| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wen-Wen Huang, Jai-Sing Yang, Meng-Wei Lin, Po-Yuan Chen, Shang-Ming Chiou, Fu-Shin Chueh, Yu-Hsuan Lan, Shu-Jen Pai, Minoru Tsuzuki, Wai-Jane Ho, Jing-Gung Chun. Cucurbitacin E Induces G(2)/M Phase Arrest through STAT3/p53/p21 Signaling and Provokes Apoptosis via Fas/CD95 and Mitochondria-Dependent Pathways in Human Bladder Cancer T24 Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2012. 2012-08-23. PMID:22272214. |
our results demonstrated that cucurbitacin e-induced g(2)/m arrest was associated with a marked increase in the levels of p53, p21 and a decrease in phospho-signal transducer and activator of transcription 3 (stat3), cyclin-dependent kinase 1 (cdk1) and cyclin b. cucurbitacin e-triggered apoptosis was accompanied with up-regulation of fas/cd95, truncated bid (t-bid) and a loss of ΔΨ(m), resulting in the releases of cytochrome c, apoptotic protease activating factor 1 (apaf-1) and apoptosis-inducing factor (aif), and sequential activation of caspase-8, caspase-9, and caspase-3. |
2012-08-23 |
2023-08-12 |
human |
| Peramaiyan Rajendran, Feng Li, Muthu K Shanmugam, Radhamani Kannaiyan, Jen Nee Goh, Kwong Fai Wong, Wei Wang, Ester Khin, Vinay Tergaonkar, Alan Prem Kumar, John M Luk, Gautam Seth. Celastrol suppresses growth and induces apoptosis of human hepatocellular carcinoma through the modulation of STAT3/JAK2 signaling cascade in vitro and in vivo. Cancer prevention research (Philadelphia, Pa.). vol 5. issue 4. 2012-08-09. PMID:22369852. |
the effect of celastrol on stat3 activation, associated protein kinases, stat3-regulated gene products, cellular proliferation, and apoptosis was investigated. |
2012-08-09 |
2023-08-12 |
mouse |
| Gamal Bad. Supplementation with undenatured whey protein during diabetes mellitus improves the healing and closure of diabetic wounds through the rescue of functional long-lived wound macrophages. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 29. issue 3-4. 2012-08-09. PMID:22508064. |
moreover, in the diabetic mice, the wound-resident macrophages were dysfunctional and demonstrated increased apoptosis, a significant reduction in their phagocytotic ability, aberrant activation of stat3 and a marked reduction in the activation of akt. |
2012-08-09 |
2023-08-12 |
mouse |
| Dmitri V Pechkovsky, Cecilia M Prêle, John Wong, Cory M Hogaboam, Robin J McAnulty, Geoffrey J Laurent, Samuel S-M Zhang, Moisés Selman, Steven E Mutsaers, Darryl A Knigh. STAT3-mediated signaling dysregulates lung fibroblast-myofibroblast activation and differentiation in UIP/IPF. The American journal of pathology. vol 180. issue 4. 2012-07-25. PMID:22322297. |
suppression of stat3 signaling diminished resistance of ipf lfs to staurosporine-induced apoptosis and responsiveness to transforming growth factor β(1) but increased basal α-sma and restored β(3) integrin expression in lfs via an alk-5-dependent, smad3/7-independent mechanism. |
2012-07-25 |
2023-08-12 |
human |
| Karuppaiyah Selvendiran, Shabnam Ahmed, Alex Dayton, M Lakshmi Kuppusamy, Brian K Rivera, Tamás Kálai, Kálmán Hideg, Periannan Kuppusam. HO-3867, a curcumin analog, sensitizes cisplatin-resistant ovarian carcinoma, leading to therapeutic synergy through STAT3 inhibition. Cancer biology & therapy. vol 12. issue 9. 2012-07-20. PMID:21885917. |
overexpression of stat3 decreased the ho-3867-induced apoptosis. |
2012-07-20 |
2023-08-12 |
mouse |
| Tobias Ettl, Clemens Stiegler, Katharina Zeitler, Abbas Agaimy, Johannes Zenk, Torsten E Reichert, Martin Gosau, Thomas Kühnel, Gero Brockhoff, Stephan Schwar. EGFR, HER2, survivin, and loss of pSTAT3 characterize high-grade malignancy in salivary gland cancer with impact on prognosis. Human pathology. vol 43. issue 6. 2012-07-18. PMID:22154363. |
stat3 and the apoptosis inhibitor survivin represent distinct oncogenes in various human neoplasms. |
2012-07-18 |
2023-08-12 |
human |
| Chen Huang, Keping Xi. Crosstalk of Sp1 and Stat3 signaling in pancreatic cancer pathogenesis. Cytokine & growth factor reviews. vol 23. issue 1-2. 2012-07-16. PMID:22342309. |
specificity protein 1 (sp1) and signal transducer and activator of transcription 3 (stat3) are central transcription factors that regulate a number of pathways important to tumorigenesis, including tumor cell-cycle progression, apoptosis, angiogenesis, metastasis, and evasion of the immune system. |
2012-07-16 |
2023-08-12 |
Not clear |
| Trisha R Stankiewicz, F Alexandra Loucks, Emily K Schroeder, Marja T Nevalainen, Kenneth L Tyler, Klaus Aktories, Ron J Bouchard, Daniel A Linsema. Signal transducer and activator of transcription-5 mediates neuronal apoptosis induced by inhibition of Rac GTPase activity. The Journal of biological chemistry. vol 287. issue 20. 2012-07-13. PMID:22378792. |
stat3 displayed enhanced tyrosine phosphorylation following treatment with toxb, and a reputed inhibitor of stat3, cucurbitacin (jsi-124), reduced cgn apoptosis. |
2012-07-13 |
2023-08-12 |
mouse |
| C Huang, R Huang, W Chang, T Jiang, K Huang, J Cao, X Sun, Z Qi. The expression and clinical significance of pSTAT3, VEGF and VEGF-C in pancreatic adenocarcinoma. Neoplasma. vol 59. issue 1. 2012-07-12. PMID:22082308. |
signal transducers and activators of transcription 3 (stat3) is a central cytoplasmic transcription factor and regulates a number of pathways important in tumorigenesis including cell cycle progression, apoptosis, tumor angiogenesis, invasion and metastasis.this study aims to investigate the expression of pstat3, vegf and vegf-c in pancreatic adenocarcinoma and their relations to the clinicopathological features, tumor angiogenesis and prognosis. |
2012-07-12 |
2023-08-12 |
Not clear |
| Qunchuan Zhuang, Fei Hong, Aling Shen, Liangpu Zheng, Jianwei Zeng, Wei Lin, Youqin Chen, Thomas J Sferra, Zhenfeng Hong, Jun Pen. Pien Tze Huang inhibits tumor cell proliferation and promotes apoptosis via suppressing the STAT3 pathway in a colorectal cancer mouse model. International journal of oncology. vol 40. issue 5. 2012-06-29. PMID:22218594. |
pien tze huang inhibits tumor cell proliferation and promotes apoptosis via suppressing the stat3 pathway in a colorectal cancer mouse model. |
2012-06-29 |
2023-08-12 |
mouse |
| Qunchuan Zhuang, Fei Hong, Aling Shen, Liangpu Zheng, Jianwei Zeng, Wei Lin, Youqin Chen, Thomas J Sferra, Zhenfeng Hong, Jun Pen. Pien Tze Huang inhibits tumor cell proliferation and promotes apoptosis via suppressing the STAT3 pathway in a colorectal cancer mouse model. International journal of oncology. vol 40. issue 5. 2012-06-29. PMID:22218594. |
consequently, the inhibitory effect of pzh on stat3 activation resulted in the up-regulation of bax/bcl-2 ratio as well as down-regulation of cyclin d1 and cdk4 expression, leading to the induction of apoptosis as well as the inhibition of cell proliferation. |
2012-06-29 |
2023-08-12 |
mouse |
| Qunchuan Zhuang, Fei Hong, Aling Shen, Liangpu Zheng, Jianwei Zeng, Wei Lin, Youqin Chen, Thomas J Sferra, Zhenfeng Hong, Jun Pen. Pien Tze Huang inhibits tumor cell proliferation and promotes apoptosis via suppressing the STAT3 pathway in a colorectal cancer mouse model. International journal of oncology. vol 40. issue 5. 2012-06-29. PMID:22218594. |
these results suggest that promotion of cancer cell apoptosis and inhibition of proliferation via suppression of stat3 pathway might be one of the mechanisms by which pzh treats colorectal cancer. |
2012-06-29 |
2023-08-12 |
mouse |
| Karen A Nahmod, Thomas Walther, Nadia Cambados, Natalia Fernandez, Roberto Meiss, Nils Tappenbeck, Yong Wang, Diego Raffo, Marina Simian, Anja Schwiebs, Roberto G Pozner, Juan I Fuxman Bass, Andrea G Pozzi, Jorge R Geffner, Edith C Kordon, Carolina Schere-Lev. AT1 receptor blockade delays postlactational mammary gland involution: a novel role for the renin angiotensin system. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 26. issue 5. 2012-06-29. PMID:22286690. |
we found that exogenous administration of angii in mammary glands of lactating balb/c mice induced epithelium apoptosis [2.9±0.5% (control) vs. 9.6±1.1% (angii); p < 0.001] and activation of the proapoptotic factor stat3, an effect inhibited by irbesartan, an at(1) receptor blocker. |
2012-06-29 |
2023-08-12 |
mouse |
| Sumit Kumar Hira, Partha Pratim Mann. Down regulation of CD24 and HER-2/neu in breast carcinoma cells by activated human dendritic cell. Role of STAT3. Cellular immunology. vol 275. issue 1-2. 2012-06-29. PMID:22480875. |
pretreatment of tumor cells with stat3 specific inhibitors or knocking down of stat3 by sirna makes the tumor cell more susceptible to apoptosis and dc mediated inhibition of both cd24 and her-2/neu. |
2012-06-29 |
2023-08-12 |
human |
| Yi Zhang, Jun-Wei Zhang, Guo-Yue Lv, Shu-Li Xie, Guang-Yi Wan. Effects of STAT3 gene silencing and rapamycin on apoptosis in hepatocarcinoma cells. International journal of medical sciences. vol 9. issue 3. 2012-06-25. PMID:22408571. |
effects of stat3 gene silencing and rapamycin on apoptosis in hepatocarcinoma cells. |
2012-06-25 |
2023-08-12 |
human |
| Yi Zhang, Jun-Wei Zhang, Guo-Yue Lv, Shu-Li Xie, Guang-Yi Wan. Effects of STAT3 gene silencing and rapamycin on apoptosis in hepatocarcinoma cells. International journal of medical sciences. vol 9. issue 3. 2012-06-25. PMID:22408571. |
in this study, we targeted stat3 and mtor in human hepatocellular carcinoma bel-7402 cells and examined the subsequent alterations in cellular apoptosis. |
2012-06-25 |
2023-08-12 |
human |
| Yi Zhang, Jun-Wei Zhang, Guo-Yue Lv, Shu-Li Xie, Guang-Yi Wan. Effects of STAT3 gene silencing and rapamycin on apoptosis in hepatocarcinoma cells. International journal of medical sciences. vol 9. issue 3. 2012-06-25. PMID:22408571. |
combined treatments using rapamycin and stat3 gene silencing significantly increases apoptosis in bel-7402 cells, displaying more dramatic effect than any single treatment. |
2012-06-25 |
2023-08-12 |
human |
| Kuen-Feng Chen, Jung-Chen Su, Chun-Yu Liu, Jui-Wen Huang, Kuei-Chiu Chen, Wei-Lin Chen, Wei-Tien Tai, Chung-Wai Shia. A novel obatoclax derivative, SC-2001, induces apoptosis in hepatocellular carcinoma cells through SHP-1-dependent STAT3 inactivation. Cancer letters. vol 321. issue 1. 2012-06-22. PMID:22465052. |
a novel obatoclax derivative, sc-2001, induces apoptosis in hepatocellular carcinoma cells through shp-1-dependent stat3 inactivation. |
2012-06-22 |
2023-08-12 |
Not clear |
| Kuen-Feng Chen, Jung-Chen Su, Chun-Yu Liu, Jui-Wen Huang, Kuei-Chiu Chen, Wei-Lin Chen, Wei-Tien Tai, Chung-Wai Shia. A novel obatoclax derivative, SC-2001, induces apoptosis in hepatocellular carcinoma cells through SHP-1-dependent STAT3 inactivation. Cancer letters. vol 321. issue 1. 2012-06-22. PMID:22465052. |
in conclusion, our results suggest that sc-2001 induces apoptosis in hcc, and that this effect is mediated through shp-1-dependent stat3 inactivation. |
2012-06-22 |
2023-08-12 |
Not clear |
| Hyun-Jin Nam, Keith A Ching, Julie Kan, Hwang-Phill Kim, Sae-Won Han, Seock-Ah Im, Tae-You Kim, James G Christensen, Do-Youn Oh, Yung-Jue Ban. Evaluation of the antitumor effects and mechanisms of PF00299804, a pan-HER inhibitor, alone or in combination with chemotherapy or targeted agents in gastric cancer. Molecular cancer therapeutics. vol 11. issue 2. 2012-06-18. PMID:22135232. |
pf00299804 induced apoptosis and g(1) arrest and inhibited phosphorylation of receptors in the her family and downstream signaling pathways including stat3, akt, and extracellular signal-regulated kinases (erk) in her2-amplified gastric cancer cells. |
2012-06-18 |
2023-08-12 |
Not clear |