| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Heng-Chao Yu, Hong-Yan Qin, Fei He, Lin Wang, Wei Fu, Dong Liu, Feng-Cheng Guo, Liang Liang, Ke-Feng Dou, Hua Ha. Canonical notch pathway protects hepatocytes from ischemia/reperfusion injury in mice by repressing reactive oxygen species production through JAK2/STAT3 signaling. Hepatology (Baltimore, Md.). vol 54. issue 3. 2012-02-06. PMID:21633967. |
notch signal blockade resulted in down-regulation of hes5, leading to reduced formation of the hes5-stat3 complex and hypophosphorylation of stat3, which further attenuated manganese superoxide dismutase (mnsod) expression and increased ros and apoptosis. |
2012-02-06 |
2023-08-12 |
mouse |
| Heng-Chao Yu, Hong-Yan Qin, Fei He, Lin Wang, Wei Fu, Dong Liu, Feng-Cheng Guo, Liang Liang, Ke-Feng Dou, Hua Ha. Canonical notch pathway protects hepatocytes from ischemia/reperfusion injury in mice by repressing reactive oxygen species production through JAK2/STAT3 signaling. Hepatology (Baltimore, Md.). vol 54. issue 3. 2012-02-06. PMID:21633967. |
indeed, overexpression of a constitutively active stat3 rescued mnsod expression and i/r injury-induced apoptosis in the absence of notch signaling. |
2012-02-06 |
2023-08-12 |
mouse |
| Heng-Chao Yu, Hong-Yan Qin, Fei He, Lin Wang, Wei Fu, Dong Liu, Feng-Cheng Guo, Liang Liang, Ke-Feng Dou, Hua Ha. Canonical notch pathway protects hepatocytes from ischemia/reperfusion injury in mice by repressing reactive oxygen species production through JAK2/STAT3 signaling. Hepatology (Baltimore, Md.). vol 54. issue 3. 2012-02-06. PMID:21633967. |
finally, forced notch activation by ligand stimulation or hes5 overexpression reduced intracellular ros and protected hepatocytes from apoptosis after i/r injury through the activation of stat3 and mnsod expression. |
2012-02-06 |
2023-08-12 |
mouse |
| Sanjiv Dhingra, Ashim K Bagchi, Ana L Ludke, Anita K Sharma, Pawan K Singa. Akt regulates IL-10 mediated suppression of TNFα-induced cardiomyocyte apoptosis by upregulating Stat3 phosphorylation. PloS one. vol 6. issue 9. 2012-02-03. PMID:21949832. |
akt regulates il-10 mediated suppression of tnfα-induced cardiomyocyte apoptosis by upregulating stat3 phosphorylation. |
2012-02-03 |
2023-08-12 |
Not clear |
| Seong-Kyu Kim, Ki-Yeun Park, Wern-Chan Yoon, Sung-Hoon Park, Kwan-Kyu Park, Dae-Hyun Yoo, Jung-Yoon Cho. Melittin enhances apoptosis through suppression of IL-6/sIL-6R complex-induced NF-κB and STAT3 activation and Bcl-2 expression for human fibroblast-like synoviocytes in rheumatoid arthritis. Joint bone spine. vol 78. issue 5. 2012-01-31. PMID:21354845. |
melittin enhances apoptosis through suppression of il-6/sil-6r complex-induced nf-κb and stat3 activation and bcl-2 expression for human fibroblast-like synoviocytes in rheumatoid arthritis. |
2012-01-31 |
2023-08-12 |
human |
| Jinbing Zhao, Guangzhao Li, Yang Zhang, Xingfen Su, Chunhua Han. The potential role of JAK2/STAT3 pathway on the anti-apoptotic effect of recombinant human erythropoietin (rhEPO) after experimental traumatic brain injury of rats. Cytokine. vol 56. issue 2. 2012-01-30. PMID:21843949. |
as a result, we found that tbi could activate jak2 and stat3, and increase cell apoptosis in pericontusional cortex. |
2012-01-30 |
2023-08-12 |
human |
| Nicodemus Mautsa, Earl Prinsloo, Özlem Tastan Bishop, Gregory L Blatc. The PINIT domain of PIAS3: structure-function analysis of its interaction with STAT3. Journal of molecular recognition : JMR. vol 24. issue 5. 2012-01-26. PMID:21812053. |
the protein inhibitor of activated signal transducer and activator of transcription 3 (pias3) regulates the transcriptional activity of signal transducer and activator of transcription 3 (stat3) which regulates transcription of genes involved in cell growth, proliferation and apoptosis. |
2012-01-26 |
2023-08-12 |
Not clear |
| Jun Liu, Xinnv Xu, Xuequan Feng, Biao Zhang, Jinhuan Wan. Adenovirus-mediated delivery of bFGF small interfering RNA reduces STAT3 phosphorylation and induces the depolarization of mitochondria and apoptosis in glioma cells U251. Journal of experimental & clinical cancer research : CR. vol 30. 2012-01-17. PMID:21906308. |
adenovirus-mediated delivery of bfgf small interfering rna reduces stat3 phosphorylation and induces the depolarization of mitochondria and apoptosis in glioma cells u251. |
2012-01-17 |
2023-08-12 |
human |
| Jun Liu, Xinnv Xu, Xuequan Feng, Biao Zhang, Jinhuan Wan. Adenovirus-mediated delivery of bFGF small interfering RNA reduces STAT3 phosphorylation and induces the depolarization of mitochondria and apoptosis in glioma cells U251. Journal of experimental & clinical cancer research : CR. vol 30. 2012-01-17. PMID:21906308. |
therefore, we hypothesized that the proliferation inhibition and apoptosis induction by ad-bfgf-sirna may result from the interruption of stat3 phosphorylation. |
2012-01-17 |
2023-08-12 |
human |
| Jun Liu, Xinnv Xu, Xuequan Feng, Biao Zhang, Jinhuan Wan. Adenovirus-mediated delivery of bFGF small interfering RNA reduces STAT3 phosphorylation and induces the depolarization of mitochondria and apoptosis in glioma cells U251. Journal of experimental & clinical cancer research : CR. vol 30. 2012-01-17. PMID:21906308. |
in the current study, we found that in glioma cells u251, ad-bfgf-sirna impedes the activation of erk1/2 and jak2, but not src, decreases il-6 secretion, reduces stat3 phosphorylation, decreases the levels of downstream molecules cyclind1 and bcl-xl, and ultimately results in the collapse of mitochondrial membrane potentials as well as the induction of mitochondrial-related apoptosis. |
2012-01-17 |
2023-08-12 |
human |
| Yan Liu, Aiguo Liu, Huameng Li, Chenglong Li, Jiayuh Li. Celecoxib inhibits interleukin-6/interleukin-6 receptor-induced JAK2/STAT3 phosphorylation in human hepatocellular carcinoma cells. Cancer prevention research (Philadelphia, Pa.). vol 4. issue 8. 2012-01-05. PMID:21490132. |
our results showed that celecoxib decreased stat3 phosphorylation by reducing janus-activated kinase (jak2) phosphorylation and caused apoptosis in hcc cells. |
2012-01-05 |
2023-08-12 |
human |
| Yu-Ching Lin, Ming-Szu Hung, Chin-Kuo Lin, Jhy-Ming Li, Kuan-Der Lee, Ya-Chin Li, Miao-Fen Chen, Jan-Kan Chen, Cheng-Ta Yan. CK2 inhibitors enhance the radiosensitivity of human non-small cell lung cancer cells through inhibition of stat3 activation. Cancer biotherapy & radiopharmaceuticals. vol 26. issue 3. 2012-01-05. PMID:21711111. |
inhibition of ck2 activity can induce apoptosis and suppression of stat3 activation in cancer cells. |
2012-01-05 |
2023-08-12 |
human |
| Francesca Zammarchi, Elisa de Stanchina, Eirini Bournazou, Teerawit Supakorndej, Kathryn Martires, Elyn Riedel, Adriana D Corben, Jacqueline F Bromberg, Luca Cartegn. Antitumorigenic potential of STAT3 alternative splicing modulation. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 43. 2011-12-19. PMID:22006329. |
induction of endogenous stat3β leads to apoptosis and cell-cycle arrest in cell lines with persistent stat3 tyrosine phosphorylation compared with total stat3 knockdown obtained by forced splicing-dependent nonsense-mediated decay (fsd-nmd). |
2011-12-19 |
2023-08-12 |
Not clear |
| Yi-Chieh Nancy Du, Chen-Kung Chou, David S Klimstra, Harold Varmu. Receptor for hyaluronan-mediated motility isoform B promotes liver metastasis in a mouse model of multistep tumorigenesis and a tail vein assay for metastasis. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 40. 2011-12-13. PMID:21940500. |
in initial efforts to identify signaling pathways activated by rhamm(b), we found that rhamm(b) induced phosphorylation of epidermal growth factor receptor (egfr), erk1/2, and stat3 and conferred susceptibility to apoptosis after treatment with an egfr inhibitor, gefitinib. |
2011-12-13 |
2023-08-12 |
mouse |
| Shu Wen, Hong Li, Mo-Li Wu, Shao-Hua Fan, Qian Wang, Xiao-Hong Shu, Qing-You Kong, Xiao-Yan Chen, Jia Li. Inhibition of NF-κB signaling commits resveratrol-treated medulloblastoma cells to apoptosis without neuronal differentiation. Journal of neuro-oncology. vol 104. issue 1. 2011-12-07. PMID:21161674. |
resveratrol promotes differentiation and apoptosis of medulloblastoma cells by suppressing stat3 signaling and a range of cancer-associated gene expression. |
2011-12-07 |
2023-08-12 |
Not clear |
| Andrzej Wincewicz, Marek Baltaziak, Luiza Kanczuga-Koda, Mariusz Koda, Urszula Sulkowska, Waldemar Famulski, Stanislaw Sulkowski, Stanislaw Sulkows. STAT3 and apoptosis regulators: Bak and Bcl-xL in endometrioid adenocarcinomas of different estrogen receptor-α immunoprofile. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. vol 27. issue 8. 2011-12-05. PMID:21726118. |
stat3 and apoptosis regulators: bak and bcl-xl in endometrioid adenocarcinomas of different estrogen receptor-α immunoprofile. |
2011-12-05 |
2023-08-12 |
Not clear |
| Andrzej Wincewicz, Marek Baltaziak, Luiza Kanczuga-Koda, Mariusz Koda, Urszula Sulkowska, Waldemar Famulski, Stanislaw Sulkowski, Stanislaw Sulkows. STAT3 and apoptosis regulators: Bak and Bcl-xL in endometrioid adenocarcinomas of different estrogen receptor-α immunoprofile. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. vol 27. issue 8. 2011-12-05. PMID:21726118. |
the aim of our study was to detect immunohistochemically and compare expressions of stat3 with apoptosis regulators (bak and bcl-xl) in regard to different pathological features and variably pronounced er-α immunoprofile in 78 endometrioid adenocarcinomas. |
2011-12-05 |
2023-08-12 |
Not clear |
| Jin-Jin Zhang, You-Lei Wang, Xue-Bin Feng, Xiao-Dong Song, Wen-Bo Li. Rosmarinic acid inhibits proliferation and induces apoptosis of hepatic stellate cells. Biological & pharmaceutical bulletin. vol 34. issue 3. 2011-11-22. PMID:21372382. |
in conclusion, these results suggested that rosa was able to inhibit proliferation and induce apoptosis in hsc-t6, partly due to the inhibition of phosphorylation in stat3, which contributed to the reversal of hepatic fibrosis. |
2011-11-22 |
2023-08-12 |
Not clear |
| Sahdeo Prasad, Manoj K Pandey, Vivek R Yadav, Bharat B Aggarwa. Gambogic acid inhibits STAT3 phosphorylation through activation of protein tyrosine phosphatase SHP-1: potential role in proliferation and apoptosis. Cancer prevention research (Philadelphia, Pa.). vol 4. issue 7. 2011-11-15. PMID:21490133. |
gambogic acid inhibits stat3 phosphorylation through activation of protein tyrosine phosphatase shp-1: potential role in proliferation and apoptosis. |
2011-11-15 |
2023-08-12 |
human |
| Sahdeo Prasad, Manoj K Pandey, Vivek R Yadav, Bharat B Aggarwa. Gambogic acid inhibits STAT3 phosphorylation through activation of protein tyrosine phosphatase SHP-1: potential role in proliferation and apoptosis. Cancer prevention research (Philadelphia, Pa.). vol 4. issue 7. 2011-11-15. PMID:21490133. |
we found that ga induced apoptosis in human multiple myeloma cells that correlated with the inhibition of both constitutive and inducible stat3 activation. |
2011-11-15 |
2023-08-12 |
human |