| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei-Tien Tai, Ann-Lii Cheng, Chung-Wai Shiau, Chun-Yu Liu, Ching-Huai Ko, Mai-Wei Lin, Pei-Jer Chen, Kuen-Feng Che. Dovitinib induces apoptosis and overcomes sorafenib resistance in hepatocellular carcinoma through SHP-1-mediated inhibition of STAT3. Molecular cancer therapeutics. vol 11. issue 2. 2012-06-18. PMID:22180308. |
dovitinib induces apoptosis and overcomes sorafenib resistance in hepatocellular carcinoma through shp-1-mediated inhibition of stat3. |
2012-06-18 |
2023-08-12 |
Not clear |
| Wei-Tien Tai, Ann-Lii Cheng, Chung-Wai Shiau, Chun-Yu Liu, Ching-Huai Ko, Mai-Wei Lin, Pei-Jer Chen, Kuen-Feng Che. Dovitinib induces apoptosis and overcomes sorafenib resistance in hepatocellular carcinoma through SHP-1-mediated inhibition of STAT3. Molecular cancer therapeutics. vol 11. issue 2. 2012-06-18. PMID:22180308. |
in addition, dovitinib induced apoptosis in two sorafenib-resistant cell lines through inhibition of stat3, and sorafenib-resistant cells showed significant activation of stat3, suggesting that targeting stat3 may be a useful approach to overcome drug resistance in hcc. |
2012-06-18 |
2023-08-12 |
Not clear |
| Wei-Tien Tai, Ann-Lii Cheng, Chung-Wai Shiau, Chun-Yu Liu, Ching-Huai Ko, Mai-Wei Lin, Pei-Jer Chen, Kuen-Feng Che. Dovitinib induces apoptosis and overcomes sorafenib resistance in hepatocellular carcinoma through SHP-1-mediated inhibition of STAT3. Molecular cancer therapeutics. vol 11. issue 2. 2012-06-18. PMID:22180308. |
in conclusion, dovitinib induces significant apoptosis in hcc cells and sorafenib-resistant cells via shp-1-mediated inhibition of stat3. |
2012-06-18 |
2023-08-12 |
Not clear |
| Li Lin, Don M Benson, Stephanie DeAngelis, Courtney E Bakan, Pui-Kai Li, Chenglong Li, Jiayuh Li. A small molecule, LLL12 inhibits constitutive STAT3 and IL-6-induced STAT3 signaling and exhibits potent growth suppressive activity in human multiple myeloma cells. International journal of cancer. vol 130. issue 6. 2012-06-01. PMID:21520044. |
lll12 specifically inhibited stat3 phosphorylation, nuclear localization, dna binding activity, down-regulated stat3 downstream genes, and induced apoptosis in mm cells. |
2012-06-01 |
2023-08-12 |
mouse |
| Li Lin, Don M Benson, Stephanie DeAngelis, Courtney E Bakan, Pui-Kai Li, Chenglong Li, Jiayuh Li. A small molecule, LLL12 inhibits constitutive STAT3 and IL-6-induced STAT3 signaling and exhibits potent growth suppressive activity in human multiple myeloma cells. International journal of cancer. vol 130. issue 6. 2012-06-01. PMID:21520044. |
importantly, lll12 significantly inhibited stat3 phosphorylation, induced apoptosis in primary mm cells which came from patients that were clinically resistant to lenalidomide and bortezomib. |
2012-06-01 |
2023-08-12 |
mouse |
| Jessie-F Fecteau, Ila S Bharati, Morgan O'Hayre, Tracy M Handel, Thomas J Kipps, Davorka Messme. Sorafenib-induced apoptosis of chronic lymphocytic leukemia cells is associated with downregulation of RAF and myeloid cell leukemia sequence 1 (Mcl-1). Molecular medicine (Cambridge, Mass.). vol 18. 2012-06-01. PMID:21979753. |
one single dose of 10 μmol/l or the repeated addition of 1 μmol/l sorafenib caused caspase-dependent apoptosis and reduced levels of phosphorylated b-raf, c-raf, extracellular signal-regulated kinase (erk), signal transducer and activator of transcription 3 (stat3) and myeloid cell leukemia sequence 1 (mcl-1) in cll cells in the presence of the microenvironment. |
2012-06-01 |
2023-08-12 |
Not clear |
| Yaming Xu, Xinyan Li, Shiyun Zhang, Di Shen, Hong Li, Yue Wu, Yongming Qiu, Yonghua Ji, Fuxue Che. Targeting Stat3 suppresses growth of U251 cell-derived tumours in nude mice. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 19. issue 3. 2012-05-31. PMID:22260960. |
we have previously shown that downregulation of stat3 decreases invasiveness and induces apoptosis in u251 human glioma cells in vitro, but to date it has been unclear whether this treatment would be beneficial in vivo. |
2012-05-31 |
2023-08-12 |
mouse |
| Yaming Xu, Xinyan Li, Shiyun Zhang, Di Shen, Hong Li, Yue Wu, Yongming Qiu, Yonghua Ji, Fuxue Che. Targeting Stat3 suppresses growth of U251 cell-derived tumours in nude mice. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 19. issue 3. 2012-05-31. PMID:22260960. |
in the present study, we found that downregulation of stat3 via rnai suppressed tumour growth in a xenograft mouse model by inducing apoptosis of u251 tumour cells and inhibiting tumour neo-angiogenesis. |
2012-05-31 |
2023-08-12 |
mouse |
| Yaming Xu, Xinyan Li, Shiyun Zhang, Di Shen, Hong Li, Yue Wu, Yongming Qiu, Yonghua Ji, Fuxue Che. Targeting Stat3 suppresses growth of U251 cell-derived tumours in nude mice. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 19. issue 3. 2012-05-31. PMID:22260960. |
we also found that stat3 rnai suppresses the expression of bcl-2 in vivo to induce apoptosis. |
2012-05-31 |
2023-08-12 |
mouse |
| Saleela M Ruwanpura, Louise McLeod, Alistair Miller, Jessica Jones, Ross Vlahos, Georg Ramm, Anthony Longano, Philip G Bardin, Steven Bozinovski, Gary P Anderson, Brendan J Jenkin. Deregulated Stat3 signaling dissociates pulmonary inflammation from emphysema in gp130 mutant mice. American journal of physiology. Lung cellular and molecular physiology. vol 302. issue 7. 2012-05-31. PMID:22268122. |
collectively, our data suggest that il-6 promotes emphysema via upregulation of stat3-independent apoptosis, whereas il-6 induction of lung inflammation occurs via stat3. |
2012-05-31 |
2023-08-12 |
mouse |
| Zhenjie Yin, Yan Zhang, Yu Li, Tingting Lv, Jie Liu, Xinbo Wan. Prognostic significance of STAT3 expression and its correlation with chemoresistance of non-small cell lung cancer cells. Acta histochemica. vol 114. issue 2. 2012-05-16. PMID:21549414. |
furthermore, two stably transfected cell lines (a549/shstat3 and spc-a1/shstat3) were successfully established, and rnai-mediated stat3 inhibition could significantly increase the sensitivity of nsclc cells to cisplatin by enhancing caspase-3-dependent apoptosis. |
2012-05-16 |
2023-08-12 |
Not clear |
| Xiaoying Liu, Wei Guo, Shuhong Wu, Li Wang, Ji Wang, Bingbing Dai, Edward S Kim, John V Heymach, Michael Wang, Luc Girard, John Minna, Jack A Roth, Stephen G Swisher, Bingliang Fan. Antitumor activity of a novel STAT3 inhibitor and redox modulator in non-small cell lung cancer cells. Biochemical pharmacology. vol 83. issue 10. 2012-05-14. PMID:22387047. |
blocking ros generation with the antioxidant ndga dramatically abolished nsc-743380-induced growth suppression and apoptosis, but had minimal effect on nsc-743380-induced stat3 inhibition, suggesting that stat3 inhibition is not caused by ros production. |
2012-05-14 |
2023-08-12 |
human |
| Shu Yuan Chiang, Sung-Moo Kim, Chulwon Kim, Jae-Young Um, Kyung-Ran Park, Seong Won Kim, Seok-Geun Lee, Hyeung-Jin Jang, Dongwoo Nam, Kyoo Seok Ahn, Sung-Hoon Kim, Seung-Hoon Choi, Bum Sang Shim, Yun-Cheol Na, Eun-Kyung Jeong, Somi K Cho, Kwang Seok Ah. Antiproliferative effects of Dangyuja (Citrus grandis Osbeck) leaves through suppression of constitutive signal transducer and activator of transcription 3 activation in human prostate carcinoma DU145 cells. Journal of medicinal food. vol 15. issue 2. 2012-05-07. PMID:22273151. |
consistent with stat3 inactivation, dcf down-regulated the expression of stat3 target genes, including bcl-2, bcl-xl, and cyclin d1; this correlated with the suppression of proliferation, the accumulation of cell cycle at the sub-g(1) phase, and the induction of apoptosis. |
2012-05-07 |
2023-08-12 |
human |
| Shu Yuan Chiang, Sung-Moo Kim, Chulwon Kim, Jae-Young Um, Kyung-Ran Park, Seong Won Kim, Seok-Geun Lee, Hyeung-Jin Jang, Dongwoo Nam, Kyoo Seok Ahn, Sung-Hoon Kim, Seung-Hoon Choi, Bum Sang Shim, Yun-Cheol Na, Eun-Kyung Jeong, Somi K Cho, Kwang Seok Ah. Antiproliferative effects of Dangyuja (Citrus grandis Osbeck) leaves through suppression of constitutive signal transducer and activator of transcription 3 activation in human prostate carcinoma DU145 cells. Journal of medicinal food. vol 15. issue 2. 2012-05-07. PMID:22273151. |
nobiletin, a major active constituent of dcf, could induce apoptosis via the suppression of constitutive stat3 activation. |
2012-05-07 |
2023-08-12 |
human |
| Pratibha Singh, Jonathan Hoggatt, Peirong Hu, Jennifer M Speth, Seiji Fukuda, Richard M Breyer, Louis M Pelu. Blockade of prostaglandin E2 signaling through EP1 and EP3 receptors attenuates Flt3L-dependent dendritic cell development from hematopoietic progenitor cells. Blood. vol 119. issue 7. 2012-05-01. PMID:22110249. |
inhibition of pge(2) biosynthesis reduces flt3-mediated activation of stat3 and expression of the antiapoptotic protein survivin, resulting in increased apoptosis of dc-committed progenitor cells. |
2012-05-01 |
2023-08-12 |
Not clear |
| Yi-Ping Yang, Yuh-Lih Chang, Pin-I Huang, Guang-Yuh Chiou, Ling-Ming Tseng, Shih-Hwa Chiou, Ming-Hsiung Chen, Ming-Teh Chen, Yang-Hsin Shih, Chin-Hong Chang, Chuan-Chih Hsu, Hsin-I Ma, Chin-Tien Wang, Lo-Lin Tsai, Cheng-Chia Yu, Charn-Jung Chan. Resveratrol suppresses tumorigenicity and enhances radiosensitivity in primary glioblastoma tumor initiating cells by inhibiting the STAT3 axis. Journal of cellular physiology. vol 227. issue 3. 2012-04-25. PMID:21503893. |
furthermore, treatment of gbm-cd133(+) with 100 µm rv induced apoptosis and enhanced radiosensitivity by suppressing stat3 signaling. |
2012-04-25 |
2023-08-12 |
Not clear |
| Shun Li, Ni Wang, Pnina Brod. Metastatic cells can escape the proapoptotic effects of TNF-α through increased autocrine IL-6/STAT3 signaling. Cancer research. vol 72. issue 4. 2012-04-20. PMID:22194466. |
in turn, tumor cell-derived il-6 induced gp130 and il-6r-dependent activation of stat3, leading to reduced caspase-3 activation and apoptosis. |
2012-04-20 |
2023-08-12 |
Not clear |
| Kuen-Feng Chen, Hui-Ling Chen, Chun-Yu Liu, Wei-Tien Tai, Kimihisa Ichikawa, Pei-Jer Chen, Ann-Lii Chen. Dovitinib sensitizes hepatocellular carcinoma cells to TRAIL and tigatuzumab, a novel anti-DR5 antibody, through SHP-1-dependent inhibition of STAT3. Biochemical pharmacology. vol 83. issue 6. 2012-04-13. PMID:22230479. |
here, we report that dovitinib sensitizes resistant hcc cells to trail- and tigatuzumab-induced apoptosis through inhibition of signal transducers and activators of transcription 3 (stat3). |
2012-04-13 |
2023-08-12 |
Not clear |
| Kuen-Feng Chen, Hui-Ling Chen, Chun-Yu Liu, Wei-Tien Tai, Kimihisa Ichikawa, Pei-Jer Chen, Ann-Lii Chen. Dovitinib sensitizes hepatocellular carcinoma cells to TRAIL and tigatuzumab, a novel anti-DR5 antibody, through SHP-1-dependent inhibition of STAT3. Biochemical pharmacology. vol 83. issue 6. 2012-04-13. PMID:22230479. |
knockdown of stat3 by rna-interference overcame apoptotic resistance to trail in hcc cells, and ectopic expression of stat3 in hcc cells abolished the sensitizing effect of dovitinib on trail-induced apoptosis. |
2012-04-13 |
2023-08-12 |
Not clear |
| Kuen-Feng Chen, Hui-Ling Chen, Chun-Yu Liu, Wei-Tien Tai, Kimihisa Ichikawa, Pei-Jer Chen, Ann-Lii Chen. Dovitinib sensitizes hepatocellular carcinoma cells to TRAIL and tigatuzumab, a novel anti-DR5 antibody, through SHP-1-dependent inhibition of STAT3. Biochemical pharmacology. vol 83. issue 6. 2012-04-13. PMID:22230479. |
in conclusion, dovitinib sensitizes resistant hcc cells to trail- and tigatuzumab-induced apoptosis through a novel machinery: shp-1 dependent stat3 inhibition. |
2012-04-13 |
2023-08-12 |
Not clear |