomes sorafenib resistance in hepatocellular carcinoma through shp-1-mediated inhibition of stat3. |
2012-06-18 |
2023-08-12 |
Not clear |
| Wei-Tien Tai, Ann-Lii Cheng, Chung-Wai Shiau, Chun-Yu Liu, Ching-Huai Ko, Mai-Wei Lin, Pei-Jer Chen, Kuen-Feng Che. Dovitinib induces apoptosis and overcomes sorafenib resistance in hepatocellular carcinoma through SHP-1-mediated inhibition of STAT3. Molecular cancer therapeutics. vol 11. issue 2. 2012-06-18. PMID:22180308. |
in addition, dovitinib induced apoptosis in two sorafenib-resistant cell lines through inhibition of stat3, and sorafenib-resistant cells showed significant activation of stat3, suggesting that targeting stat3 may be a useful approach to overcome drug resistance in hcc. |
2012-06-18 |
2023-08-12 |
Not clear |
| Wei-Tien Tai, Ann-Lii Cheng, Chung-Wai Shiau, Chun-Yu Liu, Ching-Huai Ko, Mai-Wei Lin, Pei-Jer Chen, Kuen-Feng Che. Dovitinib induces apoptosis and overcomes sorafenib resistance in hepatocellular carcinoma through SHP-1-mediated inhibition of STAT3. Molecular cancer therapeutics. vol 11. issue 2. 2012-06-18. PMID:22180308. |
in conclusion, dovitinib induces significant apoptosis in hcc cells and sorafenib-resistant cells via shp-1-mediated inhibition of stat3. |
2012-06-18 |
2023-08-12 |
Not clear |
| Li Lin, Don M Benson, Stephanie DeAngelis, Courtney E Bakan, Pui-Kai Li, Chenglong Li, Jiayuh Li. A small molecule, LLL12 inhibits constitutive STAT3 and IL-6-induced STAT3 signaling and exhibits potent growth suppressive activity in human multiple myeloma cells. International journal of cancer. vol 130. issue 6. 2012-06-01. PMID:21520044. |
lll12 specifically inhibited stat3 phosphorylation, nuclear localization, dna binding activity, down-regulated stat3 downstream genes, and induced apoptosis in mm cells. |
2012-06-01 |
2023-08-12 |
mouse |
| Li Lin, Don M Benson, Stephanie DeAngelis, Courtney E Bakan, Pui-Kai Li, Chenglong Li, Jiayuh Li. A small molecule, LLL12 inhibits constitutive STAT3 and IL-6-induced STAT3 signaling and exhibits potent growth suppressive activity in human multiple myeloma cells. International journal of cancer. vol 130. issue 6. 2012-06-01. PMID:21520044. |
importantly, lll12 significantly inhibited stat3 phosphorylation, induced apoptosis in primary mm cells which came from patients that were clinically resistant to lenalidomide and bortezomib. |
2012-06-01 |
2023-08-12 |
mouse |
| Jessie-F Fecteau, Ila S Bharati, Morgan O'Hayre, Tracy M Handel, Thomas J Kipps, Davorka Messme. Sorafenib-induced apoptosis of chronic lymphocytic leukemia cells is associated with downregulation of RAF and myeloid cell leukemia sequence 1 (Mcl-1). Molecular medicine (Cambridge, Mass.). vol 18. 2012-06-01. PMID:21979753. |
one single dose of 10 μmol/l or the repeated addition of 1 μmol/l sorafenib caused caspase-dependent apoptosis and reduced levels of phosphorylated b-raf, c-raf, extracellular signal-regulated kinase (erk), signal transducer and activator of transcription 3 (stat3) and myeloid cell leukemia sequence 1 (mcl-1) in cll cells in the presence of the microenvironment. |
2012-06-01 |
2023-08-12 |
Not clear |
| Yaming Xu, Xinyan Li, Shiyun Zhang, Di Shen, Hong Li, Yue Wu, Yongming Qiu, Yonghua Ji, Fuxue Che. Targeting Stat3 suppresses growth of U251 cell-derived tumours in nude mice. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 19. issue 3. 2012-05-31. PMID:22260960. |
we have previously shown that downregulation of stat3 decreases invasiveness and induces apoptosis in u251 human glioma cells in vitro, but to date it has been unclear whether this treatment would be beneficial in vivo. |
2012-05-31 |
2023-08-12 |
mouse |
| Yaming Xu, Xinyan Li, Shiyun Zhang, Di Shen, Hong Li, Yue Wu, Yongming Qiu, Yonghua Ji, Fuxue Che. Targeting Stat3 suppresses growth of U251 cell-derived tumours in nude mice. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 19. issue 3. 2012-05-31. PMID:22260960. |
in the present study, we found that downregulation of stat3 via rnai suppressed tumour growth in a xenograft mouse model by inducing apoptosis of u251 tumour cells and inhibiting tumour neo-angiogenesis. |
2012-05-31 |
2023-08-12 |
mouse |
| Yaming Xu, Xinyan Li, Shiyun Zhang, Di Shen, Hong Li, Yue Wu, Yongming Qiu, Yonghua Ji, Fuxue Che. Targeting Stat3 suppresses growth of U251 cell-derived tumours in nude mice. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 19. issue 3. 2012-05-31. PMID:22260960. |
we also found that stat3 rnai suppresses the expression of bcl-2 in vivo to induce apoptosis. |
2012-05-31 |
2023-08-12 |
mouse |
| Saleela M Ruwanpura, Louise McLeod, Alistair Miller, Jessica Jones, Ross Vlahos, Georg Ramm, Anthony Longano, Philip G Bardin, Steven Bozinovski, Gary P Anderson, Brendan J Jenkin. Deregulated Stat3 signaling dissociates pulmonary inflammation from emphysema in gp130 mutant mice. American journal of physiology. Lung cellular and molecular physiology. vol 302. issue 7. 2012-05-31. PMID:22268122. |
collectively, our data suggest that il-6 promotes emphysema via upregulation of stat3-independent apoptosis, whereas il-6 induction of lung inflammation occurs via stat3. |
2012-05-31 |
2023-08-12 |
mouse |