| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eunju Park, Jinah Park, Sae-Won Han, Seock-Ah Im, Tae-You Kim, Do-Youn Oh, Yung-Jue Ban. NVP-BKM120, a novel PI3K inhibitor, shows synergism with a STAT3 inhibitor in human gastric cancer cells harboring KRAS mutations. International journal of oncology. vol 40. issue 4. 2012-08-31. PMID:22159814. |
the synergistic efficacy study demonstrated that dual pi3k and stat3 blockade showed a synergism in cells harboring mutated kras by inducing apoptosis. |
2012-08-31 |
2023-08-12 |
human |
| Xiaofei Wang, Yan Zhang, Xiwen Zhang, Wenxia Tian, Wenli Feng, Tingmei Che. The curcumin analogue hydrazinocurcumin exhibits potent suppressive activity on carcinogenicity of breast cancer cells via STAT3 inhibition. International journal of oncology. vol 40. issue 4. 2012-08-31. PMID:22179587. |
the results demonstrated that compared to curcumin, hc was more effective in inhibiting stat3 phosphorylation and downregulation of an array of stat3 downstream targets which contributed to suppression of cell proliferation, loss of colony formation, depression of cell migration and invasion as well as induction of cell apoptosis. |
2012-08-31 |
2023-08-12 |
human |
| Seiji Umehara, Hitoshi Fujiwara, Atsushi Shiozaki, Momoko Todo, Akinobu Furutani, Masayuki Yoneda, Atsushi Ikai, Hiroyuki Tada, Shuhei Komatsu, Daisuke Ichikawa, Kazuma Okamoto, Toshiya Ochiai, Yukihito Kokuba, Eigo Otsuj. PSK induces apoptosis through the inhibition of activated STAT3 in human esophageal carcinoma cells. International journal of oncology. vol 41. issue 1. 2012-08-31. PMID:22552778. |
psk induces apoptosis through the inhibition of activated stat3 in human esophageal carcinoma cells. |
2012-08-31 |
2023-08-12 |
human |
| Seiji Umehara, Hitoshi Fujiwara, Atsushi Shiozaki, Momoko Todo, Akinobu Furutani, Masayuki Yoneda, Atsushi Ikai, Hiroyuki Tada, Shuhei Komatsu, Daisuke Ichikawa, Kazuma Okamoto, Toshiya Ochiai, Yukihito Kokuba, Eigo Otsuj. PSK induces apoptosis through the inhibition of activated STAT3 in human esophageal carcinoma cells. International journal of oncology. vol 41. issue 1. 2012-08-31. PMID:22552778. |
in the present study, stat3 was constitutively activated in kyse170 and te13 esophageal carcinoma cells, and psk inhibited proliferation and induced apoptosis in these cells in a dose-dependent manner. |
2012-08-31 |
2023-08-12 |
human |
| Seiji Umehara, Hitoshi Fujiwara, Atsushi Shiozaki, Momoko Todo, Akinobu Furutani, Masayuki Yoneda, Atsushi Ikai, Hiroyuki Tada, Shuhei Komatsu, Daisuke Ichikawa, Kazuma Okamoto, Toshiya Ochiai, Yukihito Kokuba, Eigo Otsuj. PSK induces apoptosis through the inhibition of activated STAT3 in human esophageal carcinoma cells. International journal of oncology. vol 41. issue 1. 2012-08-31. PMID:22552778. |
based on these findings, the relationship between stat3 and apoptosis in these cells was investigated. |
2012-08-31 |
2023-08-12 |
human |
| Seiji Umehara, Hitoshi Fujiwara, Atsushi Shiozaki, Momoko Todo, Akinobu Furutani, Masayuki Yoneda, Atsushi Ikai, Hiroyuki Tada, Shuhei Komatsu, Daisuke Ichikawa, Kazuma Okamoto, Toshiya Ochiai, Yukihito Kokuba, Eigo Otsuj. PSK induces apoptosis through the inhibition of activated STAT3 in human esophageal carcinoma cells. International journal of oncology. vol 41. issue 1. 2012-08-31. PMID:22552778. |
these results indicate that psk may induce apoptosis in esophageal carcinoma cells by inhibiting the expression of activated stat3. |
2012-08-31 |
2023-08-12 |
human |
| Xin-Sheng Deng, Shuiliang Wang, Anlong Deng, Bolin Liu, Susan M Edgerton, Stuart E Lind, Reema Wahdan-Alaswad, Ann D Tho. Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers. Cell cycle (Georgetown, Tex.). vol 11. issue 2. 2012-08-30. PMID:22189713. |
metformin targets stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers. |
2012-08-30 |
2023-08-12 |
human |
| Xin-Sheng Deng, Shuiliang Wang, Anlong Deng, Bolin Liu, Susan M Edgerton, Stuart E Lind, Reema Wahdan-Alaswad, Ann D Tho. Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers. Cell cycle (Georgetown, Tex.). vol 11. issue 2. 2012-08-30. PMID:22189713. |
ca-stat3 transfection attenuated, whereas stat3 knockdown enhanced, the effects of metformin upon growth inhibition and apoptosis induction. |
2012-08-30 |
2023-08-12 |
human |
| Xin-Sheng Deng, Shuiliang Wang, Anlong Deng, Bolin Liu, Susan M Edgerton, Stuart E Lind, Reema Wahdan-Alaswad, Ann D Tho. Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers. Cell cycle (Georgetown, Tex.). vol 11. issue 2. 2012-08-30. PMID:22189713. |
a stat3 specific inhibitor acted synergistically with metformin in reducing cell growth and inducing apoptosis. |
2012-08-30 |
2023-08-12 |
human |
| Dong-bo Liu, Guang-yuan Hu, Guo-xian Long, Hong Qiu, Qi Mei, Guo-qing H. Celecoxib induces apoptosis and cell-cycle arrest in nasopharyngeal carcinoma cell lines via inhibition of STAT3 phosphorylation. Acta pharmacologica Sinica. vol 33. issue 5. 2012-08-28. PMID:22504904. |
celecoxib induces apoptosis and cell-cycle arrest in nasopharyngeal carcinoma cell lines via inhibition of stat3 phosphorylation. |
2012-08-28 |
2023-08-12 |
Not clear |
| Wen-Wen Huang, Jai-Sing Yang, Meng-Wei Lin, Po-Yuan Chen, Shang-Ming Chiou, Fu-Shin Chueh, Yu-Hsuan Lan, Shu-Jen Pai, Minoru Tsuzuki, Wai-Jane Ho, Jing-Gung Chun. Cucurbitacin E Induces G(2)/M Phase Arrest through STAT3/p53/p21 Signaling and Provokes Apoptosis via Fas/CD95 and Mitochondria-Dependent Pathways in Human Bladder Cancer T24 Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2012. 2012-08-23. PMID:22272214. |
our results demonstrated that cucurbitacin e-induced g(2)/m arrest was associated with a marked increase in the levels of p53, p21 and a decrease in phospho-signal transducer and activator of transcription 3 (stat3), cyclin-dependent kinase 1 (cdk1) and cyclin b. cucurbitacin e-triggered apoptosis was accompanied with up-regulation of fas/cd95, truncated bid (t-bid) and a loss of ΔΨ(m), resulting in the releases of cytochrome c, apoptotic protease activating factor 1 (apaf-1) and apoptosis-inducing factor (aif), and sequential activation of caspase-8, caspase-9, and caspase-3. |
2012-08-23 |
2023-08-12 |
human |
| Peramaiyan Rajendran, Feng Li, Muthu K Shanmugam, Radhamani Kannaiyan, Jen Nee Goh, Kwong Fai Wong, Wei Wang, Ester Khin, Vinay Tergaonkar, Alan Prem Kumar, John M Luk, Gautam Seth. Celastrol suppresses growth and induces apoptosis of human hepatocellular carcinoma through the modulation of STAT3/JAK2 signaling cascade in vitro and in vivo. Cancer prevention research (Philadelphia, Pa.). vol 5. issue 4. 2012-08-09. PMID:22369852. |
the effect of celastrol on stat3 activation, associated protein kinases, stat3-regulated gene products, cellular proliferation, and apoptosis was investigated. |
2012-08-09 |
2023-08-12 |
mouse |
| Gamal Bad. Supplementation with undenatured whey protein during diabetes mellitus improves the healing and closure of diabetic wounds through the rescue of functional long-lived wound macrophages. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 29. issue 3-4. 2012-08-09. PMID:22508064. |
moreover, in the diabetic mice, the wound-resident macrophages were dysfunctional and demonstrated increased apoptosis, a significant reduction in their phagocytotic ability, aberrant activation of stat3 and a marked reduction in the activation of akt. |
2012-08-09 |
2023-08-12 |
mouse |
| Dmitri V Pechkovsky, Cecilia M Prêle, John Wong, Cory M Hogaboam, Robin J McAnulty, Geoffrey J Laurent, Samuel S-M Zhang, Moisés Selman, Steven E Mutsaers, Darryl A Knigh. STAT3-mediated signaling dysregulates lung fibroblast-myofibroblast activation and differentiation in UIP/IPF. The American journal of pathology. vol 180. issue 4. 2012-07-25. PMID:22322297. |
suppression of stat3 signaling diminished resistance of ipf lfs to staurosporine-induced apoptosis and responsiveness to transforming growth factor β(1) but increased basal α-sma and restored β(3) integrin expression in lfs via an alk-5-dependent, smad3/7-independent mechanism. |
2012-07-25 |
2023-08-12 |
human |
| Karuppaiyah Selvendiran, Shabnam Ahmed, Alex Dayton, M Lakshmi Kuppusamy, Brian K Rivera, Tamás Kálai, Kálmán Hideg, Periannan Kuppusam. HO-3867, a curcumin analog, sensitizes cisplatin-resistant ovarian carcinoma, leading to therapeutic synergy through STAT3 inhibition. Cancer biology & therapy. vol 12. issue 9. 2012-07-20. PMID:21885917. |
overexpression of stat3 decreased the ho-3867-induced apoptosis. |
2012-07-20 |
2023-08-12 |
mouse |
| Tobias Ettl, Clemens Stiegler, Katharina Zeitler, Abbas Agaimy, Johannes Zenk, Torsten E Reichert, Martin Gosau, Thomas Kühnel, Gero Brockhoff, Stephan Schwar. EGFR, HER2, survivin, and loss of pSTAT3 characterize high-grade malignancy in salivary gland cancer with impact on prognosis. Human pathology. vol 43. issue 6. 2012-07-18. PMID:22154363. |
stat3 and the apoptosis inhibitor survivin represent distinct oncogenes in various human neoplasms. |
2012-07-18 |
2023-08-12 |
human |
| Chen Huang, Keping Xi. Crosstalk of Sp1 and Stat3 signaling in pancreatic cancer pathogenesis. Cytokine & growth factor reviews. vol 23. issue 1-2. 2012-07-16. PMID:22342309. |
specificity protein 1 (sp1) and signal transducer and activator of transcription 3 (stat3) are central transcription factors that regulate a number of pathways important to tumorigenesis, including tumor cell-cycle progression, apoptosis, angiogenesis, metastasis, and evasion of the immune system. |
2012-07-16 |
2023-08-12 |
Not clear |
| Trisha R Stankiewicz, F Alexandra Loucks, Emily K Schroeder, Marja T Nevalainen, Kenneth L Tyler, Klaus Aktories, Ron J Bouchard, Daniel A Linsema. Signal transducer and activator of transcription-5 mediates neuronal apoptosis induced by inhibition of Rac GTPase activity. The Journal of biological chemistry. vol 287. issue 20. 2012-07-13. PMID:22378792. |
stat3 displayed enhanced tyrosine phosphorylation following treatment with toxb, and a reputed inhibitor of stat3, cucurbitacin (jsi-124), reduced cgn apoptosis. |
2012-07-13 |
2023-08-12 |
mouse |
| C Huang, R Huang, W Chang, T Jiang, K Huang, J Cao, X Sun, Z Qi. The expression and clinical significance of pSTAT3, VEGF and VEGF-C in pancreatic adenocarcinoma. Neoplasma. vol 59. issue 1. 2012-07-12. PMID:22082308. |
signal transducers and activators of transcription 3 (stat3) is a central cytoplasmic transcription factor and regulates a number of pathways important in tumorigenesis including cell cycle progression, apoptosis, tumor angiogenesis, invasion and metastasis.this study aims to investigate the expression of pstat3, vegf and vegf-c in pancreatic adenocarcinoma and their relations to the clinicopathological features, tumor angiogenesis and prognosis. |
2012-07-12 |
2023-08-12 |
Not clear |
| Qunchuan Zhuang, Fei Hong, Aling Shen, Liangpu Zheng, Jianwei Zeng, Wei Lin, Youqin Chen, Thomas J Sferra, Zhenfeng Hong, Jun Pen. Pien Tze Huang inhibits tumor cell proliferation and promotes apoptosis via suppressing the STAT3 pathway in a colorectal cancer mouse model. International journal of oncology. vol 40. issue 5. 2012-06-29. PMID:22218594. |
pien tze huang inhibits tumor cell proliferation and promotes apoptosis via suppressing the stat3 pathway in a colorectal cancer mouse model. |
2012-06-29 |
2023-08-12 |
mouse |