| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huijie Jia, Yang Li, Tiesuo Zhao, Xin Li, Jiadi Hu, Di Yin, Baofeng Guo, Dennis J Kopecko, Xuejian Zhao, Ling Zhang, De Qi X. Antitumor effects of Stat3-siRNA and endostatin combined therapies, delivered by attenuated Salmonella, on orthotopically implanted hepatocarcinoma. Cancer immunology, immunotherapy : CII. vol 61. issue 11. 2013-01-30. PMID:22527247. |
correlated with this finding, the combination treatment resulted in significant alteration of stat3 and endostatin levels and that of the downstream gene vegf, decreased cell proliferation, induced cell apoptosis and inhibited angiogenesis. |
2013-01-30 |
2023-08-12 |
mouse |
| Jie Yang, Xueting Cai, Wuguang Lu, Chunping Hu, Xiaojun Xu, Qiang Yu, Peng Ca. Evodiamine inhibits STAT3 signaling by inducing phosphatase shatterproof 1 in hepatocellular carcinoma cells. Cancer letters. vol 328. issue 2. 2013-01-30. PMID:23032719. |
evodiamine also suppressed stat3 dna binding activity and down-regulated the expression of stat3-mediated genes leading to the suppression of proliferation, induction of cell apoptosis and cell cycle arrest. |
2013-01-30 |
2023-08-12 |
Not clear |
| Sangkil Nam, Jun Xie, Angela Perkins, Yuelong Ma, Fan Yang, Jun Wu, Yan Wang, Rong-Zhen Xu, Wendong Huang, David A Horne, Richard Jov. Novel synthetic derivatives of the natural product berbamine inhibit Jak2/Stat3 signaling and induce apoptosis of human melanoma cells. Molecular oncology. vol 6. issue 5. 2013-01-28. PMID:22717603. |
bbmd3 also down-regulated expression of the stat3 target proteins mcl-1and bcl-x(l), associated with induction of apoptosis. |
2013-01-28 |
2023-08-12 |
human |
| Mareike Seelinger, Ruxandra Popescu, Benedikt Giessrigl, Kanokwan Jarukamjorn, Christine Unger, Bruno Wallnöfer, Monika Fritzer-Szekeres, Thomas Szekeres, Rene Diaz, Walter Jäger, Richard Frisch, Brigitte Kopp, Georg Krupitz. Methanol extract of the ethnopharmaceutical remedy Smilax spinosa exhibits anti-neoplastic activity. International journal of oncology. vol 41. issue 3. 2013-01-23. PMID:22752086. |
the derivative fraction f2 induced apoptosis through the intrinsic pathway, which correlated with the inhibition of stat3 phosphorylation and concomitant induction of caspase 9, then caspase 8 and caspase 3. |
2013-01-23 |
2023-08-12 |
Not clear |
| Tiffany A Doucette, Ling-Yuan Kong, Yuhui Yang, Sherise D Ferguson, Jinbo Yang, Jun Wei, Wei Qiao, Gregory N Fuller, Krishna P Bhat, Kenneth Aldape, Waldemar Priebe, Oliver Bögler, Amy B Heimberger, Ganesh Ra. Signal transducer and activator of transcription 3 promotes angiogenesis and drives malignant progression in glioma. Neuro-oncology. vol 14. issue 9. 2013-01-17. PMID:22753228. |
in hggs, expression of stat3 was associated with suppression of apoptosis and an increase in tumor cell proliferation. |
2013-01-17 |
2023-08-12 |
mouse |
| Andres Jerez, Michael J Clemente, Hideki Makishima, Hanna Koskela, Francis Leblanc, Kwok Peng Ng, Thomas Olson, Bartlomiej Przychodzen, Manuel Afable, Ines Gomez-Segui, Kathryn Guinta, Lisa Durkin, Eric D Hsi, Kathy McGraw, Dan Zhang, Marcin W Wlodarski, Kimmo Porkka, Mikkael A Sekeres, Alan List, Satu Mustjoki, Thomas P Loughran, Jaroslaw P Maciejewsk. STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia. Blood. vol 120. issue 15. 2013-01-17. PMID:22859607. |
treatment with stat3 inhibitors, both in wild-type and mutant cases, resulted in accelerated apoptosis. |
2013-01-17 |
2023-08-12 |
Not clear |
| Laurie A Davidson, Jennifer S Goldsby, Evelyn S Callaway, Manasvi S Shah, Nick Barker, Robert S Chapki. Alteration of colonic stem cell gene signatures during the regenerative response to injury. Biochimica et biophysica acta. vol 1822. issue 10. 2013-01-15. PMID:22750333. |
stem cell number, cell proliferation, apoptosis, expression of stem cell (lgr5, sox9, bmi1, hopx, mtert, ascl2, and dcamkl-1) and inflammation (stat3) markers were quantified. |
2013-01-15 |
2023-08-12 |
mouse |
| Niko P Bretz, Alexei V Salnikov, Claudia Perne, Sascha Keller, Xiaoli Wang, Claudia T Mierke, Mina Fogel, Natalie Erbe-Hofmann, Thomas Schlange, Gerhard Moldenhauer, Peter Altevog. CD24 controls Src/STAT3 activity in human tumors. Cellular and molecular life sciences : CMLS. vol 69. issue 22. 2013-01-08. PMID:22760497. |
depletion of cd24 reduced cell proliferation and adhesion, enhanced apoptosis, and regulated the expression of various genes some of which were identified as stat3 target genes. |
2013-01-08 |
2023-08-12 |
mouse |
| Lorna W Harries, Alexander D Fellows, Luke C Pilling, Dena Hernandez, Andrew Singleton, Stefania Bandinelli, Jack Guralnik, Jonathan Powell, Luigi Ferrucci, David Melze. Advancing age is associated with gene expression changes resembling mTOR inhibition: evidence from two human populations. Mechanisms of ageing and development. vol 133. issue 8. 2012-12-31. PMID:22813852. |
genes involved in insulin signaling (pten, pi3k, pdk1), ribosomal biogenesis (s6k), lipid metabolism (srebf1), cellular apoptosis (sgk1), angiogenesis (vegfb), insulin production and sensitivity (foxo), cellular stress response (hif1a) and cytoskeletal remodeling (pkc) were inversely correlated with age, whereas genes relating to inhibition of ribosomal components (4ebp1) and inflammatory mediators (stat3) were positively associated with age in one or both datasets. |
2012-12-31 |
2023-08-12 |
human |
| Burçin Tezcanli Kaymaz, Nur Selvi, Güray Saydam, Fahri Sahin, Buket Kosov. Methylprednisolone induces apoptosis by interacting with the JAK/STAT pathway in HL-60 and K-562 leukemic cells. Hematology (Amsterdam, Netherlands). vol 17. issue 2. 2012-12-14. PMID:22664047. |
to determine the gene expression profiles of the jak/stat pathway members stat3, stat5a, stat5b at both mrna and protein levels in hl-60 and k-562 leukemia cells that were undergoing apoptosis following high-dose methylprednisolone (mp) treatment. |
2012-12-14 |
2023-08-12 |
Not clear |
| Chunhua Yu, Qiuyang Zhang, Hui Ying Zhang, Xi Zhang, Xiaofang Huo, Edaire Cheng, David H Wang, Jack L Arbiser, Stuart Jon Spechler, Rhonda F Souz. Targeting the intrinsic inflammatory pathway: honokiol exerts proapoptotic effects through STAT3 inhibition in transformed Barrett's cells. American journal of physiology. Gastrointestinal and liver physiology. vol 303. issue 5. 2012-12-11. PMID:22744336. |
we used human barrett's epithelial and esophageal adenocarcinoma cell lines to determine effects of honokiol on cell number, necrosis, apoptosis, and anchorage-independent growth and to explore stat3's role in those effects. |
2012-12-11 |
2023-08-12 |
human |
| Chunhua Yu, Qiuyang Zhang, Hui Ying Zhang, Xi Zhang, Xiaofang Huo, Edaire Cheng, David H Wang, Jack L Arbiser, Stuart Jon Spechler, Rhonda F Souz. Targeting the intrinsic inflammatory pathway: honokiol exerts proapoptotic effects through STAT3 inhibition in transformed Barrett's cells. American journal of physiology. Gastrointestinal and liver physiology. vol 303. issue 5. 2012-12-11. PMID:22744336. |
cells were infected with constitutively active stat3-c to assess effects of honokiol-induced stat3 inhibition on apoptosis. |
2012-12-11 |
2023-08-12 |
human |
| Chunhua Yu, Qiuyang Zhang, Hui Ying Zhang, Xi Zhang, Xiaofang Huo, Edaire Cheng, David H Wang, Jack L Arbiser, Stuart Jon Spechler, Rhonda F Souz. Targeting the intrinsic inflammatory pathway: honokiol exerts proapoptotic effects through STAT3 inhibition in transformed Barrett's cells. American journal of physiology. Gastrointestinal and liver physiology. vol 303. issue 5. 2012-12-11. PMID:22744336. |
within 30 min of honokiol treatment, transformed barrett's cells decreased expression of phosphorylated stat3; decreases in ras activity and phosphorylated erk1/2 expression were detected at 24 h. infection with stat3-c significantly reduced apoptosis after honokiol treatment. |
2012-12-11 |
2023-08-12 |
human |
| Chunhua Yu, Qiuyang Zhang, Hui Ying Zhang, Xi Zhang, Xiaofang Huo, Edaire Cheng, David H Wang, Jack L Arbiser, Stuart Jon Spechler, Rhonda F Souz. Targeting the intrinsic inflammatory pathway: honokiol exerts proapoptotic effects through STAT3 inhibition in transformed Barrett's cells. American journal of physiology. Gastrointestinal and liver physiology. vol 303. issue 5. 2012-12-11. PMID:22744336. |
honokiol causes necrosis and apoptosis in transformed barrett's and esophageal adenocarcinoma cells, but not in nontransformed barrett's cells, and the proapoptotic effects of honokiol are mediated by its inhibition of stat3 signaling. |
2012-12-11 |
2023-08-12 |
human |
| Wan Du, Jie Hong, Ying-Chao Wang, Yan-Jie Zhang, Ping Wang, Wen-Yu Su, Yan-Wei Lin, Rong Lu, Wei-Ping Zou, Hua Xiong, Jing-Yuan Fan. Inhibition of JAK2/STAT3 signalling induces colorectal cancer cell apoptosis via mitochondrial pathway. Journal of cellular and molecular medicine. vol 16. issue 8. 2012-12-03. PMID:22050790. |
to investigate the role of both jak2 and stat3 in the mechanism underlying crc apoptosis, we inhibited jak2 with ag490 and depleted stat3 with a small interfering rna. |
2012-12-03 |
2023-08-12 |
Not clear |
| Karolina Swiatek-Machado, Bozena Kaminsk. STAT signaling in glioma cells. Advances in experimental medicine and biology. vol 986. 2012-11-29. PMID:22879070. |
while stat1 is believed to play an important role in growth arrest and apoptosis, and to act as a tumor suppressor, stat3 and 5 are involved in promoting cell cycle progression, cellular transformation, and preventing apoptosis. |
2012-11-29 |
2023-08-12 |
human |
| Brent J Tierney, Georgia A McCann, David E Cohn, Eric Eisenhauer, Meryl Sudhakar, Periannan Kuppusamy, Kálmán Hideg, Karuppaiyah Selvendira. HO-3867, a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1-mutated ovarian cancer cells. Cancer biology & therapy. vol 13. issue 9. 2012-11-26. PMID:22801507. |
ho-3867, a stat3 inhibitor induces apoptosis by inactivation of stat3 activity in brca1-mutated ovarian cancer cells. |
2012-11-26 |
2023-08-12 |
Not clear |
| Brent J Tierney, Georgia A McCann, David E Cohn, Eric Eisenhauer, Meryl Sudhakar, Periannan Kuppusamy, Kálmán Hideg, Karuppaiyah Selvendira. HO-3867, a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1-mutated ovarian cancer cells. Cancer biology & therapy. vol 13. issue 9. 2012-11-26. PMID:22801507. |
in addition, overexpression of stat3 cdna provided resistance to ho-3867-induced apoptosis. |
2012-11-26 |
2023-08-12 |
Not clear |
| J L Ríos, I Andújar, J M Escandell, R M Giner, M C Reci. Cucurbitacins as inducers of cell death and a rich source of potential anticancer compounds. Current pharmaceutical design. vol 18. issue 12. 2012-10-17. PMID:22443631. |
in general, cucurbitacins are considered to be selective inhibitors of the jak/stat pathways; however, other mechanisms may be implicated in their apoptotic effects, including the mapk pathway (known to be important for cancer cell proliferation and survival), parp cleavage, expression of active caspase-3, decreased pstat3 and jak3 levels, as well as decreases in various downstream stat3 targets such as mcl-1, bcl-2, bcl-xl, and cyclin d3, all of which are implicated in apoptosis and the cell cycle. |
2012-10-17 |
2023-08-12 |
Not clear |
| Mercedes Tkach, Lorena Coria, Cinthia Rosemblit, Martín A Rivas, Cecilia J Proietti, María Celeste Díaz Flaqué, Wendy Beguelin, Isabel Frahm, Eduardo H Charreau, Juliana Cassataro, Patricia V Elizalde, Roxana Schillac. Targeting Stat3 induces senescence in tumor cells and elicits prophylactic and therapeutic immune responses against breast cancer growth mediated by NK cells and CD4+ T cells. Journal of immunology (Baltimore, Md. : 1950). vol 189. issue 3. 2012-10-15. PMID:22753933. |
aberrant stat3 activation and signaling contribute to malignant transformation by promoting cell cycle progression, inhibiting apoptosis, and mediating tumor immune evasion. |
2012-10-15 |
2023-08-12 |
mouse |