| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhenjie Yin, Yan Zhang, Yu Li, Tingting Lv, Jie Liu, Xinbo Wan. Prognostic significance of STAT3 expression and its correlation with chemoresistance of non-small cell lung cancer cells. Acta histochemica. vol 114. issue 2. 2012-05-16. PMID:21549414. |
furthermore, two stably transfected cell lines (a549/shstat3 and spc-a1/shstat3) were successfully established, and rnai-mediated stat3 inhibition could significantly increase the sensitivity of nsclc cells to cisplatin by enhancing caspase-3-dependent apoptosis. |
2012-05-16 |
2023-08-12 |
Not clear |
| Xiaoying Liu, Wei Guo, Shuhong Wu, Li Wang, Ji Wang, Bingbing Dai, Edward S Kim, John V Heymach, Michael Wang, Luc Girard, John Minna, Jack A Roth, Stephen G Swisher, Bingliang Fan. Antitumor activity of a novel STAT3 inhibitor and redox modulator in non-small cell lung cancer cells. Biochemical pharmacology. vol 83. issue 10. 2012-05-14. PMID:22387047. |
blocking ros generation with the antioxidant ndga dramatically abolished nsc-743380-induced growth suppression and apoptosis, but had minimal effect on nsc-743380-induced stat3 inhibition, suggesting that stat3 inhibition is not caused by ros production. |
2012-05-14 |
2023-08-12 |
human |
| Shu Yuan Chiang, Sung-Moo Kim, Chulwon Kim, Jae-Young Um, Kyung-Ran Park, Seong Won Kim, Seok-Geun Lee, Hyeung-Jin Jang, Dongwoo Nam, Kyoo Seok Ahn, Sung-Hoon Kim, Seung-Hoon Choi, Bum Sang Shim, Yun-Cheol Na, Eun-Kyung Jeong, Somi K Cho, Kwang Seok Ah. Antiproliferative effects of Dangyuja (Citrus grandis Osbeck) leaves through suppression of constitutive signal transducer and activator of transcription 3 activation in human prostate carcinoma DU145 cells. Journal of medicinal food. vol 15. issue 2. 2012-05-07. PMID:22273151. |
consistent with stat3 inactivation, dcf down-regulated the expression of stat3 target genes, including bcl-2, bcl-xl, and cyclin d1; this correlated with the suppression of proliferation, the accumulation of cell cycle at the sub-g(1) phase, and the induction of apoptosis. |
2012-05-07 |
2023-08-12 |
human |
| Shu Yuan Chiang, Sung-Moo Kim, Chulwon Kim, Jae-Young Um, Kyung-Ran Park, Seong Won Kim, Seok-Geun Lee, Hyeung-Jin Jang, Dongwoo Nam, Kyoo Seok Ahn, Sung-Hoon Kim, Seung-Hoon Choi, Bum Sang Shim, Yun-Cheol Na, Eun-Kyung Jeong, Somi K Cho, Kwang Seok Ah. Antiproliferative effects of Dangyuja (Citrus grandis Osbeck) leaves through suppression of constitutive signal transducer and activator of transcription 3 activation in human prostate carcinoma DU145 cells. Journal of medicinal food. vol 15. issue 2. 2012-05-07. PMID:22273151. |
nobiletin, a major active constituent of dcf, could induce apoptosis via the suppression of constitutive stat3 activation. |
2012-05-07 |
2023-08-12 |
human |
| Pratibha Singh, Jonathan Hoggatt, Peirong Hu, Jennifer M Speth, Seiji Fukuda, Richard M Breyer, Louis M Pelu. Blockade of prostaglandin E2 signaling through EP1 and EP3 receptors attenuates Flt3L-dependent dendritic cell development from hematopoietic progenitor cells. Blood. vol 119. issue 7. 2012-05-01. PMID:22110249. |
inhibition of pge(2) biosynthesis reduces flt3-mediated activation of stat3 and expression of the antiapoptotic protein survivin, resulting in increased apoptosis of dc-committed progenitor cells. |
2012-05-01 |
2023-08-12 |
Not clear |
| Yi-Ping Yang, Yuh-Lih Chang, Pin-I Huang, Guang-Yuh Chiou, Ling-Ming Tseng, Shih-Hwa Chiou, Ming-Hsiung Chen, Ming-Teh Chen, Yang-Hsin Shih, Chin-Hong Chang, Chuan-Chih Hsu, Hsin-I Ma, Chin-Tien Wang, Lo-Lin Tsai, Cheng-Chia Yu, Charn-Jung Chan. Resveratrol suppresses tumorigenicity and enhances radiosensitivity in primary glioblastoma tumor initiating cells by inhibiting the STAT3 axis. Journal of cellular physiology. vol 227. issue 3. 2012-04-25. PMID:21503893. |
furthermore, treatment of gbm-cd133(+) with 100 µm rv induced apoptosis and enhanced radiosensitivity by suppressing stat3 signaling. |
2012-04-25 |
2023-08-12 |
Not clear |
| Shun Li, Ni Wang, Pnina Brod. Metastatic cells can escape the proapoptotic effects of TNF-α through increased autocrine IL-6/STAT3 signaling. Cancer research. vol 72. issue 4. 2012-04-20. PMID:22194466. |
in turn, tumor cell-derived il-6 induced gp130 and il-6r-dependent activation of stat3, leading to reduced caspase-3 activation and apoptosis. |
2012-04-20 |
2023-08-12 |
Not clear |
| Kuen-Feng Chen, Hui-Ling Chen, Chun-Yu Liu, Wei-Tien Tai, Kimihisa Ichikawa, Pei-Jer Chen, Ann-Lii Chen. Dovitinib sensitizes hepatocellular carcinoma cells to TRAIL and tigatuzumab, a novel anti-DR5 antibody, through SHP-1-dependent inhibition of STAT3. Biochemical pharmacology. vol 83. issue 6. 2012-04-13. PMID:22230479. |
here, we report that dovitinib sensitizes resistant hcc cells to trail- and tigatuzumab-induced apoptosis through inhibition of signal transducers and activators of transcription 3 (stat3). |
2012-04-13 |
2023-08-12 |
Not clear |
| Kuen-Feng Chen, Hui-Ling Chen, Chun-Yu Liu, Wei-Tien Tai, Kimihisa Ichikawa, Pei-Jer Chen, Ann-Lii Chen. Dovitinib sensitizes hepatocellular carcinoma cells to TRAIL and tigatuzumab, a novel anti-DR5 antibody, through SHP-1-dependent inhibition of STAT3. Biochemical pharmacology. vol 83. issue 6. 2012-04-13. PMID:22230479. |
knockdown of stat3 by rna-interference overcame apoptotic resistance to trail in hcc cells, and ectopic expression of stat3 in hcc cells abolished the sensitizing effect of dovitinib on trail-induced apoptosis. |
2012-04-13 |
2023-08-12 |
Not clear |
| Kuen-Feng Chen, Hui-Ling Chen, Chun-Yu Liu, Wei-Tien Tai, Kimihisa Ichikawa, Pei-Jer Chen, Ann-Lii Chen. Dovitinib sensitizes hepatocellular carcinoma cells to TRAIL and tigatuzumab, a novel anti-DR5 antibody, through SHP-1-dependent inhibition of STAT3. Biochemical pharmacology. vol 83. issue 6. 2012-04-13. PMID:22230479. |
in conclusion, dovitinib sensitizes resistant hcc cells to trail- and tigatuzumab-induced apoptosis through a novel machinery: shp-1 dependent stat3 inhibition. |
2012-04-13 |
2023-08-12 |
Not clear |
| Xiangyang Yao, Fenfen Zhu, Zhihui Zhao, Chang Liu, Lan Luo, Zhimin Yi. Arctigenin enhances chemosensitivity of cancer cells to cisplatin through inhibition of the STAT3 signaling pathway. Journal of cellular biochemistry. vol 112. issue 10. 2012-04-12. PMID:21608020. |
furthermore, the constitutive activation level of stat3 was found to be correlated to the resistance of cancer cells to cisplatin-induced apoptosis. |
2012-04-12 |
2023-08-12 |
Not clear |
| Hua Xiong, Jie Hong, Wan Du, Yan-wei Lin, Lin-lin Ren, Ying-chao Wang, Wen-yu Su, Ji-lin Wang, Yun Cui, Zhen-hua Wang, Jing-Yuan Fan. Roles of STAT3 and ZEB1 proteins in E-cadherin down-regulation and human colorectal cancer epithelial-mesenchymal transition. The Journal of biological chemistry. vol 287. issue 8. 2012-04-09. PMID:22205702. |
activation of stat3 significantly increased crc cell invasiveness and resistance to apoptosis. |
2012-04-09 |
2023-08-12 |
human |
| Peramaiyan Rajendran, Feng Li, Muthu K Shanmugam, Shireen Vali, Taher Abbasi, Shweta Kapoor, Kwang Seok Ahn, Alan Prem Kumar, Gautam Seth. Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1. Journal of cellular physiology. vol 227. issue 5. 2012-04-02. PMID:21792937. |
the effect of honokiol on stat3 activation, associated protein kinases, and phosphatase, stat3-regulated gene products and apoptosis was investigated using both functional proteomics tumor pathway technology platform and different hcc cell lines. |
2012-04-02 |
2023-08-12 |
Not clear |
| R C T McKenzie, C L Jones, I Tosi, J A Caesar, S J Whittaker, T J Mitchel. Constitutive activation of STAT3 in Sézary syndrome is independent of SHP-1. Leukemia. vol 26. issue 2. 2012-03-30. PMID:21818116. |
in contrast, treatment of ss tumour cells with the pan-jak inhibitor pyridone 6 led to downregulation of phosphorylated stat3 (pstat3), its target genes and induction of apoptosis. |
2012-03-30 |
2023-08-12 |
Not clear |
| Hanrui Zhang, Cuihua Zhan. Vasoprotection by dietary supplements and exercise: role of TNFα signaling. Experimental diabetes research. vol 2012. 2012-03-25. PMID:22110483. |
tnfα induces vascular inflammation, monocyte adhesion to endothelial cells, vascular oxidative stress, apoptosis, and atherogenic response and participates in the regulation of thrombosis and coagulation through multiple signaling pathways involving nfκb, sp1, activator protein 1, jnk, p38, stat3, and so forth. |
2012-03-25 |
2023-08-12 |
Not clear |
| J R Matthews, O J Sansom, A R Clark. Absolute requirement for STAT3 function in small-intestine crypt stem cell survival. Cell death and differentiation. vol 18. issue 12. 2012-03-06. PMID:21637293. |
following cre recombinase expression, apoptosis increased in stat3(fl/-) experimental crypts relative to stat3(wt/-) controls before declining. |
2012-03-06 |
2023-08-12 |
mouse |
| J R Matthews, O J Sansom, A R Clark. Absolute requirement for STAT3 function in small-intestine crypt stem cell survival. Cell death and differentiation. vol 18. issue 12. 2012-03-06. PMID:21637293. |
rapid clearance of recombined stat3(fl/-) cells involves apoptosis potentially induced by elevated c-myc in non-recombined cells and involves elevated p53 expression and caspase 3 activation. |
2012-03-06 |
2023-08-12 |
mouse |
| Yongzhi Wang, Lingchao Chen, Zhaoshi Bao, Shouwei Li, Gan You, Wei Yan, Zhendong Shi, Yanwei Liu, Pei Yang, Wei Zhang, Lei Han, Chunsheng Kang, Tao Jian. Inhibition of STAT3 reverses alkylator resistance through modulation of the AKT and β-catenin signaling pathways. Oncology reports. vol 26. issue 5. 2012-03-01. PMID:21887474. |
inhibition of stat3 dramatically decreased the ic50 of tmz, increasing tmz-induced apoptosis while up-regulating expression of bcl-2 and down-regulating expression of bax. |
2012-03-01 |
2023-08-12 |
human |
| Shuling Huang, Min Chen, Yonghua Shen, Weidong Shen, Huimin Guo, Qian Gao, Xiaoping Zo. Inhibition of activated Stat3 reverses drug resistance to chemotherapeutic agents in gastric cancer cells. Cancer letters. vol 315. issue 2. 2012-02-13. PMID:22104727. |
inhibition of stat3 function resulted in significant decreases in cisplatin resistance and enhanced apoptosis in drug resistant cells. |
2012-02-13 |
2023-08-12 |
human |
| Jin-fang Zhang, Ming-liang He, Wei-ming Fu, Hua Wang, Lian-zhou Chen, Xiao Zhu, Ying Chen, Dan Xie, Paul Lai, Gong Chen, Gang Lu, Marie C M Lin, Hsiang-fu Kun. Primate-specific microRNA-637 inhibits tumorigenesis in hepatocellular carcinoma by disrupting signal transducer and activator of transcription 3 signaling. Hepatology (Baltimore, Md.). vol 54. issue 6. 2012-02-07. PMID:21809363. |
the transcription factor, signal transducer and activator of transcription 3 (stat3), is constitutively activated in multiple tumors, and aberrant stat3 activation is linked to the promotion of growth and desensitization of apoptosis. |
2012-02-07 |
2023-08-12 |
mouse |